• 894 Citations
  • 18 h-Index
20052019
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Research Output 2005 2019

  • 894 Citations
  • 18 h-Index
  • 30 Article
  • 2 Chapter
  • 2 Comment/debate
  • 1 Review article
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Article
2019
1 Citation (Scopus)

Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development

Gui, X., Deng, M., Song, H., Chen, Y., Xie, J., Li, Z., He, L., Huang, F., Xu, Y., Anami, Y., Yu, H., Yu, C., Li, L., Yuan, Z., Xu, X., Wang, Q., Chai, Y., Huang, T., Shi, Y., Tsuchikama, K. & 6 others, Charlene Liao, X., Xia, N., Gao, G. F., Zhang, N., Zhang, C. C. & An, Z., Jan 1 2019, In : Cancer Immunology Research. 7, 8, p. 1244-1257 14 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Acute Myeloid Leukemia
Immunoglobulins
Leukocytes
T-Lymphocytes
2018
7 Citations (Scopus)

A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML

John, S., Chen, H., Deng Ph.D., M., Gui, X., Wu, G., Chen, W., Li, Z., Zhang, N., An, Z. & Zhang, C., Jan 1 2018, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Acute Myeloid Leukemia
Immunoglobulins
Leukocytes
Myeloid Cells
1 Citation (Scopus)

NK cell-mediated anti-leukemia cytotoxicity is enhanced using a NKG2D ligand MICA and anti-CD20 scfv chimeric protein

Zou, Y., Luo, W., Guo, J., Luo, Q., Deng Ph.D., M., Lu, Z., Fang, Y. & Zhang, C., Oct 1 2018, In : European Journal of Immunology. 48, 10, p. 1750-1763 14 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Leukemia
Ligands
Proteins
Recombinant Proteins
1 Citation (Scopus)

The Sumoylation Modulated Tumor Suppressor p53 Regulates Cell Cycle Checking Genes to Mediate Lens Differentiation

Tang, X., Chen, Z., Deng Ph.D., M., Wang, L., Nie, Q., Xiang, J. W., Xiao, Y., Yang, L., Liu, Y. & Li, D. W. C., Jan 1 2018, In : Current molecular medicine. 18, 8, p. 556-565 10 p.

Research output: Contribution to journalArticle

Sumoylation
cdc Genes
Lenses
Tumors
Genes
2017
20 Citations (Scopus)

Enzymatic conjugation using branched linkers for constructing homogeneous antibody-drug conjugates with high potency

Anami, Y., Xiong, W., Gui, X., Deng Ph.D., M., Zhang, C., Zhang, N., An, Z. & Tsuchikama, K., 2017, In : Organic and Biomolecular Chemistry. 15, 26, p. 5635-5642 8 p.

Research output: Contribution to journalArticle

antibodies
conjugation
drugs
Antibodies
Pharmaceutical Preparations
2016
42 Citations (Scopus)

Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors

Kang, X., Kim, J., Deng Ph.D., M., John, S., Chen, H., Wu, G., Phan, H. & Zhang, C., Jan 1 2016, In : Cell Cycle. 15, 1, p. 25-40 16 p.

Research output: Contribution to journalArticle

Immunoglobulins
Leukocytes
Non-Receptor Type 6 Protein Tyrosine Phosphatase
Neoplasms
Proteins
2 Citations (Scopus)

The small heat shock protein βA-crystallin negatively regulates pancreatic tumorigenesis

Liu, J., Luo, Z., Zhang, L., Wang, L., Nie, Q., Wang, Z. F., Huang, Z., Hu, X., Gong, L., Arrigo, A. P., Tang, X., Xiang, J. W., Liu, F., Deng, M., Ji, W., Hu, W., Zhu, J. Y., Chen, B., Bridge, J., Hollingsworth, M. A. & 4 others, Gigantelli, J., Liu, Y., Nguyen, Q. D. & Li, D. W. C., Jan 1 2016, In : Oncotarget. 7, 40, p. 65808-65824 17 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Crystallins
Staphylococcal Protein A
Carcinogenesis
Pancreatic Neoplasms
2015
11 Citations (Scopus)

Inhibitory leukocyte immunoglobulin-like receptors in cancer development

Zhang, F. F., Zheng, J. K., Kang, X. L., Deng Ph.D., M., Lu, Z., Kim, J. & Zhang, C., Dec 1 2015, In : Science China Life Sciences. 58, 12, p. 1216-1225 10 p.

Research output: Contribution to journalArticle

Non-Receptor Type 6 Protein Tyrosine Phosphatase
immunoglobulins
Immunoglobulins
cancer
leukocytes
7 Citations (Scopus)

Pias1 is essential for erythroid and vascular development in the mouse embryo

Constanzo, J. D., Deng Ph.D., M., Rindhe, S., Tang, K. J., Zhang, C. & Scaglioni, P. P., Nov 17 2015, (Accepted/In press) In : Developmental Biology.

Research output: Contribution to journalArticle

Protein Inhibitors of Activated STAT
Yolk Sac
Blood Vessels
Embryonic Structures
Myocardium
51 Citations (Scopus)

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

Kang, X., Lu, Z., Cui, C., Deng Ph.D., M., Fan, Y., Dong, B., Han, X., Xie, F., Tyner, J. W., Coligan, J. E., Collins, R. H., Xiao, X., You, M. J. & Zhang, C., May 5 2015, In : Nature Cell Biology. 17, 5, p. 665-677 13 p.

Research output: Contribution to journalArticle

Immunoreceptor Tyrosine-Based Inhibition Motif
Acute Myeloid Leukemia
Leukemia
Myeloid Progenitor Cells
Hematopoiesis
2014
36 Citations (Scopus)

A motif in LILRB2 critical for Angptl2 binding and activation

Deng Ph.D., M., Lu, Z., Zheng, J., Wan, X., Chen, X., Hirayasu, K., Sun, H., Lam, Y., Chen, L., Wang, Q., Song, C., Huang, N., Gao, G. F., Jiang, Y., Arase, H. & Zhang, C., Aug 7 2014, In : Blood. 124, 6, p. 924-935 12 p.

Research output: Contribution to journalArticle

Immunoglobulins
Leukocytes
Chemical activation
Stem cells
Hematopoietic Stem Cells
122 Citations (Scopus)

The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

Yu, X., Wang, Y., Deng Ph.D., M., Li, Y., Ruhn, K. A., Zhang, C. & Hooper, L. V., Oct 13 2014, In : eLife. 3

Research output: Contribution to journalArticle

Basic-Leucine Zipper Transcription Factors
Bone
Transcription Factors
Cells
Lymphocytes
2013
2 Citations (Scopus)

PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells

Chen, P. C., Li, C., Wang, D., Luo, Z. W., Fu, S. J., Li, X., Li, Z. L., Chen, X. W., Li, L., Huang, Z. X., Ji, W. K., Hu, W. F., Hu, X. H., Deng, M., Gong, L., Chen, H. G., Liu, J. P. & Li, D. W. C., Jan 1 2013, In : Current Molecular Medicine. 13, 1, p. 220-227 8 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Display devices
Cells
Phosphoprotein Phosphatases
Protein Isoforms
2012
34 Citations (Scopus)

A novel spider peptide toxin suppresses tumor growth through dual signaling pathways

Liu, Z., Deng, M., Xiang, J., Ma, H., Hu, W., Zhao, Y., Li, D. W. C. & Liang, S., Dec 3 2012, In : Current Molecular Medicine. 12, 10, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

Spiders
Tumors
Spider Venoms
Peptides
Growth
19 Citations (Scopus)

The p53-Bak apoptotic signaling axis plays an essential role in regulating differentiation of the ocular lens

Deng, M., Chen, P., Liu, F., Fu, S., Tang, H., Fu, Y., Xiong, Z., Hui, S., Ji, W., Zhang, X., Zhang, L., Gong, L., Hu, X., Hu, W., Sun, S., Liu, J., Xiao, L., Liu, W. B., Xiao, Y. M., Liu, S. J. & 2 others, Liu, Y. & Li, D. W. C., Sep 27 2012, In : Current Molecular Medicine. 12, 8, p. 901-916 16 p.

Research output: Contribution to journalArticle

Crystalline Lens
Lenses
Cell Differentiation
Cytoplasm
Apoptosis
8 Citations (Scopus)

The PP2A-Aβ gene is regulated by multiple transcriptional factors including Ets-1, SP1/SP3, and RXRα/β

Liu, J., Ji, W., Sun, S., Zhang, L., Chen, H. G., Mao, Y., Liu, L., Zhang, X., Gong, L., Deng, M., Chen, L., Han, W. J., Chen, P. C., Hu, W. F., Hu, X., Liu, J., Woodward, Z., Liu, W. B., Xiao, Y. M., Liang, S. P. & 3 others, Liu, Y., Liu, S. J. & Li, D. W. C., Sep 27 2012, In : Current Molecular Medicine. 12, 8, p. 982-994 13 p.

Research output: Contribution to journalArticle

Genes
Protein Phosphatase 2
Assays
Reporter Genes
Scaffolds
19 Citations (Scopus)

The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation

Liu, F. Y., Tang, X. C., Deng, M., Chen, P., Ji, W., Zhang, X., Gong, L., Woodward, Z., Liu, J., Zhang, L., Sun, S., Liu, J. P., Wu, K., Wu, M. X., Liu, X. L., Yu, M. B., Liu, Y. & Li, D. W. C., Sep 27 2012, In : Current Molecular Medicine. 12, 8, p. 917-928 12 p.

Research output: Contribution to journalArticle

Naproxen
Lenses
Tumors
Crystalline Lens
MafF Transcription Factor
44 Citations (Scopus)

αA- and αB-crystallins interact with caspase-3 and bax to guard mouse lens development

Hu, W. F., Gong, L., Cao, Z., Ma, H., Ji, W., Deng, M., Liu, M., Hu, X. H., Chen, P., Yan, Q., Chen, H. G., Liu, J., Sun, S., Zhang, L., Liu, J. P., Wawrousek, E. & Li, D. W. C., Feb 1 2012, In : Current Molecular Medicine. 12, 2, p. 177-187 11 p.

Research output: Contribution to journalArticle

Crystallins
Caspase 3
Lenses
Caspase 2
Caspases
2011
18 Citations (Scopus)

Knockdown of akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways

Zhang, L., Sun, S., Zhou, J., Liu, J., Lv, J. H., Yu, X. Q., Li, C., Gong, L., Yan, Q., Deng, M., Xiao, L., Ma, H., Liu, J. P., Peng, Y. L., Wang, D., Liao, G. P., Zou, L. J., Liu, W. B., Xiao, Y. M. & Li, D. W. C., Jul 1 2011, In : Antioxidants and Redox Signaling. 15, 1, p. 1-17 17 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Up-Regulation
Apoptosis
Phosphorylation
2010
29 Citations (Scopus)

Apoptosis: Its functions and control in the ocular lens

Zhang, L., Yan, Q., Liu, J. P., Zou, L. J., Liu, J., Sun, S., Deng, M., Gong, L., Ji, W. K. & Li, D. W. C., Dec 1 2010, In : Current Molecular Medicine. 10, 9, p. 864-875 12 p.

Research output: Contribution to journalArticle

Crystalline Lens
Lenses
Apoptosis
Ectoderm
Epithelial Cells
10 Citations (Scopus)

Molecular cloning of the genes encoding the pr55/bβ/δ regulatory subunits for PP-2A and analysis of their functions in regulating development of goldfish, Carassius auratus

Zhao, J. Q., Xie, S. S., Liu, W. B., Xiao, Y. M., Zeng, X. M., Deng, M., Gong, L., Liu, J. P., Chen, P. C., Zhou, J., Hu, X. H., Lv, J. H., Yu, X. Q., Wang, D., Li, C., Peng, Y. L., Liao, G. P., Liu, Y. & Li, D. W. C., Dec 1 2010, In : Gene Regulation and Systems Biology. 2010, 4, p. 135-148 14 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
phosphoprotein phosphatase
Goldfish
Gene encoding
Carassius auratus
61 Citations (Scopus)

Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation

Xiao, L., Gong, L. L., Yuan, D., Deng, M., Zeng, X. M., Chen, L. L., Zhang, L., Yan, Q., Liu, J. P., Hu, X. H., Sun, S. M., Liu, J., Ma, H. L., Zheng, C. B., Fu, H., Chen, P. C., Zhao, J. Q., Xie, S. S., Zou, L. J., Xiao, Y. M. & 4 others, Liu, W. B., Zhang, J., Liu, Y. & Li, D. W. C., Sep 1 2010, In : Cell Death and Differentiation. 17, 9, p. 1448-1462 15 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Phosphoric Monoester Hydrolases
Cell Differentiation
Signal Transduction
Cell Survival
74 Citations (Scopus)

Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development

Yan, Q., Gong, L., Deng, M., Zhang, L., Sun, S., Liu, J., Ma, H., Yuan, D., Chen, P. C., Hu, X., Liu, J., Qin, J., Xiao, L., Huang, X. Q., Zhang, J. & Li, D. W. C., Dec 7 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 49, p. 21034-21039 6 p.

Research output: Contribution to journalArticle

Sumoylation
Protein Isoforms
Transcription Factors
DNA
Brain
19 Citations (Scopus)

The small heat shock protein α A-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis

Deng, M., Chen, P. C., Xie, S., Zhao, J., Gong, L., Liu, J., Zhang, L., Sun, S., Liu, J., Ma, H., Batra, S. K. & Li, D. W. C., Jul 1 2010, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1802, 7-8, p. 621-631 11 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Crystallins
Staphylococcal Protein A
Pancreas
Carcinogenesis
2009
17 Citations (Scopus)

Transcriptional regulation of PP2A-Aα is mediated by multiple factors including AP-2α, CREB, ETS-1, and SP-1

Chen, H. G., Han, W. J., Deng, M., Qin, J., Yuan, D., Liu, J. P., Xiao, L., Gong, L., Liang, S., Zhang, J., Liu, Y. & Li, D. W. C., Sep 14 2009, In : PLoS One. 4, 9, e7019.

Research output: Contribution to journalArticle

Genes
promoter regions
Protein Phosphatase 2
phosphoprotein phosphatase
Transcription Factor AP-1
2008
49 Citations (Scopus)

Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-bak apoptotic pathway

Qin, J., Chen, H. G., Yan, Q., Deng, M., Liu, J., Doerge, S., Ma, W., Dong, Z. & Li, D. W. C., Jun 1 2008, In : Cancer Research. 68, 11, p. 4150-4162 13 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Phosphoric Monoester Hydrolases
Apoptosis
Down-Regulation
Chemoprevention
2007
39 Citations (Scopus)

Protein phosphatase-1 modulates the function of Pax-6, a transcription factor controlling brain and eye development

Yan, Q., Liu, W. B., Qin, J., Liu, J., Chen, H. G., Huang, X., Chen, L., Sun, S., Deng, M., Gong, L., Li, Y., Zhang, L., Liu, Y., Feng, H., Xiao, Y., Liu, Y. & Li, D. W. C., May 11 2007, In : Journal of Biological Chemistry. 282, 19, p. 13954-13965 12 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Brain
Transcription Factors
Phosphorylation
Phosphoprotein Phosphatases
2006
71 Citations (Scopus)

Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities

Li, D. W. C., Liu, J. P., Schmid, P. C., Schlosser, R., Feng, H., Liu, W. B., Yan, Q., Gong, L., Sun, S. M., Deng, M. & Liu, Y., May 18 2006, In : Oncogene. 25, 21, p. 3006-3022 17 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Phosphoprotein Phosphatases
Phosphorylation
Cell Survival
Threonine
2005
32 Citations (Scopus)

hTERT extends proliferative lifespan and prevents oxidative stress-induced apoptosis in human lens epithelial cells

Huang, X. Q., Wang, J., Liu, J. P., Feng, H., Liu, W. B., Yan, Q., Liu, Y., Sun, S. M., Deng, M., Gong, L., Liu, Y. & Li, D. W. C., Dec 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 7, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

Lenses
Oxidative Stress
Epithelial Cells
Apoptosis
Telomere
29 Citations (Scopus)

Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway

Wang, J., Feng, H., Huang, X. Q., Xiang, H., Mao, Y. W., Liu, J. P., Yan, Q., Liu, W. B., Liu, Y., Deng, M., Gong, L., Sun, S., Luo, C., Liu, S. J., Zhang, X. J., Liu, Y. & Li, D. W. C., Jun 17 2005, In : Journal of Biological Chemistry. 280, 24, p. 22776-22787 12 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Telomerase
Lenses
Cell Differentiation
Epithelial Cells