• 3453 Citations
  • 28 h-Index
20002019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade

Pai, C. C. S., Huang, J. T., Lu, X., Simons, D. M., Park, C., Chang, A., Tamaki, W., Liu, E., Roybal, K. T., Seagal, J., Chen, M., Hagihara, K., Wei, X. X., DuPage, M., Kwek, S. S., Oh, D. Y., Daud, A., Tsai, K. K., Wu, C., Zhang, L. & 7 others, Fasso, M., Sachidanandam, R., Jayaprakash, A., Lin, I., Casbon, A. J., Kinsbury, G. A. & Fong, L., Feb 19 2019, In : Immunity. 50, 2, p. 477-492.e8

Research output: Contribution to journalArticle

15 Scopus citations

Disruption of the RBM38-eIF4E complex with a synthetic peptide PEP8 increases p53 expression

Lucchesi, C. A., Zhang, J., Ma, B., Chen, M. & Chen, X., Feb 15 2019, In : Cancer Research. 79, 4, p. 807-818 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Evolving myelodysplastic syndrome in an HIV patient with history of anal cancer and chemotherapy

Shi, M., Hu, X. & Chen, M., Dec 1 2019, In : Journal of Hematopathology. 12, 4, p. 213-214 2 p.

Research output: Contribution to journalArticle

Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity

Liu, Z., Han, C., Dong, C., Shen, A., Hsu, E., Ren, Z., Lu, C., Liu, L., Zhang, A., Timmerman, C., Pu, Y., Wang, Y., Chen, M., Qiao, J. & Fu, Y. X., Aug 9 2019, In : Science Immunology. 4, 38

Research output: Contribution to journalArticle

2 Scopus citations

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Gu, Z., Liu, Y., Cai, F., Patrick, M., Zmajkovic, J., Cao, H., Zhang, Y., Tasdogan, A., Chen, M., Qi, L., Liu, X., Li, K., Lyu, J., Dickerson, K. E., Chen, W., Ni, M., Merritt, M. E., Morrison, S. J., Skoda, R. C., DeBerardinis, R. J. & 1 others, Xu, J., Sep 1 2019, In : Cancer discovery. 9, 9, p. 1228-1247 20 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mantle Cell Lymphoma With Mantle Zone Growth Pattern

Yuan, J., Li, S., Liu, X., Su, R. J., Chen, M., Wu, X., Zheng, G., Smith, L. M., Wang, L., Li, Y., Liu, C., Zhou, J., Shen, Q., Zhang, L., Wang, E., Xu, M. L. & Pan, Z., Jul 5 2019, In : American journal of clinical pathology. 152, 2, p. 132-145 14 p.

Research output: Contribution to journalArticle

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity

Pai, C. C. S., Simons, D. M., Lu, X., Evans, M., Wei, J., Wang, Y. H., Chen, M., Huang, J., Park, C., Chang, A., Wang, J., Westmoreland, S., Beam, C., Banach, D., Bowley, D., Dong, F., Seagal, J., Ritacco, W., Richardson, P. L., Mitra, S. & 5 others, Lynch, G., Bousquet, P., Mankovich, J., Kingsbury, G. & Fong, L., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI123391.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas

Henderson, T., Chen, M., Darrow, M. A., Li, C. S., Chiu, C. L., Monjazeb, A. M., Murphy, W. J. & Canter, R. J., Mar 1 2018, In : Journal of Surgical Research. 223, p. 207-214 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

An empirical approach leveraging tumorgrafts to dissect the tumor microenvironment in renal cell carcinoma identifies missing link to prognostic inflammatory factors

Wang, T., Lu, R., Kapur, P., Jaiswal, B. S., Hannan, R., Zhang, Z., Pedrosa, I., Luke, J. J., Zhang, H., Goldstein, L. D., Yousuf, Q., Gu, Y. F., McKenzie, T., Joyce, A., Kim, M. S., Wang, X., Luo, D., Onabolu, O., Stevens, C., Xie, Z. & 11 others, Chen, M., Filatenkov, A., Torrealba, J., Luo, X., Guo, W., He, J., Stawiski, E., Modrusan, Z., Durinck, S., Seshagiri, S. & Brugarolas, J., Sep 1 2018, In : Cancer Discovery. 8, 9, p. 1142-1155 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

CD3-positive plasmablastic B-cell neoplasms: A diagnostic pitfall

Pan, Z., Chen, M., Zhang, Q., Wang, E., Yin, L., Xu, Y., Huang, Q., Yuan, Y., Zhang, X., Zheng, G. & Yuan, J., May 1 2018, In : Modern Pathology. 31, 5, p. 718-731 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Genetic ablation of Rbm38 promotes lymphomagenesis in the context of mutant p53 by downregulating PTEN

Zhang, J., Xu, E., Ren, C., Yang, H. J., Zhang, Y., Sun, W., Kong, X., Zhang, W., Chen, M., Huang, E. & Chen, X., Mar 15 2018, In : Cancer Research. 78, 6, p. 1511-1521 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression

Tang, H., Liang, Y., Anders, R. A., Taube, J. M., Qiu, X., Mulgaonkar, A., Liu, X., Harrington, S. M., Guo, J., Xin, Y., Xiong, Y., Nham, K., Silvers, W., Hao, G., Sun, X., Chen, M., Hannan, R., Qiao, J., Dong, H., Peng, H. & 1 others, Fu, Y. X., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 580-588 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

The Rbm38-p63 feedback loop is critical for tumor suppression and longevity

Jiang, Y., Xu, E., Zhang, J., Chen, M., Flores, E. & Chen, X., May 1 2018, In : Oncogene. 37, 21, p. 2863-2872 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017
3 Scopus citations

Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2

Zhang, Y., Qian, Y., Zhang, J., Yan, W., Jung, Y. S., Chen, M., Huang, E., Lloyd, K., Duan, Y., Wang, J., Liu, G. & Chen, X., Jun 15 2017, In : Genes and Development. 31, 12, p. 1243-1256 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner

Yang, H. J., Zhang, J., Yan, W., Cho, S. J., Lucchesi, C., Chen, M., Huang, E. C., Scoumanne, A., Zhang, W. & Chen, X., Oct 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. 11500-11505 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial

Canter, R. J., Grossenbacher, S. K., Foltz, J. A., Sturgill, I. R., Park, J. S., Luna, J. I., Kent, M. S., Culp, W. T. N., Chen, M., Modiano, J. F., Monjazeb, A. M., Lee, D. A. & Murphy, W. J., Dec 19 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 98.

Research output: Contribution to journalArticle

24 Scopus citations

Therapeutic Effects of a NEDD8-Activating Enzyme Inhibitor, Pevonedistat, on Sclerodermatous Graft-versus-Host Disease in Mice

Pai, C. C. S., Khuat, L. T., Chen, M., Murphy, W. J. & Abedi, M., Jan 1 2017, In : Biology of Blood and Marrow Transplantation. 23, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Blocking indolamine-2,3-dioxygenase rebound immune suppression boosts antitumor effects of radio-immunotherapy in murine models and spontaneous canine malignancies

Monjazeb, A. M., Kent, M. S., Grossenbacher, S. K., Mall, C., Zamora, A. E., Mirsoian, A., Chen, M., Kol, A., Shiao, S. L., Reddy, A., Perks, J. R., Culp, W. T. N., Sparger, E. E., Canter, R. J., Sckisel, G. D. & Murphy, W. J., Sep 1 2016, In : Clinical Cancer Research. 22, 17, p. 4328-4340 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Chronic eosinophilic leukemia, NOS with t(5;12)(q31;p13)/ETV6-ACSL6 gene fusion: A novel variant of myeloid proliferative neoplasm with eosinophilia

Su, R. J., Jonas, B. A., Welborn, J., Gregg, J. P. & Chen, M., Sep 1 2016, In : Human Pathology: Case Reports. 5, p. 6-9 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy

Chen, M., Qiu, H., Lin, X., Nam, D., Ogbu-Nwobodo, L., Archibald, H., Joslin, A., Wun, T., Sawamura, T. & Green, R., Sep 1 2016, In : Blood Cells, Molecules, and Diseases. 60, p. 44-48 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

LRIG1 opposes epithelial-To-mesenchymal transition and inhibits invasion of basal-like breast cancer cells

Yokdang, N., Hatakeyama, J., Wald, J. H., Simion, C., Tellez, J. D., Chang, D. Z., Swamynathan, M. M., Chen, M., Murphy, W. J., Carraway, K. L. & Sweeney, C., Jun 2 2016, In : Oncogene. 35, 22, p. 2932-2947 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer

Mall, C., Sckisel, G. D., Proia, D. A., Mirsoian, A., Grossenbacher, S. K., Pai, C. C. S., Chen, M., Monjazeb, A. M., Kelly, K., Blazar, B. R. & Murphy, W. J., Feb 1 2016, In : OncoImmunology. 5, 2

Research output: Contribution to journalArticle

12 Scopus citations
2015

Acute myeloid leukemia with isolated trisomy 19 associated with diffuse myelofibrosis and osteosclerosis

Stelling, A., Jonas, B. A., Rashidi, H. H., Abedi, M. & Chen, M., Dec 14 2015, In : Cancers. 7, 4, p. 2459-2465 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Enhanced targeting of stem-like solid tumor cells with radiation and natural killer cells

Ames, E., Canter, R. J., Grossenbacher, S. K., Mac, S., Smith, R. C., Monjazeb, A. M., Chen, M. & Murphy, W. J., Jan 1 2015, In : OncoImmunology. 4, 9, p. 1-11 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Late administration of murine CTLA-4 blockade prolongs CD8-mediated anti-tumor effects following stimulatory cancer immunotherapy

Sckisel, G. D., Mirsoian, A., Bouchlaka, M. N., Tietze, J. K., Chen, M., Blazar, B. R. & Murphy, W. J., Dec 1 2015, In : Cancer Immunology, Immunotherapy. 64, 12, p. 1541-1552 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

NK cells preferentially target tumor cells with a cancer stem cell phenotype

Ames, E., Canter, R. J., Grossenbacher, S. K., Mac, S., Chen, M., Smith, R. C., Hagino, T., Perez-Cunningham, J., Sckisel, G. D., Urayama, S., Monjazeb, A. M., Fragoso, R. C., Sayers, T. J. & Murphy, W. J., Jan 1 2015, In : Journal of Immunology. 195, 8, p. 4010-4019 10 p.

Research output: Contribution to journalArticle

65 Scopus citations
2014

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

Mirsoian, A., Bouchlaka, M. N., Sckisel, G. D., Chen, M., Pai, C. C. S., Maverakis, E., Spencer, R. G., Fishbein, K. W., Siddiqui, S., Monjazeb, A. M., Martin, B., Maudsley, S., Hesdorffer, C., Ferrucci, L., Longo, D. L., Blazar, B. R., Wiltrout, R. H., Taub, D. D. & Murphy, W. J., Jan 1 2014, In : Journal of Experimental Medicine. 211, 12, p. 2373-2383 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma

Canter, R. J., Ames, E., Mac, S., Grossenbacher, S. K., Chen, M., Li, C. S., Borys, D., Smith, R. C., Tellez, J., Sayers, T. J., Monjazeb, A. M. & Murphy, W. J., Jan 1 2014, In : BMC Cancer. 14, 1, 756.

Research output: Contribution to journalArticle

15 Scopus citations

Detection of Epstein-Barr virus (EBV) in human lymphoma tissue by a novel microbial detection array

Tellez, J., Jaing, C., Wang, J., Green, R. & Chen, M., Dec 5 2014, In : Biomarker Research. 2, 1, 24.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Increased antitumor effects using IL-2 with Anti-TGF-β reveals competition between mouse NK and CD8 T Cells

Alvarez, M., Bouchlaka, M. N., Sckisel, G. D., Sungur, C. M., Chen, M. & Murphy, W. J., Aug 15 2014, In : Journal of Immunology. 193, 4, p. 1709-1716 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors

Zhang, J., Xu, E., Ren, C., Yan, W., Zhang, M., Chen, M., Cardiff, R. D., Imai, D. M., Wisner, E. & Chen, X., Dec 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 52, p. 18637-18642 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Nanomicelle formulation modifies the pharmacokinetic profiles and cardiac toxicity of daunorubicin

Zhang, H., Li, Y., Lin, T. Y., Xiao, K., Haddad, A. S., Henderson, P. T., Jonas, B. A., Chen, M., Xiao, W., Liu, R., Lam, K. S. & Pan, C. X., Aug 1 2014, In : Nanomedicine. 9, 12, p. 1807-1820 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels

Pai, C. C. S., Hsiao, H. H., Sun, K., Chen, M., Hagino, T., Tellez, J., Mall, C., Blazar, B. R., Monjazeb, A., Abedi, M. & Murphy, W. J., Dec 1 2014, In : Biology of Blood and Marrow Transplantation. 20, 12, p. 1899-1904 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Treatment of chronic graft-versus-host disease with bortezomib

Pai, C. C. S., Chen, M., Mirsoian, A., Grossenbacher, S. K., Tellez, J., Ames, E., Sun, K., Jagdeo, J., Blazar, B. R., Murphy, W. J. & Abedi, M., Jan 1 2014, In : Blood. 124, 10, p. 1677-1688 12 p.

Research output: Contribution to journalArticle

42 Scopus citations
2013

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

Bouchlaka, M. N., Sckisel, G. D., Chen, M., Mirsoian, A., Zamora, A. E., Maverakis, E., Wilkins, D. E. C., Alderson, K. L., Hsiao, H. H., Weiss, J. M., Monjazeb, A. M., Hesdorffer, C., Ferrucci, L., Longo, D. L., Blazar, B. R., Wiltrout, R. H., Redelman, D., Taub, D. D. & Murphy, W. J., Oct 1 2013, In : Journal of Experimental Medicine. 210, 11, p. 2223-2237 15 p.

Research output: Contribution to journalArticle

65 Scopus citations
2 Scopus citations

Murine natural killer cell licensing and regulation by T regulatory cells in viral responses

Sungur, C. M., Tang-Feldman, Y. J., Ames, E., Alvarez, M., Chen, M., Longo, D. L., Pomeroy, C. & Murphy, W. J., Apr 30 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 18, p. 7401-7406 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
2012

IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation

Sun, K., Hsiao, H. H., Li, M., Ames, E., Bouchlaka, M., Welniak, L. A., Hagino, T., Jagdeo, J., Pai, C. C., Chen, M., Blazar, B. R., Abedi, M. & Murphy, W. J., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 2033-2042 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Indeterminate cell tumor of the spleen

Chen, M., Agrawal, R., Nasseri-Nik, N., Sloman, A. & Weiss, L. M., Feb 2012, In : Human Pathology. 43, 2, p. 307-311 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing

Sun, K., Alvarez, M., Ames, E., Barao, I., Chen, M., Longo, D. L., Redelman, D. & Murphy, W. J., Feb 9 2012, In : Blood. 119, 6, p. 1590-1598 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Splenic marginal zone lymphoma with t(8;14)(q24.1;q32)/MYC rearrangement

Sonu, R., Gregg, J. & Chen, M., Sep 1 2012, In : Journal of Hematopathology. 5, 3, p. 141-147 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Acute myeloid leukemia with an unusual histologic pattern mimicking metastatic carcinoma in bone marrow: A diagnostic pitfall

Chen, M., Kim, Y., Huang, Q., Chang, K., Gaal, K. K. & Weiss, L. M., Jun 1 2011, In : Journal of Hematopathology. 4, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

2008

Gaucher disease: Review of the literature

Chen, M. & Wang, J., May 1 2008, In : Archives of Pathology and Laboratory Medicine. 132, 5, p. 851-853 3 p.

Research output: Contribution to journalArticle

61 Scopus citations
2007

Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE

Bradley, M. N., Hong, C., Chen, M., Joseph, S. B., Wilpitz, D. C., Wang, X., Lusis, A. J., Collins, A., Hseuh, W. A., Collins, J. L., Tangirala, R. K. & Tontonoz, P., Aug 1 2007, In : Journal of Clinical Investigation. 117, 8, p. 2337-2346 10 p.

Research output: Contribution to journalArticle

197 Scopus citations
2006

Phosphorylation of the liver X receptors

Chen, M., Bradley, M. N., Beaven, S. W. & Tontonoz, P., Sep 4 2006, In : FEBS Letters. 580, 20, p. 4835-4841 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2005

A role for the apoptosis inhibitory factor AIM/Spα/Api6 in atherosclerosis development

Arai, S., Shelton, J. M., Chen, M., Bradley, M. N., Castrillo, A., Bookout, A. L., Mak, P. A., Edwards, P. A., Mangelsdorf, D. J., Tontonoz, P. & Miyazaki, T., Mar 1 2005, In : Cell Metabolism. 1, 3, p. 201-213 13 p.

Research output: Contribution to journalArticle

196 Scopus citations
14 Scopus citations