• 3513 Citations
  • 26 h-Index
20052019

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Article
2019

In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma

Suh, E. H., Hackett, E. P., Wynn, R. M., Chuang, D. T., Zhang, B., Luo, W., Sherry, A. D. & Park, J. M., Dec 1 2019, In : Scientific Reports. 9, 1, 340.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

Bao, L., Chen, Y., Lai, H. T., Wu, S. Y., Wang, J. E., Hatanpaa, K. J., Raisanen, J. M., Fontenot, M., Lega, B. C., Chiang, C. M., Semenza, G. L., Wang, Y. & Luo, W., Jan 1 2018, In : Nucleic Acids Research. 46, 13, p. 6576-6591 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

Chen, Y., Zhang, B., Bao, L., Jin, L., Yang, M., Peng, Y., Kumar, A., Wang, J. E., Wang, C., Zou, X., Xing, C., Wang, Y. & Luo, W., May 1 2018, In : Journal of Clinical Investigation. 128, 5, p. 1937-1955 19 p.

Research output: Contribution to journalArticle

15 Scopus citations

ZMYND8 is a primary HIF coactivator that mediates breast cancer progression

Chen, Y., Wang, Y. & Luo, W., Jul 4 2018, In : Molecular and Cellular Oncology. 5, 4, e1479619.

Research output: Contribution to journalArticle

2 Scopus citations
2017
9 Scopus citations
2016

PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia

Luo, W., Chen, I., Chen, Y., Alkam, D., Wang, Y. & Semenza, G. L., Jan 1 2016, In : Oncotarget. 7, 6, p. 6379-6397 19 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

Xiang, L., Gilkes, D. M., Hu, H., Luo, W., Bullen, J. W., Liang, H. & Semenza, G. L., Jan 1 2015, In : Oncotarget. 6, 14, p. 11768-11778 11 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

Xiang, L., Gilkes, D. M., Chaturvedi, P., Luo, W., Hu, H., Takano, N., Liang, H. & Semenza, G. L., Feb 1 2014, In : Journal of Molecular Medicine. 92, 2, p. 151-164 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

Xiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H. & Semenza, G. L., Jan 1 2014, In : Oncotarget. 5, 24, p. 12509-12527 19 p.

Research output: Contribution to journalArticle

67 Scopus citations

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Wang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J. & Semenza, G. L., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31

Research output: Contribution to journalArticle

173 Scopus citations

Hypoxia-inducible factors enhance glutamate signaling in cancer cells

Hu, H., Takano, N., Xiang, L., Gilkes, D. M., Luo, W. & Semenza, G. L., Jan 1 2014, In : Oncotarget. 5, 19, p. 8853-8868 16 p.

Research output: Contribution to journalArticle

29 Scopus citations

Hypoxia-inducible factors regulate human and rat cystathionine â-synthase gene expression

Takano, N., Peng, Y. J., Kumar, G. K., Luo, W., Hu, H., Shimoda, L. A., Suematsu, M., Prabhakar, N. R. & Semenza, G. L., Mar 1 2014, In : Biochemical Journal. 458, 2, p. 203-211 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

Luo, W., Lin, B., Wang, Y., Zhong, J., O'Meally, R., Cole, R. N., Pandey, A., Levchenko, A. & Semenza, G. L., Jan 1 2014, In : Molecular Biology of the Cell. 25, 18, p. 2788-2796 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

Luo, W., Lin, B., Wang, Y., Zhong, J., O'Meally, R., Cole, R. N., Pandey, A., Levchenko, A. & Semenza, G. L., Sep 15 2014, In : Molecular Biology of the Cell. 25, 18, p. 2788-2796 9 p.

Research output: Contribution to journalArticle

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

Chapiro, J., Sur, S., Savic, L. J., Ganapathy-Kanniappan, S., Reyes, J., Duran, R., Thiruganasambandam, S. C., Moats, C. R., Lin, M. D., Luo, W., Tran, P. T., Herman, J. M., Semenza, G. L., Ewald, A. J., Vogelstein, B. & Geschwind, J. F., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6406-6417 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication

Hubbi, M. E., Kshitiz, Gilkes, D. M., Rey, S., Wong, C. C., Luo, W., Kim, D. H., Dang, C. V., Levchenko, A. & Semenza, G. L., Feb 12 2013, In : Science Signaling. 6, 262, ra10.

Research output: Contribution to journalArticle

52 Scopus citations

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart

Cai, Z., Luo, W., Zhan, H. & Semenza, G. L., Oct 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 43, p. 17462-17467 6 p.

Research output: Contribution to journalArticle

85 Scopus citations

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis

Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A. & Semenza, G. L., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 189-205 17 p.

Research output: Contribution to journalArticle

155 Scopus citations

The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

Chen, Z., Barbi, J., Bu, S., Yang, H. Y., Li, Z., Gao, Y., Jinasena, D., Fu, J., Lin, F., Chen, C., Zhang, J., Yu, N., Li, X., Shan, Z., Nie, J., Gao, Z., Tian, H., Li, Y., Yao, Z., Zheng, Y. & 16 others, Park, B. V., Pan, Z., Zhang, J., Dang, E., Li, Z., Wang, H., Luo, W., Li, L., Semenza, G. L., Zheng, S. G., Loser, K., Tsun, A., Greene, M. I., Pardoll, D. M., Pan, F. & Li, B., Aug 22 2013, In : Immunity. 39, 2, p. 272-285 14 p.

Research output: Contribution to journalArticle

130 Scopus citations
2012
118 Scopus citations
2011

Control of TH17/Treg balance by hypoxia-inducible factor 1

Dang, E. V., Barbi, J., Yang, H. Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H. R., Luo, W., Zeller, K., Shimoda, L., Topalian, S. L., Semenza, G. L., Dang, C. V., Pardoll, D. M. & Pan, F., Sep 2 2011, In : Cell. 146, 5, p. 772-784 13 p.

Research output: Contribution to journalArticle

706 Scopus citations

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

Yuan, G., Khan, S. A., Luo, W., Nanduri, J., Semenza, G. L. & Prabhakar, N. R., Nov 1 2011, In : Journal of Cellular Physiology. 226, 11, p. 2925-2933 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1

Hubbi, M. E., Luo, W., Baek, J. H. & Semenza, G. L., Jun 10 2011, In : Molecular Cell. 42, 5, p. 700-712 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

Rey, S., Luo, W., Shimoda, L. A. & Semenza, G. L., May 5 2011, In : Blood. 117, 18, p. 4988-4998 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
21 Scopus citations

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Luo, W., Hu, H., Chang, R., Zhong, J., Knabel, M., O'Meally, R., Cole, R. N., Pandey, A. & Semenza, G. L., May 27 2011, In : Cell. 145, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

644 Scopus citations

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

Luo, W. & Semenza, G. L., Jul 1 2011, In : Oncotarget. 2, 7, p. 551-556 6 p.

Research output: Contribution to journalArticle

113 Scopus citations
2010

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Luo, W., Zhong, J., Chang, R., Hu, H., Pandey, A. & Semenza, G. L., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 3651-3663 13 p.

Research output: Contribution to journalArticle

134 Scopus citations
2007
41 Scopus citations
45 Scopus citations
45 Scopus citations

The role of calcium in protease-activated receptor-induced secretion of chemokine GRO/CINC-1 in rat brain astrocytes

Wang, Y., Luo, W. & Reiser, G., Oct 1 2007, In : Journal of Neurochemistry. 103, 2, p. 814-819 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2006

Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1

Luo, W., Wang, Y., Hanck, T., Stricker, R. & Reiser, G., Mar 24 2006, In : Journal of Biological Chemistry. 281, 12, p. 7927-7936 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes

Wang, Y., Luo, W., Wartmann, T., Halangk, W., Sahin-Tóth, M. & Reiser, G., Nov 1 2006, In : Journal of Neurochemistry. 99, 3, p. 759-769 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1

Wang, Y., Luo, W., Stricker, R. & Reiser, G., Aug 1 2006, In : Journal of Neurochemistry. 98, 4, p. 1046-1060 15 p.

Research output: Contribution to journalArticle

50 Scopus citations
2005

Two types of protease-activated receptors (PAR-1 and PAR-2) mediate calcium signaling in rat retinal ganglion cells RGC-5

Luo, W., Wang, Y. & Reiser, G., Jun 21 2005, In : Brain Research. 1047, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

20 Scopus citations