• 7937 Citations
  • 43 h-Index
1993 …2019

Research output per year

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Research Output

  • 7937 Citations
  • 43 h-Index
  • 100 Article
  • 3 Conference contribution
  • 2 Chapter
  • 1 Comment/debate
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Article
2019

Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase

Lee, C. F., Dang, A., Hernandez, E., Pong, R. C., Chen, P. B., Sonavane, R., Raj, G., Kapur, P., Lin, H. Y., Wu, S. R., Ko, C. J., Lo, U. G., Lee, H. Y., Hsieh, J-T. & Lee, M. S., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

A nanodroplet cell processing platform facilitating drug synergy evaluations for anti-cancer treatments

Kuo, C. T., Wang, J. Y., Lu, S. R., Lai, Y. S., Chang, H. H., Hsieh, J-T., Wo, A. M., Chen, P. B., Lu, J. H. & Lee, H., Dec 1 2019, In : Scientific Reports. 9, 1, 10120.

Research output: Contribution to journalArticle

Open Access

Downregulation of human DAB2IP gene expression in renal cell carcinoma results in resistance to ionizing radiation

Yun, E. J., Lin, C. J., Dang, A., Hernandez, E., Guo, J., Chen, W. M., Allison, J., Kim, N., Kapur, P., Brugarolas, J. B., Wu, K., He, D., Lai, C. H., Lin, H., Saha, D., Baek, S. T., Chen, P. B. & Hsieh, J-T., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4542-4551 10 p.

Research output: Contribution to journalArticle

Lysophosphatidic acid receptor LPA3 prevents oxidative stress and cellular senescence in Hutchinson–Gilford progeria syndrome

Chen, W. M., Chiang, J. C., Lin, Y. C., Lin, Y. N., Chuang, P. Y., Chang, Y. C., Chen, C. C., Wu, K. Y., Hsieh, J. C., Chen, S. K., Huang, W. P., Chen, B. P. C. & Lee, H., Jan 1 2019, (Accepted/In press) In : Aging Cell. e13064.

Research output: Contribution to journalArticle

Open Access

Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation

Han, Y., Wu, P., Wang, Z., Zhang, Z., Sun, S., Liu, J., Gong, S., Gao, P., Iwakuma, T., Molina-Vila, M. A., Chen, P. B., Zhang, Y., Ji, T., Mo, Q., Chen, P., Hu, J., Wang, S., Zhou, J., Lu, H. & Gao, Q., Jan 1 2019, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Facilitating tumor spheroid-based bioassays and: In vitro blood vessel modeling via bioinspired self-formation microstructure devices

Kuo, C. T., Lu, S. R., Chen, W. M., Wang, J. Y., Lee, S. C., Chang, H. H., Wo, A. M., Chen, B. P. C. & Lee, H., Jan 1 2018, In : Lab on a Chip. 18, 16, p. 2453-2465 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

High Glucose Induces VEGF-C Expression via the LPA 1/3 -Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells

Huang, Y. L., Lin, Y. C., Lin, C. C., Chen, W. M., Chen, P. B. & Lee, H., Oct 1 2018, In : Cellular Physiology and Biochemistry. 50, 2, p. 612-628 17 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway

Lin, Y. F., Shih, H. Y., Shang, Z. F., Kuo, C. T., Guo, J., Du, C., Lee, H. & Chen, B. P. C., Feb 28 2018, In : Nucleic Acids Research. 46, 4, p. 1847-1859 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Whole-body 12C irradiation transiently decreases mouse hippocampal dentate gyrus proliferation and immature neuron number, but does not change new neuron survival rate

Zanni, G., Deutsch, H. M., Rivera, P. D., Shih, H. Y., Leblanc, J. A., Amaral, W. Z., Lucero, M. J., Redfield, R. L., Desalle, M. J., Chen, P. B., Whoolery, C. W., Reynolds, R. P., Yun, S. & Eisch, A. J., Oct 9 2018, In : International Journal of Molecular Sciences. 19, 10, 3078.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Androgen receptor variants mediate DNA repair after prostate cancer irradiation

Yin, Y., Li, R., Xu, K., Ding, S., Li, J., Baek, G. H., Ramanand, S. G., Ding, S., Liu, Z., Gao, Y., Kanchwala, M. S., Li, X., Hutchinson, R., Liu, X., Woldu, S. L., Xing, C., Desai, N. B., Feng, F. Y., Burma, S., De Bono, J. S. & 4 others, Dehm, S. M., Mani, R. S., Chen, B. P. C. & Raj, G. V., Sep 15 2017, In : Cancer Research. 77, 18, p. 4745-4754 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells

Nagasawa, H., Lin, Y. F., Kato, T. A., Brogan, J. R., Shih, H. Y., Kurimasa, A., Bedford, J. S., Chen, B. P. C. & Little, J. B., Feb 1 2017, In : Radiation Research. 187, 2, p. 259-267 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Looping-out mechanism for resolution of replicative stress at telomeres

Zhang, T., Zhang, Z., Li, F., Hu, Q., Liu, H., Tang, M., Ma, W., Huang, J., Songyang, Z., Rong, Y., Zhang, S., Chen, B. P. & Zhao, Y., 2017, (Accepted/In press) In : EMBO Reports.

Research output: Contribution to journalArticle

11 Scopus citations

ParaStamp and Its Applications to Cell Patterning, Drug Synergy Screening, and Rewritable Devices for Droplet Storage

Kuo, C. T., Wang, J. Y., Wo, A. M., Chen, P. B. & Lee, H., May 1 2017, In : Advanced Biosystems. 1, 5, 1700048.

Research output: Contribution to journalArticle

5 Scopus citations

Three-dimensional spheroid culture targeting versatile tissue bioassays using a PDMS-based hanging drop array

Kuo, C. T., Wang, J. Y., Lin, Y. F., Wo, A. M., Chen, B. P. C. & Lee, H., Dec 1 2017, In : Scientific Reports. 7, 1, 4718.

Research output: Contribution to journalArticle

17 Scopus citations

Whole-body exposure to 28Si-radiation dose-dependently disrupts dentate gyrus neurogenesis and proliferation in the short term and new neuron survival and contextual fear conditioning in the long term

Whoolery, C. W., Walker, A. K., Richardson, D. R., Lucero, M. J., Reynolds, R. P., Beddow, D. H., Clark, K. L., Shih, H. Y., Leblanc, J. A., Cole, M. G., Amaral, W. Z., Mukherjee, S., Zhang, S., Ahn, F., Bulin, S. E., Decarolis, N. A., Rivera, P. D., Chen, B. P. C., Yun, S. & Eisch, A. J., Nov 1 2017, In : Radiation Research. 188, 5, p. 532-551 20 p.

Research output: Contribution to journalArticle

13 Scopus citations
2016
7 Scopus citations
2015

DNA-PKcs phosphorylates hnRNP-A1 to facilitate the RPA-to-POT1 switch and telomere capping after replication

Sui, J., Lin, Y. F., Xu, K., Lee, K. J., Wang, D. & Chen, B. P. C., 2015, In : Nucleic Acids Research. 43, 12, p. 5971-5983 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

Yang, Y., Liu, Z., Wang, F., Temviriyanukul, P., Ma, X., Tu, Y., Lv, L., Lin, Y. F., Huang, M., Zhang, T., Pei, H., Chen, B. P. C., Jansen, J. G., De Wind, N., Fischhaber, P. L., Friedberg, E. C., Tang, T. S. & Guo, C., Sep 30 2015, In : Nucleic Acids Research. 43, 17, p. 8325-8339 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNAPKcs inhibitor

Yu, L., Shang, Z. F., Hsu, F. M., Zhang, Z., Tumati, V., Lin, Y. F., Chen, B. P. C. & Saha, D., 2015, In : Oncotarget. 6, 6, p. 3848-3860 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection

Zhang, S., Matsunaga, S., Lin, Y. F., Sishc, B., Shang, Z., Sui, J., Shih, H. Y., Zhao, Y., Foreman, O., Story, M. D., Chen, D. J. & Chen, B. P. C., Nov 30 2015, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

6 Scopus citations

The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry

Lee, K. J., Shang, Z. F., Lin, Y. F., Sun, J., Morotomi-Yano, K., Saha, D. & Chen, B. P. C., Apr 1 2015, In : Neoplasia. 17, 4, p. 329-338 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transcriptional elongation requires DNA break-induced signalling

Bunch, H., Lawney, B. P., Lin, Y. F., Asaithamby, A., Murshid, A., Wang, Y. E., Chen, B. P. C. & Calderwood, S. K., Dec 16 2015, In : Nature Communications. 6, 10191.

Research output: Contribution to journalArticle

63 Scopus citations
2014

56Fe particle exposure results in a long-lasting increase in a cellular index of genomic instability and transiently suppresses adult hippocampal neurogenesis in vivo

Decarolis, N. A., Rivera, P. D., Ahn, F., Amaral, W. Z., Leblanc, J. A., Malhotra, S., Shih, H. Y., Petrik, D., Melvin, N. R., Chen, B. P. C. & Eisch, A. J., 2014, In : Life Sciences in Space Research. 2, p. 70-79 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles

Lin, Y. F., Nagasawa, H., Little, J. B., Kato, T. A., Shih, H. Y., Xie, X. J., Wilson, P. F., Brogan, J. R., Kurimasa, A., Chen, D. J., Bedford, J. S. & Chen, B. P. C., Apr 8 2014, In : PLoS One. 9, 4, e93579.

Research output: Contribution to journalArticle

8 Scopus citations

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

Davis, A. J., Chen, B. P. C. & Chen, D. J., 2014, In : DNA Repair. 17, p. 21-29 9 p.

Research output: Contribution to journalArticle

137 Scopus citations

DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability

Shang, Z., Yu, L., Lin, Y. F., Matsunaga, S., Shen, C. Y. & Chen, B. P. C., 2014, In : Oncogenesis. 3, 201349.

Research output: Contribution to journalArticle

22 Scopus citations

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response

Lin, Y. F., Shih, H. Y., Shang, Z., Matsunaga, S. & Chen, B. P., 2014, In : Nucleic Acids Research. 42, 7, p. 4463-4473 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1

Sui, J., Li, M., Qian, C., Wang, S., Cheng, Y., Chen, B. P. C. & Wang, D., Nov 3 2014, In : Drug Design, Development and Therapy. 8, p. 2147-2160 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation

Wu, R. T. Y., Cao, L., Chen, B. P. C. & Cheng, W. H., Dec 5 2014, In : Journal of Biological Chemistry. 289, 49, p. 34378-34388 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair

Li, M., Lin, Y. F., Palchik, G. A., Matsunaga, S., Wang, D. & Chen, B. P. C., 2014, In : Free Radical Biology and Medicine. 76, p. 278-285 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Acute and fractionated exposure to High-LET 56Fe HZE-particle radiation both result in similar long-term deficits in adult hippocampal neurogenesis

Rivera, P. D., Shih, H. Y., Leblanc, J. A., Cole, M. G., Amaral, W. Z., Mukherjee, S., Zhang, S., Lucero, M. J., Decarolis, N. A., Chen, B. P. C. & Eisch, A. J., Dec 2013, In : Radiation Research. 180, 6, p. 658-667 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response

Liu, H., Galka, M., Mori, E., Liu, X., Lin, Y. F., Wei, R., Pittock, P., Voss, C., Dhami, G., Li, X., Miyaji, M., Lajoie, G., Chen, B. & Li, S. C., Jun 6 2013, In : Molecular Cell. 50, 5, p. 723-735 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Effect of PF-02341066 and radiation on non-small cell lung cancer cells

Tumati, V., Kumar, S., Yu, L., Chen, B., Choy, H. & Saha, D., Mar 2013, In : Oncology Reports. 29, 3, p. 1094-1100 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination

Lee, B. S., Gapud, E. J., Zhang, S., Dorsett, Y., Bredemeyer, A., George, R., Callen, E., Daniel, J. A., Osipovich, O., Oltz, E. M., Bassing, C. H., Nussenzweig, A., Lees-Miller, S., Hammel, M., Chen, B. P. C. & Sleckman, B. P., 2013, In : Molecular and Cellular Biology. 33, 18, p. 3568-3579 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest

Singh, M., Hunt, C. R., Pandita, R. K., Kumar, R., Yang, C. R., Horikoshi, N., Bachoo, R., Serag, S., Story, M. D., Shay, J. W., Powell, S. N., Gupta, A., Jeffery, J., Pandita, S., Chen, B. P. C., Deckbar, D., Löbrich, M., Yang, Q., Khanna, K. K., Worman, H. J. & 1 others, Panditaa, T. K., Mar 2013, In : Molecular and Cellular Biology. 33, 6, p. 1210-1222 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest

Singh, M., Hunt, C. R., Pandita, R. K., Kumar, R., Yang, C. R., Horikoshi, N., Bachoo, R., Serag, S., Story, M. D., Shay, J. W., Powell, S. N., Gupta, A., Jeffery, J., Pandita, S., Chen, B. P. C., Deckbar, D., Löbrich, M., Yang, Q., Khanna, K. K., Worman, H. J. & 1 others, Pandita, T. K., 2013, In : Molecular and Cellular Biology. 33, 16, p. 3390 1 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks

Zhang, X., Lv, L., Chen, Q., Yuan, F., Zhang, T., Yang, Y., Zhang, H., Wang, Y., Jia, Y., Qian, L., Chen, B., Zhang, Y., Friedberg, E. C., Tang, T. S. & Guo, C., May 1 2013, In : DNA Repair. 12, 5, p. 377-388 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length

Gao, P., Yoo, S. H., Lee, K. J., Rosensweig, C., Takahashi, J. S., Chen, B. P. & Green, C. B., Dec 6 2013, In : Journal of Biological Chemistry. 288, 49, p. 35277-35286 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Preface

Chen, B. P. C. & Chen, D. J., Jun 1 2013, In : Translational Cancer Research. 2, 3, p. 106 1 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Akt promotes post-irradiation survival of human tumor cells through initiation, progression, and termination of DNA-PKcs-dependent DNA double-strand break repair

Toulany, M., Lee, K. J., Fattah, K. R., Lin, Y. F., Fehrenbacher, B., Schaller, M., Chen, B. P., Chen, D. J. & Rodemann, H. P., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 945-957 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

A sensitive and quantitative polymerase chain reaction-based cell free in vitro non-homologous end joining assay for hematopoietic stem cells

Shao, L., Feng, W., Lee, K. J., Chen, B. P. C. & Zhou, D., Mar 20 2012, In : PLoS One. 7, 3, e33499.

Research output: Contribution to journalArticle

13 Scopus citations

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

Chen, B. P. C., Li, M. & Asaithamby, A., Dec 31 2012, In : Cancer Letters. 327, 1-2, p. 103-110 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage

Olsen, B. B., Wang, S. Y., Svenstrup, T. H., Chen, B. P. C. & Guerra, B., Mar 9 2012, In : BMC Molecular Biology. 13, 7.

Research output: Contribution to journalArticle

38 Scopus citations

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Hsu, F. M., Zhang, S. & Chen, B. P. C., Jun 1 2012, In : Translational Cancer Research. 1, 1, p. 22-34 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance

Javvadi, P., Makino, H., Das, A. K., Lin, Y. F., Chen, D. J., Chen, B. P. & Nirodi, C. S., Oct 2012, In : Molecular Cancer Research. 10, 10, p. 1359-1368 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

Zhang, S., Yajima, H., Huynh, H., Zheng, J., Callen, E., Chen, H. T., Wong, N., Bunting, S., Lin, Y. F., Li, M., Lee, K-J., Story, M. D., Gapud, E., Sleckman, B. P., Nussenzweig, A., Zhang, C., Chen, D. J. & Chen, P. B., Apr 18 2011, In : Journal of Cell Biology. 193, 2, p. 295-305 11 p.

Research output: Contribution to journalArticle

82 Scopus citations

Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability

Nagasawa, H., Little, J. B., Lin, Y. F., So, S., Kurimasa, A., Peng, Y., Brogan, J. R., Chen, D. J., Bedford, J. S. & Chen, B. P. C., Jan 2011, In : Radiation Research. 175, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Erratum: Retraction notice to: DNA-PKcs-PIDDosome: A nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance ((Cell (2009) 136 (508-520))

Shi, M., Vivian, C. J., Lee, K. J., Ge, C., Morotomi-Yano, K., Manzl, C., Bock, F., Sato, S., Tomomori-Sato, C., Zhu, R., Haug, J. S., Swanson, S. K., Washburn, M. P., Chen, D. J., Chen, B. P. C., Villunger, A., Florens, L. & Du, C., Apr 1 2011, In : Cell. 145, 1, p. 161 1 p.

Research output: Contribution to journalArticle

1 Scopus citations