• 943 Citations
  • 16 h-Index
20032020

Research output per year

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Research Output

  • 943 Citations
  • 16 h-Index
  • 25 Article
  • 3 Chapter
  • 2 Review article
  • 1 Comment/debate
2020

Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review

Khan, S. & Gerber, D. E., Aug 2020, In : Seminars in Cancer Biology. 64, p. 93-101 9 p.

Research output: Contribution to journalReview article

7 Scopus citations

Investigational Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Event Prediction and Diagnosis

von Itzstein, M. S., Khan, S. & Gerber, D. E., Jun 1 2020, In : Clinical chemistry. 66, 6, p. 779-793 15 p.

Research output: Contribution to journalArticle

Late-Onset Immunotherapy Toxicity and Delayed Autoantibody Changes: Checkpoint Inhibitor–Induced Raynaud's-Like Phenomenon

Khan, S., von Itzstein, M. S., Lu, R., Bermas, B. L., Karp, D. R., Khan, S. A., Fattah, F. J., Park, J. Y., Saltarski, J. M., Gloria-McCutchen, Y., Xie, Y., Li, Q. Z., Wakeland, E. K. & Gerber, D. E., May 1 2020, In : Oncologist. 25, 5, p. e753-e757

Research output: Contribution to journalArticle

Open Access

Statin Intolerance, Anti-HMGCR Antibodies, and Immune Checkpoint Inhibitor-Associated Myositis: A “Two-Hit” Autoimmune Toxicity or Clinical Predisposition?

von Itzstein, M. S., Khan, S., Popat, V., Lu, R., Khan, S. A., Fattah, F. J., Park, J. Y., Bermas, B. L., Karp, D. R., Ahmed, M., Saltarski, J. M., Gloria-McCutchen, Y., Xie, Y., Li, Q. Z., Wakeland, E. K. & Gerber, D. E., 2020, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
2019

FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans

Du, Q., Huynh, L. K., Coskun, F., Molina, E., King, M. A., Raj, P., Khan, S., Dozmorov, I., Seroogy, C. M., Wysocki, C. A., Padron, G. T., Yates, T. R., Louise Markert, M., Teresa de la Morena, M. & van Oers, N. S. C., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4724-4738 15 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

Du, Q., Hoover, A. R., Dozmorov, I., Raj, P., Khan, S., Molina, E., Chang, T. C., de la Morena, M. T., Cleaver, O. B., Mendell, J. T. & van Oers, N. S. C., May 20 2019, In : Developmental cell. 49, 4, p. 618-631.e5

Research output: Contribution to journalArticle

6 Scopus citations

Single-cell RNA-sequencing of peripheral blood mononuclear cells with ddSEQ

Khan, S. & Kaihara, K. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 155-176 22 p. (Methods in Molecular Biology; vol. 1979).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Immune dysregulation in cancer patients developing immune-related adverse events

Khan, S., Khan, S., Luo, X., Fattah, F. J., Saltarski, J., Gloria-McCutchen, Y., Lu, R., Xie, Y., Li, Q., Wakeland, E. K. & Gerber, D. E., Jan 1 2018, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

15 Scopus citations
2016

DNA polymerase-α regulates the activation of type i interferons through cytosolic RNA:DNA synthesis

Starokadomskyy, P., Gemelli, T., Rios, J. J., Xing, C., Wang, R. C., Li, H., Pokatayev, V., Dozmorov, I., Khan, S., Miyata, N., Fraile, G., Raj, P., Xu, Z., Xu, Z., Ma, L., Lin, Z., Wang, H., Yang, Y., Ben-Amitai, D., Orenstein, N. & 11 others, Mussaffi, H., Baselga, E., Tadini, G., Grunebaum, E., Sarajlija, A., Krzewski, K., Wakeland, E. K., Yan, N., De La Morena, M. T., Zinn, A. R. & Burstein, E., May 1 2016, In : Nature immunology. 17, 5, p. 495-504 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Erratum: Personalized immunomonitoring uncovers molecular networks that stratify lupus patients ((Cell (2016) 165 (551-565))

Banchereau, R., Hong, S., Cantarel, B., Baldwin, N., Baisch, J., Edens, M., Cepika, A. M., Acs, P., Turner, J., Anguiano, E., Vinod, P., Khan, S., Obermoser, G., Blankenship, D., Wakeland, E., Nassi, L., Gotte, A., Punaro, M., Liu, Y. J., Banchereau, J. & 3 others, Rossello-Urgell, J., Wright, T. & Pascual, V., Jun 2 2016, In : Cell. 165, 6, p. 1548-1550 3 p.

Research output: Contribution to journalComment/debate

39 Scopus citations

Fatty acid amide hydrolase regulates peripheral B cell receptor revision, polyreactivity, and B1 cells in lupus

Pathak, S., Kumar, K. R., Kanta, H., Carr-Johnson, F., Han, J., Bashmakov, A., Faure, L., Ding, H., Vanarsa, K., Khan, S., Li, Q. Z., Chapman, K., Wakeland, E. K. & Mohan, C., Feb 15 2016, In : Journal of Immunology. 196, 4, p. 1507-1516 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B. E., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I., Carr-Johnson, F., Mitrovic, M., Wiley, G. B., Kelly, J. A., Lauwerys, B. R., Olsen, N. J., Cotsapas, C., Garcia, C. K., Wise, C. A., Harley, J. B. & 9 others, Nath, S. K., James, J. A., Jacob, C. O., Tsao, B. P., Pasare, C., Karp, D. R., Li, Q. Z., Gaffney, P. M. & Wakeland, E. K., Feb 15 2016, In : eLife. 5, FEBRUARY2016, e12089.

Research output: Contribution to journalArticle

52 Scopus citations

RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8

Khan, S., Kuruvilla, M., Hagin, D., Wakeland, B., Liang, C., Vishwanathan, K., Gatti, R. A., Torgersen, T. R., Abraham, R. S., Wakeland, E. K., van Oers, N. S. C. & de la Morena, M. T., Jul 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 289-292.e6

Research output: Contribution to journalArticle

4 Scopus citations
2015

A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

Shields, B. B., Pecot, C. V., Gao, H., McMillan, E., Potts, M., Nagel, C., Purinton, S., Wang, Y., Ivan, C., Kim, H. S., Borkowski, R. J., Khan, S., Rodriguez-Aguayo, C., Lopez-Berestein, G., Lea, J., Gazdar, A., Baggerly, K. A., Sood, A. K. & White, M. A., Dec 1 2015, In : Molecular Systems Biology. 11, 12, p. 1-17 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cutting edge: Inhibiting TBK1 by compound II ameliorates autoimmune disease in mice

Hasan, M., Dobbs, N., Khan, S., White, M. A., Wakeland, E. K., Li, Q. Z. & Yan, N., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 4573-4577 5 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism

He, C., Wei, Y., Sun, K., Li, B., Dong, X., Zou, Z., Liu, Y., Kinch, L. N., Khan, S., Sinha, S., Xavier, R. J., Grishin, N. V., Xiao, G., Eskelinen, E. L., Scherer, P. E., Whistler, J. L. & Levine, B., Aug 29 2013, In : Cell. 154, 5, p. 1085-1099 15 p.

Research output: Contribution to journalArticle

87 Scopus citations
2012

Chemical-induced estrogenicity

Safe, S. H., Khan, S., Wu, F., Li, X. & Sreevalsan, S., Dec 1 2012, Veterinary Toxicology. Elsevier Inc., p. 999-1011 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2011

Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors

Yoon, K., Lee, S. O., Cho, S. D., Kim, K., Khan, S. & Safe, S., Jun 14 2011, In : Carcinogenesis. 32, 6, p. 836-842 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Targeting NR4A1 (TR3) in cancer cells and tumors

Lee, S. O., Li, X., Khan, S. & Safe, S., Feb 1 2011, In : Expert Opinion on Therapeutic Targets. 15, 2, p. 195-206 12 p.

Research output: Contribution to journalReview article

62 Scopus citations
2010

Activation of nerve growth factor-induced Bα by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth

Cho, S. D., Lee, S. O., Chintharlapalli, S., Abdelrahim, M., Khan, S., Yoon, K., Kamat, A. M. & Safe, S., Mar 1 2010, In : Molecular Pharmacology. 77, 3, p. 396-404 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2008

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways

Vanderlaag, K., Su, Y., Frankel, A. E., Grage, H., Smith, R., Khan, S. & Safe, S., May 2008, In : Breast Cancer Research and Treatment. 109, 2, p. 273-283 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Ligand structure-dependent activation of estrogen receptor α/Sp by estrogens and xenoestrogens

Wu, F., Khan, S., Wu, Q., Barhoumi, R., Burghardt, R. & Safe, S., May 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 110, 1-2, p. 104-115 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
2007

Chemical-induced estrogenicity

Safe, S. H., Khan, S., Wu, F. & Li, X., Dec 1 2007, Veterinary Toxicology. Elsevier Ltd, p. 811-822 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells

Khan, S., Liu, S., Stoner, M. & Safe, S., Aug 15 2007, In : Toxicology and Applied Pharmacology. 223, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways

Sung, D. C., Yoon, K., Chintharlapalli, S., Abdelrahim, M., Lei, P., Hamilton, S., Khan, S., Ramaiah, S. K. & Safe, S., Jan 15 2007, In : Cancer research. 67, 2, p. 674-683 10 p.

Research output: Contribution to journalArticle

114 Scopus citations

Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells

Khan, S., Wu, F., Liu, S., Wu, Q. & Safe, S., Sep 1 2007, In : Journal of molecular endocrinology. 39, 3-4, p. 289-304 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
2006

3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor α

Abdelrahim, M., Ariazi, E., Kim, K., Khan, S., Barhoumi, R., Burghardt, R., Liu, S., Hill, D., Finnell, R., Wlodarczyk, B., Jordan, V. C. & Safe, S., Feb 15 2006, In : Cancer research. 66, 4, p. 2459-2467 9 p.

Research output: Contribution to journalArticle

98 Scopus citations

Aryl hydrocarbon receptor agonists directly activate estrogen receptor α in MCF-7 breast cancer cells

Liu, S., Abdelrahim, M., Khan, S., Ariazi, E., Jordan, V. C. & Safe, S., Sep 1 2006, In : Biological Chemistry. 387, 9, p. 1209-1213 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Molecular mechanism of inhibitory aryl hydrocarbon receptor - Estrogen receptor/Sp1 cross talk in breast cancer cells

Khan, S., Barhoumi, R., Burghardt, R., Liu, S., Kim, K. & Safe, S., Aug 31 2006, In : Molecular Endocrinology. 20, 9, p. 2199-2214 16 p.

Research output: Contribution to journalArticle

44 Scopus citations

Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes

Khan, S., Konstantinov, A., Chittim, B., McAlees, A., Yeo, B. & Safe, S., Oct 1 2006, In : Toxicology in Vitro. 20, 7, p. 1234-1237 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2003

Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17β-estradiol in breast cancer cells

Khan, S., Abdelrahim, M., Samudio, I. & Safe, S., Jun 1 2003, In : Endocrinology. 144, 6, p. 2325-2335 11 p.

Research output: Contribution to journalArticle

67 Scopus citations