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1986 …2020

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2000

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., Maloney, P. R., Willson, T. M. & Kliewer, S. A., Jan 1 2000, In : Molecular cell. 6, 3, p. 517-526 10 p.

Research output: Contribution to journalArticle

Open Access
1257 Scopus citations

Asymmetry in the PPARγ/RXRα crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

Gampe, R. T., Montana, V. G., Lambert, M. H., Miller, A. B., Bledsoe, R. K., Milburn, M. V., Kliewer, S. A., Willson, T. M. & Xu, H. E., Jan 1 2000, In : Molecular cell. 5, 3, p. 545-555 11 p.

Research output: Contribution to journalArticle

Open Access
476 Scopus citations

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

Moore, L. B., Parks, D. J., Jones, S. A., Bledsoe, R. K., Consler, T. G., Stimmel, J. B., Goodwin, B., Liddle, C., Blanchard, S. G., Willson, T. M., Collins, J. L. & Kliewer, S. A., May 19 2000, In : Journal of Biological Chemistry. 275, 20, p. 15122-15127 6 p.

Research output: Contribution to journalArticle

707 Scopus citations

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Moore, L. B., Goodwin, B., Jones, S. A., Wisely, G. B., Serabjit-Singh, C. J., Willson, T. M., Collins, J. L. & Kliewer, S. A., Jun 20 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 13, p. 7500-7502 3 p.

Research output: Contribution to journalArticle

813 Scopus citations

The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution

Jones, S. A., Moore, L. B., Shenk, J. L., Wisely, G. B., Hamilton, G. A., McKee, D. D., Tomkinson, N. C. O., LeCluyse, E. L., Lambert, M. H., Willson, T. M., Kliewer, S. A. & Moore, J. T., Jan 1 2000, In : Molecular Endocrinology. 14, 1, p. 27-39 13 p.

Research output: Contribution to journalArticle

Open Access
578 Scopus citations

Use of the nuclear receptor PXR to predict drug interactions

Moore, J. T. & Kliewer, S. A., Nov 16 2000, In : Toxicology. 153, 1-3, p. 1-10 10 p.

Research output: Contribution to journalArticle

162 Scopus citations
1999

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat

Brown, K. K., Henke, B. R., Blanchard, S. G., Cobb, J. E., Mook, R., Kaldor, I., Kliewer, S. A., Lehmann, J. M., Lenhard, J. M., Harrington, W. W., Novak, P. J., Faison, W., Binz, J. G., Hashim, M. A., Oliver, W. O., Brown, H. R., Parks, D. J., Plunket, K. D., Tong, W. Q., Menius, J. A. & 3 others, Adkison, K., Noble, S. A. & Willson, T. M., Jul 8 1999, In : Diabetes. 48, 7, p. 1415-1424 10 p.

Research output: Contribution to journalArticle

154 Scopus citations

A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation

Oberfield, J. L., Collins, J. L., Holmes, C. P., Goreham, D. M., Cooper, J. P., Cobb, J. E., Lenhard, J. M., Hull-Ryde, E. A., Mohr, C. P., Blanchard, S. G., Parks, D. J., Moore, L. B., Lehmann, J. M., Plunket, K., Miller, A. B., Milburn, M. V., Kliewer, S. A. & Willson, T. M., May 25 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 11, p. 6102-6106 5 p.

Research output: Contribution to journalArticle

302 Scopus citations

Bile acids: Natural ligands for an orphan nuclear receptor

Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D. & Lehmann, J. M., May 21 1999, In : Science. 284, 5418, p. 1365-1368 4 p.

Research output: Contribution to journalArticle

1560 Scopus citations

Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis- retinoic acid receptor heterodimer

Grobert, J., Zaghini, I., Fujii, H., Jones, S. A., Kliewer, S. A., Willson, T. M., Ono, T. & Besnard, P., Oct 15 1999, In : Journal of Biological Chemistry. 274, 42, p. 29749-29754 6 p.

Research output: Contribution to journalArticle

271 Scopus citations

Molecular recognition of fatty acids by peroxisome proliferator- activated receptors

Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., Kliewer, S. A. & Milburn, M. V., Mar 1999, In : Molecular cell. 3, 3, p. 397-403 7 p.

Research output: Contribution to journalArticle

885 Scopus citations

Structural requirements of ligands for the oxysterol liver X receptors LXRa and LXRβ

Janowski, B. A., Grogan, M. J., Jones, S. A., Wisely, G. B., Kliewer, S. A., Corey, E. J. & Mangelsdorf, D. J., Jan 5 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 1, p. 266-271 6 p.

Research output: Contribution to journalArticle

712 Scopus citations

The PPARs and PXRs: Nuclear xenobiotic receptors that define novel hormone signaling pathways

Kliewer, S. A., Lehmann, J. M., Milburn, M. V. & Willson, T. M., Dec 1 1999, In : Recent progress in hormone research. 54, p. 345-368 24 p.

Research output: Contribution to journalArticle

93 Scopus citations
1998

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., Perlmann, T. & Lehmann, J. M., Jan 9 1998, In : Cell. 92, 1, p. 73-82 10 p.

Research output: Contribution to journalArticle

1229 Scopus citations

Cloning and characterization of human estrogen receptor β isoforms

Moore, J. T., McKee, D. D., Slentz-Kesler, K., Moore, L. B., Jones, S. A., Horne, E. L., Su, J. L., Kliewer, S. A., Lehmann, J. M. & Willson, T. M., Jun 9 1998, In : Biochemical and Biophysical Research Communications. 247, 1, p. 75-78 4 p.

Research output: Contribution to journalArticle

439 Scopus citations

N-(2-benzoylphenyl)-L-tyrosine PPARγ agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents

Henke, B. R., Blanchard, S. G., Brackeen, M. F., Brown, K. K., Cobb, J. E., Collins, J. L., Harrington, W. W., Hashim, M. A., Hull-Ryde, E. A., Kaldor, I., Kliewer, S. A., Lake, D. H., Leesnitzer, L. M., Lehmann, J. M., Lenhard, J. M., Orband-Miller, L. A., Miller, J. F., Mook, R. A., Noble, S. A., Oliver, W. & 4 others, Parks, D. J., Plunket, K. D., Szewczyk, J. R. & Willson, T. M., Dec 3 1998, In : Journal of Medicinal Chemistry. 41, 25, p. 5020-5036 17 p.

Research output: Contribution to journalArticle

275 Scopus citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T. & Kliewer, S. A., Sep 1 1998, In : Journal of Clinical Investigation. 102, 5, p. 1016-1023 8 p.

Research output: Contribution to journalArticle

Open Access
1286 Scopus citations

The nuclear receptor PPARγ - Bigger than fat

Kliewer, S. A. & Willson, T. M., Oct 1998, In : Current Opinion in Genetics and Development. 8, 5, p. 576-581 6 p.

Research output: Contribution to journalArticle

132 Scopus citations
1997

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A. & Willson, T. M., Feb 20 1997, In : Journal of Biological Chemistry. 272, 6, p. 3137-3140 4 p.

Research output: Contribution to journalArticle

961 Scopus citations

Activation of the orphan receptor RIP14 by retinoids

Zavacki, A. M., Lehmann, J. M., Seol, W., Willson, T. M., Kliewer, S. A. & Moore, D. D., Jul 22 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 15, p. 7909-7914 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

Effects of troglitazone and metformin on glucose and lipid metabolism. Alterations of two distinct molecular pathways

Lenhard, J. M., Kliewer, S. A., Paulik, M. A., Plunket, K. D., Lehmann, J. M. & Weiel, J. E., Oct 1 1997, In : Biochemical Pharmacology. 54, 7, p. 801-808 8 p.

Research output: Contribution to journalArticle

105 Scopus citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M. & Lehmann, J. M., Apr 29 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 9, p. 4318-4323 6 p.

Research output: Contribution to journalArticle

1748 Scopus citations

Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library

Brown, P. J., Smith-Oliver, T. A., Charifson, P. S., Tomkinson, N. C. O., Fivush, A. M., Sternbach, D. D., Wade, L. E., Orband-Miller, L., Parks, D. J., Blanchard, S. G., Kliewer, S. A., Lehmann, J. M. & Willson, T. M., Dec 1997, In : Chemistry and Biology. 4, 12, p. 909-918 10 p.

Research output: Contribution to journalArticle

Open Access
90 Scopus citations
29 Scopus citations

Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs

Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M. & Kliewer, S. A., Feb 20 1997, In : Journal of Biological Chemistry. 272, 6, p. 3406-3410 5 p.

Research output: Contribution to journalArticle

1021 Scopus citations
1996

Activation of the nuclear receptor peroxisome proliferator-activated receptor γ promotes brown adipocyte differentiation

Tai, T. A. C., Jennermann, C., Brown, K. K., Oliver, B. B., MacGinnitie, M. A., Wilkison, W. O., Roger Brown, H., Lehmann, J. M., Kliewer, S. A., Morris, D. C. & Graves, R. A., Nov 30 1996, In : Journal of Biological Chemistry. 271, 47, p. 29909-29914 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

Discovery of ligands for the nuclear peroxisome proliferator-activated receptors

Willson, T. M., Lehmann, J. M. & Kliewer, S. A., Jan 1 1996, In : Annals of the New York Academy of Sciences. 804, p. 276-283 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Peroxisome proliferator-activated aeceptor-γ activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells

Gimble, J. M., Robinson, C. E., Wu, X., Kelly, K. A., Rodriguez, B. R., Kliewer, S. A., Lehmann, J. M. & Morris, D. C., Nov 1996, In : Molecular Pharmacology. 50, 5, p. 1087-1094 8 p.

Research output: Contribution to journalArticle

269 Scopus citations

The structure - Activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones

Willson, T. M., Cobb, J. E., Cowan, D. J., Wiethe, R. W., Correa, I. D., Prakash, S. R., Beck, K. D., Moore, L. B., Kliewer, S. A. & Lehmann, J. M., Feb 2 1996, In : Journal of Medicinal Chemistry. 39, 3, p. 665-668 4 p.

Research output: Contribution to journalArticle

637 Scopus citations
1995

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M. & Kliewer, S. A., Jun 2 1995, In : Journal of Biological Chemistry. 270, 22, p. 12953-12956 4 p.

Research output: Contribution to journalArticle

3303 Scopus citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C. & Lehmann, J. M., Dec 1 1995, In : Cell. 83, 5, p. 813-819 7 p.

Research output: Contribution to journalArticle

1794 Scopus citations
1994

Cross-talk among RORα1 and the Rev-erb family of orphan nuclear receptors

Forman, B. M., Chen, J., Blumberg, B., Kliewer, S. A., Henshaw, R., Ong, E. S. & Evans, R. M., Sep 1 1994, In : Molecular Endocrinology. 8, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

175 Scopus citations

Cross-talk among RORα 1 and the Rev-erb family of orphan nuclear receptors

Forman, B. M., Chen, J., Blumberg, B., Kliewer, S. A., Henshaw, R., Ong, E. S. & Evans, R. M., 1994, In : Molecular Endocrinology. 8, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K. & Evans, R. M., Jul 19 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 15, p. 7355-7359 5 p.

Research output: Contribution to journalArticle

1219 Scopus citations

NMR Assignments and Secondary Structure of the Retinoid X Receptor α DNA‐binding Domain: Evidence for the Novel C‐terminal Helix

Lee, M. S., Sem, D. S., Kliewer, S. A., Provencal, J., Evans, R. M. & Wright, P. E., Sep 1994, In : European Journal of Biochemistry. 224, 2, p. 639-650 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
1993

Retinoid receptors

Mangelsdorf, D. J., Kliewer, S. A., Kakizuka, A., Umesono, K. & Evans, R. M., Jan 1 1993, In : Recent progress in hormone research. 48, 1, p. 99-121 23 p.

Research output: Contribution to journalArticle

113 Scopus citations

Structure of the retinoid X receptor α DNA binding domain: A helix required for homodimeric DNA binding

Lee, M. S., Kliewer, S. A., Provencal, J., Wright, P. E. & Evans, R. M., Jan 1 1993, In : Science. 260, 5111, p. 1117-1121 5 p.

Research output: Contribution to journalArticle

240 Scopus citations
1992

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A. & Evans, R. M., 1992, In : Nature. 358, 6389, p. 771-774 4 p.

Research output: Contribution to journalArticle

1456 Scopus citations

Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells

Ghazal, P., Demattei, C., Giulietti, E., Kliewer, S. A., Umesono, K. & Evans, R. M., 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 16, p. 7630-7634 5 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling

Kliewer, S. A., Umesono, K., Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A. & Evans, R. M., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 4, p. 1448-1452 5 p.

Research output: Contribution to journalArticle

Open Access
335 Scopus citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

Kliewer, S. A., Umesono, K., Mangelsdorf, D. J. & Evans, R. M., Jan 1 1992, In : Nature. 355, 6359, p. 446-449 4 p.

Research output: Contribution to journalArticle

1184 Scopus citations
1991

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

Mangelsdorf, D. J., Umesono, K., Kliewer, S. A., Borgmeyer, U., Ong, E. S. & Evans, R. M., Aug 9 1991, In : Cell. 66, 3, p. 555-561 7 p.

Research output: Contribution to journalArticle

506 Scopus citations

Retinoic acid is a negative regulator of AP-1-responsive genes

Schüle, R., Rangarajan, P., Yang, N., Kliewer, S., Ransone, L. J., Bolado, J., Verma, I. M. & Evans, R. M., Jul 15 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 14, p. 6092-6096 5 p.

Research output: Contribution to journalArticle

Open Access
486 Scopus citations
1990

Adenovirus early region 3 promoter regulation by E1A/E1B is independent of alterations in DNA binding and gene activation of CREB/ATF and AP1

Kornuc, M., Kliewer, S., Garcia, J., Harrich, D., Li, C. & Gaynor, R., 1990, In : Journal of virology. 64, 5, p. 2004-2013 10 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

Schüle, R., Rangarajan, P., Kliewer, S., Ransone, L. J., Bolado, J., Yang, N., Verma, I. M. & Evans, R. M., Sep 21 1990, In : Cell. 62, 6, p. 1217-1226 10 p.

Research output: Contribution to journalArticle

1003 Scopus citations

Loss of a phosphorylated form of transcription factor CREB/ATF in poliovirus-infected cells

Kliewer, S., Muchardt, C., Gaynor, R. & Dasgupta, A., 1990, In : Journal of virology. 64, 9, p. 4507-4515 9 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
1989

Multiple transcriptional regulatory domains in the human immunodeficiency virus type 1 long terminal repeat are involved in basal and E1A/E1B-induced promoter activity

Kliewer, S., Garcia, J., Pearson, L., Soultanakis, E., Dasgupta, A. & Gaynor, R., 1989, In : Journal of virology. 63, 11, p. 4616-4625 10 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations
1988
Open Access
22 Scopus citations
1986

B‐Lyl Cells: Immortal Ly‐1 + B Lymphocyte Cell Lines Spontaneously Arising in Murine Splenic Cultures

Braun, J., Citr, Y., Baltimore, D., Forouzanpour, F., King, L., Teheranizadeh, K., Bray, M. & Kliewer, S., Oct 1986, In : Immunological Reviews. 93, 1, p. 5-22 18 p.

Research output: Contribution to journalArticle

28 Scopus citations