• 1367 Citations
  • 18 h-Index
20072018
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Research Output 2007 2018

  • 1367 Citations
  • 18 h-Index
  • 25 Article
  • 7 Conference contribution
  • 1 Chapter
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Article
2018
17 Citations (Scopus)

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

Lung Neoplasms
Neoplasms
Oncology
Biosynthesis
Small Molecule Libraries
2017
20 Citations (Scopus)

Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma

Aguilera, K. Y., Huang, H., Du, W., Hagopian, M. M., Wang, Z., Hinz, S., Hwang, T. H., Wang, H., Fleming, J. B., Castrillon, D. H., Ren, X., Ding, K. & Brekken, R. A., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2473-2485 13 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Collagen
Fibrillar Collagens
Pancreatic Neoplasms
Focal Adhesion Kinase 1
15 Citations (Scopus)

PROTOCADHERIN 7 acts through SET and PP2A to potentiate MAPK signaling by EGFR and KRAS during lung tumorigenesis

Zhou, X., Updegraff, B. L., Guo, Y., Peyton, M., Girard, L., Larsen, J. E., Xie, X-J., Zhou, Y., Hwang, T. H., Xie, Y., Rodriguez-Canales, J., Villalobos, P., Behrens, C., Wistuba, I. I., Minna, J. D. & O'Donnell-Mendell, K. A., Jan 1 2017, In : Cancer Research. 77, 1, p. 187-197 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
Non-Small Cell Lung Carcinoma
Lung
Neoplasms
Phosphoprotein Phosphatases
28 Citations (Scopus)

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Wang, X., Yang, K., Xie, Q., Wu, Q., Mack, S. C., Shi, Y., Kim, L. J. Y., Prager, B. C., Flavahan, W. A., Liu, X., Singer, M., Hubert, C. G., Miller, T. E., Zhou, W., Huang, Z., Fang, X., Regev, A., Suvà, M. L., Hwang, T. H., Locasale, J. W. & 2 others, Bao, S. & Rich, J. N., May 1 2017, In : Nature Neuroscience. 20, 5, p. 661-673 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Brain Neoplasms
Glioma
Maintenance
Enzymes
23 Citations (Scopus)

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Tagal, V., Wei, S., Zhang, W., Brekken, R. A., Posner, B. A., Peyton, M., Girard, L., Hwang, T., Wheeler, D. A., Minna, J. D., White, M. A., Gazdar, A. F. & Roth, M. G., Jan 19 2017, In : Nature Communications. 8, 14098.

Research output: Contribution to journalArticle

Aurora Kinase A
mutations
Non-Small Cell Lung Carcinoma
lungs
inhibitors
6 Citations (Scopus)

Transfer learning across ontologies for phenome-genome association prediction

Petegrosso, R., Park, S., Hwang, T. H. & Kuang, R., Feb 15 2017, In : Bioinformatics. 33, 4, p. 529-536 8 p.

Research output: Contribution to journalArticle

Transfer Learning
Phenotype
Ontology
Genome
Genes
2016
12 Citations (Scopus)

An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types

Park, S., Kim, S. J., Yu, D., Peña-Llopis, S., Gao, J., Park, J. S., Chen, B., Norris, J., Wang, X., Chen, M., Kim, M., Yong, J., Wardak, Z., Choe, K., Story, M., Starr, T., Cheong, J. H. & Hwang, T. H., Jun 1 2016, In : Bioinformatics. 32, 11, p. 1643-1651 9 p.

Research output: Contribution to journalArticle

Pathway
Cancer
Mutation
Genes
Survival
10 Citations (Scopus)

Comprehensive ex vivo transposon mutagenesis identifies genes that promote growth factor independence and leukemogenesis

Guo, Y., Updegraff, B. L., Park, S., Durakoglugil, D., Cruz, V. H., Maddux, S., Hwang, T. H. & O'Donnell-Mendell, K. A., Feb 15 2016, In : Cancer Research. 76, 4, p. 773-786 14 p.

Research output: Contribution to journalArticle

Mutagenesis
Intercellular Signaling Peptides and Proteins
Cytokines
Aptitude
Genes
5 Citations (Scopus)

Integrated omics-analysis reveals Wnt-mediated NAD+ metabolic reprogramming in cancer stem-like cells

Lee, J., Kee, H. J., Min, S., Park, K. C., Park, S., Hwang, T. H., Ryu, D. H., Hwang, G. S. & Cheong, J. H., 2016, In : Oncotarget. 7, 30, p. 48562-48576 15 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Metabolic Networks and Pathways
NAD
Apoptosis
Calcium
189 Citations (Scopus)

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., Joyce, A., Pedrosa, I., Geiger, H., Zhang, H., Chang, J., Gardner, K. H., Bruick, R. K., Reeves, C. & 14 others, Hwang, T. H., Courtney, K., Frenkel, E., Sun, X., Zojwalla, N., Wong, T., Rizzi, J. P., Wallace, E. M., Josey, J. A., Xie, Y., Xie, X. J., Kapur, P., McKay, R. M. & Brugarolas, J., 2016, In : Nature. 539, 7627, p. 112-117 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Carcinogenesis
Genetic Suppression
Mutation
57 Citations (Scopus)

Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer

Henzler, C., Li, Y., Yang, R., McBride, T., Ho, Y., Sprenger, C., Liu, G., Coleman, I., Lakely, B., Li, R., Ma, S., Landman, S. R., Kumar, V., Hwang, T. H., Raj, G. V., Higano, C. S., Morrissey, C., Nelson, P. S., Plymate, S. R. & Dehm, S. M., Nov 29 2016, In : Nature Communications. 7, 13668.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
cancer
Chemical activation
activation
2015
1 Citation (Scopus)

Intersection of DNA privacy and whole-genome sequencing

Changjin, H., Jason, W., Chao, X., Tae, H. H. & Park, J. Y., Jul 1 2015, In : Clinical Chemistry. 61, 7, p. 900-902 3 p.

Research output: Contribution to journalArticle

Genetic Privacy
Human Genome Project
Genetic Databases
Forensic Sciences
Law Enforcement
18 Citations (Scopus)

MRNA 3′-UTR shortening is a molecular signature of mTORC1 activation

Chang, J. W., Zhang, W., Yeh, H. S., De Jong, E. P., Jun, S., Kim, K. H., Bae, S. S., Beckman, K., Hwang, T. H., Kim, K. S., Kim, D. H., Griffin, T. J., Kuang, R. & Yong, J., Jun 15 2015, In : Nature Communications. 6, 7218.

Research output: Contribution to journalArticle

3' Untranslated Regions
Sirolimus
Chemical activation
signatures
activation
16 Citations (Scopus)

Network-based phenome-genome association prediction by bi-random walk

Xie, M., Xu, Y., Zhang, Y., Hwang, T. & Kuang, R., May 1 2015, In : PLoS One. 10, 5, e0125138.

Research output: Contribution to journalArticle

Genes
Genome
Phenotype
phenotype
genome
2014

Erratum: Reconstructing Disease Phenome-genome Association by Bi-Random Walk (Bioinformatics (2012))

Xie, M., Hwang, T. & Kuang, R., Aug 15 2014, In : Bioinformatics. 30, 16, p. 2391 1 p.

Research output: Contribution to journalArticle

Bioinformatics
Computational Biology
Random walk
Genome
Genes
3 Citations (Scopus)

SHEAR: Sample heterogeneity estimation and assembly by reference

Landman, S. R., Hwang, T. H., Silverstein, K. A. T., Li, Y., Dehm, S. M., Steinbach, M. & Kumar, V., Jan 29 2014, In : BMC Genomics. 15, 1, 84.

Research output: Contribution to journalArticle

Genome
Tumor Cell Line
Neoplasms
RNA
Lead
2013
367 Citations (Scopus)

Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines

Li, Y., Chan, S. C., Brand, L. J., Hwang, T. H., Silverstein, K. A. T. & Dehm, S. M., Jan 15 2013, In : Cancer Research. 73, 2, p. 483-489 7 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Cell Line
Androgens
18 Citations (Scopus)

Large-scale integrative network-based analysis identifies common pathways disrupted by copy number alterations across cancers

Hwang, T. H., Atluri, G., Kuang, R., Kumar, V., Starr, T., Silverstein, K. A. T., Haverty, P. M., Zhang, Z. & Liu, J., Jul 3 2013, In : BMC Genomics. 14, 1, 440.

Research output: Contribution to journalArticle

Neoplasms
Protein Interaction Maps
Cell Differentiation
Cell Cycle
Carcinogenesis
83 Citations (Scopus)

TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer

Nyquist, M. D., Li, Y., Hwang, T. H., Manlove, L. S., Vessella, R. L., Silverstein, K. A. T., Voytas, D. F. & Dehm, S. M., Oct 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 43, p. 17492-17497 6 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Androgen Receptors
Prostatic Neoplasms
Castration
Transcription Activator-Like Effector Nucleases
2012
134 Citations (Scopus)

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

Li, Y., Hwang, T. H., Oseth, L. A., Hauge, A., Vessella, R. L., Schmechel, S. C., Hirsch, B., Beckman, K. B., Silverstein, K. A. & Dehm, S. M., Nov 8 2012, In : Oncogene. 31, 45, p. 4759-4767 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Castration
Androgens
Heterografts
41 Citations (Scopus)

Co-clustering phenome-genome for phenotype classification and disease gene discovery

Hwang, T., Atluri, G., Xie, M., Dey, S., Hong, C., Kumar, V. & Kuang, R., Oct 2012, In : Nucleic Acids Research. 40, 19

Research output: Contribution to journalArticle

Genetic Association Studies
Cluster Analysis
Genome
Phenotype
Genes
48 Citations (Scopus)

SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling

Kim, Y. M., Stone, M., Hwang, T. H., Kim, Y. G., Dunlevy, J. R., Griffin, T. J. & Kim, D. H., Jun 29 2012, In : Molecular Cell. 46, 6, p. 833-846 14 p.

Research output: Contribution to journalArticle

src Homology Domains
Guanosine
Carrier Proteins
Amino Acids
Autophagy
2011
30 Citations (Scopus)

Inferring disease and gene set associations with rank coherence in networks

Hwang, T., Zhang, W., Xie, M., Liu, J. & Kuang, R., Oct 2011, In : Bioinformatics. 27, 19, p. 2692-2699 8 p., btr463.

Research output: Contribution to journalArticle

Genes
Gene
Phenotype
DNA Copy Number Variations
Learning
2009
52 Citations (Scopus)

A hypergraph-based learning algorithm for classifying gene expression and arrayCGH data with prior knowledge

Tian, Z., Hwang, T. & Kuang, R., 2009, In : Bioinformatics. 25, 21, p. 2831-2838 8 p.

Research output: Contribution to journalArticle

Comparative Genomics
Comparative Genomic Hybridization
Hypergraph
Prior Knowledge
Gene expression
2008
25 Citations (Scopus)

Robust and efficient identification of biomarkers by classifying features on graphs

Hwang, T., Sicotte, H., Tian, Z., Wu, B., Kocher, J. P., Wigle, D. A., Kumar, V. & Kuang, R., Sep 2008, In : Bioinformatics. 24, 18, p. 2023-2029 7 p.

Research output: Contribution to journalArticle

Biomarkers
Graph in graph theory
Single nucleotide Polymorphism
Bipartite Graph
Nucleotides