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20072020

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Article
2020

Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing

Li, K., Liu, Y., Cao, H., Zhang, Y., Gu, Z., Liu, X., Yu, A., Kaphle, P., Dickerson, K. E., Ni, M. & Xu, J., Dec 1 2020, In : Nature communications. 11, 1, 485.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies

Li, K., Zhang, Y., Liu, X., Liu, Y., Gu, Z., Cao, H., Dickerson, K. E., Chen, M., Chen, W., Shao, Z., Ni, M. & Xu, J., May 1 2020, In : Cancer discovery. 10, 5, p. 724-745 22 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L. G., Faubert, B., Vu, H. S., Jiang, L., Ko, B., Morales, N. M., Pei, J., Vale, G., Rakheja, D., Grishin, N. V., McDonald, J. G., Gotway, G. K. & 3 others, McNutt, M. C., Pascual, J. M. & DeBerardinis, R. J., Apr 30 2019, In : Cell Reports. 27, 5, p. 1376-1386.e6

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Gu, Z., Liu, Y., Cai, F., Patrick, M., Zmajkovic, J., Cao, H., Zhang, Y., Tasdogan, A., Chen, M., Qi, L., Liu, X., Li, K., Lyu, J., Dickerson, K. E., Chen, W., Ni, M., Merritt, M. E., Morrison, S. J., Skoda, R. C., DeBerardinis, R. J. & 1 others, Xu, J., Sep 1 2019, In : Cancer discovery. 9, 9, p. 1228-1247 20 p.

Research output: Contribution to journalArticle

15 Scopus citations
2018

Gain-of-function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities

Rodan, L. H., Anyane-Yeboa, K., Chong, K., Klein Wassink-Ruiter, J. S., Wilson, A., Smith, L., Kothare, S. V., Rajabi, F., Blaser, S., Ni, M., DeBerardinis, R. J., Poduri, A. & Berry, G. T., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

4 Scopus citations

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

Huang, F., Ni, M., Chalishazar, M. D., Huffman, K. E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L. G., Ireland, A. S., Li, K., Gu, W., Kaushik, A. K., Liu, X., Gazdar, A. F., Oliver, T. G., Minna, J. D., Hu, Z. & DeBerardinis, R. J., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

27 Scopus citations
2017

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

69 Scopus citations

In Situ Capture of Chromatin Interactions by Biotinylated dCas9

Liu, X., Zhang, Y., Chen, Y., Li, M., Zhou, F., Li, K., Cao, H., Ni, M., Liu, Y., Gu, Z., Dickerson, K. E., Xie, S., Hon, G. C., Xuan, Z., Zhang, M. Q., Shao, Z. & Xu, J., Aug 24 2017, In : Cell. 170, 5, p. 1028-1043.e19

Research output: Contribution to journalArticle

80 Scopus citations

Lactate Metabolism in Human Lung Tumors

Faubert, B., Li, K. Y., Cai, L., Hensley, C. T., Kim, J., Zacharias, L. G., Yang, C., Do, Q. N., Doucette, S., Burguete, D., Li, H., Huet, G., Yuan, Q., Wigal, T., Butt, Y., Ni, M., Torrealba, J., Oliver, D., Lenkinski, R. E., Malloy, C. R. & 4 others, Wachsmann, J. W., Young, J. D., Kernstine, K. & DeBerardinis, R. J., Oct 5 2017, In : Cell. 171, 2, p. 358-371.e9

Research output: Contribution to journalArticle

261 Scopus citations

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

Liu, X., Zhang, Y., Ni, M., Cao, H., Signer, R. A. J., Li, D., Li, M., Gu, Z., Hu, Z., Dickerson, K. E., Weinberg, S. E., Chandel, N. S., Deberardinis, R. J., Zhou, F., Shao, Z. & Xu, J., May 31 2017, In : Nature cell biology. 19, 6, p. 626-638 13 p.

Research output: Contribution to journalArticle

41 Scopus citations
2016

Metabolic Heterogeneity in Human Lung Tumors

Hensley, C. T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., Jiang, L., Ko, B., Skelton, R., Loudat, L., Wodzak, M., Klimko, C., McMillan, E., Butt, Y., Ni, M., Oliver, D., Torrealba, J., Malloy, C. R., Kernstine, K., Lenkinski, R. E. & 1 others, DeBerardinis, R. J., Feb 11 2016, In : Cell. 164, 4, p. 681-694 14 p.

Research output: Contribution to journalArticle

353 Scopus citations

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

Shu, S., Lin, C. Y., He, H. H., Witwicki, R. M., Tabassum, D. P., Roberts, J. M., Janiszewska, M., Huh, S. J., Liang, Y., Ryan, J., Doherty, E., Mohammed, H., Guo, H., Stover, D. G., Ekram, M. B., Peluffo, G., Brown, J., D'Santos, C., Krop, I. E., Dillon, D. & 20 others, McKeown, M., Ott, C., Qi, J., Ni, M., Rao, P. K., Duarte, M., Wu, S. Y., Chiang, C. M., Anders, L., Young, R. A., Winer, E. P., Letai, A., Barry, W. T., Carroll, J. S., Long, H. W., Brown, M., Liu, X. S., Meyer, C. A., Bradner, J. E. & Polyak, K., Jan 21 2016, In : Nature. 529, 7586, p. 413-417 5 p.

Research output: Contribution to journalArticle

246 Scopus citations
2014

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Chen, X., Iliopoulos, D., Zhang, Q., Tang, Q., Greenblatt, M. B., Hatziapostolou, M., Lim, E., Tam, W. L., Ni, M., Chen, Y., Mai, J., Shen, H., Hu, D. Z., Adoro, S., Hu, B., Song, M., Tan, C., Landis, M. D., Ferrari, M., Shin, S. J. & 4 others, Brown, M., Chang, J. C., Liu, X. S. & Glimcher, L. H., Jan 1 2014, In : Nature. 508, 1, p. 103-107 5 p.

Research output: Contribution to journalArticle

376 Scopus citations
2013

Amplitude modulation of androgen signaling by c-MYC

Ni, M., Chen, Y., Fei, T., Li, D., Lim, E., Liu, X. S. & Brown, M., Apr 1 2013, In : Genes and Development. 27, 7, p. 734-748 15 p.

Research output: Contribution to journalArticle

57 Scopus citations
2012

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis andAKT oncogenic signaling

Wey, S., Luo, B., Tseng, C. C., Ni, M., Zhou, H., Fu, Y., Bhojwani, D., Carroll, W. L. & Lee, A. S., Jan 19 2012, In : Blood. 119, 3, p. 817-825 9 p.

Research output: Contribution to journalArticle

57 Scopus citations
2011

Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes

Ye, R., Ni, M., Wang, M., Luo, S., Zhu, G., Chow, R. H. & Lee, A. S., Aug 1 2011, In : Journal of Endocrinology. 210, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B

Baba, A., Ohtake, F., Okuno, Y., Yokota, K., Okada, M., Imai, Y., Ni, M., Meyer, C. A., Igarashi, K., Kanno, J., Brown, M. & Kato, S., Jun 1 2011, In : Nature Cell Biology. 13, 6, p. 668-675 8 p.

Research output: Contribution to journalArticle

104 Scopus citations

Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer

Ni, M., Chen, Y., Lim, E., Wimberly, H., Bailey, S. T., Imai, Y., Rimm, D. L., Shirley Liu, X. & Brown, M., Jul 12 2011, In : Cancer Cell. 20, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

226 Scopus citations
2010

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP

Zhang, Y., Liu, R., Ni, M., Gill, P. & Lee, A. S., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15065-15075 11 p.

Research output: Contribution to journalArticle

190 Scopus citations

Nucleosome dynamics define transcriptional enhancers

He, H. H., Meyer, C. A., Shin, H., Bailey, S. T., Wei, G., Wang, Q., Zhang, Y., Xu, K., Ni, M., Lupien, M., Mieczkowski, P., Lieb, J. D., Zhao, K., Brown, M. & Liu, X. S., Apr 1 2010, In : Nature genetics. 42, 4, p. 343-347 5 p.

Research output: Contribution to journalArticle

335 Scopus citations

Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W. & Orkin, S. H., Apr 15 2010, In : Genes and Development. 24, 8, p. 783-789 7 p.

Research output: Contribution to journalArticle

218 Scopus citations
2009

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

Zhang, Q., Gu, J., Li, L., Liu, J., Luo, B., Cheung, H. W., Boehm, J. S., Ni, M., Geisen, C., Root, D. E., Polyak, K., Brown, M., Richardson, A. L., Hahn, W. C., Kaelin, W. G. & Bommi-Reddy, A., Nov 6 2009, In : Cancer Cell. 16, 5, p. 413-424 12 p.

Research output: Contribution to journalArticle

92 Scopus citations

Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP

Ni, M., Zhou, H., Wey, S., Baumeister, P. & Lee, A. S., Aug 31 2009, In : PloS one. 4, 8, e6868.

Research output: Contribution to journalArticle

102 Scopus citations
2008

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development

Dong, D., Ni, M., Li, J., Xiong, S., Ye, W., Virrey, J. J., Mao, C., Ye, R., Wang, M., Pen, L., Dubeau, L., Groshen, S., Hofman, F. M. & Lee, A. S., Jan 15 2008, In : Cancer research. 68, 2, p. 498-505 8 p.

Research output: Contribution to journalArticle

286 Scopus citations

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells

Virrey, J. J., Dong, D., Stiles, C., Patterson, J. B., Pen, L., Ni, M., Schönthal, A. H., Chen, T. C., Hofman, F. M. & Lee, A. S., Aug 1 2008, In : Molecular Cancer Research. 6, 8, p. 1268-1275 8 p.

Research output: Contribution to journalArticle

115 Scopus citations

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

Li, J., Ni, M., Lee, B., Barron, E., Hinton, D. R. & Lee, A. S., Jul 21 2008, In : Cell Death and Differentiation. 15, 9, p. 1460-1471 12 p.

Research output: Contribution to journalArticle

293 Scopus citations