• 3472 Citations
  • 26 h-Index
20052019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2005 2019

2019
2 Citations (Scopus)

Hypoxia mediates tumor malignancy and therapy resistance

Luo, W. & Wang, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 1-18 18 p. (Advances in Experimental Medicine and Biology; vol. 1136).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumors
Neoplasms
Chemotherapy
Stem cells
Therapeutics
1 Citation (Scopus)

In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma

Suh, E. H., Hackett, E. P., Wynn, R. M., Chuang, D. T., Zhang, B., Luo, W., Sherry, A. D. & Park, J. M., Dec 1 2019, In : Scientific Reports. 9, 1, 340.

Research output: Contribution to journalArticle

Branched Chain Amino Acids
Glioblastoma
Leucine
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Glioma
1 Citation (Scopus)

PARP-1 and its associated nucleases in DNA damage response

Wang, Y., Luo, W. & Wang, Y., Jan 1 2019, In : DNA repair. 102651.

Research output: Contribution to journalReview article

DNA Fragmentation
DNA Repair
DNA Damage
DNA Replication
DNA
2018
10 Citations (Scopus)

Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

Bao, L., Chen, Y., Lai, H. T., Wu, S. Y., Wang, J. E., Hatanpaa, K. J., Raisanen, J. M., Fontenot, M., Lega, B. C., Chiang, C. M., Semenza, G. L., Wang, Y. & Luo, W., Jan 1 2018, In : Nucleic Acids Research. 46, 13, p. 6576-6591 16 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Methylation
Cell Movement
Glioblastoma
Lysine
14 Citations (Scopus)

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

Chen, Y., Zhang, B., Bao, L., Jin, L., Yang, M., Peng, Y., Kumar, A., Wang, J. E., Wang, C., Zou, X., Xing, C., Wang, Y. & Luo, W., May 1 2018, In : Journal of Clinical Investigation. 128, 5, p. 1937-1955 19 p.

Research output: Contribution to journalArticle

Zinc Fingers
Acetylation
Breast Neoplasms
Neoplasm Metastasis
Epigenomics
2 Citations (Scopus)

ZMYND8 is a primary HIF coactivator that mediates breast cancer progression

Chen, Y., Wang, Y. & Luo, W., Jul 4 2018, In : Molecular and Cellular Oncology. 5, 4, e1479619.

Research output: Contribution to journalArticle

Zinc Fingers
Breast Neoplasms
Epigenomics
Neoplasm Metastasis
Hypoxia
2017
7 Citations (Scopus)
Protein Stability
Epigenomics
Proteins
Transcriptional Activation
Transcription Factors
2016
1 Citation (Scopus)

HIF repressors under chronic hypoxia

Luo, W. & Wang, Y., Mar 1 2016, In : Aging. 8, 3, p. 418-419 2 p.

Research output: Contribution to journalEditorial

Molecular Targeted Therapy
Peroxiredoxins
Hypoxia-Inducible Factor 1
Antineoplastic Agents
Neoplasms
13 Citations (Scopus)

PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia

Luo, W., Chen, I., Chen, Y., Alkam, D., Wang, Y. & Semenza, G. L., Jan 1 2016, In : Oncotarget. 7, 6, p. 6379-6397 19 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Genes
Hypoxia-Inducible Factor 1
Hypoxia
RNA Polymerase II
2015
33 Citations (Scopus)

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

Xiang, L., Gilkes, D. M., Hu, H., Luo, W., Bullen, J. W., Liang, H. & Semenza, G. L., Jan 1 2015, In : Oncotarget. 6, 14, p. 11768-11778 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Transcriptional Activation
Hypoxia
Proteins
Neoplasm Metastasis
2014
55 Citations (Scopus)

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

Xiang, L., Gilkes, D. M., Chaturvedi, P., Luo, W., Hu, H., Takano, N., Liang, H. & Semenza, G. L., Feb 1 2014, In : Journal of Molecular Medicine. 92, 2, p. 151-164 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Hypoxia-Inducible Factor 1
Stem Cells
Maintenance
Neoplasm Metastasis
66 Citations (Scopus)

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

Xiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H. & Semenza, G. L., Jan 1 2014, In : Oncotarget. 5, 24, p. 12509-12527 19 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Neoplastic Stem Cells
Breast Neoplasms
Phenotype
Genes
167 Citations (Scopus)

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Wang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J. & Semenza, G. L., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Cell-Derived Microparticles
Exosomes
28 Citations (Scopus)

Hypoxia-inducible factors enhance glutamate signaling in cancer cells

Hu, H., Takano, N., Xiang, L., Gilkes, D. M., Luo, W. & Semenza, G. L., Jan 1 2014, In : Oncotarget. 5, 19, p. 8853-8868 16 p.

Research output: Contribution to journalArticle

Glutamic Acid
Glutamate Receptors
Amino Acid Transport System X-AG
Neoplasms
Renal Cell Carcinoma
18 Citations (Scopus)

Hypoxia-inducible factors regulate human and rat cystathionine â-synthase gene expression

Takano, N., Peng, Y. J., Kumar, G. K., Luo, W., Hu, H., Shimoda, L. A., Suematsu, M., Prabhakar, N. R. & Semenza, G. L., Mar 1 2014, In : Biochemical Journal. 458, 2, p. 203-211 9 p.

Research output: Contribution to journalArticle

Cystathionine
Human engineering
Gene expression
Rats
Gene Expression
16 Citations (Scopus)

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

Luo, W., Lin, B., Wang, Y., Zhong, J., O'Meally, R., Cole, R. N., Pandey, A., Levchenko, A. & Semenza, G. L., Jan 1 2014, In : Molecular Biology of the Cell. 25, 18, p. 2788-2796 9 p.

Research output: Contribution to journalArticle

Hydroxylation
Polymerization
Cell Movement
Actins
Post Translational Protein Processing

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

Luo, W., Lin, B., Wang, Y., Zhong, J., O'Meally, R., Cole, R. N., Pandey, A., Levchenko, A. & Semenza, G. L., Sep 15 2014, In : Molecular Biology of the Cell. 25, 18, p. 2788-2796 9 p.

Research output: Contribution to journalArticle

Hydroxylation
Polymerization
Cell Movement
Actins
Post Translational Protein Processing
22 Citations (Scopus)

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

Chapiro, J., Sur, S., Savic, L. J., Ganapathy-Kanniappan, S., Reyes, J., Duran, R., Thiruganasambandam, S. C., Moats, C. R., Lin, M. D., Luo, W., Tran, P. T., Herman, J. M., Semenza, G. L., Ewald, A. J., Vogelstein, B. & Geschwind, J. F., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6406-6417 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
gemcitabine
Therapeutics
Adenocarcinoma
Heterografts
2013
52 Citations (Scopus)

A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication

Hubbi, M. E., Kshitiz, Gilkes, D. M., Rey, S., Wong, C. C., Luo, W., Kim, D. H., Dang, C. V., Levchenko, A. & Semenza, G. L., Feb 12 2013, In : Science Signaling. 6, 262, ra10.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
DNA Replication
DNA
Cell Cycle Checkpoints
Maintenance
1 Citation (Scopus)

Erratum: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (Journal of Clinical Investigation (2013) 123: 1 (189-205) DOI: 10.1172/JCI64993)

Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A. & Semenza, G. L., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, 1 p.

Research output: Contribution to journalComment/debate

Neoplastic Stem Cells
Mesenchymal Stromal Cells
Breast Neoplasms
Neoplasm Metastasis
Hypoxia
85 Citations (Scopus)

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart

Cai, Z., Luo, W., Zhan, H. & Semenza, G. L., Oct 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 43, p. 17462-17467 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Ischemic Preconditioning
Interleukin-10
Muscle Cells
Reperfusion
155 Citations (Scopus)

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis

Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A. & Semenza, G. L., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 189-205 17 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Mesenchymal Stromal Cells
Breast Neoplasms
Neoplasm Metastasis
Coculture Techniques
128 Citations (Scopus)

The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

Chen, Z., Barbi, J., Bu, S., Yang, H. Y., Li, Z., Gao, Y., Jinasena, D., Fu, J., Lin, F., Chen, C., Zhang, J., Yu, N., Li, X., Shan, Z., Nie, J., Gao, Z., Tian, H., Li, Y., Yao, Z., Zheng, Y. & 16 others, Park, B. V., Pan, Z., Zhang, J., Dang, E., Li, Z., Wang, H., Luo, W., Li, L., Semenza, G. L., Zheng, S. G., Loser, K., Tsun, A., Greene, M. I., Pardoll, D. M., Pan, F. & Li, B., Aug 22 2013, In : Immunity. 39, 2, p. 272-285 14 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Ligases
Ubiquitin
Transcription Factors
Th1 Cells
2012
172 Citations (Scopus)

Emerging roles of PKM2 in cell metabolism and cancer progression

Luo, W. & Semenza, G. L., Nov 1 2012, In : Trends in Endocrinology and Metabolism. 23, 11, p. 560-566 7 p.

Research output: Contribution to journalReview article

Pyruvate Kinase
Neoplasms
Lactic Acid
Sumoylation
Hydroxylation
118 Citations (Scopus)
Jumonji Domain-Containing Histone Demethylases
Hypoxia-Inducible Factor 1
Breast Neoplasms
Neural Cell Adhesion Molecule L1
Proteins
2011
699 Citations (Scopus)

Control of TH17/Treg balance by hypoxia-inducible factor 1

Dang, E. V., Barbi, J., Yang, H. Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H. R., Luo, W., Zeller, K., Shimoda, L., Topalian, S. L., Semenza, G. L., Dang, C. V., Pardoll, D. M. & Pan, F., Sep 2 2011, In : Cell. 146, 5, p. 772-784 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
T-cells
T-Lymphocytes
Regulatory T-Lymphocytes
Interleukin-17
119 Citations (Scopus)

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

Yuan, G., Khan, S. A., Luo, W., Nanduri, J., Semenza, G. L. & Prabhakar, N. R., Nov 1 2011, In : Journal of Cellular Physiology. 226, 11, p. 2925-2933 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
NADPH Oxidase
Reactive Oxygen Species
Enzyme activity
Fibroblasts
51 Citations (Scopus)

MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1

Hubbi, M. E., Luo, W., Baek, J. H. & Semenza, G. L., Jun 10 2011, In : Molecular Cell. 42, 5, p. 700-712 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
DNA Helicases
Proteins
Cell Cycle
Cell Hypoxia
41 Citations (Scopus)

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

Rey, S., Luo, W., Shimoda, L. A. & Semenza, G. L., May 5 2011, In : Blood. 117, 18, p. 4988-4998 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Bone
Bone Marrow
Tissue
Cell- and Tissue-Based Therapy
21 Citations (Scopus)
Proteinase-Activated Receptors
PAR-2 Receptor
Opioid Receptors
Nucleotides
G-Protein-Coupled Receptors
635 Citations (Scopus)

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Luo, W., Hu, H., Chang, R., Zhong, J., Knabel, M., O'Meally, R., Cole, R. N., Pandey, A. & Semenza, G. L., May 27 2011, In : Cell. 145, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Pyruvate Kinase
Genes
Cells
Metabolism
113 Citations (Scopus)

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

Luo, W. & Semenza, G. L., Jul 1 2011, In : Oncotarget. 2, 7, p. 551-556 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Pyruvate Kinase
Glucose
Neoplasms
Lactic Acid
2010
131 Citations (Scopus)

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Luo, W., Zhong, J., Chang, R., Hu, H., Pandey, A. & Semenza, G. L., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 3651-3663 13 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
Hypoxia-Inducible Factor 1
Ubiquitination
Degradation
Proteins
2009
8 Citations (Scopus)

The role of thrombin and thrombin receptors in the brain

Luo, W., Wang, Y. & Reiser, G., Jan 1 2009, Thrombin: Physiology and Disease. Springer US, p. 133-159 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thrombin Receptors
Thrombin
Brain
Prothrombin
Neurodegenerative Diseases
2008
91 Citations (Scopus)

Trypsin and trypsin-like proteases in the brain: Proteolysis and cellular functions

Wang, Y., Luo, W. & Reiser, G., Jan 1 2008, In : Cellular and Molecular Life Sciences. 65, 2, p. 237-252 16 p.

Research output: Contribution to journalReview article

Trypsin
Proteolysis
Peptide Hydrolases
Brain
Proteinase-Activated Receptors
2007
41 Citations (Scopus)
Proteinase-Activated Receptors
Chemotactic Factors
Oncogenes
Chemokines
Astrocytes
45 Citations (Scopus)
ADP-Ribosylation Factor 1
PAR-2 Receptor
Golgi Apparatus
Proteins
Cell membranes
125 Citations (Scopus)

Protease-activated receptors in the brain: Receptor expression, activation, and functions in neurodegeneration and neuroprotection

Luo, W., Wang, Y. & Reiser, G., Dec 1 2007, In : Brain Research Reviews. 56, 2, p. 331-345 15 p.

Research output: Contribution to journalReview article

Proteinase-Activated Receptors
Brain
Neurodegenerative Diseases
PAR-2 Receptor
Tryptases
44 Citations (Scopus)
PAR-2 Receptor
PAR-1 Receptor
JNK Mitogen-Activated Protein Kinases
Oncogenes
Chemokines
13 Citations (Scopus)

The role of calcium in protease-activated receptor-induced secretion of chemokine GRO/CINC-1 in rat brain astrocytes

Wang, Y., Luo, W. & Reiser, G., Oct 1 2007, In : Journal of Neurochemistry. 103, 2, p. 814-819 6 p.

Research output: Contribution to journalArticle

Proteinase-Activated Receptors
Chemotactic Factors
Oncogenes
Chemokines
Astrocytes
2006
29 Citations (Scopus)

Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1

Luo, W., Wang, Y., Hanck, T., Stricker, R. & Reiser, G., Mar 24 2006, In : Journal of Biological Chemistry. 281, 12, p. 7927-7936 10 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
PAR-2 Receptor
Transcription Factor AP-1
Carrier Proteins
Chemical activation
29 Citations (Scopus)

Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes

Wang, Y., Luo, W., Wartmann, T., Halangk, W., Sahin-Tóth, M. & Reiser, G., Nov 1 2006, In : Journal of Neurochemistry. 99, 3, p. 759-769 11 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
PAR-1 Receptor
Astrocytes
Trypsin
Proteinase-Activated Receptors
50 Citations (Scopus)

Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1

Wang, Y., Luo, W., Stricker, R. & Reiser, G., Aug 1 2006, In : Journal of Neurochemistry. 98, 4, p. 1046-1060 15 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Chemotactic Factors
Cell death
Oncogenes
Chemokines
2005
20 Citations (Scopus)

Two types of protease-activated receptors (PAR-1 and PAR-2) mediate calcium signaling in rat retinal ganglion cells RGC-5

Luo, W., Wang, Y. & Reiser, G., Jun 21 2005, In : Brain Research. 1047, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

Proteinase-Activated Receptors
PAR-2 Receptor
PAR-1 Receptor
Calcium Signaling
Retinal Ganglion Cells