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1990 …2019

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2019

A composition-dependent molecular clutch between T cell signaling condensates and actin

Ditlev, J. A., Vega, A. R., Köster, D. V., Su, X., Tani, T., Lakoduk, A. M., Vale, R. D., Mayor, S., Jaqaman, K. & Rosen, M. K., Jul 3 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris

Ali, R., Clark, L. D., Zahm, J. A., Lemoff, A., Ramesh, K., Rosenbaum, D. M. & Rosen, M. K., Dec 1 2019, In : Journal of biomolecular NMR. 73, 12, p. 687-697 11 p.

Research output: Contribution to journalArticle

Open Access

Organization of Chromatin by Intrinsic and Regulated Phase Separation

Gibson, B. A., Doolittle, L. K., Schneider, M. W. G., Jensen, L. E., Gamarra, N., Henry, L., Gerlich, D. W., Redding, S. & Rosen, M. K., Oct 3 2019, In : Cell. 179, 2, p. 470-484.e21

Research output: Contribution to journalArticle

30 Scopus citations

Phosphorylation of nephrin induces phase separated domains that move through actomyosin contraction

Kim, S., Kalappurakkal, J. M., Mayor, S. & Rosen, M. K., Nov 15 2019, In : Molecular biology of the cell. 30, 24, p. 2996-3012 17 p.

Research output: Contribution to journalArticle

Open Access

Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

Case, L. B., Zhang, X., Ditlev, J. A. & Rosen, M. K., Mar 8 2019, In : Science (New York, N.Y.). 363, 6431, p. 1093-1097 5 p.

Research output: Contribution to journalArticle

25 Scopus citations
2018

Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly

Protter, D. S. W., Rao, B. S., Van Treeck, B., Lin, Y., Mizoue, L., Rosen, M. K. & Parker, R., Feb 6 2018, In : Cell Reports. 22, 6, p. 1401-1412 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Yoshizawa, T., Ali, R., Jiou, J., Fung, H. Y. J., Burke, K. A., Kim, S. J., Lin, Y., Peeples, W. B., Saltzberg, D., Soniat, M., Baumhardt, J. M., Oldenbourg, R., Sali, A., Fawzi, N. L., Rosen, M. K. & Chook, Y. M., Jan 1 2018, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

55 Scopus citations

Who's In and Who's Out—Compositional Control of Biomolecular Condensates

Ditlev, J. A., Case, L. B. & Rosen, M. K., Jan 1 2018, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

35 Scopus citations
2017

Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation

Huang, W. Y. C., Ditlev, J. A., Chiang, H. K., Rosen, M. K. & Groves, J. T., Dec 13 2017, In : Journal of the American Chemical Society. 139, 49, p. 18009-18015 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biomolecular condensates: organizers of cellular biochemistry

Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K., Feb 22 2017, (Accepted/In press) In : Nature Reviews Molecular Cell Biology.

Research output: Contribution to journalArticle

648 Scopus citations

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

Harmon, T. S., Holehouse, A. S., Rosen, M. K. & Pappu, R. V., Nov 1 2017, In : eLife. 6, e30294.

Research output: Contribution to journalArticle

92 Scopus citations

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

Lin, Y., Currie, S. L. & Rosen, M. K., Nov 17 2017, In : Journal of Biological Chemistry. 292, 46, p. 19110-19120 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

Chen, B., Chou, H. T., Brautigam, C. A., Xing, W., Yang, S., Henry, L., Doolittle, L. K., Walz, T. & Rosen, M. K., Sep 26 2017, In : eLife. 6, e29795.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster

Srinivasan, N., Gordon, O., Ahrens, S., Franz, A., Deddouche, S., Chakravarty, P., Phillips, D., Yunus, A. A., Rosen, M. K., Valente, R. S., Teixeira, L., Thompson, B., Dionne, M. S., Wood, W. & Reis e Sousa, C., Nov 22 2016, In : eLife. 5, NOVEMBER2016, e19662.

Research output: Contribution to journalArticle

22 Scopus citations

Compositional Control of Phase-Separated Cellular Bodies

Banani, S. F., Rice, A. M., Peeples, W. B., Lin, Y., Jain, S., Parker, R. & Rosen, M. K., Jul 28 2016, In : Cell. 166, 3, p. 651-663 13 p.

Research output: Contribution to journalArticle

203 Scopus citations

Data publication with the structural biology data grid supports live analysis

Meyer, P. A., Socias, S., Key, J., Ransey, E., Tjon, E. C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J., Neau, D., Rajashankar, K., Anderson, K. S., Baxter, R. H., Blacklow, S. C., Boggon, T. J., Bonvin, A. M. J. J., Borek, D., Brett, T. J., Caflisch, A., Chang, C. I. & 50 others, Chazin, W. J., Corbett, K. D., Cosgrove, M. S., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C. L., Eck, M. J., Eichman, B. F., Fan, Q. R., Ferré-D'Amaré, A. R., Fromme, J. C., Garcia, K. C., Gaudet, R., Gong, P., Harrison, S. C., Heldwein, E. E., Jia, Z., Keenan, R. J., Kruse, A. C., Kvansakul, M., McLellan, J. S., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E. F., Pereira, P. J. B., Petosa, C., Raman, C. S., Rapoport, T. A., Roll-Mecak, A., Rosen, M. K., Rudenko, G., Schlessinger, J., Schwartz, T. U., Shamoo, Y., Sondermann, H., Tao, Y. J., Tolia, N. H., Tsodikov, O. V., Westover, K. D., Wu, H., Foster, I., Fraser, J. S., Maia, F. R. N. C., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M. & Sliz, P., Mar 7 2016, In : Nature communications. 7, 10882.

Research output: Contribution to journalArticle

61 Scopus citations

Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. K. & Rosenbaum, D. M., Feb 19 2016, (Accepted/In press) In : Journal of Biomolecular NMR. p. 1 1 p.

Research output: Contribution to journalArticle

Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation

Squarr, A. J., Brinkmann, K., Chen, B., Steinbacher, T., Ebnet, K., Rosen, M. K. & Bogdan, S., 2016, In : Journal of Cell Biology. 212, 5, p. 591-603 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Phase separation of signaling molecules promotes T cell receptor signal transduction

Su, X., A. Ditlev, J., Hui, E., Xing, W., Banjade, S., Okrut, J., King, D. S., Taunton, J., Rosen, M. K. & Vale, R. D., Apr 29 2016, In : Science. 352, 6285, p. 595-599 5 p.

Research output: Contribution to journalArticle

209 Scopus citations

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

Pak, C. W., Kosno, M., Holehouse, A. S., Padrick, S. B., Mittal, A., Ali, R., Yunus, A. A., Liu, D. R., Pappu, R. V. & Rosen, M. K., Jul 7 2016, In : Molecular Cell. 63, 1, p. 72-85 14 p.

Research output: Contribution to journalArticle

175 Scopus citations

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

Jia, D., Zhang, J. S., Li, F., Wang, J., Deng, Z., White, M. A., Osborne, D. G., Phillips-Krawczak, C., Gomez, T. S., Li, H., Singla, A., Burstein, E., Billadeau, D. D. & Rosen, M. K., Nov 9 2016, In : Nature Communications. 7, 13305.

Research output: Contribution to journalArticle

31 Scopus citations

Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives

Rujirawanich, J., Kim, S., Ma, A. J., Butler, J. R., Wang, Y., Wang, C., Rosen, M., Posner, B., Nijhawanc, D. & Ready, J. M., Aug 24 2016, In : Journal of the American Chemical Society. 138, 33, p. 10561-10570 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

Banjade, S., Wu, Q., Mittal, A., Peeples, W. B., Pappu, R. V. & Rosen, M. K., Nov 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 47, p. E6426-E6435

Research output: Contribution to journalArticle

53 Scopus citations

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

Lin, Y., Protter, D. S. W., Rosen, M. K. & Parker, R., Oct 15 2015, In : Molecular Cell. 60, 2, p. 208-219 12 p.

Research output: Contribution to journalArticle

470 Scopus citations

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. & Rosenbaum, D. M., May 30 2015, (Accepted/In press) In : Journal of Biomolecular NMR.

Research output: Contribution to journalArticle

28 Scopus citations
2014

Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton

Chen, X. J., Squarr, A. J., Stephan, R., Chen, B., Higgins, T. E., Barry, D. J., Martin, M. C., Rosen, M. K., Bogdan, S. & Way, M., Sep 8 2014, In : Developmental Cell. 30, 5, p. 569-584 16 p.

Research output: Contribution to journalArticle

44 Scopus citations

Local F-actin network links synapse formation and axon branching

Chia, P. H., Chen, B., Li, P., Rosen, M. K. & Shen, K., Jan 27 2014, In : Cell. 156, 1-2, p. 208-220 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Phase transitions of multivalent proteins can promote clustering of membrane receptors

Banjade, S. & Rosen, M. K., 2014, In : eLife. 3

Research output: Contribution to journalArticle

139 Scopus citations

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation

McGough, I. J., Steinberg, F., Jia, D., Barbuti, P. A., McMillan, K. J., Heesom, K. J., Whone, A. L., Caldwell, M. A., Billadeau, D. D., Rosen, M. K. & Cullen, P. J., Jul 21 2014, In : Current Biology. 24, 14, p. 1670-1676 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

The haemophilus ducreyi lspa1 protein inhibits phagocytosis by using a new mechanism involving Activation of C-terminal src kinase

Dodd, D. A., Worth, R. G., Rosen, M. K., Grinstein, S., van Oers, N. S. C. & Hansen, E. J., May 20 2014, In : mBio. 5, 3

Research output: Contribution to journalArticle

7 Scopus citations

The WAVE regulatory complex links diverse receptors to the actin cytoskeleton

Chen, B., Brinkmann, K., Chen, Z., Pak, C. W., Liao, Y., Shi, S., Henry, L., Grishin, N. V., Bogdan, S. & Rosen, M. K., Jan 27 2014, In : Cell. 156, 1-2, p. 195-207 13 p.

Research output: Contribution to journalArticle

125 Scopus citations
2013

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination

Hao, Y. H., Doyle, J. M., Ramanathan, S., Gomez, T. S., Jia, D., Xu, M., Chen, Z. J., Billadeau, D. D., Rosen, M. K. & Potts, P. R., Feb 28 2013, In : Cell. 152, 5, p. 1051-1064 14 p.

Research output: Contribution to journalArticle

102 Scopus citations

The bacterial effector VopL organizes actin into filament-like structures

Zahm, J. A., Padrick, S. B., Chen, Z., Pak, C. W., Yunus, A. A., Henry, L., Tomchick, D. R., Chen, Z. & Rosen, M. K., Oct 10 2013, In : Cell. 155, 2, p. 423-434 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

Smith, B. A., Padrick, S. B., Doolittle, L. K., Daugherty-Clarke, K., Corrêa, I. R., Xu, M. Q., Goode, B. L., Rosen, M. K. & Gelles, J., Sep 3 2013, In : eLife. 2013, 2, e01008.

Research output: Contribution to journalArticle

55 Scopus citations
2012

In support of the BMRB.

Markley, J. L., Akutsu, H., Asakura, T., Baldus, M., Boelens, R., Bonvin, A., Kaptein, R., Bax, A., Bezsonova, I., Gryk, M. R., Hoch, J. C., Korzhnev, D. M., Maciejewski, M. W., Case, D., Chazin, W. J., Cross, T. A., Dames, S., Kessler, H., Lange, O., Madl, T. & 71 others, Reif, B., Sattler, M., Eliezer, D., Fersht, A., Forman-Kay, J., Kay, L. E., Fraser, J., Gross, J., Kortemme, T., Sali, A., Fujiwara, T., Gardner, K. H., Luo, X., Rizo-Rey, J., Rosen, M. K., Gil, R. R., Ho, C., Rule, G., Gronenborn, A. M., Ishima, R., Klein-Seetharaman, J., Tang, P., van der Wel, P., Xu, Y., Grzesiek, S., Hiller, S., Seelig, J., Laue, E. D., Mott, H., Nietlispach, D., Barsukov, I., Lian, L. Y., Middleton, D., Blumenschein, T., Moore, G., Campbell, I., Schnell, J., Vakonakis, I. J., Watts, A., Conte, M. R., Mason, J., Pfuhl, M., Sanderson, M. R., Craven, J., Williamson, M., Dominguez, C., Roberts, G., Günther, U., Overduin, M., Werner, J., Williamson, P., Blindauer, C., Crump, M., Driscoll, P., Frenkiel, T., Golovanov, A., Matthews, S., Parkinson, J., Uhrin, D., Williams, M., Neuhaus, D., Oschkinat, H., Ramos, A., Shaw, D. E., Steinbeck, C., Vendruscolo, M., Vuister, G. W., Walters, K. J., Weinstein, H., Wüthrich, K. & Yokoyama, S., Sep 2012, In : Nature structural & molecular biology. 19, 9, p. 854-860 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer

Jia, D., Gomez, T. S., Billadeau, D. D. & Rosen, M. K., Jun 15 2012, In : Molecular biology of the cell. 23, 12, p. 2352-2361 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Phase transitions in the assembly of multivalent signalling proteins

Li, P., Banjade, S., Cheng, H. C., Kim, S., Chen, B., Guo, L., Llaguno, M., Hollingsworth, J. V., King, D. S., Banani, S. F., Russo, P. S., Jiang, Q. X., Nixon, B. T. & Rosen, M. K., Mar 15 2012, In : Nature. 483, 7389, p. 336-340 5 p.

Research output: Contribution to journalArticle

633 Scopus citations
2011

Arp2/3 complex is bound and activated by two WASP proteins

Padrick, S. B., Doolittle, L. K., Brautigam, C. A., King, D. S. & Rosen, M. K., Aug 16 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 33, p. E472-E479

Research output: Contribution to journalArticle

111 Scopus citations

Mechanism of actin filament nucleation by the bacterial effector VopL

Yu, B., Cheng, H. C., Brautigam, C. A., Tomchick, D. R. & Rosen, M. K., Sep 1 2011, In : Nature Structural and Molecular Biology. 18, 9, p. 1068-1074 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements

Li, P., Martins, I. R. S. & Rosen, M. K., Sep 1 2011, In : Journal of Biomolecular NMR. 51, 1-2, p. 57-70 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Westerberg, L. S., Meelu, P., Baptista, M., Eston, M. A., Adamovich, D. A., Cotta-de-Almeida, V., Seed, B., Rosen, M. K., Vandenberghe, P., Thrasher, A. J., Klein, C., Alt, F. W. & Snapper, S. B., Jun 7 2010, In : Journal of Experimental Medicine. 207, 6, p. 1145-1152 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Crystal structure of the formin mDIA1 in autoinhibited conformation

Otomo, T., Tomchick, D. R., Otomo, C., Machius, M. & Rosen, M. K., Nov 1 2010, In : PloS one. 5, 9, p. 1-13 13 p., e12896.

Research output: Contribution to journalArticle

29 Scopus citations

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments

Padrick, S. B., Deka, R. K., Chuang, J. L., Wynn, R. M., Chuang, D. T., Norgard, M. V., Rosen, M. K. & Brautigam, C. A., Dec 2010, In : Analytical biochemistry. 407, 1, p. 89-103 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Rationally improving LOV domainĝ€"based photoswitches

Strickland, D., Yao, X., Gawlak, G., Rosen, M. K., Gardner, K. H. & Sosnick, T. R., Aug 1 2010, In : Nature methods. 7, 8, p. 623-626 4 p.

Research output: Contribution to journalArticle

126 Scopus citations

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

Yu, B., Martins, I. R. S., Li, P., Amarasinghe, G. K., Umetani, J., Fernandez-Zapico, M. E., Billadeau, D. D., Machius, M., Tomchick, D. R. & Rosen, M. K., Jan 22 2010, In : Cell. 140, 2, p. 246-256 11 p.

Research output: Contribution to journalArticle

89 Scopus citations

Structure and control of the actin regulatory WAVE complex

Chen, Z., Borek, D., Padrick, S. B., Gomez, T. S., Metlagel, Z., Ismail, A. M., Umetani, J., Billadeau, D. D., Otwinowski, Z. & Rosen, M. K., Nov 25 2010, In : Nature. 468, 7323, p. 533-538 6 p.

Research output: Contribution to journalArticle

230 Scopus citations

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

Jia, D., Gomez, T. S., Metlagel, Z., Umetani, J., Otwinowski, Z., Rosen, M. K. & Billadeau, D. D., Jun 8 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 23, p. 10442-10447 6 p.

Research output: Contribution to journalArticle

126 Scopus citations
2009

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene

Beel, K., Cotter, M. M., Blatny, J., Bond, J., Lucas, G., Green, F., Vanduppen, V., Leung, D. W., Rooney, S., Smith, O. P., Rosen, M. K. & Vandenberghe, P., Jan 1 2009, In : British Journal of Haematology. 144, 1, p. 120-126 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF U during pedestal formation

Vingadassalom, D., Kazlauskas, A., Skehan, B., Cheng, H. C., Magoun, L., Robbins, D., Rosen, M. K., Saksela, K. & Leong, J. M., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6754-6759 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

The WAVE regulatory complex is inhibited

Ismail, A. M., Padrick, S. B., Chen, B., Umetani, J. & Rosen, M. K., May 1 2009, In : Nature Structural and Molecular Biology. 16, 5, p. 561-563 3 p.

Research output: Contribution to journalArticle

95 Scopus citations