• 750 Citations
  • 9 h-Index
20062017

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 750 Citations
  • 9 h-Index
  • 9 Article
  • 1 Review article
Filter
Article
2017

FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination

Tsai, N. P., Wilkerson, J. R., Guo, W. & Huber, K. M., 2017, In : Human Molecular Genetics. 26, 2, p. 293-304 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice

Ade, K. K., Wan, Y., Hamann, H. C., O'Hare, J. K., Guo, W., Quian, A., Kumar, S., Bhagat, S., Rodriguiz, R. M., Wetsel, W. C., Conn, P. J., Dzirasa, K., Huber, K. M. & Calakos, N., Oct 1 2016, In : Biological Psychiatry. 80, 7, p. 522-533 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Selective disruption of metabotropic glutamate receptor 5-homer interactions mimics phenotypes of fragile X syndrome in mice

Guo, W., Molinaro, G., Collins, K. A., Hays, S. A., Paylor, R., Worley, P. F., Szumlinski, K. K. & Huber, K. M., Feb 17 2016, In : Journal of Neuroscience. 36, 7, p. 2131-2147 17 p.

Research output: Contribution to journalArticle

22 Scopus citations
2015

Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model

Guo, W., Ceolin, L., Collins, K. A., Perroy, J. & Huber, K. M., Jan 1 2015, In : Cell Reports. 13, 10, p. 2297-2311 15 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

Ronesi, J. A., Collins, K. A., Hays, S. A., Tsai, N. P., Guo, W., Birnbaum, S. G., Hu, J. H., Worley, P. F., Gibson, J. R. & Huber, K. M., Mar 1 2012, In : Nature neuroscience. 15, 3, p. 431-440 10 p.

Research output: Contribution to journalArticle

150 Scopus citations

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

Tsai, N. P., Wilkerson, J. R., Guo, W., Maksimova, M. A., Demartino, G. N., Cowan, C. W. & Huber, K. M., Dec 21 2012, In : Cell. 151, 7, p. 1581-1594 14 p.

Research output: Contribution to journalArticle

159 Scopus citations
2011

An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

Guo, W., Chen, Y., Zhou, X., Kar, A., Ray, P., Chen, X., Rao, E. J., Yang, M., Ye, H., Zhu, L., Liu, J., Xu, M., Yang, Y., Wang, C., Zhang, D., Bigio, E. H., Mesulam, M., Shen, Y., Xu, Q., Fushimi, K. & 1 others, Wu, J. Y., Jul 1 2011, In : Nature Structural and Molecular Biology. 18, 7, p. 822-831 10 p.

Research output: Contribution to journalArticle

167 Scopus citations
2010

A Drosophila model for TDP-43 proteinopathy

Li, Y., Ray, P., Rao, E. J., Shi, C., Guo, W., Chen, X., Woodruff, E. A., Fushimi, K. & Wu, J. Y., Feb 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 3169-3174 6 p.

Research output: Contribution to journalArticle

181 Scopus citations

Candidate Mycobacterium tuberculosis genes targeted by human microRNAs

Guo, W., Li, J. T., Pan, X., Wei, L. & Wu, J. Y., May 2010, In : Protein and Cell. 1, 5, p. 419-421 3 p.

Research output: Contribution to journalArticle

12 Scopus citations