• 2516 Citations
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19992019

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Article
1999

Extensive zygotic control of the anteroposterior axis in the wasp Nasonia vitripennis

Pultz, M. A., Pitt, J. N. & Alto, N. M., Feb 1999, In : Development. 126, 4, p. 701-710 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

Westphal, R. S., Tavalin, S. J., Lin, J. W., Alto, N. M., Fraser, I. D. C., Langeberg, L. K., Sheng, M. & Scott, J. D., Jul 2 1999, In : Science. 285, 5424, p. 93-96 4 p.

Research output: Contribution to journalArticle

410 Scopus citations
2000

A genetic screen for zygotic embryonic lethal mutations affecting cuticular morphology in the wasp Nasonia vitripennis

Pultz, M. A., Zimmerman, K. K., Alto, N. M., Kaeberlein, M., Lange, S. K., Pitt, J. N., Reeves, N. L. & Zehrung, D. L., Mar 2000, In : Genetics. 154, 3, p. 1213-1229 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells

Kraiss, L. W., Weyrich, A. S., Alto, N. M., Dixon, D. A., Ennis, T. M., Modur, V., McIntyre, T. M., Prescott, S. M. & Zimmerman, G. A., May 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 278, 5 47-5

Research output: Contribution to journalArticle

64 Scopus citations

Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold

Westphal, R. S., Soderling, S. H., Alto, N. M., Langeberg, L. K. & Scott, J. D., Sep 1 2000, In : EMBO Journal. 19, 17, p. 4589-4600 12 p.

Research output: Contribution to journalArticle

171 Scopus citations
2001

Flow-induced DNA synthesis requires signaling to a translational control pathway

Kraiss, L. W., Ennis, T. M. & Alto, N. M., Jan 1 2001, In : Journal of Surgical Research. 97, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
2002

Intracellular targeting of protein kinases and phosphatases

Alto, N., Carlisle Michel, J. J., Dodge, K. L., Langeberg, L. K. & Scott, J. D., Dec 1 2002, In : Diabetes. 51, SUPPL. 3

Research output: Contribution to journalArticle

39 Scopus citations

Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics

Alto, N. M., Soderling, J. & Scott, J. D., Aug 19 2002, In : Journal of Cell Biology. 158, 4, p. 659-668 10 p.

Research output: Contribution to journalArticle

162 Scopus citations
2003

Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring

Alto, N. M., Soderling, S. H., Hoshi, N., Langeberg, L. K., Fayos, R., Jennings, P. A. & Scott, J. D., Apr 15 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 8, p. 4445-4450 6 p.

Research output: Contribution to journalArticle

136 Scopus citations

Fluid flow regulates E-selectin protein levels in human endothelial cells by inhibiting translation

Kraiss, L. W., Alto, N. M., Dixon, D. A., McIntyre, T. M., Weyrich, A. S. & Zimmerman, G. A., Jan 1 2003, In : Journal of Vascular Surgery. 37, 1, p. 161-168 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2004

The role of A-Kinase anchoring proteins in cAMP-mediated signal transduction pathways.

Alto, N. M. & Scott, J. D., 2004, In : Cell Biochemistry and Biophysics. 40, 3 Suppl, p. 201-208 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2006

Identification of a bacterial type III effector family with G protein mimicry functions

Alto, N. M., Shao, F., Lazar, C. S., Brost, R. L., Chua, G., Mattoo, S., McMahon, S. A., Ghosh, P., Hughes, T. R., Boone, C. & Dixon, J. E., Jan 13 2006, In : Cell. 124, 1, p. 133-145 13 p.

Research output: Contribution to journalArticle

191 Scopus citations
2007

Shigella Puts the Brakes on the Host Cell Cycle

Alto, N. M., Sep 13 2007, In : Cell Host and Microbe. 2, 3, p. 141-142 2 p.

Research output: Contribution to journalArticle

The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways

Alto, N. M., Weflen, A. W., Rardin, M. J., Yarar, D., Lazar, C. S., Tonikian, R., Koller, A., Taylor, S. S., Boone, C., Sidhu, S. S., Schmid, S. L., Hecht, G. A. & Dixon, J. E., Sep 24 2007, In : Journal of Cell Biology. 178, 7, p. 1265-1278 14 p.

Research output: Contribution to journalArticle

95 Scopus citations
2008

Analysis of Rho-GTPase Mimicry by a Family of Bacterial Type III Effector Proteins

Alto, N. M. & Dixon, J. E., 2008, In : Methods in Enzymology. 439, p. 131-143 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation

Ohlson, M. B., Huang, Z., Alto, N. M., Blanc, M. P., Dixon, J. E., Chai, J. & Miller, S. I., Nov 13 2008, In : Cell Host and Microbe. 4, 5, p. 434-446 13 p.

Research output: Contribution to journalArticle

113 Scopus citations

Subversion of Myosin Function by E. coli

Mattoo, S., Alto, N. M. & Dixon, J. E., Jan 15 2008, In : Developmental Cell. 14, 1, p. 8-10 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity

Hodges, K., Alto, N. M., Ramaswamy, K., Dudeja, P. K. & Hecht, G., Aug 2008, In : Cellular Microbiology. 10, 8, p. 1735-1745 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2009

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

Huang, Z., Sutton, S. E., Wallenfang, A. J., Orchard, R. C., Wu, X., Feng, Y., Chai, J. & Alto, N. M., Aug 2009, In : Nature Structural and Molecular Biology. 16, 8, p. 853-860 8 p.

Research output: Contribution to journalArticle

97 Scopus citations
2010

E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism

Weflen, A. W., Alto, N. M., Viswanathan, V. K. & Hecht, G., Jul 2010, In : Cellular Microbiology. 12, 7, p. 919-929 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Rab32 modulates apoptosis onset and Mitochondria-associated Membrane (MAM) properties

Bui, M., Gilady, S. Y., Fitzsimmons, R. E. B., Benson, M. D., Lynes, E. M., Gesson, K., Alto, N. M., Strack, S., Scott, J. D. & Simmen, T., Oct 8 2010, In : Journal of Biological Chemistry. 285, 41, p. 31590-31602 13 p.

Research output: Contribution to journalArticle

99 Scopus citations

Salmonella taking charge

Weigele, B. A. & Alto, N. M., Jun 17 2010, In : Cell Host and Microbe. 7, 6, p. 421-422 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Activation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation

Selyunin, A. S. & Alto, N. M., Jul 2011, In : Small GTPases. 2, 4, p. 217-221 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold

Selyunin, A. S., Sutton, S. E., Weigele, B. A., Reddick, L. E., Orchard, R. C., Bresson, S. M., Tomchick, D. R. & Alto, N. M., Jan 6 2011, In : Nature. 469, 7328, p. 107-113 7 p.

Research output: Contribution to journalArticle

83 Scopus citations
2012

Express Your LOV: An Engineered Flavoprotein as a Reporter for Protein Expression and Purification

Gawthorne, J. A., Reddick, L. E., Akpunarlieva, S. N., Beckham, K. S. H., Christie, J. M., Alto, N. M., Gabrielsen, M. & Roe, A. J., Dec 27 2012, In : PLoS One. 7, 12, e52962.

Research output: Contribution to journalArticle

18 Scopus citations

Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit

Orchard, R. C., Kittisopikul, M., Altschuler, S. J., Wu, L. F., Süel, G. M. & Alto, N. M., Feb 17 2012, In : Cell. 148, 4, p. 803-815 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mimicking GEFs: A common theme for bacterial pathogens

Orchard, R. C. & Alto, N. M., Jan 2012, In : Cellular Microbiology. 14, 1, p. 10-18 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Subversion of cell signaling by pathogens

Alto, N. M. & Orth, K., Sep 2012, In : Cold Spring Harbor perspectives in biology. 4, 9

Research output: Contribution to journalArticle

56 Scopus citations
2013

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ

Burnaevskiy, N., Fox, T. G., Plymire, D. A., Ertelt, J. M., Weigele, B. A., Selyunin, A. S., Way, S. S., Patrie, S. M. & Alto, N. M., Apr 4 2013, In : Nature. 496, 7443, p. 106-109 4 p.

Research output: Contribution to journalArticle

76 Scopus citations
2014

Bacteria fighting back: How pathogens target and subvert the host innate immune system

Reddick, L. E. & Alto, N. M., Apr 24 2014, In : Molecular Cell. 54, 2, p. 321-328 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration

Glotfelty, L. G., Zahs, A., Hodges, K., Shan, K., Alto, N. M. & Hecht, G. A., Dec 1 2014, In : Cellular Microbiology. 16, 12, p. 1767-1783 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

Selective protection of an ARF1-GTP signaling axis by a bacterial scaffold induces bidirectional trafficking arrest

Selyunin, A. S., Reddick, L. E., Weigele, B. A. & Alto, N. M., 2014, In : Cell Reports. 6, 5, p. 878-891 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Thinking outside the Osp(G) - Kinase activation by E2-ubiquitin

De Jong, M. F. & Alto, N. M., Mar 3 2014, In : EMBO Journal. 33, 5, p. 403-404 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ

Burnaevskiy, N., Peng, T., Reddick, L. E., Hang, H. C. & Alto, N. M., Apr 2 2015, In : Molecular Cell. 58, 1, p. 110-122 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

STING activation by translocation from the ER is associated with infection and autoinflammatory disease

Dobbs, N., Burnaevskiy, N., Chen, D., Gonugunta, V. K., Alto, N. M. & Yan, N., Aug 12 2015, In : Cell Host and Microbe. 18, 2, p. 157-168 12 p.

Research output: Contribution to journalArticle

115 Scopus citations
2016

Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection

Perelman, S. S., Abrams, M. E., Eitson, J. L., Chen, D., Jimenez, A., Mettlen, M., Schoggins, J. W. & Alto, N. M., Dec 21 2016, In : PLoS Pathogens. 12, 12, e1006102.

Research output: Contribution to journalArticle

7 Scopus citations

How Bacteria Subvert Animal Cell Structure and Function

Jimenez, A., Chen, D. & Alto, N. M., Oct 6 2016, In : Annual Review of Cell and Developmental Biology. 32, p. 373-397 25 p.

Research output: Contribution to journalArticle

14 Scopus citations

Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation

De Jong, M. F., Liu, Z., Chen, D. & Alto, N. M., May 27 2016, In : Nature Microbiology. 1, 7, 16084.

Research output: Contribution to journalArticle

34 Scopus citations
2017

A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

Weigele, B. A., Orchard, R. C., Jimenez, A., Cox, G. W. & Alto, N. M., Dec 1 2017, In : Nature Communications. 8, 1, 532.

Research output: Contribution to journalArticle

15 Scopus citations
2019

Screening Mycobacterium tuberculosis secreted proteins identifies Mpt64 as a eukaryotic membrane-binding bacterial effector

Stamm, C. E., Pasko, B. L., Chaisavaneeyakorn, S., Franco, L. H., Nair, V. R., Weigele, B. A., Alto, N. M. & Shiloh, M. U., May 1 2019, In : mSphere. 4, 3, e00354-19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations