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19992019

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Activation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation

Selyunin, A. S. & Alto, N. M., Jan 1 2011, In : Small GTPases. 2, 4, p. 217-221 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

A genetic screen for zygotic embryonic lethal mutations affecting cuticular morphology in the wasp Nasonia vitripennis

Pultz, M. A., Zimmerman, K. K., Alto, N. M., Kaeberlein, M., Lange, S. K., Pitt, J. N., Reeves, N. L. & Zehrung, D. L., Mar 1 2000, In : Genetics. 154, 3, p. 1213-1229 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

Analysis of Rho-GTPase Mimicry by a Family of Bacterial Type III Effector Proteins

Alto, N. M. & Dixon, J. E., 2008, In : Methods in Enzymology. 439, p. 131-143 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

Weigele, B. A., Orchard, R. C., Jimenez, A., Cox, G. W. & Alto, N. M., Dec 1 2017, In : Nature communications. 8, 1, 532.

Research output: Contribution to journalArticle

17 Scopus citations

Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring

Alto, N. M., Soderling, S. H., Hoshi, N., Langeberg, L. K., Fayos, R., Jennings, P. A. & Scott, J. D., Apr 15 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 8, p. 4445-4450 6 p.

Research output: Contribution to journalArticle

136 Scopus citations

Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection

Perelman, S. S., Abrams, M. E., Eitson, J. L., Chen, D., Jimenez, A., Mettlen, M., Schoggins, J. W. & Alto, N. M., Dec 21 2016, In : PLoS Pathogens. 12, 12, e1006102.

Research output: Contribution to journalArticle

8 Scopus citations

E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism

Weflen, A. W., Alto, N. M., Viswanathan, V. K. & Hecht, G., Jul 1 2010, In : Cellular Microbiology. 12, 7, p. 919-929 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration

Glotfelty, L. G., Zahs, A., Hodges, K., Shan, K., Alto, N. M. & Hecht, G. A., Dec 1 2014, In : Cellular Microbiology. 16, 12, p. 1767-1783 17 p.

Research output: Contribution to journalArticle

22 Scopus citations

Express Your LOV: An Engineered Flavoprotein as a Reporter for Protein Expression and Purification

Gawthorne, J. A., Reddick, L. E., Akpunarlieva, S. N., Beckham, K. S. H., Christie, J. M., Alto, N. M., Gabrielsen, M. & Roe, A. J., Dec 27 2012, In : PloS one. 7, 12, e52962.

Research output: Contribution to journalArticle

18 Scopus citations

Extensive zygotic control of the anteroposterior axis in the wasp Nasonia vitripennis

Pultz, M. A., Pitt, J. N. & Alto, N. M., Feb 1 1999, In : Development. 126, 4, p. 701-710 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Flow-induced DNA synthesis requires signaling to a translational control pathway

Kraiss, L. W., Ennis, T. M. & Alto, N. M., Jan 1 2001, In : Journal of Surgical Research. 97, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells

Kraiss, L. W., Weyrich, A. S., Alto, N. M., Dixon, D. A., Ennis, T. M., Modur, V., McIntyre, T. M., Prescott, S. M. & Zimmerman, G. A., May 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 278, 5 47-5, p. H1537-H1544

Research output: Contribution to journalArticle

64 Scopus citations

Fluid flow regulates E-selectin protein levels in human endothelial cells by inhibiting translation

Kraiss, L. W., Alto, N. M., Dixon, D. A., McIntyre, T. M., Weyrich, A. S. & Zimmerman, G. A., Jan 1 2003, In : Journal of vascular surgery. 37, 1, p. 161-168 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

How Bacteria Subvert Animal Cell Structure and Function

Jimenez, A., Chen, D. & Alto, N. M., Oct 6 2016, In : Annual Review of Cell and Developmental Biology. 32, p. 373-397 25 p.

Research output: Contribution to journalArticle

15 Scopus citations

Identification of a bacterial type III effector family with G protein mimicry functions

Alto, N. M., Shao, F., Lazar, C. S., Brost, R. L., Chua, G., Mattoo, S., McMahon, S. A., Ghosh, P., Hughes, T. R., Boone, C. & Dixon, J. E., Jan 13 2006, In : Cell. 124, 1, p. 133-145 13 p.

Research output: Contribution to journalArticle

192 Scopus citations

Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit

Orchard, R. C., Kittisopikul, M., Altschuler, S. J., Wu, L. F., Süel, G. M. & Alto, N. M., Feb 17 2012, In : Cell. 148, 4, p. 803-815 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Intracellular targeting of protein kinases and phosphatases

Alto, N., Carlisle Michel, J. J., Dodge, K. L., Langeberg, L. K. & Scott, J. D., Dec 1 2002, In : Diabetes. 51, SUPPL. 3, p. S385-S388

Research output: Contribution to journalArticle

39 Scopus citations

Mimicking GEFs: A common theme for bacterial pathogens

Orchard, R. C. & Alto, N. M., Jan 1 2012, In : Cellular Microbiology. 14, 1, p. 10-18 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ

Burnaevskiy, N., Peng, T., Reddick, L. E., Hang, H. C. & Alto, N. M., Apr 2 2015, In : Molecular cell. 58, 1, p. 110-122 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ

Burnaevskiy, N., Fox, T. G., Plymire, D. A., Ertelt, J. M., Weigele, B. A., Selyunin, A. S., Way, S. S., Patrie, S. M. & Alto, N. M., Apr 4 2013, In : Nature. 496, 7443, p. 106-109 4 p.

Research output: Contribution to journalArticle

81 Scopus citations

Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics

Alto, N. M., Soderling, J. & Scott, J. D., Aug 19 2002, In : Journal of Cell Biology. 158, 4, p. 659-668 10 p.

Research output: Contribution to journalArticle

163 Scopus citations

Rab32 modulates apoptosis onset and Mitochondria-associated Membrane (MAM) properties

Bui, M., Gilady, S. Y., Fitzsimmons, R. E. B., Benson, M. D., Lynes, E. M., Gesson, K., Alto, N. M., Strack, S., Scott, J. D. & Simmen, T., Oct 8 2010, In : Journal of Biological Chemistry. 285, 41, p. 31590-31602 13 p.

Research output: Contribution to journalArticle

101 Scopus citations

Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

Westphal, R. S., Tavalin, S. J., Lin, J. W., Alto, N. M., Fraser, I. D. C., Langeberg, L. K., Sheng, M. & Scott, J. D., Jul 2 1999, In : Science. 285, 5424, p. 93-96 4 p.

Research output: Contribution to journalArticle

410 Scopus citations

Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold

Westphal, R. S., Soderling, S. H., Alto, N. M., Langeberg, L. K. & Scott, J. D., Sep 1 2000, In : EMBO Journal. 19, 17, p. 4589-4600 12 p.

Research output: Contribution to journalArticle

171 Scopus citations

Screening Mycobacterium tuberculosis secreted proteins identifies Mpt64 as a eukaryotic membrane-binding bacterial effector

Stamm, C. E., Pasko, B. L., Chaisavaneeyakorn, S., Franco, L. H., Nair, V. R., Weigele, B. A., Alto, N. M. & Shiloh, M. U., May 1 2019, In : mSphere. 4, 3, e00354-19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Selective protection of an ARF1-GTP signaling axis by a bacterial scaffold induces bidirectional trafficking arrest

Selyunin, A. S., Reddick, L. E., Weigele, B. A. & Alto, N. M., Jan 1 2014, In : Cell Reports. 6, 5, p. 878-891 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation

De Jong, M. F., Liu, Z., Chen, D. & Alto, N. M., May 27 2016, In : Nature Microbiology. 1, 7, 16084.

Research output: Contribution to journalArticle

35 Scopus citations

STING activation by translocation from the ER is associated with infection and autoinflammatory disease

Dobbs, N., Burnaevskiy, N., Chen, D., Gonugunta, V. K., Alto, N. M. & Yan, N., Aug 12 2015, In : Cell Host and Microbe. 18, 2, p. 157-168 12 p.

Research output: Contribution to journalArticle

122 Scopus citations

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

Huang, Z., Sutton, S. E., Wallenfang, A. J., Orchard, R. C., Wu, X., Feng, Y., Chai, J. & Alto, N. M., Aug 1 2009, In : Nature Structural and Molecular Biology. 16, 8, p. 853-860 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation

Ohlson, M. B., Huang, Z., Alto, N. M., Blanc, M. P., Dixon, J. E., Chai, J. & Miller, S. I., Nov 13 2008, In : Cell Host and Microbe. 4, 5, p. 434-446 13 p.

Research output: Contribution to journalArticle

114 Scopus citations

Subversion of cell signaling by pathogens

Alto, N. M. & Orth, K., Sep 1 2012, In : Cold Spring Harbor Perspectives in Biology. 4, 9

Research output: Contribution to journalArticle

56 Scopus citations

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold

Selyunin, A. S., Sutton, S. E., Weigele, B. A., Reddick, L. E., Orchard, R. C., Bresson, S. M., Tomchick, D. R. & Alto, N. M., Jan 6 2011, In : Nature. 469, 7328, p. 107-113 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity

Hodges, K., Alto, N. M., Ramaswamy, K., Dudeja, P. K. & Hecht, G., Aug 1 2008, In : Cellular Microbiology. 10, 8, p. 1735-1745 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways

Alto, N. M., Weflen, A. W., Rardin, M. J., Yarar, D., Lazar, C. S., Tonikian, R., Koller, A., Taylor, S. S., Boone, C., Sidhu, S. S., Schmid, S. L., Hecht, G. A. & Dixon, J. E., Sep 24 2007, In : Journal of Cell Biology. 178, 7, p. 1265-1278 14 p.

Research output: Contribution to journalArticle

96 Scopus citations

Thinking outside the Osp(G) - Kinase activation by E2-ubiquitin

De Jong, M. F. & Alto, N. M., Mar 3 2014, In : EMBO Journal. 33, 5, p. 403-404 2 p.

Research output: Contribution to journalArticle

2 Scopus citations