• 2477 Citations
  • 22 h-Index
19952013
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Research Output 1995 2013

  • 2477 Citations
  • 22 h-Index
  • 27 Article
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Article
2013
93 Citations (Scopus)

Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations

Sato, M., Larsen, J. E., Lee, W., Sun, H., Shames, D. S., Dalvi, M. P., Ramirez, R. D., Tang, H., DiMaio, J. M., Gao, B., Xie, Y., Wistuba, I. I., Gazdar, A. F., Shay, J. W. & Minna, J. D., Jun 2013, In : Molecular Cancer Research. 11, 6, p. 638-650 13 p.

Research output: Contribution to journalArticle

Epithelial Cells
Lung
Lung Neoplasms
Neoplasms
Growth
2012
42 Citations (Scopus)

The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling

Garcia-Oscos, F., Salgado, H., Hall, S., Thomas, F., Farmer, G. E., Bermeo, J., Galindo, L. C., Ramirez, R. D., D'Mello, S., Rose-John, S. & Atzori, M., Apr 1 2012, In : Biological Psychiatry. 71, 7, p. 574-582 9 p.

Research output: Contribution to journalArticle

Temporal Lobe
Interleukin-6
Cytokines
Inhibitory Postsynaptic Potentials
Dynamins
2011
2 Citations (Scopus)
Type C Niemann-Pick Disease
Intestinal Absorption
Membrane Proteins
Triglycerides
Cholesterol
2009
19 Citations (Scopus)

H-Ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents

Vaughan, M. B., Ramirez, R. D., Andrews, C. M., Wright, W. E. & Shay, J. W., Nov 19 2009, In : PLoS One. 4, 11, e7908.

Research output: Contribution to journalArticle

keratinocytes
Keratinocytes
skin (animal)
Skin
epithelium
2007
45 Citations (Scopus)

Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells

Feagins, L. A., Zhang, H. Y., Hormi-Carver, K., Quinones, M. H., Thomas, D., Zhang, X., Terada, L. S., Spechler, S. J., Ramirez, R. D. & Souza, R. F., Jan 2007, In : American Journal of Gastroenterology. 102, 1, p. 10-20 11 p.

Research output: Contribution to journalArticle

Epithelial Cells
Acids
Cell Count
Barrett Esophagus
Apoptosis
59 Citations (Scopus)

Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T)

Jaiswal, K. R., Morales, C. P., Feagins, L. A., Gandia, K. G., Zhang, X., Zhang, H. Y., Hormi-Carver, K., Shen, Y., Elder, F., Ramirez, R. D., Sarosi, G. A., Spechler, S. J. & Souza, R. F., Jun 2007, In : Diseases of the Esophagus. 20, 3, p. 256-264 9 p.

Research output: Contribution to journalArticle

Telomerase
Barrett Esophagus
Cell Line
T-Lymphocytes
Diploidy
28 Citations (Scopus)

EGFR signaling is required for TGF-β1-mediated COX-2 induction in human bronchial epithelial cells

Liu, M., Yang, S. C., Sharma, S., Luo, J., Cui, X., Peebles, K. A., Huang, M., Sato, M., Ramirez, R. D., Shay, J. W., Minna, J. D. & Dubinett, S. M., Nov 2007, In : American Journal of Respiratory Cell and Molecular Biology. 37, 5, p. 578-588 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Cyclooxygenase 2
Epidermal Growth Factor Receptor
Epithelial Cells
Epidermal Growth Factor
165 Citations (Scopus)

Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers

Lam, D. C. L., Girard, L., Ramirez, R., Chau, W. S., Suen, W. S., Sheridan, S., Tin, V. P. C., Chung, L. P., Wong, M. P., Shay, J. W., Gazdar, A. F., Lam, W. K. & Minna, J. D., May 15 2007, In : Cancer Research. 67, 10, p. 4638-4647 10 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Non-Small Cell Lung Carcinoma
Nicotine
Genes
Gene Expression
12 Citations (Scopus)

GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus

Souza, R. F., Lunsford, T., Ramirez, R. D., Zhang, X., Lee, E. L., Shen, Y., Owen, C., Shay, J. W., Morales, C. & Spechler, S. J., Jul 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 1

Research output: Contribution to journalArticle

Telomere Shortening
Gastroesophageal Reflux
Esophagus
Epithelium
Telomere
2006
74 Citations (Scopus)

A three-dimensional model of differentiation of immortalized human bronchial epithelial cells

Vaughan, M. B., Ramirez, R. D., Wright, W. E., Minna, J. D. & Shay, J. W., Apr 2006, In : Differentiation. 74, 4, p. 141-148 8 p.

Research output: Contribution to journalArticle

Epithelial Cells
Mucins
Cell Aging
Regeneration
Keratin-14
8 Citations (Scopus)

Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus

Feagins, L. A., Susnow, N., Hui, Y. Z., Pearson, S., Owen, C., Schmalstieg, W. F., Terada, L. S., Spechler, S. J., Ramirez, R. D. & Souza, R. F., May 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 290, 5

Research output: Contribution to journalArticle

Insulin-Like Growth Factor II
Barrett Esophagus
Gene Expression
Epithelium
Stomach
194 Citations (Scopus)

Multiple oncogenic changes (K-RASV12, p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells

Sato, M., Vaughan, M. B., Girard, L., Peyton, M., Lee, W., Shames, D. S., Ramirez, R. D., Sunaga, N., Gazdar, A. F., Shay, J. W. & Minna, J. D., Feb 15 2006, In : Cancer Research. 66, 4, p. 2116-2128 13 p.

Research output: Contribution to journalArticle

Telomerase
Epidermal Growth Factor Receptor
Epithelial Cells
Phenotype
Growth
2005
29 Citations (Scopus)

Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux disease with and without Barrett's esophagus

Souza, R. F., Shewmake, K. L., Shen, Y., Ramirez, R. D., Bullock, J. S., Hladik, C. L., Lee, E. L., Terada, L. S. & Spechler, S. J., Mar 2005, In : American Journal of Gastroenterology. 100, 3, p. 551-559 9 p.

Research output: Contribution to journalArticle

Barrett Esophagus
Gastroesophageal Reflux
Mucous Membrane
Phosphotransferases
Acids
37 Citations (Scopus)

IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression

Heuzé-Vourc'h, N., Liu, M., Dalwadi, H., Baratelli, F. E., Zhu, L., Goodglick, L., Põld, M., Sharma, S., Ramirez, R. D., Shay, J. W., Minna, J. D., Strieter, R. M. & Dubinett, S. M., Jul 29 2005, In : Biochemical and Biophysical Research Communications. 333, 2, p. 470-475 6 p.

Research output: Contribution to journalArticle

Dinoprostone
Cytokines
Flow cytometry
Endothelial cells
Non-Small Cell Lung Carcinoma
2004
65 Citations (Scopus)
p38 Mitogen-Activated Protein Kinases
Cyclooxygenase 2
Adenocarcinoma
Acids
Barrett Esophagus
28 Citations (Scopus)

A reproducible laser-wounded skin equivalent model to study the effects of aging in vitro

Vaughan, M. B., Ramirez, R. D., Brown, S. A., Yang, J. C., Wright, W. E. & Shay, J. W., Jun 2004, In : Rejuvenation Research. 7, 2, p. 99-110 12 p.

Research output: Contribution to journalArticle

Lasers
Keratinocytes
Skin
Wounds and Injuries
Excimer Lasers
157 Citations (Scopus)

Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer

Sunaga, N., Miyajima, K., Suzuki, M., Sato, M., White, M. A., Ramirez, R. D., Shay, J. W., Gazdar, A. F. & Minna, J. D., Jun 15 2004, In : Cancer Research. 64, 12, p. 4277-4285 9 p.

Research output: Contribution to journalArticle

Caveolin 1
Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
Focal Adhesion Protein-Tyrosine Kinases
Tumor Suppressor Genes
411 Citations (Scopus)

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

Ramirez, R. D., Sheridan, S., Girard, L., Sato, M., Kim, Y., Pollack, J., Peyton, M., Zou, Y., Kurie, J. M., DiMaio, J. M., Milchgrub, S., Smith, A. L., Souza, R. F., Gilbey, L., Zhang, X., Gandia, K., Vaughan, M. B., Wright, W. E., Gazdar, A. F., Shay, J. W. & 1 others, Minna, J. D., Dec 15 2004, In : Cancer Research. 64, 24, p. 9027-9034 8 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Epithelial Cells
Lung Neoplasms
Cell Line
Keratin-14
2003
65 Citations (Scopus)

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells

Ramirez, R. D., Herbert, B. S., Vaughan, M. B., Zou, Y., Gandia, K., Morales, C. P., Wright, W. E. & Shay, J. W., Jan 23 2003, In : Oncogene. 22, 3, p. 433-444 12 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 4
Cell Aging
Telomere
Epithelial Cells
Up-Regulation
47 Citations (Scopus)

Characterisation of telomerase immortalised normal human oesophageal squamous cells

Morales, C. P., Gandia, K. G., Ramirez, R. D., Wright, W. E., Shay, J. W. & Spechler, S. J., Mar 1 2003, In : Gut. 52, 3, p. 327-333 7 p.

Research output: Contribution to journalArticle

Telomerase
Epithelial Cells
Cell Line
Cell Cycle Checkpoints
Differentiation Antigens
44 Citations (Scopus)

Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer

Sato, M., Girard, L., Sekine, I., Sunaga, N., Ramirez, R. D., Kamibayashi, C. & Minna, J. D., Oct 16 2003, In : Oncogene. 22, 46, p. 7243-7246 4 p.

Research output: Contribution to journalArticle

Flap Endonucleases
Small Cell Lung Carcinoma
Lung Neoplasms
Cell Line
Mutation
2001
372 Citations (Scopus)

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

Ramirez, R. D., Morales, C. P., Herbert, B. S., Rohde, J. M., Passons, C., Shay, J. W. & Wright, W. E., 2001, In : Genes and Development. 15, 4, p. 398-403 6 p.

Research output: Contribution to journalArticle

Telomere
Telomere Shortening
Feeder Cells
Telomerase
Growth
1999
39 Citations (Scopus)

Progressive increase in telomerase activity from benign melanocytic conditions to malignant melanoma.

Ramirez, R. D., D'Atri, S., Pagani, E., Faraggiana, T., Lacal, P. M., Taylor, R. S. & Shay, J. W., Apr 1999, In : Neoplasia (New York, N.Y.). 1, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

Telomerase
Melanoma
Neoplasm Metastasis
In Situ Hybridization
Lymph Nodes
1997
23 Citations (Scopus)

Mutation analysis of the coding sequences of MEK-1 and MEK-2 genes in human lung cancer cell lines

Bansal, A., Ramirez, R. D. & Minna, J. D., 1997, In : Oncogene. 14, 10, p. 1231-1234 4 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase Kinases
Sequence Analysis
Lung Neoplasms
Cell Line
143 Citations (Scopus)

Telomerase activity concentrates in the mitotically active segments of human hair follicles

Ramirez, R. D., Wright, W. E., Shay, J. W. & Taylor, R. S., 1997, In : Journal of Investigative Dermatology. 108, 1, p. 113-117 5 p.

Research output: Contribution to journalArticle

Hair Follicle
Telomerase
Stem cells
Stem Cells
Tissue
1996
261 Citations (Scopus)

Detection of telomerase activity in malignant and nonmalignant skin conditions

Taylor, R. S., Ramirez, R. D., Ogoshi, M., Chaffins, M., Piatyszek, M. A. & Shay, J. W., 1996, In : Journal of Investigative Dermatology. 106, 4, p. 759-765 7 p.

Research output: Contribution to journalArticle

Telomerase
Skin
Solar System
Sun
Telomere
1995
15 Citations (Scopus)

Retinyl ester hydrolase and the visual cycle in the chicken eye

Bustamante, J. J., Ziari, S., Ramirez, R. D. & Tsin, A. T. C., Dec 1 1995, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 269, 6 38-6

Research output: Contribution to journalArticle

hydrolases
retina
Retinal Pigment Epithelium
Retina
Chickens