• 37359 Citations
  • 110 h-Index
1955 …2018

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2018

Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial

Pettus, J., Reeds, D., Cavaiola, T. S., Boeder, S., Levin, M., Tobin, G., Cava, E., Thai, D., Shi, J., Yan, H., Bautista, E., McMillan, J., Unger, R. H., Henry, R. R. & Klein, S., May 1 2018, In : Diabetes, Obesity and Metabolism. 20, 5, p. 1302-1305 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Sharma, A. X., Quittner-Strom, E. B., Lee, Y. H., Johnson, J. A., Martin, S. A., Yu, X., Li, J., Lu, J., Cai, Z., Chen, S., Wang, M-Y., Zhang, Y., Pearson, M. J., Dorn, A. C., McDonald, J. G., Gordillo, R., Yan, H., Thai, D., Wang, Z., Unger, R. H. & 1 others, Holland, W. L., Feb 13 2018, In : Cell Reports. 22, 7, p. 1760-1773 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, J., Okamoto, H., Huang, Z. J., Anguiano, G., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., Lee, J., Zambrowicz, B., Unger, R. H., Murphy, A. J., Xu, Y., Yancopoulos, G. D., Li, W-H. & Gromada, J., Jun 6 2017, In : Cell Metabolism. 25, 6, p. 1348-1361.e8

Research output: Contribution to journalArticle

48 Scopus citations

Dapagliflozin suppresses glucagon signaling in rodent models of diabetes

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Chen, S., Li, J., Wang, Z., Davidson, J. A., Scherer, P. E., Holland, W. L., Unger, R. H. & Roth, M. G., Jun 20 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6611-6616 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hypoglycemic effect of combined ghrelin and glucagon receptor blockade

Mani, B. K., Uchida, A., Lee, Y. H., Osborne-Lawrence, S., Charron, M. J., Unger, R. H., Berglund, E. D. & Zigman, J. M., Jul 1 2017, In : Diabetes. 66, 7, p. 1847-1857 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon Production

Evans, M. R., Wei, S., Posner, B. A., Unger, R. H. & Roth, M. G., Apr 1 2016, In : Journal of Biomolecular Screening. 21, 4, p. 325-332 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In : Diabetes. 65, 6, p. 1534-1555 22 p.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Alveolar-capillary adaptation to chronic hypoxia in the fatty lung

Yilmaz, C., Ravikumar, P., Gyawali, D., Iyer, R., Unger, R. H. & Hsia, C. C. W., Apr 1 2015, In : Acta Physiologica. 213, 4, p. 933-946 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Erratum: A new biology of diabetes revealed by leptin (Cell Metabolism (2015) 21 (15-20))

Unger, R. H. & Roth, M. G., Apr 7 2015, In : Cell Metabolism. 21, 4, p. 647 1 p.

Research output: Contribution to journalArticle

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

Wang, M-Y., Yan, H., Shi, Z., Evans, M. R., Yu, X., Lee, Y. H., Chen, S., Williams, A., Philippe, J., Roth, M. G. & Unger, R. H., Feb 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 8, p. 2503-2508 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
2014

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

Lee, Y. H., Berglund, E. D., Yu, X., Wang, M-Y., Evans, M. R., Scherer, P. E., Holland, W. L., Charron, M. J., Roth, M. G. & Unger, R. H., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 36, p. 13217-13222 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Noninvasive assessment of alveolar microvascular recruitment in conscious non-sedated rats

Yilmaz, C., Dane, D. M., Ravikumar, P., Unger, R. H. & Hsia, C. C., Jan 1 2014, In : Respiratory Physiology and Neurobiology. 190, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

Iatrogenic hyperinsulinemia in type 1 diabetes: Its effect on atherogenic risk markers

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Clark, G. O., Strowig, S., Unger, R. H. & Raskin, P., Jan 1 2013, In : Journal of Diabetes and Its Complications. 27, 1, p. 70-74 5 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012
87 Scopus citations

Pancreatic steatosis and its relationship to β-cell dysfunction in humans: Racial and ethnic variations

Szczepaniak, L. S., Victor, R. G., Mathur, R., Nelson, M. D., Szczepaniak, E. W., Tyer, N., Chen, I., Unger, R. H., Bergman, R. N. & Lingvay, I., Nov 1 2012, In : Diabetes care. 35, 11, p. 2377-2383 7 p.

Research output: Contribution to journalArticle

60 Scopus citations
2011

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

Lee, Y. H., Wang, M-Y., Du, X. Q., Charron, M. J. & Unger, R. H., Feb 1 2011, In : Diabetes. 60, 2, p. 391-397 7 p.

Research output: Contribution to journalArticle

218 Scopus citations

Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin

Chen, L., Philippe, J. & Unger, R. H., Sep 1 2011, In : Endocrine Practice. 17, 5, p. 819-825 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats

Kruger, A. J., Yang, C., Lipson, K. L., Pino, S. C., Leif, J. H., Hogan, C. M., Whalen, B. J., Guberski, D. L., Lee, Y. H., Unger, R. H., Greiner, D. L., Rossini, A. A. & Bortell, R., Mar 1 2011, In : Autoimmunity. 44, 2, p. 137-148 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2010

Fatty diabetic lung: Altered alveolar structure and surfactant protein expression

Foster, D. J., Ravikumar, P., Bellotto, D. J., Unger, R. H. & Hsia, C. C., Mar 1 2010, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 298, 3, p. L392-L403

Research output: Contribution to journalArticle

35 Scopus citations

Fatty diabetic lung: Functional impairment in a model of metabolic syndrome

Yilmaz, C., Ravikumar, P., Bellotto, D. J., Unger, R. H. & Hsia, C. C., Dec 1 2010, In : Journal of applied physiology. 109, 6, p. 1913-1919 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Leptin therapy in insulin-deficient type I diabetes

Wang, M-Y., Chen, L., Clark, G. O., Lee, Y. H., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B. & Unger, R. H., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 4813-4819 7 p.

Research output: Contribution to journalArticle

220 Scopus citations

Pancreatic steatosis: Harbinger of type 2 diabetes in obese rodents

Lee, Y. H., Lingvay, I., Szczepaniak, L. S., Ravazzola, M., Orci, L. & Unger, R. H., Feb 1 2010, In : International Journal of Obesity. 34, 2, p. 396-400 5 p.

Research output: Contribution to journalArticle

61 Scopus citations
2009

Noninvasive quantification of pancreatic fat in humans

Lingvay, I., Esser, V., Legendre, J. L., Price, A. L., Wertz, K. M., Huet, B. A., Zhang, S., Unger, R. H. & Szczepaniak, L. S., Jan 1 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 10, p. 4070-4076 7 p.

Research output: Contribution to journalArticle

119 Scopus citations
2008

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

Wang, M-Y., Grayburn, P., Chen, S., Ravazzola, M., Orci, L. & Unger, R. H., Apr 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 16, p. 6139-6144 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Making insulin-deficient type 1 diabetic rodents thrive without insulin

Yu, X., Park, B. H., Wang, M-Y., Wang, Z. & Unger, R. H., Sep 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 37, p. 14070-14075 6 p.

Research output: Contribution to journalArticle

160 Scopus citations
2007

Cardiac steatosis in diabetes mellitus: A 1H-magnetic resonance spectroscopy study

McGavock, J. M., Lingvay, I., Zib, I., Tillery, T., Salas, N., Unger, R. H., Levine, B. D., Raskin, P., Victor, R. G. & Szczepaniak, L. S., Sep 1 2007, In : Circulation. 116, 10, p. 1170-1175 6 p.

Research output: Contribution to journalArticle

391 Scopus citations

Metabolic mechanisms of failure of intraportally transplanted pancreatic β-cells in rats: Role of lipotoxicity and prevention by leptin

Lee, Y. H., Ravazzola, M., Park, B. H., Bashmakov, Y. K., Orci, L. & Unger, R. H., Sep 1 2007, In : Diabetes. 56, 9, p. 2295-2301 7 p.

Research output: Contribution to journalArticle

61 Scopus citations
2006

Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: Implications for obesity treatment

Park, B. H., Wang, M-Y., Lee, Y. H., Yu, X., Ravazzola, M., Orci, L. & Unger, R. H., Dec 29 2006, In : Journal of Biological Chemistry. 281, 52, p. 40283-40291 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

α-Lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice

Lee, Y. H., Naseem, R. H., Park, B. H., Garry, D. J., Richardson, J. A., Schaffer, J. E. & Unger, R. H., May 26 2006, In : Biochemical and Biophysical Research Communications. 344, 1, p. 446-452 7 p.

Research output: Contribution to journalArticle

61 Scopus citations
2005
116 Scopus citations

Longevity, lipotoxicity and leptin: The adipocyte defense against feasting and famine

Unger, R. H., Jan 2005, In : Biochimie. 87, 1 SPEC. ISS., p. 57-64 8 p.

Research output: Contribution to journalArticle

111 Scopus citations
67 Scopus citations
2004

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

Boucher, A., Lu, D., Burgess, S. C., Telemaque-Potts, S., Jensen, M. V., Mulder, H., Wang, M-Y., Unger, R. H., Sherry, D. & Newgard, C. B., Jun 25 2004, In : Journal of Biological Chemistry. 279, 26, p. 27263-27271 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

Demonstration of reverse fatty acid transport from rat cardiomyocytes

Park, B. H., Lee, Y. H., Walton, M., Duplomb, L. & Unger, R. H., Nov 1 2004, In : Journal of lipid research. 45, 11, p. 1992-1999 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
86 Scopus citations

Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice

Lee, Y. H., Naseem, R. H., Duplomb, L., Park, B. H., Carry, D. J., Richardson, J. A., Schaffer, J. E. & Unger, R. H., Sep 14 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 37, p. 13624-13629 6 p.

Research output: Contribution to journalArticle

110 Scopus citations

Increased expression and activity of 11β-HSD-1 in diabetic islets and prevention with troglitazone

Duplomb, L., Lee, Y. H., Wang, M-Y., Park, B. H., Takaishi, K., Agarwal, A. K. & Unger, R. H., Jan 16 2004, In : Biochemical and Biophysical Research Communications. 313, 3, p. 594-599 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Independence of hyperleptinemia-induced fat disappearance from thyroid hormone

Duplomb, L., Takaishi, K., Park, B. H., Visser, T. J. & Unger, R. H., Oct 8 2004, In : Biochemical and Biophysical Research Communications. 323, 1, p. 49-51 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition

Yu, X., McCorkle, S., Wang, M-Y., Lee, Y. H., Li, J., Saha, A. K., Unger, R. H. & Ruderman, N. B., Nov 1 2004, In : Diabetologia. 47, 11, p. 2012-2021 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Metabolic and hormonal interactions between muscle and adipose tissue

Tomas, E., Kelly, M., Xiang, X., Tsao, T. S., Keller, C., Keller, P., Luo, Z., Lodish, H., Saha, A. K., Unger, R. H. & Ruderman, N. B., May 1 2004, In : Proceedings of the Nutrition Society. 63, 2, p. 381-385 5 p.

Research output: Contribution to journalArticle

54 Scopus citations
2003

Effects of leptin on endothelial function with OB-Rb gene transfer in Zucker fatty rats

Jin, X., Fukuda, N., Su, J., Takagi, H., Lai, Y., Lin, Z., Kanmatsuse, K., Wang, Z. W. & Unger, R. H., Aug 2003, In : Atherosclerosis. 169, 2, p. 225-233 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes

Li, J., Takaishi, K., Cook, W., McCorkle, S. K. & Unger, R. H., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9476-9481 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Lipid overload and overflow: Metabolic trauma and the metabolic syndrome

Unger, R. H., Nov 2003, In : Trends in Endocrinology and Metabolism. 14, 9, p. 398-403 6 p.

Research output: Contribution to journalArticle

287 Scopus citations

Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging

Szczepaniak, L. S., Dobbins, R. L., Metzger, G. J., Sartoni-D'Ambrosia, G., Arbique, D., Vongpatanasin, W., Unger, R. & Victor, R. G., Mar 1 2003, In : Magnetic resonance in medicine. 49, 3, p. 417-423 7 p.

Research output: Contribution to journalArticle

316 Scopus citations
2002

Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase

Kakuma, T., Lee, Y. H. & Unger, R. H., Nov 6 2002, In : Biochemical and Biophysical Research Communications. 297, 5, p. 1259-1263 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity

Li, J., Yu, X., Pan, W. & Unger, R. H., Jun 29 2002, In : American Journal of Physiology - Endocrinology and Metabolism. 282, 6 45-6, p. E1334-E1341

Research output: Contribution to journalArticle

133 Scopus citations

PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue

Lee, Y. H., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, M-Y., Richardson, C., Witters, L. A. & Unger, R. H., Sep 3 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 18, p. 11848-11853 6 p.

Research output: Contribution to journalArticle

144 Scopus citations

Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes

Blüher, M., Unger, R. H., Rassoul, F., Richter, V. & Paschke, R., Mar 20 2002, In : Diabetologia. 45, 2, p. 210-216 7 p.

Research output: Contribution to journalArticle

141 Scopus citations
2001

Liporegulation in Diet-induced Obesity: The antisteatotic role of hyperleptinemia

Lee, Y. H., Wang, M-Y., Kakuma, T., Wang, Z. W., Babcock, E. E., McCorkle, K., Higa, M., Zhou, Y. T. & Unger, R. H., Feb 23 2001, In : Journal of Biological Chemistry. 276, 8, p. 5629-5635 7 p.

Research output: Contribution to journalArticle

218 Scopus citations

Lipotoxicity of β-cells in obesity and in other causes of fatty acid spillover

Unger, R. H. & Zhou, Y. T., Feb 22 2001, In : Diabetes. 50, SUPPL. 1, p. S118-S121

Research output: Contribution to journalArticle

344 Scopus citations