• 37359 Citations
  • 110 h-Index
1955 …2018

Research output per year

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Research Output

2018

Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial

Pettus, J., Reeds, D., Cavaiola, T. S., Boeder, S., Levin, M., Tobin, G., Cava, E., Thai, D., Shi, J., Yan, H., Bautista, E., McMillan, J., Unger, R. H., Henry, R. R. & Klein, S., May 1 2018, In : Diabetes, Obesity and Metabolism. 20, 5, p. 1302-1305 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Sharma, A. X., Quittner-Strom, E. B., Lee, Y. H., Johnson, J. A., Martin, S. A., Yu, X., Li, J., Lu, J., Cai, Z., Chen, S., Wang, M-Y., Zhang, Y., Pearson, M. J., Dorn, A. C., McDonald, J. G., Gordillo, R., Yan, H., Thai, D., Wang, Z., Unger, R. H. & 1 others, Holland, W. L., Feb 13 2018, In : Cell Reports. 22, 7, p. 1760-1773 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, J., Okamoto, H., Huang, Z. J., Anguiano, G., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., Lee, J., Zambrowicz, B., Unger, R. H., Murphy, A. J., Xu, Y., Yancopoulos, G. D., Li, W-H. & Gromada, J., Jun 6 2017, In : Cell Metabolism. 25, 6, p. 1348-1361.e8

Research output: Contribution to journalArticle

48 Scopus citations

Dapagliflozin suppresses glucagon signaling in rodent models of diabetes

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Chen, S., Li, J., Wang, Z., Davidson, J. A., Scherer, P. E., Holland, W. L., Unger, R. H. & Roth, M. G., Jun 20 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6611-6616 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Glucagon antagonism in islet cell proliferation

Dean, E. D., Unger, R. H. & Holland, W. L., Mar 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. 3006-3008 3 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Hypoglycemic effect of combined ghrelin and glucagon receptor blockade

Mani, B. K., Uchida, A., Lee, Y. H., Osborne-Lawrence, S., Charron, M. J., Unger, R. H., Berglund, E. D. & Zigman, J. M., Jul 1 2017, In : Diabetes. 66, 7, p. 1847-1857 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Insulin and glucagon: Partners for life

Holst, J. J., Holland, W. L., Gromada, J., Lee, Y. H., Unger, R. H., Yan, H., Sloop, K. W., Kieffer, T. J., Damond, N. & Herrera, P. L., Apr 1 2017, In : Endocrinology. 158, 4, p. 696-701 6 p.

Research output: Contribution to journalReview article

32 Scopus citations
2016

An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon Production

Evans, M. R., Wei, S., Posner, B. A., Unger, R. H. & Roth, M. G., Apr 1 2016, In : Journal of Biomolecular Screening. 21, 4, p. 325-332 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Clinical trials, triumphs, and tribulations of glucagon receptor antagonists

Pearson, M. J., Unger, R. H. & Holland, W. L., Jul 1 2016, In : Diabetes Care. 39, 7, p. 1075-1077 3 p.

Research output: Contribution to journalComment/debate

28 Scopus citations

Glucagon is the key factor in the development of diabetes

Lee, Y. H., Wang, M-Y., Yu, X. X. & Unger, R. H., Jul 1 2016, In : Diabetologia. 59, 7, p. 1372-1375 4 p.

Research output: Contribution to journalReview article

53 Scopus citations

Glucagon therapeutics: Dawn of a new era for diabetes care

Davidson, J. A., Holland, W. L., Roth, M. G., Wang, M-Y., Lee, Y. H., Yu, X., McCorkle, S. K., Scherer, P. E. & Unger, R. H., Oct 1 2016, In : Diabetes/Metabolism Research and Reviews. 32, 7, p. 660-665 6 p.

Research output: Contribution to journalReview article

11 Scopus citations

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In : Diabetes. 65, 6, p. 1534-1555 22 p.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Alveolar-capillary adaptation to chronic hypoxia in the fatty lung

Yilmaz, C., Ravikumar, P., Gyawali, D., Iyer, R., Unger, R. H. & Hsia, C. C. W., Apr 1 2015, In : Acta Physiologica. 213, 4, p. 933-946 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

A new biology of diabetes revealed by leptin

Unger, R. H. & Roth, M. G., Jan 6 2015, In : Cell Metabolism. 21, 1, p. 15-20 6 p.

Research output: Contribution to journalReview article

13 Scopus citations

Erratum: A new biology of diabetes revealed by leptin (Cell Metabolism (2015) 21 (15-20))

Unger, R. H. & Roth, M. G., Apr 7 2015, In : Cell Metabolism. 21, 4, p. 647 1 p.

Research output: Contribution to journalArticle

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

Wang, M-Y., Yan, H., Shi, Z., Evans, M. R., Yu, X., Lee, Y. H., Chen, S., Williams, A., Philippe, J., Roth, M. G. & Unger, R. H., Feb 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 8, p. 2503-2508 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
2014

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

Lee, Y. H., Berglund, E. D., Yu, X., Wang, M-Y., Evans, M. R., Scherer, P. E., Holland, W. L., Charron, M. J., Roth, M. G. & Unger, R. H., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 36, p. 13217-13222 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Noninvasive assessment of alveolar microvascular recruitment in conscious non-sedated rats

Yilmaz, C., Dane, D. M., Ravikumar, P., Unger, R. H. & Hsia, C. C., Jan 1 2014, In : Respiratory Physiology and Neurobiology. 190, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine

Unger, R. H., Scherer, P. E. & Holland, W. L., Oct 1 2013, In : Molecular biology of the cell. 24, 19, p. 3011-3015 5 p.

Research output: Contribution to journalReview article

22 Scopus citations

Iatrogenic hyperinsulinemia in type 1 diabetes: Its effect on atherogenic risk markers

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Clark, G. O., Strowig, S., Unger, R. H. & Raskin, P., Jan 1 2013, In : Journal of Diabetes and Its Complications. 27, 1, p. 70-74 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Role of fibroblast growth factor 21 in biology of glucagon

Berglund, E. D. & Unger, R. H., May 1 2013, In : Diabetes. 62, 5, 1 p.

Research output: Contribution to journalComment/debate

5 Scopus citations
2012

Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover

Unger, R. H. & Cherrington, A. D., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 4-12 9 p.

Research output: Contribution to journalReview article

376 Scopus citations
87 Scopus citations

Pancreatic steatosis and its relationship to β-cell dysfunction in humans: Racial and ethnic variations

Szczepaniak, L. S., Victor, R. G., Mathur, R., Nelson, M. D., Szczepaniak, E. W., Tyer, N., Chen, I., Unger, R. H., Bergman, R. N. & Lingvay, I., Nov 1 2012, In : Diabetes care. 35, 11, p. 2377-2383 7 p.

Research output: Contribution to journalArticle

60 Scopus citations
2011

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

Lee, Y. H., Wang, M-Y., Du, X. Q., Charron, M. J. & Unger, R. H., Feb 1 2011, In : Diabetes. 60, 2, p. 391-397 7 p.

Research output: Contribution to journalArticle

218 Scopus citations

Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin

Chen, L., Philippe, J. & Unger, R. H., Sep 1 2011, In : Endocrine Practice. 17, 5, p. 819-825 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats

Kruger, A. J., Yang, C., Lipson, K. L., Pino, S. C., Leif, J. H., Hogan, C. M., Whalen, B. J., Guberski, D. L., Lee, Y. H., Unger, R. H., Greiner, D. L., Rossini, A. A. & Bortell, R., Mar 1 2011, In : Autoimmunity. 44, 2, p. 137-148 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2010

Fatty diabetic lung: Altered alveolar structure and surfactant protein expression

Foster, D. J., Ravikumar, P., Bellotto, D. J., Unger, R. H. & Hsia, C. C., Mar 1 2010, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 298, 3, p. L392-L403

Research output: Contribution to journalArticle

35 Scopus citations

Fatty diabetic lung: Functional impairment in a model of metabolic syndrome

Yilmaz, C., Ravikumar, P., Bellotto, D. J., Unger, R. H. & Hsia, C. C., Dec 1 2010, In : Journal of applied physiology. 109, 6, p. 1913-1919 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity

Unger, R. H. & Scherer, P. E., Jun 1 2010, In : Trends in Endocrinology and Metabolism. 21, 6, p. 345-352 8 p.

Research output: Contribution to journalReview article

256 Scopus citations

Leptin therapy in insulin-deficient type I diabetes

Wang, M-Y., Chen, L., Clark, G. O., Lee, Y. H., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B. & Unger, R. H., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 4813-4819 7 p.

Research output: Contribution to journalArticle

220 Scopus citations

Lipid homeostasis, lipotoxicity and the metabolic syndrome

Unger, R. H., Clark, G. O., Scherer, P. E. & Orci, L., Mar 1 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 3, p. 209-214 6 p.

Research output: Contribution to journalReview article

343 Scopus citations

Pancreatic steatosis: Harbinger of type 2 diabetes in obese rodents

Lee, Y. H., Lingvay, I., Szczepaniak, L. S., Ravazzola, M., Orci, L. & Unger, R. H., Feb 1 2010, In : International Journal of Obesity. 34, 2, p. 396-400 5 p.

Research output: Contribution to journalArticle

61 Scopus citations

Paracrinology of islets and the paracrinopathy of diabetes

Unger, R. H. & Orci, L., Sep 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16009-16012 4 p.

Research output: Contribution to journalReview article

151 Scopus citations

Special issue on lipotoxicity

Vidal-Puig, A. & Unger, R. H., Mar 1 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 3, p. 207-208 2 p.

Research output: Contribution to journalEditorial

16 Scopus citations
2009

Diabetes and apoptosis: Lipotoxicity

Kusminski, C., Shetty, S., Orci, L., Unger, R. H. & Scherer, P. E., Dec 1 2009, In : Apoptosis. 14, 12, p. 1484-1495 12 p.

Research output: Contribution to journalReview article

169 Scopus citations

Noninvasive quantification of pancreatic fat in humans

Lingvay, I., Esser, V., Legendre, J. L., Price, A. L., Wertz, K. M., Huet, B. A., Zhang, S., Unger, R. H. & Szczepaniak, L. S., Jan 1 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 10, p. 4070-4076 7 p.

Research output: Contribution to journalArticle

119 Scopus citations
2008

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

Wang, M-Y., Grayburn, P., Chen, S., Ravazzola, M., Orci, L. & Unger, R. H., Apr 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 16, p. 6139-6144 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

Wang, M-Y., Grayburn, P., Chen, S., Ravazzola, M., Orci, L. & Unger, R. H., Sep 1 2008, In : Obstetrical and Gynecological Survey. 63, 9, p. 581-582 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Insulin therapy and lipid overload in type 2 diabetes: In reply

Unger, R. H., Aug 20 2008, In : JAMA - Journal of the American Medical Association. 300, 7, 1 p.

Research output: Contribution to journalLetter

Making insulin-deficient type 1 diabetic rodents thrive without insulin

Yu, X., Park, B. H., Wang, M-Y., Wang, Z. & Unger, R. H., Sep 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 37, p. 14070-14075 6 p.

Research output: Contribution to journalArticle

160 Scopus citations
1 Scopus citations

Reinventing type 2 diabetes: Pathogenesis, treatment, and prevention

Unger, R. H., Mar 12 2008, In : JAMA - Journal of the American Medical Association. 299, 10, p. 1185-1187 3 p.

Research output: Contribution to journalComment/debate

76 Scopus citations
2007

Cardiac steatosis in diabetes mellitus: A 1H-magnetic resonance spectroscopy study

McGavock, J. M., Lingvay, I., Zib, I., Tillery, T., Salas, N., Unger, R. H., Levine, B. D., Raskin, P., Victor, R. G. & Szczepaniak, L. S., Sep 1 2007, In : Circulation. 116, 10, p. 1170-1175 6 p.

Research output: Contribution to journalArticle

391 Scopus citations

Forgotten but not gone: The rediscovery of fatty heart, the most common unrecognized disease in America

Szczepaniak, L. S., Victor, R. G., Orci, L. & Unger, R. H., Oct 1 2007, In : Circulation research. 101, 8, p. 759-767 9 p.

Research output: Contribution to journalReview article

181 Scopus citations

Metabolic mechanisms of failure of intraportally transplanted pancreatic β-cells in rats: Role of lipotoxicity and prevention by leptin

Lee, Y. H., Ravazzola, M., Park, B. H., Bashmakov, Y. K., Orci, L. & Unger, R. H., Sep 1 2007, In : Diabetes. 56, 9, p. 2295-2301 7 p.

Research output: Contribution to journalArticle

61 Scopus citations
2006

Adiposity of the heart, revisited

McGavock, J. M., Victor, R. G., Unger, R. H. & Szczepaniak, L. S., Apr 4 2006, In : Annals of internal medicine. 144, 7, p. 517-524 8 p.

Research output: Contribution to journalReview article

283 Scopus citations

Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: Implications for obesity treatment

Park, B. H., Wang, M-Y., Lee, Y. H., Yu, X., Ravazzola, M., Orci, L. & Unger, R. H., Dec 29 2006, In : Journal of Biological Chemistry. 281, 52, p. 40283-40291 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

In response [7]

Szczepaniak, L. S., McGavock, J. M., Victor, R. G. & Unger, R. H., Oct 3 2006, In : Annals of internal medicine. 145, 7, 1 p.

Research output: Contribution to journalLetter