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Research Output 2007 2019

  • 4172 Citations
  • 23 h-Index
  • 27 Article
  • 1 Conference contribution
  • 1 Comment/debate
2 Citations (Scopus)

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L. G., Faubert, B., Vu, H. S., Jiang, L., Ko, B., Morales, N. M., Pei, J., Vale, G., Rakheja, D., Grishin, N. V., McDonald, J. G., Gotway, G. K. & 3 others, McNutt, M. C., Pascual, J. M. & DeBerardinis, R. J., Apr 30 2019, In : Cell Reports. 27, 5, p. 1376-1386.e6

Research output: Contribution to journalArticle

Open Access
Functional assessment
Inborn Errors Metabolism
5 Citations (Scopus)

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Gu, Z., Liu, Y., Cai, F., Patrick, M., Zmajkovic, J., Cao, H., Zhang, Y., Tasdogan, A., Chen, M., Qi, L., Liu, X., Li, K., Lyu, J., Dickerson, K. E., Chen, W., Ni, M., Merritt, M. E., Morrison, S. J., Skoda, R. C., DeBerardinis, R. J. & 1 others, Xu, J., Sep 1 2019, In : Cancer discovery. 9, 9, p. 1228-1247 20 p.

Research output: Contribution to journalArticle

Branched Chain Amino Acids
Myeloid Leukemia
3 Citations (Scopus)

Gain-of-function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities

Rodan, L. H., Anyane-Yeboa, K., Chong, K., Klein Wassink-Ruiter, J. S., Wilson, A., Smith, L., Kothare, S. V., Rajabi, F., Blaser, S., Ni, M., DeBerardinis, R. J., Poduri, A. & Berry, G. T., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
16 Citations (Scopus)

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

Huang, F., Ni, M., Chalishazar, M. D., Huffman, K. E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L. G., Ireland, A. S., Li, K., Gu, W., Kaushik, A. K., Liu, X., Gazdar, A. F., Oliver, T. G., Minna, J. D., Hu, Z. & DeBerardinis, R. J., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Inosine Monophosphate
Small Cell Lung Carcinoma
54 Citations (Scopus)

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

Carbamyl Phosphate
Lung Neoplasms
63 Citations (Scopus)

In Situ Capture of Chromatin Interactions by Biotinylated dCas9

Liu, X., Zhang, Y., Chen, Y., Li, M., Zhou, F., Li, K., Cao, H., Ni, M., Liu, Y., Gu, Z., Dickerson, K. E., Xie, S., Hon, G. C., Xuan, Z., Zhang, M. Q., Shao, Z. & Xu, J., Aug 24 2017, In : Cell. 170, 5, p. 1028-1043.e19

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
191 Citations (Scopus)

Lactate Metabolism in Human Lung Tumors

Faubert, B., Li, K. Y., Cai, L., Hensley, C. T., Kim, J., Zacharias, L. G., Yang, C., Do, Q. N., Doucette, S., Burguete, D., Li, H., Huet, G., Yuan, Q., Wigal, T., Butt, Y., Ni, M., Torrealba, J., Oliver, D., Lenkinski, R. E., Malloy, C. R. & 4 others, Wachsmann, J. W., Young, J. D., Kernstine, K. & DeBerardinis, R. J., Oct 5 2017, In : Cell. 171, 2, p. 358-371.e9

Research output: Contribution to journalArticle

Lactic Acid
Citric Acid Cycle
34 Citations (Scopus)

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

Liu, X., Zhang, Y., Ni, M., Cao, H., Signer, R. A. J., Li, D., Li, M., Gu, Z., Hu, Z., Dickerson, K. E., Weinberg, S. E., Chandel, N. S., Deberardinis, R. J., Zhou, F., Shao, Z. & Xu, J., May 31 2017, In : Nature Cell Biology. 19, 6, p. 626-638 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Organelle Biogenesis
Hematopoietic Stem Cells
306 Citations (Scopus)

Metabolic Heterogeneity in Human Lung Tumors

Hensley, C. T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., Jiang, L., Ko, B., Skelton, R., Loudat, L., Wodzak, M., Klimko, C., McMillan, E., Butt, Y., Ni, M., Oliver, D., Torrealba, J., Malloy, C. R., Kernstine, K., Lenkinski, R. E. & 1 others, DeBerardinis, R. J., Feb 11 2016, In : Cell. 164, 4, p. 681-694 14 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
214 Citations (Scopus)

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

Shu, S., Lin, C. Y., He, H. H., Witwicki, R. M., Tabassum, D. P., Roberts, J. M., Janiszewska, M., Huh, S. J., Liang, Y., Ryan, J., Doherty, E., Mohammed, H., Guo, H., Stover, D. G., Ekram, M. B., Peluffo, G., Brown, J., D'Santos, C., Krop, I. E., Dillon, D. & 20 others, McKeown, M., Ott, C., Qi, J., Ni, M., Rao, P. K., Duarte, M., Wu, S. Y., Chiang, C. M., Anders, L., Young, R. A., Winer, E. P., Letai, A., Barry, W. T., Carroll, J. S., Long, H. W., Brown, M., Liu, X. S., Meyer, C. A., Bradner, J. E. & Polyak, K., Jan 21 2016, In : Nature. 529, 7586, p. 413-417 5 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Phosphoric Monoester Hydrolases
Drug Resistance
11 Citations (Scopus)

Importance of breast cancer subtype in the development of androgen-receptor-directed therapy

Lim, E., Ni, M., Cao, S., Hazra, A., Tamimi, R. M. & Brown, M., 2014, In : Current Breast Cancer Reports. 6, 2, p. 71-78 8 p.

Research output: Contribution to journalArticle

Androgen Receptors
Breast Neoplasms
Prostatic Neoplasms
Clinical Trials
338 Citations (Scopus)

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Chen, X., Iliopoulos, D., Zhang, Q., Tang, Q., Greenblatt, M. B., Hatziapostolou, M., Lim, E., Tam, W. L., Ni, M., Chen, Y., Mai, J., Shen, H., Hu, D. Z., Adoro, S., Hu, B., Song, M., Tan, C., Landis, M. D., Ferrari, M., Shin, S. J. & 4 others, Brown, M., Chang, J. C., Liu, X. S. & Glimcher, L. H., 2014, In : Nature. 508, 1, p. 103-107 5 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Protein Unfolding
Breast Neoplasms
Endoplasmic Reticulum Stress
54 Citations (Scopus)

Amplitude modulation of androgen signaling by c-MYC

Ni, M., Chen, Y., Fei, T., Li, D., Lim, E., Liu, X. S. & Brown, M., Apr 1 2013, In : Genes and Development. 27, 7, p. 734-748 15 p.

Research output: Contribution to journalArticle

Androgen Receptors
Breast Neoplasms
Transcription Factors
53 Citations (Scopus)

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis andAKT oncogenic signaling

Wey, S., Luo, B., Tseng, C. C., Ni, M., Zhou, H., Fu, Y., Bhojwani, D., Carroll, W. L. & Lee, A. S., Jan 19 2012, In : Blood. 119, 3, p. 817-825 9 p.

Research output: Contribution to journalArticle

Hematopoietic System
Phosphatidylinositol 3-Kinases
Stem cells
275 Citations (Scopus)

Beyond the endoplasmic reticulum: Atypical GRP78 in cell viability, signalling and therapeutic targeting

Ni, M., Zhang, Y. & Lee, A. S., Mar 1 2011, In : Biochemical Journal. 434, 2, p. 181-188 8 p.

Research output: Contribution to journalArticle

Cell signaling
Endoplasmic Reticulum
Cell Survival
24 Citations (Scopus)

Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes

Ye, R., Ni, M., Wang, M., Luo, S., Zhu, G., Chow, R. H. & Lee, A. S., Aug 2011, In : Journal of Endocrinology. 210, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
96 Citations (Scopus)

PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B

Baba, A., Ohtake, F., Okuno, Y., Yokota, K., Okada, M., Imai, Y., Ni, M., Meyer, C. A., Igarashi, K., Kanno, J., Brown, M. & Kato, S., Jun 2011, In : Nature Cell Biology. 13, 6, p. 668-675 8 p.

Research output: Contribution to journalArticle

Histone Demethylases
Cyclic AMP-Dependent Protein Kinases
219 Citations (Scopus)

Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer

Ni, M., Chen, Y., Lim, E., Wimberly, H., Bailey, S. T., Imai, Y., Rimm, D. L., Shirley Liu, X. & Brown, M., Jul 12 2011, In : Cancer Cell. 20, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

Androgen Receptors
Estrogen Receptors
Breast Neoplasms
Wnt Signaling Pathway
176 Citations (Scopus)

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP

Zhang, Y., Liu, R., Ni, M., Gill, P. & Lee, A. S., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15065-15075 11 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
324 Citations (Scopus)

Nucleosome dynamics define transcriptional enhancers

He, H. H., Meyer, C. A., Shin, H., Bailey, S. T., Wei, G., Wang, Q., Zhang, Y., Xu, K., Ni, M., Lupien, M., Mieczkowski, P., Lieb, J. D., Zhao, K., Brown, M. & Liu, X. S., Apr 2010, In : Nature Genetics. 42, 4, p. 343-347 5 p.

Research output: Contribution to journalArticle

Androgen Receptors
Transcription Factors
Binding Sites
211 Citations (Scopus)

Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W. & Orkin, S. H., Apr 15 2010, In : Genes and Development. 24, 8, p. 783-789 7 p.

Research output: Contribution to journalArticle

Developmental Genes
SOXD Transcription Factors
Locus Control Region
87 Citations (Scopus)

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

Zhang, Q., Gu, J., Li, L., Liu, J., Luo, B., Cheung, H. W., Boehm, J. S., Ni, M., Geisen, C., Root, D. E., Polyak, K., Brown, M., Richardson, A. L., Hahn, W. C., Kaelin, W. G. & Bommi-Reddy, A., Nov 6 2009, In : Cancer Cell. 16, 5, p. 413-424 12 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Cyclin D1
100 Citations (Scopus)

Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP

Ni, M., Zhou, H., Wey, S., Baumeister, P. & Lee, A. S., Aug 31 2009, In : PLoS One. 4, 8, e6868.

Research output: Contribution to journalArticle

unfolded protein response
Unfolded Protein Response
endoplasmic reticulum
cell viability
Cell Survival
273 Citations (Scopus)

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development

Dong, D., Ni, M., Li, J., Xiong, S., Ye, W., Virrey, J. J., Mao, C., Ye, R., Wang, M., Pen, L., Dubeau, L., Groshen, S., Hofman, F. M. & Lee, A. S., Jan 15 2008, In : Cancer Research. 68, 2, p. 498-505 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Unfolded Protein Response
Endoplasmic Reticulum Stress
111 Citations (Scopus)

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells

Virrey, J. J., Dong, D., Stiles, C., Patterson, J. B., Pen, L., Ni, M., Schönthal, A. H., Chen, T. C., Hofman, F. M. & Lee, A. S., Aug 1 2008, In : Molecular Cancer Research. 6, 8, p. 1268-1275 8 p.

Research output: Contribution to journalArticle

Blood Vessels
Endothelial Cells
280 Citations (Scopus)

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

Li, J., Ni, M., Lee, B., Barron, E., Hinton, D. R. & Lee, A. S., 2008, In : Cell Death and Differentiation. 15, 9, p. 1460-1471 12 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Small Interfering RNA
556 Citations (Scopus)

ER chaperones in mammalian development and human diseases

Ni, M. & Lee, A. S., Jul 31 2007, In : FEBS Letters. 581, 19, p. 3641-3651 11 p.

Research output: Contribution to journalArticle

Human Development
Endoplasmic Reticulum
Gene encoding