• 51701 Citations
  • 101 h-Index
1986 …2020

Research output per year

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Research Output

2.1 Å crystal structure of human PXR in complex with the St. John's wort compound hyperforin

Watkins, R. E., Maglich, J. M., Moore, L. B., Wisely, G. B., Noble, S. M., Davis-Searles, P. R., Lambert, M. H., Kliewer, S. A. & Redinbo, M. R., Feb 18 2003, In : Biochemistry. 42, 6, p. 1430-1438 9 p.

Research output: Contribution to journalArticle

280 Scopus citations

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A. & Willson, T. M., Feb 20 1997, In : Journal of Biological Chemistry. 272, 6, p. 3137-3140 4 p.

Research output: Contribution to journalArticle

961 Scopus citations

Activation of the nuclear receptor peroxisome proliferator-activated receptor γ promotes brown adipocyte differentiation

Tai, T. A. C., Jennermann, C., Brown, K. K., Oliver, B. B., MacGinnitie, M. A., Wilkison, W. O., Roger Brown, H., Lehmann, J. M., Kliewer, S. A., Morris, D. C. & Graves, R. A., Nov 30 1996, In : Journal of Biological Chemistry. 271, 47, p. 29909-29914 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

Activation of the orphan receptor RIP14 by retinoids

Zavacki, A. M., Lehmann, J. M., Seol, W., Willson, T. M., Kliewer, S. A. & Moore, D. D., Jul 22 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 15, p. 7909-7914 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

Adenovirus early region 3 promoter regulation by E1A/E1B is independent of alterations in DNA binding and gene activation of CREB/ATF and AP1

Kornuc, M., Kliewer, S., Garcia, J., Harrich, D., Li, C. & Gaynor, R., 1990, In : Journal of virology. 64, 5, p. 2004-2013 10 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Adipose Tissue Resistin Expression is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists

Way, J. M., Görgün, C. Z., Tong, Q., Uysal, K. T., Brown, K. K., Harrington, W. W., Oliver, W. R., Willson, T. M., Kliewer, S. A. & Hotamisligil, G. S., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25651-25653 3 p.

Research output: Contribution to journalArticle

393 Scopus citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

Mangelsdorf, D. J., Umesono, K., Kliewer, S. A., Borgmeyer, U., Ong, E. S. & Evans, R. M., Aug 9 1991, In : Cell. 66, 3, p. 555-561 7 p.

Research output: Contribution to journalArticle

506 Scopus citations

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A. & Mangelsdorf, D. J., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 246-253 8 p.

Research output: Contribution to journalReview article

30 Scopus citations

AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids

Schmidt, D. R., Schmidt, S., Holmstrom, S. R., Makishima, M., Yu, R. T., Cummins, C. L., Mangelsdorf, D. J. & Kliewer, S. A., Jan 28 2011, In : Journal of Biological Chemistry. 286, 4, p. 2425-2432 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Alteration of a single amino acid in peroxisome proliferator-activated receptor-α (PPARα) generates a PPARδ phenotype

Takada, I., Yu, R. T., Xu, H. E., Lambert, M. H., Montana, V. G., Kliewer, S. A., Evans, R. M. & Umesono, K., Dec 1 2000, In : Molecular Endocrinology. 14, 5, p. 733-740 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M. & Kliewer, S. A., Jun 2 1995, In : Journal of Biological Chemistry. 270, 22, p. 12953-12956 4 p.

Research output: Contribution to journalArticle

3303 Scopus citations

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., Perlmann, T. & Lehmann, J. M., Jan 9 1998, In : Cell. 92, 1, p. 73-82 10 p.

Research output: Contribution to journalArticle

1229 Scopus citations

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat

Brown, K. K., Henke, B. R., Blanchard, S. G., Cobb, J. E., Mook, R., Kaldor, I., Kliewer, S. A., Lehmann, J. M., Lenhard, J. M., Harrington, W. W., Novak, P. J., Faison, W., Binz, J. G., Hashim, M. A., Oliver, W. O., Brown, H. R., Parks, D. J., Plunket, K. D., Tong, W. Q., Menius, J. A. & 3 others, Adkison, K., Noble, S. A. & Willson, T. M., Jul 8 1999, In : Diabetes. 48, 7, p. 1415-1424 10 p.

Research output: Contribution to journalArticle

154 Scopus citations
Open Access
22 Scopus citations

Anthrax mounts a nuclear attack on glucocorticoid signaling

Kliewer, S. A., Nov 2003, In : Trends in Pharmacological Sciences. 24, 11, p. 558-559 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations

A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation

Oberfield, J. L., Collins, J. L., Holmes, C. P., Goreham, D. M., Cooper, J. P., Cobb, J. E., Lenhard, J. M., Hull-Ryde, E. A., Mohr, C. P., Blanchard, S. G., Parks, D. J., Moore, L. B., Lehmann, J. M., Plunket, K., Miller, A. B., Milburn, M. V., Kliewer, S. A. & Willson, T. M., May 25 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 11, p. 6102-6106 5 p.

Research output: Contribution to journalArticle

302 Scopus citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C. & Lehmann, J. M., Dec 1 1995, In : Cell. 83, 5, p. 813-819 7 p.

Research output: Contribution to journalArticle

1794 Scopus citations

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., Maloney, P. R., Willson, T. M. & Kliewer, S. A., Jan 1 2000, In : Molecular cell. 6, 3, p. 517-526 10 p.

Research output: Contribution to journalArticle

Open Access
1257 Scopus citations

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

Oliver, W. R., Shenk, J. L., Snaith, M. R., Russell, C. S., Plunket, K. D., Bodkin, N. L., Lewis, M. C., Winegar, D. A., Sznaidman, M. L., Lambert, M. H., Xu, H. E., Sternbach, D. D., Kliewer, S. A., Hansen, B. C. & Willson, T. M., Apr 24 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 9, p. 5306-5311 6 p.

Research output: Contribution to journalArticle

908 Scopus citations

Asymmetry in the PPARγ/RXRα crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

Gampe, R. T., Montana, V. G., Lambert, M. H., Miller, A. B., Bledsoe, R. K., Milburn, M. V., Kliewer, S. A., Willson, T. M. & Xu, H. E., Jan 1 2000, In : Molecular cell. 5, 3, p. 545-555 11 p.

Research output: Contribution to journalArticle

Open Access
476 Scopus citations

A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity [2]

Brown, P. J., Winegar, D. A., Plunket, K. D., Moore, L. B., Lewis, M. C., Wilson, J. G., Sundseth, S. S., Koble, C. S., Wu, Z., Chapman, J. M., Lehmann, J. M., Kliewer, S. A. & Willson, T. M., Sep 23 1999, In : Journal of Medicinal Chemistry. 42, 19, p. 3785-3788 4 p.

Research output: Contribution to journalLetter

132 Scopus citations

Bile acids: Natural ligands for an orphan nuclear receptor

Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D. & Lehmann, J. M., May 21 1999, In : Science. 284, 5418, p. 1365-1368 4 p.

Research output: Contribution to journalArticle

1560 Scopus citations

Bile acids as hormones: The FXR-FGF15/19 pathway

Kliewer, S. A. & Mangelsdorf, D. J., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 327-331 5 p.

Research output: Contribution to journalArticle

119 Scopus citations

B‐Lyl Cells: Immortal Ly‐1 + B Lymphocyte Cell Lines Spontaneously Arising in Murine Splenic Cultures

Braun, J., Citr, Y., Baltimore, D., Forouzanpour, F., King, L., Teheranizadeh, K., Bray, M. & Kliewer, S., Oct 1986, In : Immunological Reviews. 93, 1, p. 5-22 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cell-Free Ligand Binding Assays for Nuclear Receptors

Jones, S. A., Parks, D. J. & Kliewer, S. A., Jan 1 2003, In : Methods in Enzymology. 364, p. 53-71 19 p.

Research output: Contribution to journalReview article

6 Scopus citations

Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

Willson, T. M., Jones, S. A., Moore, J. T. & Kliewer, S. A., 2001, In : Medicinal Research Reviews. 21, 6, p. 513-522 10 p.

Research output: Contribution to journalArticle

99 Scopus citations

Cholesterol detoxification by the nuclear pregnane X receptor

Kliewer, S. A., Feb 22 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 8, p. 2675-2676 2 p.

Research output: Contribution to journalComment/debate

16 Scopus citations

Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M. & Potthoff, M. J., Dec 1 2014, In : Diabetes. 63, 12, p. 4057-4063 7 p.

Research output: Contribution to journalArticle

241 Scopus citations

Cloning and characterization of human estrogen receptor β isoforms

Moore, J. T., McKee, D. D., Slentz-Kesler, K., Moore, L. B., Jones, S. A., Horne, E. L., Su, J. L., Kliewer, S. A., Lehmann, J. M. & Willson, T. M., Jun 9 1998, In : Biochemical and Biophysical Research Communications. 247, 1, p. 75-78 4 p.

Research output: Contribution to journalArticle

439 Scopus citations

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

Potthoff, M. J., Potts, A., He, T., Duarte, J. A. G., Taussig, R., Mangelsdorf, D. J., Kliewer, S. A. & Burgess, S. C., Feb 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 4, p. G371-G380

Research output: Contribution to journalArticle

97 Scopus citations

Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity

Guo, G. L., Lambert, G., Negishi, M., Ward, J. M., Brewer, H. B., Kliewer, S. A., Gonzalez, F. J. & Sinal, C. J., Nov 14 2003, In : Journal of Biological Chemistry. 278, 46, p. 45062-45071 10 p.

Research output: Contribution to journalArticle

239 Scopus citations

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues

Way, J. M., Harrington, W. W., Brown, K. K., Gottschalk, W. K., Sundseth, S. S., Mansfield, T. A., Ramachandran, R. K., Willson, T. M. & Kliewer, S. A., 2001, In : Endocrinology. 142, 3, p. 1269-1277 9 p.

Research output: Contribution to journalArticle

Open Access
295 Scopus citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A. & Evans, R. M., 1992, In : Nature. 358, 6389, p. 771-774 4 p.

Research output: Contribution to journalArticle

1456 Scopus citations

Cross-talk among RORα1 and the Rev-erb family of orphan nuclear receptors

Forman, B. M., Chen, J., Blumberg, B., Kliewer, S. A., Henshaw, R., Ong, E. S. & Evans, R. M., Sep 1 1994, In : Molecular Endocrinology. 8, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

175 Scopus citations

Cross-talk among RORα 1 and the Rev-erb family of orphan nuclear receptors

Forman, B. M., Chen, J., Blumberg, B., Kliewer, S. A., Henshaw, R., Ong, E. S. & Evans, R. M., 1994, In : Molecular Endocrinology. 8, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1

Li, Y., Choi, M., Cavey, G., Daugherty, J., Suino, K., Kovach, A., Bingham, N. C., Kliewer, S. A. & Xu, H. E., Feb 18 2005, In : Molecular cell. 17, 4, p. 491-502 12 p.

Research output: Contribution to journalArticle

178 Scopus citations

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition

Xue, Y., Moore, L. B., Orans, J., Peng, L., Bencharit, S., Kliewer, S. A. & Redinbo, M. R., May 1 2007, In : Molecular Endocrinology. 21, 5, p. 1028-1038 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

CYP3A induction by N-hydroxyformamide tumor necrosis factor-α converting enzyme/matrix metalloproteinase inhibitors: Use of a pregnane X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans

Tippin, T. K., Hamilton, G., Moore, L., Beaudet, E. J., Jolley, S., Brodie, T. A., Andrews, R. C., Becherer, J. D., McDougald, D. L., Gaul, M. D., Hoivik, D. J., Mellon-Kusibab, K., Lehmann, J., Kliewer, S., Novick, S., Laethem, R., Zhao, Z. & LeCluyse, E. L., Jul 1 2003, In : Drug Metabolism and Disposition. 31, 7, p. 870-877 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation

Ayoade, K. O., Carranza, F. R., Cho, W. H., Wang, Z., Kliewer, S. A., Mangelsdorf, D. J. & Stoltzfus, J. D. C., Apr 1 2020, In : Parasites and Vectors. 13, 1, 162.

Research output: Contribution to journalArticle

Open Access

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

Holt, J. A., Luo, G., Billin, A. N., Bisi, J., McNeill, Y. Y., Kozarsky, K. F., Donahee, M., Wang, D. Y., Mansfield, T. A., Kliewer, S. A., Goodwin, B. & Jones, S. A., Jul 1 2003, In : Genes and Development. 17, 13, p. 1581-1591 11 p.

Research output: Contribution to journalArticle

467 Scopus citations

Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry

Katafuchi, T., Esterházy, D., Lemoff, A., Ding, X., Sondhi, V., Kliewer, S. A., Mirzaei, H. & Mangelsdorf, D. J., Jun 2 2015, In : Cell Metabolism. 21, 6, p. 898-904 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K. & Evans, R. M., Jul 19 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 15, p. 7355-7359 5 p.

Research output: Contribution to journalArticle

1219 Scopus citations

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

Kim, I., Ahn, S. H., Inagaki, T., Choi, M., Ito, S., Guo, G. L., Kliewer, S. A. & Gonzalez, F. J., Dec 1 2007, In : Journal of lipid research. 48, 12, p. 2664-2672 9 p.

Research output: Contribution to journalArticle

315 Scopus citations

Differential regulation of rat and human CYP7A 1 by the nuclear oxysterol receptor liver X receptor-α

Goodwin, B., Watson, M. A., Kim, H., Miao, J., Kemper, J. K. & Kliewer, S. A., Mar 1 2003, In : Molecular Endocrinology. 17, 3, p. 386-394 9 p.

Research output: Contribution to journalArticle

148 Scopus citations

Discovery of ligands for the nuclear peroxisome proliferator-activated receptors

Willson, T. M., Lehmann, J. M. & Kliewer, S. A., Jan 1 1996, In : Annals of the New York Academy of Sciences. 804, p. 276-283 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Effects of fenofibrate on lipid parameters in obese rhesus monkeys

Winegar, D. A., Brown, P. J., Wilkison, W. O., Lewis, M. C., Ott, R. J., Tong, W. Q., Brown, H. R., Lehmann, J. M., Kliewer, S. A., Plunket, K. D., Way, J. M., Bodkin, N. L. & Hansen, B. C., Nov 12 2001, In : Journal of lipid research. 42, 10, p. 1543-1551 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Effects of troglitazone and metformin on glucose and lipid metabolism. Alterations of two distinct molecular pathways

Lenhard, J. M., Kliewer, S. A., Paulik, M. A., Plunket, K. D., Lehmann, J. M. & Weiel, J. E., Oct 1 1997, In : Biochemical Pharmacology. 54, 7, p. 801-808 8 p.

Research output: Contribution to journalArticle

105 Scopus citations

Endocrine fibroblast growth factors 15/19 and 21: From feast to famine

Potthoff, M. J., Kliewer, S. A. & Mangelsdorf, D. J., Feb 15 2012, In : Genes and Development. 26, 4, p. 312-324 13 p.

Research output: Contribution to journalReview article

263 Scopus citations

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J. K., Gerard, R. D., Burgess, S. C., Hammer, R. E., Mangelsdorf, D. J. & Kliewer, S. A., Jun 6 2007, In : Cell Metabolism. 5, 6, p. 415-425 11 p.

Research output: Contribution to journalArticle

939 Scopus citations