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1955 …2018
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Research Output 1955 2018

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Article
2018
10 Citations (Scopus)

Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial

Pettus, J., Reeds, D., Cavaiola, T. S., Boeder, S., Levin, M., Tobin, G., Cava, E., Thai, D., Shi, J., Yan, H., Bautista, E., McMillan, J., Unger, R. H., Henry, R. R. & Klein, S., May 1 2018, In : Diabetes, Obesity and Metabolism. 20, 5, p. 1302-1305 4 p.

Research output: Contribution to journalArticle

Glucagon Receptors
Type 1 Diabetes Mellitus
Randomized Controlled Trials
Placebos
Insulin
10 Citations (Scopus)

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Sharma, A. X., Quittner-Strom, E. B., Lee, Y. H., Johnson, J. A., Martin, S. A., Yu, X., Li, J., Lu, J., Cai, Z., Chen, S., Wang, M-Y., Zhang, Y., Pearson, M. J., Dorn, A. C., McDonald, J. G., Gordillo, R., Yan, H., Thai, D., Wang, Z., Unger, R. H. & 1 others, Holland, W. L., Feb 13 2018, In : Cell Reports. 22, 7, p. 1760-1773 14 p.

Research output: Contribution to journalArticle

Glucagon Receptors
Adenosine Monophosphate
Metabolism
Protein Kinases
Diabetic Cardiomyopathies
2017
41 Citations (Scopus)

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, J., Okamoto, H., Huang, Z. J., Anguiano, G., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., Lee, J., Zambrowicz, B., Unger, R. H., Murphy, A. J., Xu, Y., Yancopoulos, G. D., Li, W-H. & Gromada, J., Jun 6 2017, In : Cell Metabolism. 25, 6, p. 1348-1361.e8

Research output: Contribution to journalArticle

Glucagon Receptors
Amino Acid Transport Systems
Glucagon
Hyperplasia
Amino Acids
9 Citations (Scopus)

Dapagliflozin suppresses glucagon signaling in rodent models of diabetes

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Chen, S., Li, J., Wang, Z., Davidson, J. A., Scherer, P. E., Holland, W. L., Unger, R. H. & Roth, M. G., Jun 20 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6611-6616 6 p.

Research output: Contribution to journalArticle

Glucagon
Rodentia
Sodium-Glucose Transport Proteins
Liver
Glucose
8 Citations (Scopus)

Hypoglycemic effect of combined ghrelin and glucagon receptor blockade

Mani, B. K., Uchida, A., Lee, Y. H., Osborne-Lawrence, S., Charron, M. J., Unger, R. H., Berglund, E. D. & Zigman, J. M., Jul 1 2017, In : Diabetes. 66, 7, p. 1847-1857 11 p.

Research output: Contribution to journalArticle

Glucagon Receptors
Ghrelin Receptor
Ghrelin
Hypoglycemic Agents
Blood Glucose
2016
4 Citations (Scopus)

An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon Production

Evans, M. R., Wei, S., Posner, B. A., Unger, R. H. & Roth, M. G., Apr 1 2016, In : Journal of Biomolecular Screening. 21, 4, p. 325-332 8 p.

Research output: Contribution to journalArticle

Glucagon
Assays
Medical problems
Glucagon Receptors
Insulin
21 Citations (Scopus)

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In : Diabetes. 65, 6, p. 1534-1555 22 p.

Research output: Contribution to journalArticle

Cell Survival
Insulin
Hyperglycemia
Glucose
Glucose Intolerance
2015
6 Citations (Scopus)

Alveolar-capillary adaptation to chronic hypoxia in the fatty lung

Yilmaz, C., Ravikumar, P., Gyawali, D., Iyer, R., Unger, R. H. & Hsia, C. C. W., Apr 1 2015, In : Acta Physiologica. 213, 4, p. 933-946 14 p.

Research output: Contribution to journalArticle

Lung
Hematocrit
DNA Damage
Septum of Brain
Physiological Adaptation
13 Citations (Scopus)

A new biology of diabetes revealed by leptin

Unger, R. H. & Roth, M. G., Jan 6 2015, In : Cell Metabolism. 21, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

Leptin
Poisons
Metabolic Diseases
Type 1 Diabetes Mellitus
Cell Communication

Erratum: A new biology of diabetes revealed by leptin (Cell Metabolism (2015) 21 (15-20))

Unger, R. H. & Roth, M. G., Apr 7 2015, In : Cell Metabolism. 21, 4, p. 647 1 p.

Research output: Contribution to journalArticle

Leptin
53 Citations (Scopus)

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

Wang, M-Y., Yan, H., Shi, Z., Evans, M. R., Yu, X., Lee, Y. H., Chen, S., Williams, A., Philippe, J., Roth, M. G. & Unger, R. H., Feb 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 8, p. 2503-2508 6 p.

Research output: Contribution to journalArticle

Glucagon Receptors
Type 1 Diabetes Mellitus
Insulin
Glucagon
Phenotype
2014
43 Citations (Scopus)
Hyperinsulinism
Hyperglycemia
Type 2 Diabetes Mellitus
Leptin Receptors
Rodentia
1 Citation (Scopus)

Noninvasive assessment of alveolar microvascular recruitment in conscious non-sedated rats

Yilmaz, C., Dane, D. M., Ravikumar, P., Unger, R. H. & Hsia, C. C., Jan 1 2014, In : Respiratory Physiology and Neurobiology. 190, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

Blood Volume
Pulmonary Diffusing Capacity
Lung
Membranes
Leptin
2013
22 Citations (Scopus)

Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine

Unger, R. H., Scherer, P. E. & Holland, W. L., Oct 1 2013, In : Molecular Biology of the Cell. 24, 19, p. 3011-3015 5 p.

Research output: Contribution to journalArticle

Adiponectin
Starvation
Leptin
Adipocytes
Lipids
18 Citations (Scopus)

Iatrogenic hyperinsulinemia in type 1 diabetes: Its effect on atherogenic risk markers

Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Clark, G. O., Strowig, S., Unger, R. H. & Raskin, P., Jan 2013, In : Journal of Diabetes and its Complications. 27, 1, p. 70-74 5 p.

Research output: Contribution to journalArticle

Hyperinsulinism
Type 1 Diabetes Mellitus
Insulin
Inbred NOD Mouse
Coronary Artery Disease
5 Citations (Scopus)

Role of fibroblast growth factor 21 in biology of glucagon

Berglund, E. D. & Unger, R. H., May 2013, In : Diabetes. 62, 5, p. 1376 1 p.

Research output: Contribution to journalArticle

Glucagon Receptors
Fibroblast Growth Factors
Glucagon
Hepatocytes
fibroblast growth factor 21
2012
362 Citations (Scopus)

Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover

Unger, R. H. & Cherrington, A. D., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 4-12 9 p.

Research output: Contribution to journalArticle

Glucagon
Insulin
Therapeutics
Glucagon Receptors
Glucose
82 Citations (Scopus)
Glucagon
Glucagon Receptors
Insulin
Hyperglycemia
Cyclic AMP Response Element-Binding Protein
59 Citations (Scopus)

Pancreatic steatosis and its relationship to β-cell dysfunction in humans: Racial and ethnic variations

Szczepaniak, L. S., Victor, R. G., Mathur, R., Nelson, M. D., Szczepaniak, E. W., Tyer, N., Chen, I., Unger, R. H., Bergman, R. N. & Lingvay, I., Nov 2012, In : Diabetes Care. 35, 11, p. 2377-2383 7 p.

Research output: Contribution to journalArticle

Triglycerides
Hispanic Americans
Insulin
Glucose Tolerance Test
Insulin Resistance
2011
211 Citations (Scopus)

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

Lee, Y. H., Wang, M-Y., Du, X. Q., Charron, M. J. & Unger, R. H., Feb 2011, In : Diabetes. 60, 2, p. 391-397 7 p.

Research output: Contribution to journalArticle

Glucagon Receptors
Type 1 Diabetes Mellitus
Glucagon
Insulin
Fasting
14 Citations (Scopus)

Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin

Chen, L., Philippe, J. & Unger, R. H., Sep 1 2011, In : Endocrine Practice. 17, 5, p. 819-825 7 p.

Research output: Contribution to journalArticle

Leptin
Somatostatin
Glucagon
Insulin
Glucose
24 Citations (Scopus)

Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats

Kruger, A. J., Yang, C., Lipson, K. L., Pino, S. C., Leif, J. H., Hogan, C. M., Whalen, B. J., Guberski, D. L., Lee, Y. H., Unger, R. H., Greiner, D. L., Rossini, A. A. & Bortell, R., Mar 2011, In : Autoimmunity. 44, 2, p. 137-148 12 p.

Research output: Contribution to journalArticle

Inbred BB Rats
Leptin
Type 1 Diabetes Mellitus
Parvovirus
Insulin
2010
34 Citations (Scopus)

Fatty diabetic lung: Altered alveolar structure and surfactant protein expression

Foster, D. J., Ravikumar, P., Bellotto, D. J., Unger, R. H. & Hsia, C. C., Mar 2010, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 298, 3

Research output: Contribution to journalArticle

Surface-Active Agents
Lung
Type 2 Diabetes Mellitus
Proteins
Blood-Air Barrier
6 Citations (Scopus)

Fatty diabetic lung: Functional impairment in a model of metabolic syndrome

Yilmaz, C., Ravikumar, P., Bellotto, D. J., Unger, R. H. & Hsia, C. C., Dec 2010, In : Journal of Applied Physiology. 109, 6, p. 1913-1919 7 p.

Research output: Contribution to journalArticle

Lung
Type 2 Diabetes Mellitus
Lung Compliance
Blood Volume
Pulmonary Diffusing Capacity
246 Citations (Scopus)

Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity

Unger, R. H. & Scherer, P. E., Jun 2010, In : Trends in Endocrinology and Metabolism. 21, 6, p. 345-352 8 p.

Research output: Contribution to journalArticle

Sloths
Obesity
Lipids
Leptin
Comorbidity
220 Citations (Scopus)

Leptin therapy in insulin-deficient type I diabetes

Wang, M-Y., Chen, L., Clark, G. O., Lee, Y. H., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B. & Unger, R. H., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 4813-4819 7 p.

Research output: Contribution to journalArticle

Leptin
Type 1 Diabetes Mellitus
Insulin
Therapeutics
Inbred NOD Mouse
332 Citations (Scopus)

Lipid homeostasis, lipotoxicity and the metabolic syndrome

Unger, R. H., Clark, G. O., Scherer, P. E. & Orci, L., Mar 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

Homeostasis
Fats
Lipids
Triglycerides
Physical Exertion
60 Citations (Scopus)

Pancreatic steatosis: Harbinger of type 2 diabetes in obese rodents

Lee, Y. H., Lingvay, I., Szczepaniak, L. S., Ravazzola, M., Orci, L. & Unger, R. H., Feb 2010, In : International Journal of Obesity. 34, 2, p. 396-400 5 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Rodentia
Fats
Pancreas
Exocrine Pancreas
143 Citations (Scopus)

Paracrinology of islets and the paracrinopathy of diabetes

Unger, R. H. & Orci, L., Sep 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16009-16012 4 p.

Research output: Contribution to journalArticle

Glucagon
Insulin
Volatilization
Type 1 Diabetes Mellitus
Islets of Langerhans
16 Citations (Scopus)

Special issue on lipotoxicity

Vidal-Puig, A. & Unger, R. H., Mar 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 3, p. 207-208 2 p.

Research output: Contribution to journalArticle

Metabolic Diseases
Lipid Metabolism
2009
162 Citations (Scopus)

Diabetes and apoptosis: Lipotoxicity

Kusminski, C., Shetty, S., Orci, L., Unger, R. H. & Scherer, P. E., Dec 2009, In : Apoptosis. 14, 12, p. 1484-1495 12 p.

Research output: Contribution to journalArticle

Medical problems
Apoptosis
Lipids
Insulin Resistance
Insulin
116 Citations (Scopus)

Noninvasive quantification of pancreatic fat in humans

Lingvay, I., Esser, V., Legendre, J. L., Price, A. L., Wertz, K. M., Huet, B. A., Zhang, S., Unger, R. H. & Szczepaniak, L. S., 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 10, p. 4070-4076 7 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Fats
Triglycerides
Body Mass Index
2008
99 Citations (Scopus)

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

Wang, M-Y., Grayburn, P., Chen, S., Ravazzola, M., Orci, L. & Unger, R. H., Apr 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 16, p. 6139-6144 6 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Obesity
Diet
Adipocytes
Adipose Tissue
1 Citation (Scopus)

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

Wang, M-Y., Grayburn, P., Chen, S., Ravazzola, M., Orci, L. & Unger, R. H., Sep 2008, In : Obstetrical and Gynecological Survey. 63, 9, p. 581-582 2 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus

Insulin therapy and lipid overload in type 2 diabetes: In reply

Unger, R. H., Aug 20 2008, In : JAMA - Journal of the American Medical Association. 300, 7, p. 790 1 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Insulin
Lipids
Therapeutics
158 Citations (Scopus)

Making insulin-deficient type 1 diabetic rodents thrive without insulin

Yu, X., Park, B. H., Wang, M-Y., Wang, Z. & Unger, R. H., Sep 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 37, p. 14070-14075 6 p.

Research output: Contribution to journalArticle

Rodentia
Insulin
Somatomedins
Leptin
Hyperglycemia
1 Citation (Scopus)
Whole Body Imaging
Gene Expression Regulation
Leptin
Luciferases
Transgenes
75 Citations (Scopus)

Reinventing type 2 diabetes: Pathogenesis, treatment, and prevention

Unger, R. H., Mar 12 2008, In : JAMA - Journal of the American Medical Association. 299, 10, p. 1185-1187 3 p.

Research output: Contribution to journalArticle

Lipogenesis
Hyperglycemia
Type 2 Diabetes Mellitus
Insulin Resistance
2007
382 Citations (Scopus)

Cardiac steatosis in diabetes mellitus: A 1H-magnetic resonance spectroscopy study

McGavock, J. M., Lingvay, I., Zib, I., Tillery, T., Salas, N., Unger, R. H., Levine, B. D., Raskin, P., Victor, R. G. & Szczepaniak, L. S., Sep 2007, In : Circulation. 116, 10, p. 1170-1175 6 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Diabetes Mellitus
Magnetic Resonance Spectroscopy
Glucose Intolerance
Heart Failure
180 Citations (Scopus)

Forgotten but not gone: The rediscovery of fatty heart, the most common unrecognized disease in America

Szczepaniak, L. S., Victor, R. G., Orci, L. & Unger, R. H., Oct 2007, In : Circulation Research. 101, 8, p. 759-767 9 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Volunteers
Obesity
Energy Intake
Cardiomyopathies
60 Citations (Scopus)

Metabolic mechanisms of failure of intraportally transplanted pancreatic β-cells in rats: Role of lipotoxicity and prevention by leptin

Lee, Y. H., Ravazzola, M., Park, B. H., Bashmakov, Y. K., Orci, L. & Unger, R. H., Sep 2007, In : Diabetes. 56, 9, p. 2295-2301 7 p.

Research output: Contribution to journalArticle

Lipogenesis
Leptin
Sterol Regulatory Element Binding Protein 1
Hepatocytes
Caloric Restriction
2006
280 Citations (Scopus)

Adiposity of the heart, revisited

McGavock, J. M., Victor, R. G., Unger, R. H. & Szczepaniak, L. S., Apr 4 2006, In : Annals of Internal Medicine. 144, 7, p. 517-524 8 p.

Research output: Contribution to journalArticle

Adiposity
Obesity
Lipids
Heart Diseases
Myocardium
22 Citations (Scopus)

Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: Implications for obesity treatment

Park, B. H., Wang, M-Y., Lee, Y. H., Yu, X., Ravazzola, M., Orci, L. & Unger, R. H., Dec 29 2006, In : Journal of Biological Chemistry. 281, 52, p. 40283-40291 9 p.

Research output: Contribution to journalArticle

Leptin
Adipocytes
Hypothalamus
Adipose Tissue
Rats

In response [7]

Szczepaniak, L. S., McGavock, J. M., Victor, R. G. & Unger, R. H., Oct 3 2006, In : Annals of Internal Medicine. 145, 7, p. 555 1 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Klotho-induced insulin resistance: A blessing in disguise?

Unger, R. H., Jan 2006, In : Nature Medicine. 12, 1, p. 56-57 2 p.

Research output: Contribution to journalArticle

Insulin Resistance
Insulin
Health
Availability
Hormones
4 Citations (Scopus)

Movin' on up: Adipocytes become regulators of nutrient homeostasis

Unger, R. H. & Elmquist, J. K., Mar 2006, In : Cell Metabolism. 3, 3, p. 147-148 2 p.

Research output: Contribution to journalArticle

Obese Mice
Leptin
Transgenes
Adipocytes
Homeostasis
61 Citations (Scopus)

α-Lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice

Lee, Y. H., Naseem, R. H., Park, B. H., Garry, D. J., Richardson, J. A., Schaffer, J. E. & Unger, R. H., May 26 2006, In : Biochemical and Biophysical Research Communications. 344, 1, p. 446-452 7 p.

Research output: Contribution to journalArticle

Thioctic Acid
Acyl Coenzyme A
Cardiomyopathies
Transgenic Mice
AMP-Activated Protein Kinases
2005
115 Citations (Scopus)
Leptin
White Adipose Tissue
Adipocytes
Obesity
Fats

Festschrift for Werner Creutzfeldt

Unger, R. H., Jun 15 2005, In : Regulatory Peptides. 128, 2, p. 85 1 p.

Research output: Contribution to journalArticle