Ryan E Hibbs

Former affiliation
  • 1764 Citations
  • 13 h-Index
20042020

Research output per year

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Research Output

  • 1764 Citations
  • 13 h-Index
  • 21 Article
  • 1 Short survey
  • 1 Review article
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Article
2020

Modulation of the erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site

Brams, M., Govaerts, C., Kambara, K., Price, K., Spurny, R., Gharpure, A., Pardon, E., Evans, G. L., Bertrand, D., Lummis, S. C. R., Hibbs, R. E., Steyaert, J. & Ulens, C., Jan 2020, In : eLife. 9, e51511.

Research output: Contribution to journalArticle

Open Access

Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins

Rahman, M. M., Teng, J., Worrell, B. T., Noviello, C. M., Lee, M., Karlin, A., Stowell, M. H. B. & Hibbs, R. E., Jun 17 2020, In : Neuron. 106, 6, p. 952-962.e5

Research output: Contribution to journalArticle

2019

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

Gharpure, A., Teng, J., Zhuang, Y., Noviello, C. M., Walsh, R. M., Cabuco, R., Howard, R. J., Zaveri, N. T., Lindahl, E. & Hibbs, R. E., Nov 6 2019, In : Neuron. 104, 3, p. 501-511.e6

Research output: Contribution to journalArticle

18 Scopus citations

CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations

Mann, N., Kause, F., Henze, E. K., Gharpure, A., Shril, S., Connaughton, D. M., Nakayama, M., Klämbt, V., Majmundar, A. J., Wu, C. H. W., Kolvenbach, C. M., Dai, R., Chen, J., van der Ven, A. T., Ityel, H., Tooley, M. J., Kari, J. A., Bownass, L., El Desoky, S., De Franco, E. & 13 others, Shalaby, M., Tasic, V., Bauer, S. B., Lee, R. S., Beckel, J. M., Yu, W., Mane, S. M., Lifton, R. P., Reutter, H., Ellard, S., Hibbs, R. E., Kawate, T. & Hildebrandt, F., Dec 5 2019, In : American Journal of Human Genetics. 105, 6, p. 1286-1293 8 p.

Research output: Contribution to journalArticle

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon

Zoltowski, B. D., Chelliah, Y., Wickramaratne, A., Jarocha, L., Karki, N., Xu, W., Mouritsen, H., Hore, P. J., Hibbs, R. E., Green, C. B. & Takahashi, J. S., Sep 24 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 39, p. 19449-19457 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Heteromeric neuronal nicotinic acetylcholine receptors with mutant B subunits acquire sensitivity to A7-selective positive allosteric modulatorss

Stokes, C., Garai, S., Kulkarni, A. R., Cantwell, L. N., Noviello, C. M., Hibbs, R. E., Horenstein, N. A., Abboud, K. A., Thakur, G. A. & Papke, R. L., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 2, p. 252-268 17 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Structural principles of distinct assemblies of the human α4β2 nicotinic receptor

Walsh, R. M., Roh, S. H., Gharpure, A., Morales-Perez, C. L., Teng, J. & Hibbs, R. E., May 10 2018, In : Nature. 557, 7704, p. 261-265 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Structure of a human synaptic GABAA receptor

Zhu, S., Noviello, C. M., Teng, J., Walsh, R. M., Kim, J. J. & Hibbs, R. E., Jan 1 2018, In : Nature. 559, 7712, p. 67-88 22 p.

Research output: Contribution to journalArticle

101 Scopus citations
2016

X-ray structure of the human α4β2 nicotinic receptor

Morales-Perez, C. L., Noviello, C. M. & Hibbs, R. E., 2016, In : Nature. 538, 7625, p. 411-415 5 p.

Research output: Contribution to journalArticle

198 Scopus citations
2015

Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins

Morales-Perez, C. L., Noviello, C. M. & Hibbs, R. E., Dec 16 2015, (Accepted/In press) In : Structure.

Research output: Contribution to journalArticle

24 Scopus citations
2014

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

Althoff, T., Hibbs, R. E., Banerjee, S. & Gouaux, E., Aug 21 2014, In : Nature. 512, 7514, p. 333-337 5 p.

Research output: Contribution to journalArticle

160 Scopus citations
2012

A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening

Hattori, M., Hibbs, R. E. & Gouaux, E., Aug 8 2012, In : Structure. 20, 8, p. 1293-1299 7 p.

Research output: Contribution to journalArticle

126 Scopus citations
2011

Principles of activation and permeation in an anion-selective Cys-loop receptor

Hibbs, R. E. & Gouaux, E., Jun 2 2011, In : Nature. 474, 7349, p. 54-60 7 p.

Research output: Contribution to journalArticle

692 Scopus citations
2009

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

Hibbs, R. E., Sulzenbacher, G., Shi, J., Talley, T. T., Conrod, S., Kem, W. R., Taylor, P., Marchot, P. & Bourne, Y., 2009, In : EMBO Journal. 28, 19, p. 3040-3051 12 p.

Research output: Contribution to journalArticle

124 Scopus citations
2008

Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore

Talley, T. T., Harel, M., Hibbs, R. E., Radić, Z., Tomizawa, M., Casida, J. E. & Taylor, P., May 27 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 21, p. 7606-7611 6 p.

Research output: Contribution to journalArticle

127 Scopus citations
2007

Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes

Taylor, P., Talley, T. T., Radic', Z., Hansen, S. B., Hibbs, R. E. & Shi, J., Oct 15 2007, In : Biochemical Pharmacology. 74, 8, p. 1164-1171 8 p.

Research output: Contribution to journalArticle

40 Scopus citations
2006

Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein

Hibbs, R. E., Radic, Z., Taylor, P. & Johnson, D. A., Dec 22 2006, In : Journal of Biological Chemistry. 281, 51, p. 39708-39718 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Structural dynamics of the acetylcholine binding protein: Hydrodynamic and fluorescence anisotropy decay analyses

Hibbs, R. E., Johnson, D. A., Shi, J. & Taylor, P., Sep 1 2006, In : Journal of Molecular Neuroscience. 30, 1-2, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations
2005

Structural dynamics of the α-neurotoxin-acetylcholine-binding protein complex: Hydrodynamic and fluorescence anisotropy decay analyses

Hibbs, R. E., Johnson, D. A., Shi, J., Hansen, S. B. & Taylor, P., Dec 20 2005, In : Biochemistry. 44, 50, p. 16602-16611 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2004

Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein

Hibbs, R. E., Talley, T. T. & Taylor, P., Jul 2 2004, In : Journal of Biological Chemistry. 279, 27, p. 28483-28491 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Contemporary paradigms for cholinergic ligand design guided by biological structure

Taylor, P., Hansen, S. B., Talley, T. T., Hibbs, R. E. & Radić, Z., Apr 19 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 8, p. 1875-1877 3 p.

Research output: Contribution to journalArticle

1 Scopus citations