• 870 Citations
  • 16 h-Index
20032019
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Research Output 2003 2019

  • 870 Citations
  • 16 h-Index
  • 22 Article
  • 3 Chapter
  • 2 Review article
  • 1 Comment/debate
2019
4 Citations (Scopus)
Autoimmunity
Neoplasms
Epigenomics
Autoimmune Diseases
Immune System

FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans

Du, Q., Huynh, L. K., Coskun, F., Molina, E., King, M. A., Raj, P., Khan, S., Dozmorov, I., Seroogy, C. M., Wysocki, C. A., Padron, G. T., Yates, T. R., Louise Markert, M., Teresa de la Morena, M. & van Oers, N. S. C., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4724-4738 15 p.

Research output: Contribution to journalArticle

Open Access
Mutation
Nails
Phenotype
Hair
Clustered Regularly Interspaced Short Palindromic Repeats
2 Citations (Scopus)

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

Du, Q., Hoover, A. R., Dozmorov, I., Raj, P., Khan, S., Molina, E., Chang, T-C., De La Morena, M. T., Cleaver, O., Mendell, J. T. & Van Oers, N., May 20 2019, In : Developmental Cell. 49, 4, p. 618-631.e5

Research output: Contribution to journalArticle

Long Noncoding RNA
Prolactin
Growth Hormone
MicroRNAs
Genes

Single-cell RNA-sequencing of peripheral blood mononuclear cells with ddSEQ

Khan, S. & Kaihara, K. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 155-176 22 p. (Methods in Molecular Biology; vol. 1979).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA Sequence Analysis
Blood Cells
Immune System
Gene Expression
Infection
2018
6 Citations (Scopus)

Immune dysregulation in cancer patients developing immune-related adverse events

Khan, S., Khan, S., Luo, X., Fattah, F. J., Saltarski, J., Gloria-McCutchen, Y., Lu, R., Xie, Y., Li, Q., Wakeland, E. K. & Gerber, D. E., Jan 1 2018, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

Neoplasms
Cytokines
Therapeutics
Interleukin-10
Serum
2016
45 Citations (Scopus)

DNA polymerase-α regulates the activation of type i interferons through cytosolic RNA: DNA synthesis

Starokadomskyy, P., Gemelli, T., Rios, J. J., Xing, C., Wang, R. C., Li, H., Pokatayev, V., Dozmorov, I., Khan, S., Miyata, N., Fraile, G., Raj, P., Xu, Z., Xu, Z., Ma, L., Lin, Z., Wang, H., Yang, Y., Ben-Amitai, D., Orenstein, N. & 11 others, Mussaffi, H., Baselga, E., Tadini, G., Grunebaum, E., Sarajlija, A., Krzewski, K., Wakeland, E. K., Yan, N., De La Morena, M. T., Zinn, A. R. & Burstein, E., May 1 2016, In : Nature Immunology. 17, 5, p. 495-504 10 p.

Research output: Contribution to journalArticle

Interferon Type I
DNA-Directed DNA Polymerase
Nucleic Acids
Interferons
Catalytic DNA
30 Citations (Scopus)

Erratum: Personalized immunomonitoring uncovers molecular networks that stratify lupus patients ((Cell (2016) 165 (551-565))

Banchereau, R., Hong, S., Cantarel, B., Baldwin, N., Baisch, J., Edens, M., Cepika, A. M., Acs, P., Turner, J., Anguiano, E., Vinod, P., Khan, S., Obermoser, G., Blankenship, D., Wakeland, E., Nassi, L., Gotte, A., Punaro, M., Liu, Y. J., Banchereau, J. & 3 others, Rossello-Urgell, J., Wright, T. & Pascual, V., Jun 2 2016, In : Cell. 165, 6, p. 1548-1550 3 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Fatty acid amide hydrolase regulates peripheral B cell receptor revision, polyreactivity, and B1 cells in lupus

Pathak, S., Kumar, K. R., Kanta, H., Carr-Johnson, F., Han, J., Bashmakov, A., Faure, L., Ding, H., Vanarsa, K., Khan, S., Li, Q. Z., Chapman, K., Wakeland, E. K. & Mohan, C., Feb 15 2016, In : Journal of Immunology. 196, 4, p. 1507-1516 10 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Autoantibodies
Central Tolerance
Tissue Array Analysis
Chromosomes, Human, Pair 4
44 Citations (Scopus)

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B. E., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I., Carr-Johnson, F., Mitrovic, M., Wiley, G. B., Kelly, J. A., Lauwerys, B. R., Olsen, N. J., Cotsapas, C., Garcia, C. K., Wise, C. A., Harley, J. B. & 9 others, Nath, S. K., James, J. A., Jacob, C. O., Tsao, B. P., Pasare, C., Karp, D. R., Li, Q. Z., Gaffney, P. M. & Wakeland, E. K., Feb 15 2016, In : eLife. 5, FEBRUARY2016, e12089.

Research output: Contribution to journalArticle

Polymorphism
Autoimmunity
Systemic Lupus Erythematosus
Molecules
D region
2015
8 Citations (Scopus)

A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

Shields, B. B., Pecot, C. V., Gao, H., McMillan, E., Potts, M., Nagel, C., Purinton, S., Wang, Y., Ivan, C., Kim, H. S., Borkowski, R. J., Khan, S., Rodriguez-Aguayo, C., Lopez-Berestein, G., Lea, J., Gazdar, A., Baggerly, K. A., Sood, A. K. & White, M. A., Dec 1 2015, In : Molecular Systems Biology. 11, 12, p. 1-17 17 p.

Research output: Contribution to journalArticle

Ovarian Cancer
MicroRNA
ovarian neoplasms
MicroRNAs
microRNA
29 Citations (Scopus)

Cutting edge: Inhibiting TBK1 by compound II ameliorates autoimmune disease in mice

Hasan, M., Dobbs, N., Khan, S., White, M. A., Wakeland, E. K., Li, Q. Z. & Yan, N., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 4573-4577 5 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Phosphotransferases
Systemic Lupus Erythematosus
Poly I-C
Protein-Serine-Threonine Kinases
4 Citations (Scopus)

RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8

Khan, S., Kuruvilla, M., Hagin, D., Wakeland, B., Liang, C., Vishwanathan, K., Gatti, R. A., Torgersen, T. R., Abraham, R. S., Wakeland, E. K., van Oers, N. S. C. & de la Morena, M. T., Mar 13 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

2013
80 Citations (Scopus)

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism

He, C., Wei, Y., Sun, K., Li, B., Dong, X., Zou, Z., Liu, Y., Kinch, L. N., Khan, S., Sinha, S., Xavier, R. J., Grishin, N. V., Xiao, G., Eskelinen, E. L., Scherer, P. E., Whistler, J. L. & Levine, B., Aug 29 2013, In : Cell. 154, 5, p. 1085-1099 15 p.

Research output: Contribution to journalArticle

Autophagy
G-Protein-Coupled Receptors
Metabolism
Degradation
Knockout Mice
2012

Chemical-induced estrogenicity

Safe, S. H., Khan, S., Wu, F., Li, X. & Sreevalsan, S., Dec 1 2012, Veterinary Toxicology. Elsevier Inc., p. 999-1011 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011
50 Citations (Scopus)

Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors

Yoon, K., Lee, S. O., Cho, S. D., Kim, K., Khan, S. & Safe, S., Jun 14 2011, In : Carcinogenesis. 32, 6, p. 836-842 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Apoptosis
Activating Transcription Factor 3
Growth
Genes
59 Citations (Scopus)

Targeting NR4A1 (TR3) in cancer cells and tumors

Lee, S. O., Li, X., Khan, S. & Safe, S., Feb 1 2011, In : Expert Opinion on Therapeutic Targets. 15, 2, p. 195-206 12 p.

Research output: Contribution to journalReview article

Cytoplasmic and Nuclear Receptors
Tumors
Cells
Neoplasms
Apoptosis
2010
51 Citations (Scopus)

Activation of nerve growth factor-induced Bα by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth

Cho, S. D., Lee, S. O., Chintharlapalli, S., Abdelrahim, M., Khan, S., Yoon, K., Kamat, A. M. & Safe, S., Mar 1 2010, In : Molecular Pharmacology. 77, 3, p. 396-404 9 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Urinary Bladder Neoplasms
Apoptosis
Growth
Methane
2008
12 Citations (Scopus)

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways

Vanderlaag, K., Su, Y., Frankel, A. E., Grage, H., Smith, R., Khan, S. & Safe, S., May 2008, In : Breast Cancer Research and Treatment. 109, 2, p. 273-283 11 p.

Research output: Contribution to journalArticle

Methane
Estrogen Receptors
Breast Neoplasms
Peroxisome Proliferator-Activated Receptors
Nude Mice
28 Citations (Scopus)

Ligand structure-dependent activation of estrogen receptor α/Sp by estrogens and xenoestrogens

Wu, F., Khan, S., Wu, Q., Barhoumi, R., Burghardt, R. & Safe, S., May 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 110, 1-2, p. 104-115 12 p.

Research output: Contribution to journalArticle

Luciferases
Estrogen Receptors
Estrogens
Chemical activation
Ligands
2007
2 Citations (Scopus)

Chemical-induced estrogenicity

Safe, S. H., Khan, S., Wu, F. & Li, X., Dec 1 2007, Veterinary Toxicology. Elsevier Ltd, p. 811-822 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

estrogens
Estrogens
hormones
diethylstilbestrol
tamoxifen
19 Citations (Scopus)

Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells

Khan, S., Liu, S., Stoner, M. & Safe, S., Aug 15 2007, In : Toxicology and Applied Pharmacology. 223, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Cells
Breast Neoplasms
Cytochrome P-450 CYP1A1
Cycloheximide
109 Citations (Scopus)

Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways

Sung, D. C., Yoon, K., Chintharlapalli, S., Abdelrahim, M., Lei, P., Hamilton, S., Khan, S., Ramaiah, S. K. & Safe, S., Jan 15 2007, In : Cancer Research. 67, 2, p. 674-683 10 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Colonic Neoplasms
Apoptosis
Nude Mice
Genes
20 Citations (Scopus)

Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells

Khan, S., Wu, F., Liu, S., Wu, Q. & Safe, S., Sep 1 2007, In : Journal of Molecular Endocrinology. 39, 3-4, p. 289-304 16 p.

Research output: Contribution to journalArticle

Sp Transcription Factors
Estrogens
Retinoic Acid Receptors
RNA
Breast Neoplasms
2006
96 Citations (Scopus)

3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor α

Abdelrahim, M., Ariazi, E., Kim, K., Khan, S., Barhoumi, R., Burghardt, R., Liu, S., Hill, D., Finnell, R., Wlodarczyk, B., Jordan, V. C. & Safe, S., Feb 15 2006, In : Cancer Research. 66, 4, p. 2459-2467 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Methylcholanthrene
Estrogen Receptors
Ligands
Estrogens
56 Citations (Scopus)

Aryl hydrocarbon receptor agonists directly activate estrogen receptor α in MCF-7 breast cancer cells

Liu, S., Abdelrahim, M., Khan, S., Ariazi, E., Jordan, V. C. & Safe, S., Sep 1 2006, In : Biological Chemistry. 387, 9, p. 1209-1213 5 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Estrogen Receptors
Cells
Breast Neoplasms
Methylcholanthrene
42 Citations (Scopus)

Molecular mechanism of inhibitory aryl hydrocarbon receptor - Estrogen receptor/Sp1 cross talk in breast cancer cells

Khan, S., Barhoumi, R., Burghardt, R., Liu, S., Kim, K. & Safe, S., Aug 31 2006, In : Molecular Endocrinology. 20, 9, p. 2199-2214 16 p.

Research output: Contribution to journalArticle

Receptor Cross-Talk
Aryl Hydrocarbon Receptors
Estrogen Receptors
Breast Neoplasms
Fluorescence Resonance Energy Transfer
3 Citations (Scopus)

Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes

Khan, S., Konstantinov, A., Chittim, B., McAlees, A., Yeo, B. & Safe, S., Oct 1 2006, In : Toxicology in Vitro. 20, 7, p. 1234-1237 4 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Luciferases
Assays
Cells
Cytochrome P-450 CYP1A1
2003
67 Citations (Scopus)

Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17β-estradiol in breast cancer cells

Khan, S., Abdelrahim, M., Samudio, I. & Safe, S., Jun 1 2003, In : Endocrinology. 144, 6, p. 2325-2335 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estradiol
Breast Neoplasms
Gene Expression
Genes