• 3796 Citations
  • 21 h-Index
20062019
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Research Output 2006 2019

  • 3796 Citations
  • 21 h-Index
  • 34 Article
  • 1 Chapter
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Article
2019
2 Citations (Scopus)

Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers

Hashimoto, H., Wang, Z., Garry, G. A., Malladi, V. S., Botten, G. A., Ye, W., Zhou, H., Osterwalder, M., Dickel, D. E., Visel, A., Liu, N., Bassel-Duby, R. & Olson, E. N., Jul 3 2019, In : Cell Stem Cell. 25, 1, p. 69-86.e5

Research output: Contribution to journalArticle

Transcription Factors
Genome
Cardiac Myocytes
Gene Regulatory Networks
Fibroblasts
1 Citation (Scopus)

Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling

Wang, Z., Cui, M., Shah, A. M., Ye, W., Tan, W., Min, Y. L., Botten, G. A., Shelton, J. M., Liu, N., Bassel-Duby, R. S. & Olson, E. N., Sep 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18455-18465 11 p.

Research output: Contribution to journalArticle

Open Access
Histone Code
Transcriptome
Regeneration
Genes
RNA-Binding Proteins

Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells

Li, S., Karri, D., Sanchez-Ortiz, E., Jaichander, P., Bassel-Duby, R., Liu, N. & Olson, E. N., Oct 7 2019, In : Developmental Cell. 51, 1, p. 89-98.e4

Research output: Contribution to journalArticle

Semaphorin-3A
Electric fuses
Muscle Cells
Muscle
Fibers
1 Citation (Scopus)

Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding

Li, S., Chen, K., Zhang, Y., Barnes, S. D., Jaichander, P., Zheng, Y., Hassan, M., Malladi, V. S., Skapek, S. X., Xu, L., Bassel-Duby, R., Olson, E. N. & Liu, N., Jun 1 2019, In : Genes & development. 33, 11-12, p. 626-640 15 p.

Research output: Contribution to journalArticle

Open Access
Rhabdomyosarcoma
Muscle Development
Carcinogenesis
DNA
Chromatin
2018
1 Citation (Scopus)

Identification of a multipotent Twist2-expressing cell population in the adult heart

Min, Y. L., Jaichander, P., Sanchez-Ortiz, E., Bezprozvannaya, S., Malladi, V. S., Cui, M., Wang, Z., Bassel-Duby, R., Olson, E. N. & Liu, N., Sep 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. E8430-E8439

Research output: Contribution to journalArticle

Cardiac Myocytes
Population
Tamoxifen
Drosophila
Mammals
2017
33 Citations (Scopus)

A Twist2-dependent progenitor cell contributes to adult skeletal muscle

Liu, N., Garry, G. A., Li, S., Bezprozvannaya, S., Sanchez-Ortiz, E., Chen, B., Shelton, J. M., Jaichander, P., Bassel-Duby, R. & Olson, E. N., Mar 1 2017, In : Nature Cell Biology. 19, 3, p. 202-213 12 p.

Research output: Contribution to journalArticle

Skeletal Muscle
Stem Cells
Basement Membrane
Muscles
Regeneration
8 Citations (Scopus)

Deficiency in Kelch protein Klhl31 causes congenital myopathy in mice

Papizan, J. B., Garry, G. A., Brezprozvannaya, S., McAnally, J. R., Bassel-Duby, R., Liu, N. & Olson, E. N., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3730-3740 11 p.

Research output: Contribution to journalArticle

Filamins
Myotonia Congenita
Sarcomeres
Ubiquitination
Sarcoplasmic Reticulum
12 Citations (Scopus)

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination

Ramirez-Martinez, A., Cenik, B. K., Bezprozvannaya, S., Chen, B., Bassel-Duby, R., Liu, N. & Olson, E. N., Aug 9 2017, In : eLife. 6, e26439.

Research output: Contribution to journalArticle

Sarcomeres
Ubiquitination
Muscle
Skeletal Muscle
Nemaline Myopathies
32 Citations (Scopus)

YAP/TAZ-CDC42 signaling regulates vascular tip cell migration

Sakabe, M., Fan, J., Odaka, Y., Liu, N., Hassan, A., Duan, X., Stump, P., Byerly, L., Donaldson, M., Hao, J., Fruttiger, M., Lu, Q. R., Zheng, Y., Lang, R. A. & Xin, M., Oct 10 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 41, p. 10918-10923 6 p.

Research output: Contribution to journalArticle

Cell Movement
Blood Vessels
Endothelial Cells
Gene Dosage
Monomeric GTP-Binding Proteins
2016
63 Citations (Scopus)

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

Carroll, K. J., Makarewich, C. A., McAnally, J., Anderson, D. M., Zentilin, L., Liu, N., Giacca, M., Bassel-Duby, R. & Olson, E. N., Jan 12 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 2, p. 338-343 6 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Dependovirus
Gene Deletion
Guide RNA
Transgenic Mice
6 Citations (Scopus)

Micro RNA-19a suppresses IL-10 in peripheral B cells from patients with atherosclerosis

Ren, Z. Q., Liu, N. & Zhao, K., Oct 1 2016, In : Cytokine. 86, p. 86-91 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Interleukin-10
Atherosclerosis
B-Lymphocytes
Cells
7 Citations (Scopus)

Myocardin-related transcription factors are required for skeletal muscle development

Cenik, B. K., Liu, N., Chen, B., Bezprozvannaya, S., Olson, E. N. & Bassel-Duby, R., Aug 1 2016, In : Development (Cambridge). 143, 15, p. 2853-2861 9 p.

Research output: Contribution to journalArticle

Muscle Development
Skeletal Muscle
Transcription Factors
Sarcomeres
Actins

Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106

Anderson, D. M., Cannavino, J., Li, H., Anderson, K. M., Nelson, B. R., McAnally, J., Bezprozvannaya, S., Liu, Y., Lin, W., Liu, N., Bassel-Duby, R. & Olson, E. N., Aug 2 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 31, p. E4494-E4503

Research output: Contribution to journalArticle

Muscle Denervation
RNA-Binding Proteins
Skeletal Muscle
Motor Neurons
Muscles
12 Citations (Scopus)

Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106

Anderson, D. M., Cannavino, J., Li, H., Anderson, K. M., Nelson, B. R., McAnally, J., Bezprozvannaya, S., Liu, Y., Lin, W., Liu, N., Bassel-Duby, R. & Olson, E. N., Aug 2 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 31, p. E4494-E4503

Research output: Contribution to journalArticle

Muscle Denervation
RNA-Binding Proteins
Skeletal Muscle
Motor Neurons
Muscles
2015
10 Citations (Scopus)

Myocardin-related transcription factors are required for cardiac development and function

Mokalled, M. H., Carroll, K. J., Cenik, B. K., Chen, B., Liu, N., Olson, E. N. & Bassel-Duby, R., Oct 15 2015, In : Developmental Biology. 406, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

Serum Response Factor
Transcription Factors
Sarcomeres
Gene Regulatory Networks
Muscle Contraction
13 Citations (Scopus)

Regulation of skeletal muscle development and disease by microRNAs

Liu, N. & Bassel-Duby, R., 2015, In : Results and Problems in Cell Differentiation. 56, p. 165-190 26 p.

Research output: Contribution to journalArticle

Muscle Development
MicroRNAs
Skeletal Muscle
Protein Biosynthesis
Muscular Diseases
30 Citations (Scopus)

Severe myopathy in mice lacking the MEF2/SRFdependent gene leiomodin-3

Cenik, B. K., Garg, A., McAnally, J. R., Shelton, J. M., Richardson, J. A., Bassel-Duby, R., Olson, E. N. & Liu, N., Apr 1 2015, In : Journal of Clinical Investigation. 125, 4, p. 1569-1578 10 p.

Research output: Contribution to journalArticle

Nemaline Myopathies
Muscular Diseases
Actins
Serum Response Factor
Skeletal Muscle
2014
74 Citations (Scopus)

Requirement of MEF2A, C, and D for skeletal muscle regeneration

Liu, N., Nelson, B. R., Bezprozvannaya, S., Shelton, J. M., Richardson, J. A., Bassel-Duby, R. & Olson, E. N., Mar 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 4109-4114 6 p.

Research output: Contribution to journalArticle

Regeneration
Skeletal Muscle
MEF2 Transcription Factors
Muscles
Genes
2013
68 Citations (Scopus)

miR-133a Regulates Adipocyte Browning In Vivo

Liu, W., Bi, P., Shan, T., Yang, X., Yin, H., Wang, Y. X., Liu, N., Rudnicki, M. A. & Kuang, S., Jul 2013, In : PLoS Genetics. 9, 7, e1003626.

Research output: Contribution to journalArticle

White Adipose Tissue
white adipose tissue
Subcutaneous Fat
adipocytes
Adipocytes
2012
69 Citations (Scopus)

A Mouse Model of Rhabdomyosarcoma Originating from the Adipocyte Lineage

Hatley, M. E., Tang, W., Garcia, M. R., Finkelstein, D., Millay, D. P., Liu, N., Graff, J., Galindo, R. L. & Olson, E. N., Oct 16 2012, In : Cancer Cell. 22, 4, p. 536-546 11 p.

Research output: Contribution to journalArticle

Embryonal Rhabdomyosarcoma
Rhabdomyosarcoma
Adipocytes
Hedgehogs
Skeletal Muscle
158 Citations (Scopus)

Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*

Carrer, M., Liu, N., Grueter, C. E., Williams, A. H., Frisard, M. I., Hulver, M. W., Bassel-Duby, R. & Olson, E. N., Sep 18 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 38, p. 15330-15335 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Energy Metabolism
Homeostasis
Carnitine O-Acetyltransferase
Obesity
186 Citations (Scopus)

MicroRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice

Liu, N., Williams, A. H., Maxeiner, J. M., Bezprozvannaya, S., Shelton, J. M., Richardson, J. A., Bassel-Duby, R. & Olson, E. N., Jun 1 2012, In : Journal of Clinical Investigation. 122, 6, p. 2054-2065 12 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
MicroRNAs
Regeneration
Skeletal Muscle
Wounds and Injuries
53 Citations (Scopus)

Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy

Drawnel, F. M., Wachten, D., Molkentin, J. D., Maillet, M., Aronsen, J. M., Swift, F., Sjaastad, I., Liu, N., Catalucci, D., Mikoshiba, K., Hisatsune, C., Okkenhaug, H., Andrews, S. R., Bootman, M. D. & Roderick, H. L., Nov 2012, In : Journal of Cell Biology. 199, 5, p. 783-798 16 p.

Research output: Contribution to journalArticle

Cardiomegaly
MicroRNAs
Calcium
Inositol 1,4,5-Trisphosphate Receptors
Calcium Signaling
27 Citations (Scopus)

Regulated expression of pH sensing G protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease

Russell, J. L., Goetsch, S. C., Aguilar, H. R., Coe, H., Luo, X., Liu, N., Van Rooij, E., Frantz, D. E. & Schneider, J. W., Jun 15 2012, In : ACS Chemical Biology. 7, 6, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

Isoxazoles
Myocardial Ischemia
Pericardium
Pharmaceutical Preparations
Protons
2011
85 Citations (Scopus)

Mice lacking microRNA 133a develop dynamin 2-dependent centronuclear myopathy

Liu, N., Bezprozvannaya, S., Shelton, J. M., Frisard, M. I., Hulver, M. W., McMillan, R. P., Wu, Y., Voelker, K. A., Grange, R. W., Richardson, J. A., Bassel-Duby, R. & Olson, E. N., Aug 1 2011, In : Journal of Clinical Investigation. 121, 8, p. 3258-3268 11 p.

Research output: Contribution to journalArticle

Dynamin II
Congenital Structural Myopathies
MicroRNAs
Skeletal Muscle
Excitation Contraction Coupling
2010
43 Citations (Scopus)

Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2

Vo, N. K., Dalton, R. P., Liu, N., Olson, E. N. & Goodman, R. H., Nov 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19231-19236 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Transcription Factors
Messenger RNA
3' Untranslated Regions
Computational Biology
338 Citations (Scopus)

MicroRNA Regulatory Networks in Cardiovascular Development

Liu, N. & Olson, E. N., Apr 2010, In : Developmental Cell. 18, 4, p. 510-525 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Gene expression
Gene Expression
Governors
Heart Diseases
2009
26 Citations (Scopus)

DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis

Liu, N., Barbosa, A. C., Chapman, S. L., Bezprozvannaya, S., Qi, X., Richardson, J. A., Yanagisawa, H. & Olson, E. N., Mar 15 2009, In : Development. 136, 6, p. 933-942 10 p.

Research output: Contribution to journalArticle

Embryonic Development
Transcription Factors
Embryonic Structures
DNA
Growth and Development
234 Citations (Scopus)

MicroRNA control of muscle development and disease

Williams, A. H., Liu, N., van Rooij, E. & Olson, E. N., Jun 2009, In : Current Opinion in Cell Biology. 21, 3, p. 461-469 9 p.

Research output: Contribution to journalArticle

Muscle Development
MicroRNAs
Gene Expression
Skeletal Muscle
Transcription Factors
2008
531 Citations (Scopus)

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

Liu, N., Bezprozvannaya, S., Williams, A. H., Qi, X., Richardson, J. A., Bassel-Duby, R. & Olson, E. N., Dec 1 2008, In : Genes and Development. 22, 23, p. 3242-3254 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Cardiac Myocytes
Smooth Muscle
Gene Expression
Cyclin D2
230 Citations (Scopus)

MicroRNAs flex their muscles

van Rooij, E., Liu, N. & Olson, E. N., Apr 2008, In : Trends in Genetics. 24, 4, p. 159-166 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Muscles
Gene Expression
Muscular Dystrophies
Myoblasts
2007
317 Citations (Scopus)

An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

Liu, N., Williams, A. H., Kim, Y., McAnally, J., Bezprozvannaya, S., Sutherland, L. B., Richardson, J. A., Bassel-Duby, R. & Olson, E. N., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20844-20849 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Muscle Development
Muscles
Embryonic Development
MEF2 Transcription Factors
2006
1103 Citations (Scopus)

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

Van Rooij, E., Sutherland, L. B., Liu, N., Williams, A. H., McAnally, J., Gerard, R. D., Richardson, J. A. & Olson, E. N., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18255-18260 6 p.

Research output: Contribution to journalArticle

Cardiomegaly
MicroRNAs
Heart Failure
Cardiac Myocytes
Growth
23 Citations (Scopus)

Coactivator control of cardiovascular growth and remodeling

Liu, N. & Olson, E. N., Dec 2006, In : Current Opinion in Cell Biology. 18, 6, p. 715-722 8 p.

Research output: Contribution to journalArticle

Cardiovascular System
Biological Phenomena
Gene Expression
Growth
Growth and Development