• 1238 Citations
  • 9 h-Index
20112019
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Fingerprint Dive into the research topics where Robert Orchard is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Norovirus Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Clustered Regularly Interspaced Short Palindromic Repeats Medicine & Life Sciences
Viral Nonstructural Proteins Medicine & Life Sciences
Tropism Medicine & Life Sciences
Genome Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
Guide RNA Medicine & Life Sciences

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Research Output 2011 2019

  • 1238 Citations
  • 9 h-Index
  • 12 Article
  • 1 Letter
6 Citations (Scopus)

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

Lee, S., Liu, H., Wilen, C. B., Sychev, Z. E., Desai, C., Hykes, B. L., Orchard, R. C., McCune, B. T., Kim, K. W., Nice, T. J., Handley, S. A., Baldridge, M. T., Amarasinghe, G. K. & Virgin, H. W., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 845-857.e5

Research output: Contribution to journalArticle

Viral Nonstructural Proteins
Norovirus
Enterovirus
Vaccination
Vaccines

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

Orvedahl, A., McAllaster, M. R., Sansone, A., Dunlap, B. F., Desai, C., Wang, Y. T., Balce, D. R., Luke, C. J., Lee, S., Orchard, R. C., Artyomov, M. N., Handley, S. A., Doench, J. G., Silverman, G. A. & Virgin, H. W., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16497-16506 10 p.

Research output: Contribution to journalArticle

Open Access
Autophagy
Myeloid Cells
Shock
Cell Death
Tumor Necrosis Factor-alpha
2 Citations (Scopus)

Identification of antinorovirus genes in human cells using genome-wide CRISPR activation screening

Orchard, R. C., Sullender, M. E., Dunlap, B. F., Balce, D. R., Doench, J. G. & Virgin, H. W., Jan 1 2019, In : Journal of virology. 93, 1, e01324-18.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Norovirus
Genome
screening
genome
6 Citations (Scopus)

Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection

Orchard, R. C., Wilen, C. B. & Virgin, H. W., Oct 1 2018, In : Nature Microbiology. 3, 10, p. 1109-1114 6 p.

Research output: Contribution to journalLetter

Norovirus
Sphingolipids
Serine C-Palmitoyltransferase
Virus Diseases
Viral Tropism
16 Citations (Scopus)

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor

Nelson, C. A., Wilen, C. B., Dai, Y. N., Orchard, R. C., Kim, A. S., Stegeman, R. A., Hsieh, L. L., Smith, T. J., Virgin, H. W. & Fremont, D. H., Sep 25 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 39, p. E9201-E9210

Research output: Contribution to journalArticle

Open Access
Norovirus
Bile Acids and Salts
Glycochenodeoxycholic Acid
Binding Sites
Lithocholic Acid