• 3836 Citations
  • 29 h-Index
19962019
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Research Output 1996 2019

  • 3836 Citations
  • 29 h-Index
  • 64 Article
  • 6 Chapter
  • 1 Comment/debate
  • 1 Short survey
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Article
2019

LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation

Braitsch, C. M., Azizoglu, D. B., Htike, Y., Barlow, H. R., Schnell, U., Chaney, C. P., Carroll, T. J., Stanger, B. Z. & Cleaver, O., Jul 1 2019, In : PLoS biology. 17, 7, e3000382.

Research output: Contribution to journalArticle

Open Access
Cell signaling
Epithelial-Mesenchymal Transition
pancreas
cell differentiation
Tumors
2 Citations (Scopus)

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

Du, Q., Hoover, A. R., Dozmorov, I., Raj, P., Khan, S., Molina, E., Chang, T-C., De La Morena, M. T., Cleaver, O., Mendell, J. T. & Van Oers, N., May 20 2019, In : Developmental Cell. 49, 4, p. 618-631.e5

Research output: Contribution to journalArticle

Long Noncoding RNA
Prolactin
Growth Hormone
MicroRNAs
Genes
1 Citation (Scopus)

Specifying the pancreatic islet through biomechanical forces

Cleaver, O., Mar 28 2019, In : New England Journal of Medicine. 380, 13, p. 1281-1283 3 p.

Research output: Contribution to journalArticle

Islets of Langerhans
Developmental Biology
Regenerative Medicine
Organogenesis
Endothelial Cells
Organoids
2018
77 Citations (Scopus)

Consensus guidelines for the use and interpretation of angiogenesis assays

Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., Augustin, H. G., Bates, D. O., van Beijnum, J. R., Bender, R. H. F., Bergers, G., Bikfalvi, A., Bischoff, J., Böck, B. C., Brooks, P. C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A. M. & 66 others, Cleaver, O., Coukos, G., Davis, G. E., de Palma, M., Dimberg, A., Dings, R. P. M., Djonov, V., Dudley, A. C., Dufton, N. P., Fendt, S. M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesquière, B., Gong, Y., Griffin, R. J., Harris, A. L., Hughes, C. C. W., Hultgren, N. W., Iruela-Arispe, M. L., Irving, M., Jain, R. K., Kalluri, R., Kalucka, J., Kerbel, R. S., Kitajewski, J., Klaassen, I., Kleinmann, H. K., Koolwijk, P., Kuczynski, E., Kwak, B. R., Marien, K., Melero-Martin, J. M., Munn, L. L., Nicosia, R. F., Noel, A., Nurro, J., Olsson, A. K., Petrova, T. V., Pietras, K., Pili, R., Pollard, J. W., Post, M. J., Quax, P. H. A., Rabinovich, G. A., Raica, M., Randi, A. M., Ribatti, D., Ruegg, C., Schlingemann, R. O., Schulte-Merker, S., Smith, L. E. H., Song, J. W., Stacker, S. A., Stalin, J., Stratman, A. N., van de Velde, M., van Hinsbergh, V. W. M., Vermeulen, P. B., Waltenberger, J., Weinstein, B. M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M. C. & Griffioen, A. W., May 15 2018, (Accepted/In press) In : Angiogenesis. p. 1-108 108 p.

Research output: Contribution to journalArticle

Bioassay
Biological Assay
Assays
Guidelines
Blood vessels
1 Citation (Scopus)

Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions

Liu, X., Gu, X., Ma, W., Oxendine, M., Gil, H. J., Davis, G. E., Cleaver, O. & Oliver, G., Sep 1 2018, In : Development (Cambridge). 145, 17, dev165092.

Research output: Contribution to journalArticle

Lymphatic Vessels
Intercellular Junctions
Endothelial Cells
Maintenance
Cytoskeleton
15 Citations (Scopus)

Spatiotemporal heterogeneity and patterning of developing renal blood vessels

Daniel, E., Azizoglu, D. B., Ryan, A. R., Walji, T. A., Chaney, C. P., Sutton, G. I., Carroll, T. J., Marciano, D. K. & Cleaver, O., Apr 7 2018, (Accepted/In press) In : Angiogenesis. p. 1-18 18 p.

Research output: Contribution to journalArticle

Endothelial cells
Blood vessels
Blood Vessels
Nephrons
Kidney
2017
22 Citations (Scopus)

(Re)Building a Kidney

Oxburgh, L., Carroll, T. J., Cleaver, O., Gossett, D. R., Hoshizaki, D. K., Hubbell, J. A., Humphreys, B. D., Jain, S., Jensen, J., Kaplan, D. L., Kesselman, C., Ketchum, C. J., Little, M. H., McMahon, A. P., Shankland, S. J., Spence, J. R., Valerius, M. T., Wertheim, J. A., Wessely, O., Zheng, Y. & 1 others, Drummond, I. A., May 1 2017, In : Journal of the American Society of Nephrology : JASN. 28, 5, p. 1370-1378 9 p.

Research output: Contribution to journalArticle

Kidney
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Bioengineering
Pluripotent Stem Cells
Nephrons
6 Citations (Scopus)

Afadin and Rhoa control pancreatic endocrine mass via lumen morphogenesis

Azizoglu, D. B., Braitsch, C., Marciano, D. K. & Cleaver, O., Dec 1 2017, In : Genes and Development. 31, 23-24, p. 2376-2390 15 p.

Research output: Contribution to journalArticle

Morphogenesis
Endocrine Cells
Actomyosin
Islets of Langerhans
Pancreas
14 Citations (Scopus)

Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein–Induced Retinal Angiogenesis

Lee, H. W., Chong, D. C., Ola, R., Dunworth, W. P., Meadows, S., Ka, J., Kaartinen, V. M., Qyang, Y., Cleaver, O., Bautch, V. L., Eichmann, A. & Jin, S. W., Feb 23 2017, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors
Bone and Bones
Retinal Vessels
Blood Vessels
6 Citations (Scopus)

CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane

Li, J., Miao, L., Zhao, C., Qureshi, W. M. S., Shieh, D., Guo, H., Lu, Y., Hu, S., Huang, A., Zhang, L., Cai, C. L., Wan, L. Q., Xin, H., Vincent, P., Singer, H. A., Zheng, Y., Cleaver, O., Fan, Z. C. & Wu, M., May 1 2017, In : Development (Cambridge). 144, 9, p. 1635-1647 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Pericardium
Cell Membrane
Myocardium
Cysts
2 Citations (Scopus)

Src- and Fyn-dependent apical membrane trafficking events control endothelial lumen formation during vascular tube morphogenesis

Kim, D. J., Norden, P. R., Salvador, J., Barry, D. M., Bowers, S. L. K., Cleaver, O. & Davis, G. E., Sep 1 2017, In : PLoS One. 12, 9, e0184461.

Research output: Contribution to journalArticle

Morphogenesis
blood vessels
src-Family Kinases
morphogenesis
vacuoles
2016
4 Citations (Scopus)

Blood vessel crosstalk during organogenesis—focus on pancreas and endothelial cells

Azizoglu, D. B. & Cleaver, O., Sep 1 2016, In : Wiley Interdisciplinary Reviews: Developmental Biology. 5, 5, p. 598-617 20 p.

Research output: Contribution to journalArticle

Blood Vessels
Pancreas
Endothelial Cells
Endocrine Cells
Organogenesis
15 Citations (Scopus)
Monomeric GTP-Binding Proteins
GTP Phosphohydrolases
guanosinetriphosphatase
tubulin
integrins
10 Citations (Scopus)

MicroRNA-205 maintains T cell development following stress by regulating forkhead box N1 and selected chemokines

Hoover, A. R., Dozmorov, I., MacLeod, J., Du, Q., De La Teresa Morena, M., Forbess, J., Guleserian, K., Cleaver, O. B. & Van Oers, N. S. C., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 23237-23247 11 p.

Research output: Contribution to journalArticle

T-cells
MicroRNAs
Chemokines
T-Lymphocytes
Stem Cell Factor
22 Citations (Scopus)

Pdx1 regulates pancreas tubulogenesis and E-cadherin expression

Marty-Santos, L. & Cleaver, O., Jan 1 2016, In : Development (Cambridge). 143, 1, p. 101-112 12 p.

Research output: Contribution to journalArticle

Cadherins
Pancreas
Epithelium
Stem Cells
Actomyosin
10 Citations (Scopus)

Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth

Koo, Y., Barry, D. M., Xu, K., Tanigaki, K., Davis, G. E., Mineo, C. & Cleaver, O., Feb 20 2016, (Accepted/In press) In : Angiogenesis. p. 1-18 18 p.

Research output: Contribution to journalArticle

Blood vessels
Blood Vessels
Endothelial cells
Growth
Endothelial Cells
14 Citations (Scopus)

Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II

Barry, D. M., Koo, Y., Norden, P. R., Wylie, L. A., Xu, K., Wichaidit, C., Azizoglu, D. B., Zheng, Y., Cobb, M. H., Davis, G. E. & Cleaver, O., Sep 16 2016, In : Circulation Research. 119, 7, p. 810-826 17 p.

Research output: Contribution to journalArticle

Myosin Type II
ras Proteins
rho GTP-Binding Proteins
Blood Vessels
Actomyosin
6 Citations (Scopus)

Role of CD34 family members in lumen formation in the developing kidney

Yang, Z., Zimmerman, S. E., Tsunezumi, J., Braitsch, C., Trent, C., Bryant, D. M., Cleaver, O., González-Manchón, C. & Marciano, D. K., Oct 1 2016, In : Developmental Biology. 418, 1, p. 66-74 9 p.

Research output: Contribution to journalArticle

Kidney
Nephrons
Exosomes
Microfilament Proteins
Podocytes
9 Citations (Scopus)

Vascular development in the vertebrate pancreas

Azizoglu, D. B., Chong, D. C., Villasenor, A., Magenheim, J., Barry, D. M., Lee, S., Marty-Santos, L., Fu, S., Dor, Y. & Cleaver, O., Dec 1 2016, In : Developmental Biology. 420, 1, p. 67-78 12 p.

Research output: Contribution to journalArticle

Blood Vessels
Vertebrates
Pancreas
Mesoderm
Vascular Endothelial Growth Factor A
2015
4 Citations (Scopus)

Annexin A3 regulates early blood vessel formation

Meadows, S. M. & Cleaver, O., Jul 16 2015, In : PLoS One. 10, 7, e0132580.

Research output: Contribution to journalArticle

Annexin A3
Annexins
Blood vessels
blood vessels
Blood Vessels
44 Citations (Scopus)

Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice

Barry, D. M., Xu, K., Meadows, S. M., Zheng, Y., Norden, P. R., Davis, G. E. & Cleaver, O., Sep 1 2015, In : Development (Cambridge). 142, 17, p. 3058-3070 13 p.

Research output: Contribution to journalArticle

Cell Adhesion
Blood Vessels
Endothelial Cells
Actins
Actomyosin
24 Citations (Scopus)

Endosomal sorting of notch receptors through COM MD9-dependent pathways modulates notch signaling

Li, H., Koo, Y., Mao, X., Sifuentes-Dominguez, L., Morris, L. L., Jia, D., Miyata, N., Faulkner, R. A., van Deursen, J. M., Vooijs, M., Billadeau, D. D., Van de Sluis, B., Cleaver, O. & Burstein, E., Nov 1 2015, In : Journal of Cell Biology. 211, 3, p. 605-617 13 p.

Research output: Contribution to journalArticle

Notch Receptors
Copper
Recycling
Ligands
Genes
6 Citations (Scopus)

Progenitor Epithelium: Sorting Out Pancreatic Lineages

Marty-Santos, L. & Cleaver, O., Aug 29 2015, In : Journal of Histochemistry and Cytochemistry. 63, 8, p. 559-574 16 p.

Research output: Contribution to journalArticle

Epithelium
Intrinsic Factor
Cell Lineage
Embryonic Stem Cells
Epigenomics
6 Citations (Scopus)

Vascular patterning: Coordinated signals keep blood vessels on track

Meadows, S. M. & Cleaver, O., Jun 1 2015, In : Current Opinion in Genetics and Development. 32, p. 86-91 6 p.

Research output: Contribution to journalArticle

Blood Vessels
Morphogenesis
Cues
Embryonic Structures
Endothelial Cells
21 Citations (Scopus)

Wnt4 is essential to normal mammalian lung development

Caprioli, A., Villasenor, A., Wylie, L. A., Braitsch, C., Marty-Santos, L., Barry, D., Karner, C. M., Fu, S., Meadows, S. M., Carroll, T. J. & Cleaver, O., Oct 15 2015, In : Developmental Biology. 406, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Lung
Organogenesis
Mesoderm
Wnt4 Protein
Respiratory System
2014
57 Citations (Scopus)

Autophagy is essential for cardiac morphogenesis during vertebrate development

Lee, E., Koo, Y., Ng, A., Wei, Y., Luby-Phelps, K., Juraszek, A., Xavier, R. J., Cleaver, O., Levine, B. & Amatruda, J. F., 2014, In : Autophagy. 10, 4, p. 572-587 16 p.

Research output: Contribution to journalArticle

Autophagy
Morphogenesis
Vertebrates
Zebrafish
Morpholinos
49 Citations (Scopus)

Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos

Dunworth, W. P., Cardona-Costa, J., Bozkulak, E. C., Kim, J. D., Meadows, S., Fischer, J. C., Wang, Y., Cleaver, O., Qyang, Y., Ober, E. A. & Jin, S. W., Jan 3 2014, In : Circulation Research. 114, 1, p. 56-66 11 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Vertebrates
Embryonic Structures
Endothelial Cells
Zebrafish
3 Citations (Scopus)

Outside in: Inversion of cell polarity controls epithelial lumen formation

Davis, G. E. & Cleaver, O. B., Oct 27 2014, In : Developmental Cell. 31, 2, p. 140-142 3 p.

Research output: Contribution to journalArticle

Cell Polarity
Epithelial Cells
Polarization
Membranes
podocalyxin
2013
17 Citations (Scopus)

Resolution of defective dorsal aortae patterning in Sema3E-deficient mice occurs via angiogenic remodeling

Meadows, S. M., Ratliff, L. A., Singh, M. K., Epstein, J. A. & Cleaver, O., May 2013, In : Developmental Dynamics. 242, 5, p. 580-590 11 p.

Research output: Contribution to journalArticle

Semaphorins
Aorta
Cues
Blood Vessels
Embryonic Structures
15 Citations (Scopus)

Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line

Krautkramer, K. A., Linnemann, A. K., Fontaine, D. A., Whillock, A. L., Harris, T. W., Schleis, G. J., Truchan, N. A., Marty-Santos, L., Lavine, J. A., Cleaver, O., Kimple, M. E. & Davis, D. B., 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 5

Research output: Contribution to journalArticle

Cell Line
Survival
Insulinoma
Apoptosis
Calreticulin
2012
22 Citations (Scopus)

Crosstalk between the developing pancreas and its blood vessels: An evolving dialog

Villasenor, A. & Cleaver, O., Aug 2012, In : Seminars in Cell and Developmental Biology. 23, 6, p. 685-692 8 p.

Research output: Contribution to journalArticle

Blood Vessels
Pancreas
Organogenesis
Growth and Development
Cues
18 Citations (Scopus)

EphB3 marks delaminating endocrine progenitor cells in the developing pancreas

Villasenor, A., Marty-Santos, L., Dravis, C., Fletcher, P., Henkemeyer, M. & Cleaver, O., May 2012, In : Developmental Dynamics. 241, 5, p. 1008-1019 12 p.

Research output: Contribution to journalArticle

Endocrine Cells
Pancreas
Stem Cells
Epithelium
Synaptophysin
35 Citations (Scopus)

Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels

Meadows, S. M., Fletcher, P. J., Moran, C., Xu, K., Neufeld, G., Chauvet, S., Mann, F., Krieg, P. A. & Cleaver, O., Jan 6 2012, In : Circulation Research. 110, 1, p. 34-36 3 p.

Research output: Contribution to journalArticle

Cues
Blood Vessels
Endothelial Cells
Notochord
Mesoderm
49 Citations (Scopus)

Vascular instruction of pancreas development

Cleaver, O. & Dor, Y., Aug 15 2012, In : Development (Cambridge). 139, 16, p. 2833-2843 11 p.

Research output: Contribution to journalArticle

Blood Vessels
Pancreas
Growth
Morphogenesis
Embryonic Development
2011
66 Citations (Scopus)

Blood vessels restrain pancreas branching, differentiation and growth

Magenheim, J., Ilovich, O., Lazarus, A., Klochendler, A., Ziv, O., Werman, R., Hija, A., Cleaver, O., Mishani, E., Keshet, E. & Dor, Y., Nov 1 2011, In : Development. 138, 21, p. 4743-4752 10 p.

Research output: Contribution to journalArticle

Blood Vessels
Pancreas
Growth
Endocrine Cells
Organ Size
90 Citations (Scopus)

Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling

Xu, K., Sacharidou, A., Fu, S., Chong, D. C., Skaug, B., Chen, Z. J., Davis, G. E. & Cleaver, O., Apr 19 2011, In : Developmental Cell. 20, 4, p. 526-539 14 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Blood vessels
Blood Vessels
Endothelial cells
Adhesion
58 Citations (Scopus)

HoxA3 is an apical regulator of haemogenic endothelium

Iacovino, M., Chong, D., Szatmari, I., Hartweck, L., Rux, D., Caprioli, A., Cleaver, O. & Kyba, M., Jan 2011, In : Nature Cell Biology. 13, 1, p. 72-78 7 p.

Research output: Contribution to journalArticle

Endothelium
Yolk Sac
Endothelial Cells
Hematopoiesis
Hematopoietic Stem Cells
52 Citations (Scopus)

Stepwise arteriovenous fate acquisition during mammalian vasculogenesis

Chong, D. C., Koo, Y., Xu, K., Fu, S. & Cleaver, O., Sep 2011, In : Developmental Dynamics. 240, 9, p. 2153-2165 13 p.

Research output: Contribution to journalArticle

Veins
Arteries
Mammalian Embryo
Spatio-Temporal Analysis
Blood Vessels

The developing endothelium in action

Cleaver, O., Dec 2011, In : Seminars in Cell and Developmental Biology. 22, 9, p. 975 1 p.

Research output: Contribution to journalArticle

Endothelium
46 Citations (Scopus)

Tubulogenesis during blood vessel formation

Xu, K. & Cleaver, O., Dec 2011, In : Seminars in Cell and Developmental Biology. 22, 9, p. 993-1004 12 p.

Research output: Contribution to journalArticle

Blood Vessels
Paint
Zebrafish
Morphogenesis
Mammals
2010
128 Citations (Scopus)

Epithelial dynamics of pancreatic branching morphogenesis

Villasenor, A., Chong, D. C., Henkemeyer, M. & Cleaver, O., Dec 15 2010, In : Development. 137, 24, p. 4295-4305 11 p.

Research output: Contribution to journalArticle

Cell Polarity
Cell Shape
Morphogenesis
Pancreas
Digestion
18 Citations (Scopus)

Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes

Villasenor, A., Wang, Z. V., Rivera, L. B., Ocal, O., Asterholm, I. W., Scherer, P. E., Brekken, R. A., Cleaver, O. & Wilkie, T. M., Sep 2010, In : DMM Disease Models and Mechanisms. 3, 9-10, p. 567-580 14 p.

Research output: Contribution to journalArticle

Medical problems
Islets of Langerhans
GTP-Binding Protein Regulators
Insulin
Endocrine Cells
2009
73 Citations (Scopus)

BMP and BMP receptor expression during murine organogenesis

Danesh, S. M., Villasenor, A., Chong, D., Soukup, C. & Cleaver, O., Jun 2009, In : Gene Expression Patterns. 9, 5, p. 255-265 11 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein Receptors
Bone Morphogenetic Proteins
Organogenesis
Ligands
Somites
206 Citations (Scopus)

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P., Wu, L., Hammer, R. E., Cleaver, O. & McKnight, S. L., Jul 24 2009, In : Science. 325, 5939, p. 435-439 5 p.

Research output: Contribution to journalArticle

Threonine
Embryonic Stem Cells
L-threonine 3-dehydrogenase
Glycine
Carbon
46 Citations (Scopus)

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice

Xie, J., Wu, T., Xu, K., Huang, I. K., Cleaver, O. & Huang, C. L., Sep 2009, In : American Journal of Pathology. 175, 3, p. 1315-1327 13 p.

Research output: Contribution to journalArticle

Veins
Phosphotransferases
Arteries
Lysine
Endothelial Cells
39 Citations (Scopus)
Phosphatidylinositol 3-Kinases
Endocytosis
Ligands
Mutation
Tyrosine
43 Citations (Scopus)

Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation

Xu, K., Chong, D. C., Rankin, S. A., Zorn, A. M. & Cleaver, O., May 15 2009, In : Developmental Biology. 329, 2, p. 269-279 11 p.

Research output: Contribution to journalArticle

Cell Movement
Blood Vessels
Endothelial Cells
ras Proteins
Anura
2008
79 Citations (Scopus)

Biphasic Ngn3 expression in the developing pancreas

Villasenor, A., Chong, D. C. & Cleaver, O., Nov 2008, In : Developmental Dynamics. 237, 11, p. 3270-3279 10 p.

Research output: Contribution to journalArticle

Islets of Langerhans
Pancreas
Endocrine Cells
Epithelium
Basic Helix-Loop-Helix Transcription Factors
104 Citations (Scopus)

Prospective isolation of skeletal muscle stem cells with a Pax7 reporter

Bosnakovski, D., Xu, Z., Li, W., Thet, S., Cleaver, O., Perlingeiro, R. C. R. & Kyba, M., Dec 2008, In : Stem Cells. 26, 12, p. 3194-3204 11 p.

Research output: Contribution to journalArticle

Muscle Cells
Skeletal Muscle
Stem Cells
Muscles
Suspensions