• 105252 Citations
  • 174 h-Index
1970 …2019
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Research Output 1970 2019

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Article
2019
4 Citations (Scopus)
Autophagy
Growth Hormone
Blood Glucose
Glucose
Liver
2018
3 Citations (Scopus)

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

Tian, J., Wu, J., Chen, X., Guo, T., Chen, Z. J., Goldstein, J. L. & Brown, M. S., Jun 27 2018, In : eLife. 7, e36826.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Liver
Rodentia
Transcription Factors
Insulin
5 Citations (Scopus)

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

Trinh, M. N., Brown, M. S., Seemann, J., Goldstein, J. L. & Lu, F., Jul 26 2018, In : eLife. 7, e38564.

Research output: Contribution to journalArticle

Cholesterol
Glycocalyx
Lipid Bilayers
Lysosomes
Molecules
2017
12 Citations (Scopus)
Cholesterol
Feedback
Proteins
Endoplasmic Reticulum
Membranes
2016
7 Citations (Scopus)

Direct demonstration that Loop1 of Scap binds to Loop7: A crucial event in cholesterol homeostasis

Zhang, Y., Min Lee, K., Kinch, L. N., Clark, L., Grishin, N. V., Rosenbaum, D. M., Brown, M. S., Goldstein, J. L. & Radhakrishnan, A., Jun 10 2016, In : Journal of Biological Chemistry. 291, 24, p. 12888-12896 9 p.

Research output: Contribution to journalArticle

Homeostasis
Demonstrations
Cholesterol
Endoplasmic Reticulum
Protein Transport
20 Citations (Scopus)
Sterol Regulatory Element Binding Protein 1
Rodentia
Insulin
Liver
Chromatin Immunoprecipitation
2015
300 Citations (Scopus)

A century of cholesterol and coronaries: From plaques to genes to statins

Goldstein, J. L. & Brown, M. S., Mar 26 2015, In : Cell. 161, 1, p. 161-172 12 p., 8011.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Lipoproteins
Genes
Cholesterol
Coronary Disease
93 Citations (Scopus)

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

Lu, F., Liang, Q., Abi-Mosleh, L., Das, A., de Brabander, J. K., Goldstein, J. L. & Brown, M. S., Dec 8 2015, In : eLife. 4, December2015, e12177.

Research output: Contribution to journalArticle

Ebola Hemorrhagic Fever
Anticholesteremic Agents
Cholesterol
Sterols
Crosslinking
38 Citations (Scopus)
Ghrelin
Autophagy
Growth Hormone
Fats
Liver
2014
4 Citations (Scopus)

Emerging themes in biology: Hints for the future

Nurse, P., Goldstein, J. L., Brown, M. S., Greider, C. & Baltimore, D., Mar 27 2014, In : Cell. 157, 1, p. 272-273 2 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet

McFarlane, M. R., Brown, M. S., Goldstein, J. L. & Zhao, T. J., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

Ghrelin
High Fat Diet
Eating
Body Weight
Appetite
99 Citations (Scopus)

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

Das, A., Brown, M. S., Anderson, D. D., Goldstein, J. L. & Radhakrishnan, A., Jun 11 2014, In : eLife. 2014, 3, e02882.

Research output: Contribution to journalArticle

Cell membranes
Homeostasis
Cholesterol
Cell Membrane
Sphingomyelin Phosphodiesterase
2013
15 Citations (Scopus)

Point mutation in luminal Loop 7 of scap protein blocks interaction with Loop 1 and abolishes movement to Golgi

Zhang, Y., Motamed, M., Seemann, J., Brown, M. S. & Goldstein, J. L., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14059-14067 9 p.

Research output: Contribution to journalArticle

Point Mutation
Endoplasmic Reticulum
Cholesterol
Sterol Regulatory Element Binding Proteins
Immunoprecipitation
53 Citations (Scopus)
Cholesterol
Cell Membrane
Lysosomes
Organelles
Membranes
2012
13 Citations (Scopus)

A golden era of nobel laureates

Goldstein, J. L. & Brown, M. S., Nov 23 2012, In : Science. 338, 6110, p. 1033-1034 2 p.

Research output: Contribution to journalArticle

Nobel Prize
Physicians
128 Citations (Scopus)

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Owen, J. L., Zhang, Y., Bae, S. H., Farooqi, M. S., Liang, G., Hammer, R. E., Goldstein, J. L. & Brown, M. S., Oct 2 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 40, p. 16184-16189 6 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Transgenic Rats
70-kDa Ribosomal Protein S6 Kinases
Hepatocytes
Insulin
61 Citations (Scopus)

Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids

Li, R. L., Sherbet, D. P., Elsbernd, B. L., Goldstein, J. L., Brown, M. S. & Zhao, T. J., May 25 2012, In : Journal of Biological Chemistry. 287, 22, p. 17942-17950 9 p.

Research output: Contribution to journalArticle

Ghrelin
Gluconeogenesis
Hypoglycemia
Lactic Acid
Fatty Acids
5 Citations (Scopus)

Scientific side trips: Six excursions from the beaten path

Brown, M. S. & Goldstein, J. L., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22418-22435 18 p.

Research output: Contribution to journalArticle

Monocarboxylic Acid Transporters
Dimethylallyltranstransferase
Acyltransferases
Scavenger Receptors
Biochemistry
170 Citations (Scopus)

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

Moon, Y. A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L. & Horton, J. D., Feb 8 2012, In : Cell Metabolism. 15, 2, p. 240-246 7 p.

Research output: Contribution to journalArticle

Hypertriglyceridemia
Fatty Liver
Carbohydrates
Sucrose
Insulin Resistance
2011
30 Citations (Scopus)
Amino Acid Substitution
Cholesterol
Phenotype
Lysosomes
Cyclodextrins
51 Citations (Scopus)

Identification of luminal loop 1 of scap protein as the sterol sensor that maintains cholesterol homeostasis

Motamed, M., Zhang, Y., Wang, M. L., Seemann, J., Kwon, H. J., Goldstein, J. L. & Brown, M. S., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 18002-18012 11 p.

Research output: Contribution to journalArticle

Sterols
Homeostasis
Cholesterol
Sensors
Sterol Regulatory Element Binding Proteins
54 Citations (Scopus)

Surviving starvation: Essential role of the ghrelin-growth hormone axis

Goldstein, J. L., Zhao, T. J., Li, R. L., Sherbet, D. P., Liang, G. & Brown, M. S., 2011, In : Cold Spring Harbor Symposia on Quantitative Biology. 76, p. 121-127 7 p.

Research output: Contribution to journalArticle

Ghrelin
Starvation
Growth Hormone
Blood Glucose
Neurons
2010
402 Citations (Scopus)
Lipogenesis
Gluconeogenesis
Insulin
Liver
Sterol Regulatory Element Binding Protein 1
272 Citations (Scopus)

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

Zhao, T. J., Liang, G., Li, R. L., Xie, X., Sleeman, M. W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Goldstein, J. L. & Brown, M. S., Apr 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 16, p. 7467-7472 6 p.

Research output: Contribution to journalArticle

Acyltransferases
Ghrelin
Growth Hormone
Goats
Blood Glucose
109 Citations (Scopus)
Ghrelin
Adrenergic Receptors
Cultured Cells
Atenolol
Adrenergic Agents
33 Citations (Scopus)

Hair growth defects in insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin

Evers, B. M., Farooqi, M. S., Shelton, J. M., Richardson, J. A., Goldstein, J. L., Brown, M. S. & Liang, G., May 2010, In : Journal of Investigative Dermatology. 130, 5, p. 1237-1248 12 p.

Research output: Contribution to journalArticle

Simvastatin
Knockout Mice
Hair
Skin
Cholesterol
36 Citations (Scopus)

HDL miR-ed down by SREBP introns

Brown, M. S., Ye, J. & Goldstein, J. L., Jun 18 2010, In : Science. 328, 5985, p. 1495-1496 2 p.

Research output: Contribution to journalArticle

Introns
Cholesterol
MicroRNAs
Genes
133 Citations (Scopus)

Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes

Wang, M. L., Motamed, M., Infante, R. E., Abi-Mosleh, L., Kwon, H. J., Brown, M. S. & Goldstein, J. L., Aug 4 2010, In : Cell Metabolism. 12, 2, p. 166-173 8 p.

Research output: Contribution to journalArticle

Lysosomes
Cholesterol
Water
Mutagenesis
Alanine
4 Citations (Scopus)

Joseph Goldstein and Michael Brown: demoting egos, promoting success. Interview by Ruth Williams.

Goldstein, J. & Brown, M., Apr 2 2010, In : Circulation Research. 106, 6, p. 1006-1010 5 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Nobel Prize
Ego
Cooperative Behavior
51 Citations (Scopus)

LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size

Okazaki, H., Goldstein, J. L., Brown, M. S. & Liang, G., Feb 26 2010, In : Journal of Biological Chemistry. 285, 9, p. 6801-6810 10 p.

Research output: Contribution to journalArticle

Phospholipid Transfer Proteins
Sterol Regulatory Element Binding Protein 1
VLDL Lipoproteins
Particle Size
Liver
2009
34 Citations (Scopus)

Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice

Guan, H. P., Goldstein, J. L., Brown, M. S. & Liang, G., Sep 4 2009, In : Journal of Biological Chemistry. 284, 36, p. 24644-24652 9 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Liver
Muscle
Fasting
Fatty Acids
293 Citations (Scopus)

Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL

Brown, M. S. & Goldstein, J. L., Apr 2009, In : Journal of Lipid Research. 50, SUPPL.

Research output: Contribution to journalArticle

Bottles
Cholesterol
Feedback
Sterol Regulatory Element Binding Proteins
Membranes
102 Citations (Scopus)
Cyclodextrins
Lysosomes
Endoplasmic Reticulum
Cholesterol
Esterification
1 Citation (Scopus)
Bottles
Cholesterol
Feedback
Lipids
27 Citations (Scopus)
Endoplasmic Reticulum-Associated Degradation
Proteasome Endopeptidase Complex
Sterols
Membranes
Degradation
355 Citations (Scopus)

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

Kwon, H. J., Abi-Mosleh, L., Wang, M. L., Deisenhofer, J., Goldstein, J. L., Brown, M. S. & Infante, R. E., Jun 26 2009, In : Cell. 137, 7, p. 1213-1224 12 p.

Research output: Contribution to journalArticle

Cholesterol
Lysosomes
Hydroxyl Radical
Cholesterol Esters
Endocytosis
601 Citations (Scopus)

The LDL receptor

Goldstein, J. L. & Brown, M. S., Apr 1 2009, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 29, 4, p. 431-438 8 p.

Research output: Contribution to journalArticle

LDL Receptors
Myocardial Infarction
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Endocytosis
Cell Biology
2008
27 Citations (Scopus)

From fatty streak to fatty liver: 33 Years of joint publications in the JCI

Goldstein, J. L. & Brown, M. S., Apr 1 2008, In : Journal of Clinical Investigation. 118, 4, p. 1220-1222 3 p.

Research output: Contribution to journalArticle

20th Century History
Medical Societies
Dietary Fats
Fatty Liver
Publications
Acyltransferases
Ghrelin
Peptide Hormones
Appetite
Membranes
796 Citations (Scopus)

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

Yang, J., Brown, M. S., Liang, G., Grishin, N. V. & Goldstein, J. L., Feb 8 2008, In : Cell. 132, 3, p. 387-396 10 p.

Research output: Contribution to journalArticle

Acyltransferases
Ghrelin
Peptide Hormones
Appetite
Serine
133 Citations (Scopus)

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides

Yang, J., Zhao, T. J., Goldstein, J. L. & Brown, M. S., Aug 5 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 31, p. 10750-10755 6 p.

Research output: Contribution to journalArticle

Acyltransferases
Ghrelin
Serine
Acylation
Inhibition (Psychology)
247 Citations (Scopus)
Lipid Bilayers
Lysosomes
Cholesterol
Liposomes
Lysosome-Associated Membrane Glycoproteins
150 Citations (Scopus)

Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein

Infante, R. E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J. D., Brown, M. S. & Goldstein, J. L., Jan 11 2008, In : Journal of Biological Chemistry. 283, 2, p. 1052-1063 12 p.

Research output: Contribution to journalArticle

Membrane Proteins
Cholesterol
Amino Acids
Proteins
Hydroxyl Radical
161 Citations (Scopus)

Purified NPC1 protein II. Localization of sterol binding to a 240-amino acid soluble luminal loop

Infante, R. E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L. N., Wang, M. L., Grishin, N. V., Goldstein, J. L. & Brown, M. S., Jan 11 2008, In : Journal of Biological Chemistry. 283, 2, p. 1064-1075 12 p.

Research output: Contribution to journalArticle

Sterols
Protein C
Cholesterol
Amino Acids
Proteins
487 Citations (Scopus)

Selective versus Total Insulin Resistance: A Pathogenic Paradox

Brown, M. S. & Goldstein, J. L., Feb 6 2008, In : Cell Metabolism. 7, 2, p. 95-96 2 p.

Research output: Contribution to journalArticle

Hypertriglyceridemia
Hyperglycemia
Insulin Resistance
Lipogenesis
Gluconeogenesis
267 Citations (Scopus)
Endoplasmic Reticulum
Cholesterol
Lipids
Membrane Lipids
Cultured Cells
2007
334 Citations (Scopus)
Sterol Regulatory Element Binding Proteins
Sterols
Endoplasmic Reticulum
Cholesterol
Proteins
184 Citations (Scopus)
Sterol Regulatory Element Binding Proteins
Sterols
Endoplasmic Reticulum
Cholesterol
Proteins
2006
947 Citations (Scopus)

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

Guertin, D. A., Stevens, D. M., Thoreen, C. C., Burds, A. A., Kalaany, N. Y., Moffat, J., Brown, M., Fitzgerald, K. J. & Sabatini, D. M., Dec 2006, In : Developmental Cell. 11, 6, p. 859-871 13 p.

Research output: Contribution to journalArticle

Raptors
Ablation
Embryonic Structures
Multiprotein Complexes
Phosphorylation
30 Citations (Scopus)
Sterol Regulatory Element Binding Proteins
Aspartic Acid
Hydroxymethylglutaryl CoA Reductases
Homeostasis
Cholesterol