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Research Output

2020

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis

Hight, S. K., Mootz, A., Kollipara, R. K., McMillan, E., Yenerall, P., Otaki, Y., Li, L. S., Avila, K., Peyton, M., Rodriguez-Canales, J., Mino, B., Villalobos, P., Girard, L., Dospoy, P., Larsen, J., White, M. A., Heymach, J. V., Wistuba, I. I., Kittler, R. & Minna, J. D., Aug 2020, In : Neoplasia (United States). 22, 8, p. 294-310 17 p.

Research output: Contribution to journalArticle

Open Access

GCNA Preserves Genome Integrity and Fertility Across Species

Bhargava, V., Goldstein, C. D., Russell, L., Xu, L., Ahmed, M., Li, W., Casey, A., Servage, K., Kollipara, R., Picciarelli, Z., Kittler, R., Yatsenko, A., Carmell, M., Orth, K., Amatruda, J. F., Yanowitz, J. L. & Buszczak, M., Jan 6 2020, In : Developmental cell. 52, 1, p. 38-52.e10

Research output: Contribution to journalArticle

6 Scopus citations

Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer

Wang, S., Gilbreath, C., Kollipara, R. K., Sonavane, R., Huo, X., Yenerall, P., Das, A., Ma, S., Raj, G. V. & Kittler, R., Sep 28 2020, In : Cancer Letters. 488, p. 40-49 10 p.

Research output: Contribution to journalArticle

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

Yenerall, P., Das, A., Wang, S., Kollipara, R. K., Li, L. S., Villalobos, P., Flaming, J., Lin, Y-F., Huffman, K., Timmons, B. C., Gilbreath, C., Sonavane, R., Kinch, L. N., Rodriguez-Canales, J., Moran, C., Behrens, C., Hirasawa, M., Takata, T., Murakami, R., Iwanaga, K. & 6 others, Chen, B. P. C., Grishin, N. V., Raj, G. V., Wistuba, I. I., Minna, J. D. & Kittler, R., Jan 16 2020, In : Cell Chemical Biology. 27, 1, p. 105-121.e14

Research output: Contribution to journalArticle

1 Scopus citations
2019

Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high-grade gliomas

Todorova, P. K., Fletcher-Sananikone, E., Mukherjee, B., Kollipara, R., Vemireddy, V., Xie, X. J., Guida, P. M., Story, M. D., Hatanpaa, K., Habib, A. A., Kittler, R., Bachoo, R., Hromas, R., Floyd, J. R. & Burma, S., 2019, In : Cancer research. 79, 14, p. 3749-3761 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Molecular Cytogenetics Guides Massively Parallel Sequencing of a Radiation-Induced Chromosome Translocation in Human Cells

Cornforth, M. N., Anur, P., Wang, N., Robinson, E., Ray, F. A., Bedford, J. S., Loucas, B. D., Williams, E. S., Peto, M., Spellman, P., Kollipara, R., Kittler, R., Gray, J. W. & Bailey, S. M., Jul 1 2018, In : Radiation Research. 190, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

Katafuchi, T., Holland, W. L., Kollipara, R. K., Kittler, R., Mangelsdorf, D. J. & Kliewer, S. A., Nov 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 48, p. 12102-12111 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting

Luo, J., Attard, G., Balk, S. P., Bevan, C., Burnstein, K., Cato, L., Cherkasov, A., De Bono, J. S., Dong, Y., Gao, A. C., Gleave, M., Heemers, H., Kanayama, M., Kittler, R., Lang, J. M., Lee, R. J., Logothetis, C. J., Matusik, R., Plymate, S., Sawyers, C. L. & 7 others, Selth, L. A., Soule, H., Tilley, W., Weigel, N. L., Zoubeidi, A., Dehm, S. M. & Raj, G. V., May 2018, In : European urology. 73, 5, p. 715-723 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Targeting the turnover of oncoproteins as a new avenue for therapeutics development in castration-resistant prostate cancer

Wang, S., Ekoue, D. N., Raj, G. V. & Kittler, R., Dec 1 2018, In : Cancer Letters. 438, p. 86-96 11 p.

Research output: Contribution to journalShort survey

1 Scopus citations
2017

A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas

Thu, K. L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V. D., Zhang, Y. A., Castro, I. B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D. H., Davidson, H. L., Reynolds, C. P., Lam, W. L., Lea, J. & Gazdar, A. F., Feb 7 2017, In : Oncotarget. 8, 31, p. 50489-50499 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Biomarker accessible and chemically addressable mechanistic subtypes of braf melanoma

Eskiocak, B., McMillan, E. A., Mendiratta, S., Kollipara, R. K., Zhang, H., Humphries, C. G., Wang, C., Garcia-Rodriguez, J., Ding, M., Zaman, A., Rosales, T. I., Eskiocak, U., Smith, M. P., Sudderth, J., Komurov, K., Deberardinis, R. J., Wellbrock, C., Davies, M. A., Wargo, J. A., Yu, Y. & 7 others, De Brabander, J. K., Williams, N. S., Chin, L., Rizos, H., Long, G. V., Kittler, R. & White, M. A., Jan 1 2017, In : Cancer discovery. 7, 8, p. 832-851 20 p.

Research output: Contribution to journalArticle

15 Scopus citations

FoxA transcription factor Fork head maintains the intestinal stem/progenitor cell identities in Drosophila

Lan, Q., Cao, M., Kollipara, R. K., Rosa, J. B., Kittler, R. & Jiang, H., May 13 2017, (Accepted/In press) In : Developmental Biology.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of the underlying androgen receptor defect in the Dallas Reifenstein family

Ahmad, Z., Xing, C., Panach, K., Kittler, R., McPhaul, M. J. & Wilson, J. D., Jul 2017, In : Journal of the Endocrine Society. 1, 7, p. 836-842 7 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

Singh, D. K., Kollipara, R. K., Vemireddy, V., Yang, X. L., Sun, Y., Regmi, N., Klingler, S., Hatanpaa, K. J., Raisanen, J., Cho, S. K., Sirasanagandla, S., Nannepaga, S., Piccirillo, S., Mashimo, T., Wang, S., Humphries, C. G., Mickey, B., Maher, E. A., Zheng, H., Kim, R. S. & 2 others, Kittler, R. & Bachoo, R. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 961-976 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression

Stricker, T. P., Brown, C. D., Bandlamudi, C., McNerney, M., Kittler, R., Montoya, V., Peterson, A., Grossman, R. & White, K. P., Mar 2017, In : PLoS genetics. 13, 3, e1006589.

Research output: Contribution to journalArticle

21 Scopus citations

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

Dalvi, M. P., Wang, L., Zhong, R., Kollipara, R. K., Park, H., Bayo, J., Yenerall, P., Zhou, Y., Timmons, B. C., Rodriguez-Canales, J., Behrens, C., Mino, B., Villalobos, P., Parra, E. R., Suraokar, M., Pataer, A., Swisher, S. G., Kalhor, N., Bhanu, N. V., Garcia, B. A. & 9 others, Heymach, J. V., Coombes, K., Xie, Y., Girard, L., Gazdar, A. F., Kittler, R., Wistuba, I. I., Minna, J. D. & Martinez, E. D., May 23 2017, In : Cell Reports. 19, 8, p. 1669-1684 16 p.

Research output: Contribution to journalArticle

34 Scopus citations
2016

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing

Liu, H., Liang, C., Kollipara, R. K., Matsui, M., Ke, X., Jeong, B. C., Wang, Z., Yoo, K. S., Yadav, G. P., Kinch, L. N., Grishin, N. V., Nam, Y., Corey, D. R., Kittler, R. & Liu, Q., Aug 4 2016, In : Molecular cell. 63, 3, p. 420-432 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer

Wang, S., Kollipara, R. K., Humphries, C. G., Ma, S. H., Hutchinson, R., Li, R., Siddiqui, J., Tomlins, S. A., Raj, G. V. & Kittler, R., Jan 1 2016, In : Oncotarget. 7, 40, p. 64921-64931 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

An integrated functional genomic analysis identifies the antitumorigenic mechanism of action for PPARγ in lung cancer cells

Kollipara, R. K. & Kittler, R., Mar 1 2015, In : Genomics Data. 3, p. 80-86 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Minireview: Familiar faces in unfamiliar places: The emerging role of nuclear receptors in lung cancer

Yenerall, P. & Kittler, R., Dec 2015, In : Molecular Endocrinology. 29, 12, p. 1675-1683 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy

Mootha, V., Hussain, I., Cunnusamy, K., Graham, E., Gong, X., Neelam, S., Xing, C., Kittler, R. & Petroll, W. M., Mar 1 2015, In : Investigative ophthalmology & visual science. 56, 3, p. 2003-2011 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

Kim, H., Rodriguez-Navas, C., Kollipara, R. K., Kapur, P., Pedrosa, I., Brugarolas, J., Kittler, R. & Ye, J., Oct 20 2015, In : Cell Reports. 13, 3, p. 495-503 9 p., 2062.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer

Wang, S., Kollipara, R. K., Srivastava, N., Li, R., Ravindranathan, P., Hernandez, E., Freeman, E., Humphries, C. G., Kapur, P., Lotan, Y., Fazli, L., Gleave, M. E., Plymate, S. R., Raj, G., Hsieh, J-T. & Kittler, R., Mar 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 4251-4256 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1

Yun, E. J., Baek, S. T., Xie, D., Tseng, S. F., Dobin, T., Hernandez, E., Zhou, J., Zhang, L., Yang, J., Sun, H., Xiao, G., He, D., Kittler, R. & Hsieh, J. T., Jul 21 2014, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

29 Scopus citations

Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels

Srivastava, N., Kollipara, R. K., Singh, D. K., Sudderth, J., Hu, Z., Nguyen, H., Wang, S., Humphries, C. G., Carstens, R., Huffman, K. E., Deberardinis, R. J. & Kittler, R., Oct 7 2014, In : Cell Metabolism. 20, 4, p. 650-661 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Lsd1 Restricts the Number of Germline Stem Cells by Regulating Multiple Targets in Escort Cells

Eliazer, S., Palacios, V., Wang, Z., Kollipara, R. K., Kittler, R. & Buszczak, M., Mar 2014, In : PLoS genetics. 10, 3, e1004200.

Research output: Contribution to journalArticle

37 Scopus citations
2013

A Comprehensive Nuclear Receptor Network for Breast Cancer Cells

Kittler, R., Zhou, J., Hua, S., Ma, L., Liu, Y., Pendleton, E., Cheng, C., Gerstein, M. & White, K. P., Feb 1 2013, In : Cell Reports. 3, 2, p. 538-551 14 p.

Research output: Contribution to journalArticle

47 Scopus citations

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment

Kappei, D., Butter, F., Benda, C., Scheibe, M., Draškovič, I., Stevense, M., Novo, C. L., Basquin, C., Araki, M., Araki, K., Krastev, D. B., Kittler, R., Jessberger, R., Londoño-Vallejo, J. A., Mann, M. & Buchholz, F., Jun 12 2013, In : EMBO Journal. 32, 12, p. 1681-1701 21 p.

Research output: Contribution to journalArticle

43 Scopus citations
2012
24 Scopus citations
2011

Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness

Ludwig, M. Z., Manu, Kittler, R., White, K. P. & Kreitman, M., Nov 2011, In : PLoS genetics. 7, 11, e1002364.

Research output: Contribution to journalArticle

39 Scopus citations
2010

Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations

Sun, C., Southard, C., Witonsky, D. B., Kittler, R. & Di Rienzo, A., Oct 1 2010, In : PLoS genetics. 6, 10, p. 1-10 10 p., e1001178.

Research output: Contribution to journalArticle

15 Scopus citations
2009

A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity

Ding, L., Paszkowski-Rogacz, M., Nitzsche, A., Slabicki, M. M., Heninger, A. K., Vries, I. D., Kittler, R., Junqueira, M., Shevchenko, A., Schulz, H., Hubner, N., Doss, M. X., Sachinidis, A., Hescheler, J., Iacone, R., Anastassiadis, K., Stewart, A. F., Pisabarro, M. T., Caldarelli, A., Poser, I. & 2 others, Theis, M. & Buchholz, F., May 8 2009, In : Cell Stem Cell. 4, 5, p. 403-415 13 p.

Research output: Contribution to journalArticle

188 Scopus citations

Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division

Theis, M., Slabicki, M., Junqueira, M., Paszkowski-Rogacz, M., Sontheimer, J., Kittler, R., Heninger, A. K., Glatter, T., Kruusmaa, K., Poser, I., Hyman, A. A., Pisabarro, M. T., Gstaiger, M., Aebersold, R., Shevchenko, A. & Buchholz, F., May 20 2009, In : EMBO Journal. 28, 10, p. 1453-1465 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Genomic Antagonism between Retinoic Acid and Estrogen Signaling in Breast Cancer

Hua, S., Kittler, R. & White, K. P., Jun 26 2009, In : Cell. 137, 7, p. 1259-1271 13 p.

Research output: Contribution to journalArticle

207 Scopus citations

HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity

Lawo, S., Bashkurov, M., Mullin, M., Ferreria, M. G., Kittler, R., Habermann, B., Tagliaferro, A., Poser, I., Hutchins, J. R. A., Hegemann, B., Pinchev, D., Buchholz, F., Peters, J. M., Hyman, A. A., Gingras, A. C. & Pelletier, L., May 26 2009, In : Current Biology. 19, 10, p. 816-826 11 p.

Research output: Contribution to journalArticle

147 Scopus citations
2008

BAC TransgeneOmics: A high-throughput method for exploration of protein function in mammals

Poser, I., Sarov, M., Hutchins, J. R. A., Hériché, J. K., Toyoda, Y., Pozniakovsky, A., Weigl, D., Nitzsche, A., Hegemann, B., Bird, A. W., Pelletier, L., Kittler, R., Hua, S., Naumann, R., Augsburg, M., Sykora, M. M., Hofemeister, H., Zhang, Y., Nasmyth, K., White, K. P. & 7 others, Dietzel, S., Mechtler, K., Durbin, R., Stewart, A. F., Peters, J. M., Buchholz, F. & Hyman, A. A., May 1 2008, In : Nature methods. 5, 5, p. 409-415 7 p.

Research output: Contribution to journalArticle

405 Scopus citations

Erratum: BAC TransgeneOmics: A high-throughput method for exploration of protein function in mammals (Nature Methods (2008) vol. 5 (409-415))

Poser, I., Sarov, M., Hutchins, J. R. A., Hériché, J. K., Toyoda, Y., Pozniakovsky, A., Weigl, D., Nitzsche, A., Hegemann, B., Bird, A. W., Pelletier, L., Kittler, R., Hua, S., Naumann, R., Augsburg, M., Sykora, M. M., Hofemeister, H., Zhang, Y., Nasmyth, K., White, K. P. & 7 others, Dietzel, S., Mechtler, K., Durbin, R., Stewart, A. F., Peters, J. M., Buchholz, F. & Hyman, A. A., Aug 1 2008, In : Nature methods. 5, 8, 1 p.

Research output: Contribution to journalComment/debate

Systems biology of mammalian cell division

Kittler, R., Pelletier, L. & Buchholz, F., Jul 15 2008, In : Cell Cycle. 7, 14, p. 2123-2128 6 p.

Research output: Contribution to journalReview article

Open Access
15 Scopus citations

The Mammalian SPD-2 Ortholog Cep192 Regulates Centrosome Biogenesis

Zhu, F., Lawo, S., Bird, A., Pinchev, D., Ralph, A., Richter, C., Müller-Reichert, T., Kittler, R., Hyman, A. A. & Pelletier, L., Jan 22 2008, In : Current Biology. 18, 2, p. 136-141 6 p.

Research output: Contribution to journalArticle

107 Scopus citations
2007

Genome-scale RNAi profiling of cell division in human tissue culture cells

Kittler, R., Pelletier, L., Heninger, A. K., Slabicki, M., Theis, M., Miroslaw, L., Poser, I., Lawo, S., Grabner, H., Kozak, K., Wagner, J., Surendranath, V., Richter, C., Bowen, W., Jackson, A. L., Habermann, B., Hyman, A. A. & Buchholz, F., Dec 1 2007, In : Nature cell biology. 9, 12, p. 1401-1412 12 p.

Research output: Contribution to journalArticle

237 Scopus citations

Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies

Kittler, R., Surendranath, V., Heninger, A. K., Slabicki, M., Theis, M., Putz, G., Franke, K., Caldarelli, A., Grabner, H., Kozak, K., Wagner, J., Rees, E., Korn, B., Frenzel, C., Sachse, C., Sönnichsen, B., Guo, J., Schelter, J., Burchard, J., Linsley, P. S. & 3 others, Jackson, A. L., Habermann, B. & Buchholz, F., Apr 1 2007, In : Nature methods. 4, 4, p. 337-344 8 p.

Research output: Contribution to journalArticle

140 Scopus citations
2006

Enzymatically prepared RNAi libraries

Buchholz, F., Kittler, R., Slabicki, M. & Theis, M., Sep 1 2006, In : Nature methods. 3, 9, p. 696-700 5 p.

Research output: Contribution to journalReview article

54 Scopus citations

Evaluation of saliva as a source of human DNA for population and association studies

Quinque, D., Kittler, R., Kayser, M., Stoneking, M. & Nasidze, I., Jun 15 2006, In : Analytical biochemistry. 353, 2, p. 272-277 6 p.

Research output: Contribution to journalArticle

128 Scopus citations

RNAi libraries for functional genomics

Heninger, A. K., Kozak, K., Kittler, R., Wagner, J., Lohmann, A., Poser, I., Grabner, H., Krausz, E. & Buchholz, F., Nov 1 2006, In : Genetic Engineering News. 26, 19, p. 22-23 2 p.

Research output: Contribution to journalShort survey

2005

Eine Genom-weite RNA-Interferenz-Bibliothek für die funktionelle Charakterisierung aller Gene in kultivierten, menschlichen Zellen

Translated title of the contribution: A genome-wide RNA interference library for the functional characterization of all genes in cuttured human cellsKrauß, E., Heninger, A. K., Kittler, R., Lohmann, A., Poser, I., Wagner, J., Franke, K., Kozak, K., Grabner, H. & Buchholz, F., Jul 25 2005, In : BioSpektrum. 11, 4, p. 436-441 6 p.

Research output: Contribution to journalReview article

1 Scopus citations

Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs

Kittler, R. & Buchholz, F., Apr 2005, In : Cell Cycle. 4, 4, p. 561-564 4 p.

Research output: Contribution to journalReview article

30 Scopus citations

Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells

Kittler, R., Heninger, A. K., Franke, K., Habermann, B. & Buchholz, F., Oct 1 2005, In : Nature methods. 2, 10, p. 779-784 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

RNA interference in postimplantation mouse embryos

Buchholz, F., Calegari, F., Kittler, R. & Huttner, W. B., Jan 1 2005, RNA Interference Technology: From Basic Science to Drug Development. Cambridge University Press, p. 207-219 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter