• 1023 Citations
  • 19 h-Index
20052020

Research output per year

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Research Output

  • 1023 Citations
  • 19 h-Index
  • 33 Article
  • 3 Comment/debate
  • 2 Chapter
  • 1 Review article
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Article
2020

Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells

Chen, H., Chen, Y., Deng, M., John, S., Gui, X., Kansagra, A., Chen, W., Kim, J., Lewis, C., Wu, G., Xie, J., Zhang, L., Huang, R., Liu, X., Arase, H., Huang, Y., Yu, H., Luo, W., Xia, N., Zhang, N. & 2 others, An, Z. & Zhang, C. C., Aug 7 2020, In : Journal for ImmunoTherapy of Cancer. 8, 2, e000515.

Research output: Contribution to journalArticle

Open Access

LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells

Li, Z., Deng, M., Huang, F., Jin, C., Sun, S., Chen, H., Liu, X., He, L., Sadek, A. H. & Zhang, C. C., Mar 1 2020, In : Cellular and Molecular Immunology. 17, 3, p. 272-282 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development

Gui, X., Deng, M., Song, H., Chen, Y., Xie, J., Li, Z., He, L., Huang, F., Xu, Y., Anami, Y., Yu, H., Yu, C., Li, L., Yuan, Z., Xu, X., Wang, Q., Chai, Y., Huang, T., Shi, Y., Tsuchikama, K. & 6 others, Charlene Liao, X., Xia, N., Gao, G. F., Zhang, N., Zhang, C. C. & An, Z., 2019, In : Cancer Immunology Research. 7, 8, p. 1244-1257 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2018

A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML

John, S., Chen, H., Deng Ph.D., M., Gui, X., Wu, G., Chen, W., Li, Z., Zhang, N., An, Z. & Zhang, C., Oct 3 2018, In : Molecular Therapy. 26, 10, p. 2487-2495 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Frontiers and Opportunities: Highlights of the 2nd Annual Conference of the Chinese Antibody Society

Zhang, H., Deng, M., Lin, P., Liu, J., Liu, C., Strohl, W. R., Wang, S. & Ho, M., Nov 5 2018, In : Antibody Therapeutics. 1, 2, p. 65-74 10 p., tby009.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

NK cell-mediated anti-leukemia cytotoxicity is enhanced using a NKG2D ligand MICA and anti-CD20 scfv chimeric protein

Zou, Y., Luo, W., Guo, J., Luo, Q., Deng Ph.D., M., Lu, Z., Fang, Y. & Zhang, C., Oct 2018, In : European Journal of Immunology. 48, 10, p. 1750-1763 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

The sumoylation modulated tumor suppressor p 53 regulates cell cycle checking genes to mediate lens differentiation

Tang, X., Chen, Z., Deng, M., Wang, L., Nie, Q., Xiang, J. W., Xiao, Y., Yang, L., Liu, Y. & Wan-Cheng Li, D., Jan 1 2018, In : Current molecular medicine. 18, 8, p. 556-565 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Enzymatic conjugation using branched linkers for constructing homogeneous antibody-drug conjugates with high potency

Anami, Y., Xiong, W., Gui, X., Deng Ph.D., M., Zhang, C., Zhang, N., An, Z. & Tsuchikama, K., Jan 1 2017, In : Organic and Biomolecular Chemistry. 15, 26, p. 5635-5642 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2016

Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors

Kang, X., Kim, J., Deng Ph.D., M., John, S., Chen, H., Wu, G., Phan, H. & Zhang, C., Jan 1 2016, In : Cell Cycle. 15, 1, p. 25-40 16 p.

Research output: Contribution to journalArticle

61 Scopus citations

The small heat shock protein βA-crystallin negatively regulates pancreatic tumorigenesis

Liu, J., Luo, Z., Zhang, L., Wang, L., Nie, Q., Wang, Z. F., Huang, Z., Hu, X., Gong, L., Arrigo, A. P., Tang, X., Xiang, J. W., Liu, F., Deng, M., Ji, W., Hu, W., Zhu, J. Y., Chen, B., Bridge, J., Hollingsworth, M. A. & 4 others, Gigantelli, J., Liu, Y., Nguyen, Q. D. & Li, D. W. C., 2016, In : Oncotarget. 7, 40, p. 65808-65824 17 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Inhibitory leukocyte immunoglobulin-like receptors in cancer development

Zhang, F. F., Zheng, J. K., Kang, X. L., Deng Ph.D., M., Lu, Z., Kim, J. & Zhang, C., Dec 1 2015, In : Science China Life Sciences. 58, 12, p. 1216-1225 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pias1 is essential for erythroid and vascular development in the mouse embryo

Constanzo, J. D., Deng Ph.D., M., Rindhe, S., Tang, K. J., Zhang, C. & Scaglioni, P. P., Nov 17 2015, (Accepted/In press) In : Developmental Biology.

Research output: Contribution to journalArticle

10 Scopus citations

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

Kang, X., Lu, Z., Cui, C., Deng Ph.D., M., Fan, Y., Dong, B., Han, X., Xie, F., Tyner, J. W., Coligan, J. E., Collins, R. H., Xiao, X., You, M. J. & Zhang, C., May 5 2015, In : Nature Cell Biology. 17, 5, p. 665-677 13 p.

Research output: Contribution to journalArticle

63 Scopus citations
2014

A motif in LILRB2 critical for Angptl2 binding and activation

Deng Ph.D., M., Lu, Z., Zheng, J., Wan, X., Chen, X., Hirayasu, K., Sun, H., Lam, Y., Chen, L., Wang, Q., Song, C., Huang, N., Gao, G. F., Jiang, Y., Arase, H. & Zhang, C., Aug 7 2014, In : Blood. 124, 6, p. 924-935 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

Yu, X., Wang, Y., Deng Ph.D., M., Li, Y., Ruhn, K. A., Zhang, C. & Hooper, L. V., Oct 13 2014, In : eLife. 3, e04406.

Research output: Contribution to journalArticle

140 Scopus citations
2013

PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells

Chen, P. C., Li, C., Wang, D., Luo, Z. W., Fu, S. J., Li, X., Li, Z. L., Chen, X. W., Li, L., Huang, Z. X., Ji, W. K., Hu, W. F., Hu, X. H., Deng, M., Gong, L., Chen, H. G., Liu, J. P. & Li, D. W. C., Jan 1 2013, In : Current molecular medicine. 13, 1, p. 220-227 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2012

A novel spider peptide toxin suppresses tumor growth through dual signaling pathways

Liu, Z., Deng, M., Xiang, J., Ma, H., Hu, W., Zhao, Y., Li, D. W. C. & Liang, S., Dec 3 2012, In : Current molecular medicine. 12, 10, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

The p53-Bak apoptotic signaling axis plays an essential role in regulating differentiation of the ocular lens

Deng, M., Chen, P., Liu, F., Fu, S., Tang, H., Fu, Y., Xiong, Z., Hui, S., Ji, W., Zhang, X., Zhang, L., Gong, L., Hu, X., Hu, W., Sun, S., Liu, J., Xiao, L., Liu, W. B., Xiao, Y. M., Liu, S. J. & 2 others, Liu, Y. & Li, D. W. C., 2012, In : Current molecular medicine. 12, 8, p. 901-916 16 p.

Research output: Contribution to journalArticle

20 Scopus citations

The PP2A-Aβ gene is regulated by multiple transcriptional factors including Ets-1, SP1/SP3, and RXRα/β

Liu, J., Ji, W., Sun, S., Zhang, L., Chen, H. G., Mao, Y., Liu, L., Zhang, X., Gong, L., Deng, M., Chen, L., Han, W. J., Chen, P. C., Hu, W. F., Hu, X., Liu, J., Woodward, Z., Liu, W. B., Xiao, Y. M., Liang, S. P. & 3 others, Liu, Y., Liu, S. J. & Li, D. W. C., 2012, In : Current molecular medicine. 12, 8, p. 982-994 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation

Liu, F. Y., Tang, X. C., Deng, M., Chen, P., Ji, W., Zhang, X., Gong, L., Woodward, Z., Liu, J., Zhang, L., Sun, S., Liu, J. P., Wu, K., Wu, M. X., Liu, X. L., Yu, M. B., Liu, Y. & Li, D. W. C., 2012, In : Current molecular medicine. 12, 8, p. 917-928 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

αA- and αB-crystallins interact with caspase-3 and bax to guard mouse lens development

Hu, W. F., Gong, L., Cao, Z., Ma, H., Ji, W., Deng, M., Liu, M., Hu, X. H., Chen, P., Yan, Q., Chen, H. G., Liu, J., Sun, S., Zhang, L., Liu, J. P., Wawrousek, E. & Li, D. W. C., Feb 2012, In : Current molecular medicine. 12, 2, p. 177-187 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2011

Knockdown of akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways

Zhang, L., Sun, S., Zhou, J., Liu, J., Lv, J. H., Yu, X. Q., Li, C., Gong, L., Yan, Q., Deng, M., Xiao, L., Ma, H., Liu, J. P., Peng, Y. L., Wang, D., Liao, G. P., Zou, L. J., Liu, W. B., Xiao, Y. M. & Li, D. W. C., Jul 1 2011, In : Antioxidants and Redox Signaling. 15, 1, p. 1-17 17 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Apoptosis: Its functions and control in the ocular lens

Zhang, L., Yan, Q., Liu, J. P., Zou, L. J., Liu, J., Sun, S., Deng, M., Gong, L., Ji, W. K. & Li, D. W. C., 2010, In : Current molecular medicine. 10, 9, p. 864-875 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Molecular cloning of the genes encoding the pr55/bβ/δ regulatory subunits for PP-2A and analysis of their functions in regulating development of goldfish, Carassius auratus

Zhao, J. Q., Xie, S. S., Liu, W. B., Xiao, Y. M., Zeng, X. M., Deng, M., Gong, L., Liu, J. P., Chen, P. C., Zhou, J., Hu, X. H., Lv, J. H., Yu, X. Q., Wang, D., Li, C., Peng, Y. L., Liao, G. P., Liu, Y. & Li, D. W. C., 2010, In : Gene Regulation and Systems Biology. 2010, 4, p. 135-148 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation

Xiao, L., Gong, L. L., Yuan, D., Deng, M., Zeng, X. M., Chen, L. L., Zhang, L., Yan, Q., Liu, J. P., Hu, X. H., Sun, S. M., Liu, J., Ma, H. L., Zheng, C. B., Fu, H., Chen, P. C., Zhao, J. Q., Xie, S. S., Zou, L. J., Xiao, Y. M. & 4 others, Liu, W. B., Zhang, J., Liu, Y. & Li, D. W. C., Sep 2010, In : Cell Death and Differentiation. 17, 9, p. 1448-1462 15 p.

Research output: Contribution to journalArticle

65 Scopus citations

Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development

Yan, Q., Gong, L., Deng, M., Zhang, L., Sun, S., Liu, J., Ma, H., Yuan, D., Chen, P. C., Hu, X., Liu, J., Qin, J., Xiao, L., Huang, X. Q., Zhang, J. & Li, D. W. C., Dec 7 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 49, p. 21034-21039 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

The small heat shock protein α A-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis

Deng, M., Chen, P. C., Xie, S., Zhao, J., Gong, L., Liu, J., Zhang, L., Sun, S., Liu, J., Ma, H., Batra, S. K. & Li, D. W. C., Jul 1 2010, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1802, 7-8, p. 621-631 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Transcriptional regulation of PP2A-Aα is mediated by multiple factors including AP-2α, CREB, ETS-1, and SP-1

Chen, H. G., Han, W. J., Deng, M., Qin, J., Yuan, D., Liu, J. P., Xiao, L., Gong, L., Liang, S., Zhang, J., Liu, Y. & Li, D. W. C., Sep 14 2009, In : PloS one. 4, 9, e7019.

Research output: Contribution to journalArticle

18 Scopus citations
2008

Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-bak apoptotic pathway

Qin, J., Chen, H. G., Yan, Q., Deng, M., Liu, J., Doerge, S., Ma, W., Dong, Z. & Li, D. W. C., Jun 1 2008, In : Cancer research. 68, 11, p. 4150-4162 13 p.

Research output: Contribution to journalArticle

51 Scopus citations
2007

Protein phosphatase-1 modulates the function of Pax-6, a transcription factor controlling brain and eye development

Yan, Q., Liu, W. B., Qin, J., Liu, J., Chen, H. G., Huang, X., Chen, L., Sun, S., Deng, M., Gong, L., Li, Y., Zhang, L., Liu, Y., Feng, H., Xiao, Y., Liu, Y. & Li, D. W. C., May 11 2007, In : Journal of Biological Chemistry. 282, 19, p. 13954-13965 12 p.

Research output: Contribution to journalArticle

41 Scopus citations
2006

Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities

Li, D. W. C., Liu, J. P., Schmid, P. C., Schlosser, R., Feng, H., Liu, W. B., Yan, Q., Gong, L., Sun, S. M., Deng, M. & Liu, Y., May 18 2006, In : Oncogene. 25, 21, p. 3006-3022 17 p.

Research output: Contribution to journalArticle

74 Scopus citations
2005

hTERT extends proliferative lifespan and prevents oxidative stress-induced apoptosis in human lens epithelial cells

Huang, X. Q., Wang, J., Liu, J. P., Feng, H., Liu, W. B., Yan, Q., Liu, Y., Sun, S. M., Deng, M., Gong, L., Liu, Y. & Li, D. W. C., 2005, In : Investigative Ophthalmology and Visual Science. 46, 7, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway

Wang, J., Feng, H., Huang, X. Q., Xiang, H., Mao, Y. W., Liu, J. P., Yan, Q., Liu, W. B., Liu, Y., Deng, M., Gong, L., Sun, S., Luo, C., Liu, S. J., Zhang, X. J., Liu, Y. & Li, D. W. C., Jun 17 2005, In : Journal of Biological Chemistry. 280, 24, p. 22776-22787 12 p.

Research output: Contribution to journalArticle

29 Scopus citations