• 51701 Citations
  • 101 h-Index
1986 …2020

Research output per year

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Research Output

1996

Activation of the nuclear receptor peroxisome proliferator-activated receptor γ promotes brown adipocyte differentiation

Tai, T. A. C., Jennermann, C., Brown, K. K., Oliver, B. B., MacGinnitie, M. A., Wilkison, W. O., Roger Brown, H., Lehmann, J. M., Kliewer, S. A., Morris, D. C. & Graves, R. A., Nov 30 1996, In : Journal of Biological Chemistry. 271, 47, p. 29909-29914 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

Discovery of ligands for the nuclear peroxisome proliferator-activated receptors

Willson, T. M., Lehmann, J. M. & Kliewer, S. A., Jan 1 1996, In : Annals of the New York Academy of Sciences. 804, p. 276-283 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Peroxisome proliferator-activated aeceptor-γ activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells

Gimble, J. M., Robinson, C. E., Wu, X., Kelly, K. A., Rodriguez, B. R., Kliewer, S. A., Lehmann, J. M. & Morris, D. C., Nov 1996, In : Molecular Pharmacology. 50, 5, p. 1087-1094 8 p.

Research output: Contribution to journalArticle

269 Scopus citations

The structure - Activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones

Willson, T. M., Cobb, J. E., Cowan, D. J., Wiethe, R. W., Correa, I. D., Prakash, S. R., Beck, K. D., Moore, L. B., Kliewer, S. A. & Lehmann, J. M., Feb 2 1996, In : Journal of Medicinal Chemistry. 39, 3, p. 665-668 4 p.

Research output: Contribution to journalArticle

637 Scopus citations
1995

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M. & Kliewer, S. A., Jun 2 1995, In : Journal of Biological Chemistry. 270, 22, p. 12953-12956 4 p.

Research output: Contribution to journalArticle

3303 Scopus citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C. & Lehmann, J. M., Dec 1 1995, In : Cell. 83, 5, p. 813-819 7 p.

Research output: Contribution to journalArticle

1794 Scopus citations
1994

Cross-talk among RORα1 and the Rev-erb family of orphan nuclear receptors

Forman, B. M., Chen, J., Blumberg, B., Kliewer, S. A., Henshaw, R., Ong, E. S. & Evans, R. M., Sep 1 1994, In : Molecular Endocrinology. 8, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

175 Scopus citations

Cross-talk among RORα 1 and the Rev-erb family of orphan nuclear receptors

Forman, B. M., Chen, J., Blumberg, B., Kliewer, S. A., Henshaw, R., Ong, E. S. & Evans, R. M., 1994, In : Molecular Endocrinology. 8, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K. & Evans, R. M., Jul 19 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 15, p. 7355-7359 5 p.

Research output: Contribution to journalArticle

1219 Scopus citations

NMR Assignments and Secondary Structure of the Retinoid X Receptor α DNA‐binding Domain: Evidence for the Novel C‐terminal Helix

Lee, M. S., Sem, D. S., Kliewer, S. A., Provencal, J., Evans, R. M. & Wright, P. E., Sep 1994, In : European Journal of Biochemistry. 224, 2, p. 639-650 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
1993

Retinoid receptors

Mangelsdorf, D. J., Kliewer, S. A., Kakizuka, A., Umesono, K. & Evans, R. M., Jan 1 1993, In : Recent progress in hormone research. 48, 1, p. 99-121 23 p.

Research output: Contribution to journalArticle

113 Scopus citations

Structure of the retinoid X receptor α DNA binding domain: A helix required for homodimeric DNA binding

Lee, M. S., Kliewer, S. A., Provencal, J., Wright, P. E. & Evans, R. M., Jan 1 1993, In : Science. 260, 5111, p. 1117-1121 5 p.

Research output: Contribution to journalArticle

240 Scopus citations
1992

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A. & Evans, R. M., 1992, In : Nature. 358, 6389, p. 771-774 4 p.

Research output: Contribution to journalArticle

1456 Scopus citations

Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells

Ghazal, P., Demattei, C., Giulietti, E., Kliewer, S. A., Umesono, K. & Evans, R. M., 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 16, p. 7630-7634 5 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling

Kliewer, S. A., Umesono, K., Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A. & Evans, R. M., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 4, p. 1448-1452 5 p.

Research output: Contribution to journalArticle

Open Access
335 Scopus citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

Kliewer, S. A., Umesono, K., Mangelsdorf, D. J. & Evans, R. M., Jan 1 1992, In : Nature. 355, 6359, p. 446-449 4 p.

Research output: Contribution to journalArticle

1184 Scopus citations
1991

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

Mangelsdorf, D. J., Umesono, K., Kliewer, S. A., Borgmeyer, U., Ong, E. S. & Evans, R. M., Aug 9 1991, In : Cell. 66, 3, p. 555-561 7 p.

Research output: Contribution to journalArticle

506 Scopus citations

Retinoic acid is a negative regulator of AP-1-responsive genes

Schüle, R., Rangarajan, P., Yang, N., Kliewer, S., Ransone, L. J., Bolado, J., Verma, I. M. & Evans, R. M., Jul 15 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 14, p. 6092-6096 5 p.

Research output: Contribution to journalArticle

Open Access
486 Scopus citations
1990

Adenovirus early region 3 promoter regulation by E1A/E1B is independent of alterations in DNA binding and gene activation of CREB/ATF and AP1

Kornuc, M., Kliewer, S., Garcia, J., Harrich, D., Li, C. & Gaynor, R., 1990, In : Journal of virology. 64, 5, p. 2004-2013 10 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

Schüle, R., Rangarajan, P., Kliewer, S., Ransone, L. J., Bolado, J., Yang, N., Verma, I. M. & Evans, R. M., Sep 21 1990, In : Cell. 62, 6, p. 1217-1226 10 p.

Research output: Contribution to journalArticle

1003 Scopus citations

Loss of a phosphorylated form of transcription factor CREB/ATF in poliovirus-infected cells

Kliewer, S., Muchardt, C., Gaynor, R. & Dasgupta, A., 1990, In : Journal of virology. 64, 9, p. 4507-4515 9 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
1989

Multiple transcriptional regulatory domains in the human immunodeficiency virus type 1 long terminal repeat are involved in basal and E1A/E1B-induced promoter activity

Kliewer, S., Garcia, J., Pearson, L., Soultanakis, E., Dasgupta, A. & Gaynor, R., 1989, In : Journal of virology. 63, 11, p. 4616-4625 10 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations
1988
Open Access
22 Scopus citations
1986

B‐Lyl Cells: Immortal Ly‐1 + B Lymphocyte Cell Lines Spontaneously Arising in Murine Splenic Cultures

Braun, J., Citr, Y., Baltimore, D., Forouzanpour, F., King, L., Teheranizadeh, K., Bray, M. & Kliewer, S., Oct 1986, In : Immunological Reviews. 93, 1, p. 5-22 18 p.

Research output: Contribution to journalArticle

28 Scopus citations