• 1460 Citations
  • 19 h-Index
20072020

Research output per year

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Research Output

  • 1460 Citations
  • 19 h-Index
  • 27 Article
  • 7 Conference contribution
  • 1 Chapter
  • 1 Comment/debate
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Article
2020

Diverse AR gene rearrangements mediate resistance to androgen receptor inhibitors in metastatic prostate cancer

Li, Y., Yang, R., Henzler, C. M., Ho, Y., Passow, C., Auch, B., Carreira, S., Rodrigues, D. N., Bertan, C., Hwang, T. H., Quigley, D. A., Dang, H. X., Morrissey, C., Fraser, M., Plymate, S. R., PlymateMaher, C. A., Feng, F. Y., De Bono, J. S. & Dehm, S. M., Apr 15 2020, In : Clinical Cancer Research. 26, 8, p. 1965-1976 12 p.

Research output: Contribution to journalArticle

Open Access

DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex

Nanavaty, V., Abrash, E. W., Hong, C., Park, S., Fink, E. E., Li, Z., Sweet, T. J., Bhasin, J. M., Singuri, S., Lee, B. H., Hwang, T. H. & Ting, A. H., May 21 2020, In : Molecular cell. 78, 4, p. 752-764.e6

Research output: Contribution to journalArticle

2019

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

AstraZeneca-Sanger Drug Combination DREAM Consortium, Dec 1 2019, In : Nature communications. 10, 1, 2674.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2018

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

20 Scopus citations
2017

Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma

Aguilera, K. Y., Huang, H., Du, W., Hagopian, M. M., Wang, Z., Hinz, S., Hwang, T. H., Wang, H., Fleming, J. B., Castrillon, D. H., Ren, X., Ding, K. & Brekken, R. A., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2473-2485 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

PROTOCADHERIN 7 acts through SET and PP2A to potentiate MAPK signaling by EGFR and KRAS during lung tumorigenesis

Zhou, X., Updegraff, B. L., Guo, Y., Peyton, M., Girard, L., Larsen, J. E., Xie, X-J., Zhou, Y., Hwang, T. H., Xie, Y., Rodriguez-Canales, J., Villalobos, P., Behrens, C., Wistuba, I. I., Minna, J. D. & O'Donnell-Mendell, K. A., Jan 1 2017, In : Cancer research. 77, 1, p. 187-197 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Wang, X., Yang, K., Xie, Q., Wu, Q., Mack, S. C., Shi, Y., Kim, L. J. Y., Prager, B. C., Flavahan, W. A., Liu, X., Singer, M., Hubert, C. G., Miller, T. E., Zhou, W., Huang, Z., Fang, X., Regev, A., Suvà, M. L., Hwang, T. H., Locasale, J. W. & 2 others, Bao, S. & Rich, J. N., May 1 2017, In : Nature Neuroscience. 20, 5, p. 661-673 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Tagal, V., Wei, S., Zhang, W., Brekken, R. A., Posner, B. A., Peyton, M., Girard, L., Hwang, T., Wheeler, D. A., Minna, J. D., White, M. A., Gazdar, A. F. & Roth, M. G., Jan 19 2017, In : Nature Communications. 8, 14098.

Research output: Contribution to journalArticle

27 Scopus citations

Transfer learning across ontologies for phenome-genome association prediction

Petegrosso, R., Park, S., Hwang, T. H. & Kuang, R., Feb 15 2017, In : Bioinformatics. 33, 4, p. 529-536 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types

Park, S., Kim, S. J., Yu, D., Peña-Llopis, S., Gao, J., Park, J. S., Chen, B., Norris, J., Wang, X., Chen, M., Kim, M., Yong, J., Wardak, Z., Choe, K., Story, M., Starr, T., Cheong, J. H. & Hwang, T. H., Jun 1 2016, In : Bioinformatics. 32, 11, p. 1643-1651 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Comprehensive ex vivo transposon mutagenesis identifies genes that promote growth factor independence and leukemogenesis

Guo, Y., Updegraff, B. L., Park, S., Durakoglugil, D., Cruz, V. H., Maddux, S., Hwang, T. H. & O'Donnell-Mendell, K. A., Feb 15 2016, In : Cancer Research. 76, 4, p. 773-786 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Integrated omics-analysis reveals Wnt-mediated NAD+ metabolic reprogramming in cancer stem-like cells

Lee, J., Kee, H. J., Min, S., Park, K. C., Park, S., Hwang, T. H., Ryu, D. H., Hwang, G. S. & Cheong, J. H., Jan 1 2016, In : Oncotarget. 7, 30, p. 48562-48576 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., Joyce, A., Pedrosa, I., Geiger, H., Zhang, H., Chang, J., Gardner, K. H., Bruick, R. K., Reeves, C. & 14 others, Hwang, T. H., Courtney, K., Frenkel, E., Sun, X., Zojwalla, N., Wong, T., Rizzi, J. P., Wallace, E. M., Josey, J. A., Xie, Y., Xie, X. J., Kapur, P., McKay, R. M. & Brugarolas, J., 2016, In : Nature. 539, 7627, p. 112-117 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer

Henzler, C., Li, Y., Yang, R., McBride, T., Ho, Y., Sprenger, C., Liu, G., Coleman, I., Lakely, B., Li, R., Ma, S., Landman, S. R., Kumar, V., Hwang, T. H., Raj, G. V., Higano, C. S., Morrissey, C., Nelson, P. S., Plymate, S. R. & Dehm, S. M., Nov 29 2016, In : Nature Communications. 7, 13668.

Research output: Contribution to journalArticle

65 Scopus citations
2015

Intersection of DNA privacy and whole-genome sequencing

Changjin, H., Jason, W., Chao, X., Tae, H. H. & Park, J. Y., Jul 1 2015, In : Clinical Chemistry. 61, 7, p. 900-902 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

MRNA 3′-UTR shortening is a molecular signature of mTORC1 activation

Chang, J. W., Zhang, W., Yeh, H. S., De Jong, E. P., Jun, S., Kim, K. H., Bae, S. S., Beckman, K., Hwang, T. H., Kim, K. S., Kim, D. H., Griffin, T. J., Kuang, R. & Yong, J., Jun 15 2015, In : Nature Communications. 6, 7218.

Research output: Contribution to journalArticle

18 Scopus citations

Network-based phenome-genome association prediction by bi-random walk

Xie, M., Xu, Y., Zhang, Y., Hwang, T. & Kuang, R., May 1 2015, In : PLoS One. 10, 5, e0125138.

Research output: Contribution to journalArticle

17 Scopus citations
2014

SHEAR: Sample heterogeneity estimation and assembly by reference

Landman, S. R., Hwang, T. H., Silverstein, K. A. T., Li, Y., Dehm, S. M., Steinbach, M. & Kumar, V., Jan 29 2014, In : BMC Genomics. 15, 1, 84.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines

Li, Y., Chan, S. C., Brand, L. J., Hwang, T. H., Silverstein, K. A. T. & Dehm, S. M., Jan 15 2013, In : Cancer research. 73, 2, p. 483-489 7 p.

Research output: Contribution to journalArticle

382 Scopus citations

Large-scale integrative network-based analysis identifies common pathways disrupted by copy number alterations across cancers

Hwang, T. H., Atluri, G., Kuang, R., Kumar, V., Starr, T., Silverstein, K. A. T., Haverty, P. M., Zhang, Z. & Liu, J., Jan 1 2013, In : BMC Genomics. 14, 1, 440.

Research output: Contribution to journalArticle

20 Scopus citations

TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer

Nyquist, M. D., Li, Y., Hwang, T. H., Manlove, L. S., Vessella, R. L., Silverstein, K. A. T., Voytas, D. F. & Dehm, S. M., Oct 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 43, p. 17492-17497 6 p.

Research output: Contribution to journalArticle

89 Scopus citations
2012

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

Li, Y., Hwang, T. H., Oseth, L. A., Hauge, A., Vessella, R. L., Schmechel, S. C., Hirsch, B., Beckman, K. B., Silverstein, K. A. & Dehm, S. M., Nov 8 2012, In : Oncogene. 31, 45, p. 4759-4767 9 p.

Research output: Contribution to journalArticle

137 Scopus citations

Co-clustering phenome-genome for phenotype classification and disease gene discovery

Hwang, T., Atluri, G., Xie, M., Dey, S., Hong, C., Kumar, V. & Kuang, R., Oct 1 2012, In : Nucleic acids research. 40, 19, p. e146

Research output: Contribution to journalArticle

42 Scopus citations

SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling

Kim, Y. M., Stone, M., Hwang, T. H., Kim, Y. G., Dunlevy, J. R., Griffin, T. J. & Kim, D. H., Jun 29 2012, In : Molecular cell. 46, 6, p. 833-846 14 p.

Research output: Contribution to journalArticle

50 Scopus citations
2011

Inferring disease and gene set associations with rank coherence in networks

Hwang, T., Zhang, W., Xie, M., Liu, J. & Kuang, R., Oct 1 2011, In : Bioinformatics. 27, 19, p. 2692-2699 8 p., btr463.

Research output: Contribution to journalArticle

30 Scopus citations
2009

A hypergraph-based learning algorithm for classifying gene expression and arrayCGH data with prior knowledge

Tian, Z., Hwang, T. & Kuang, R., Nov 9 2009, In : Bioinformatics. 25, 21, p. 2831-2838 8 p.

Research output: Contribution to journalArticle

52 Scopus citations
2008

Robust and efficient identification of biomarkers by classifying features on graphs

Hwang, T., Sicotte, H., Tian, Z., Wu, B., Kocher, J. P., Wigle, D. A., Kumar, V. & Kuang, R., Sep 1 2008, In : Bioinformatics. 24, 18, p. 2023-2029 7 p.

Research output: Contribution to journalArticle

26 Scopus citations