• 11178 Citations
  • 57 h-Index
1993 …2019

Research output per year

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Research Output

2019

Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21

Kim, D. S., Camacho, C. V., Nagari, A., Malladi, V. S., Challa, S. & Kraus, W. L., Sep 19 2019, In : Molecular cell. 75, 6, p. 1270-1285.e14

Research output: Contribution to journalArticle

7 Scopus citations
2018

Dynamic evolution of regulatory element ensembles in primate CD4+ T cells

Danko, C. G., Choate, L. A., Marks, B. A., Rice, E. J., Wang, Z., Chu, T., Martins, A. L., Dukler, N., Coonrod, S. A., Tait Wojno, E. D., Lis, J. T., Kraus, W. L. & Siepel, A., Jan 29 2018, (Accepted/In press) In : Nature Ecology and Evolution. p. 1-12 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis

Franco, H. L., Nagari, A., Malladi, V. S., Li, W., Xi, Y., Richardson, D., Allton, K. L., Tanaka, K., Li, J., Murakami, S., Keyomarsi, K., Bedford, M. T., Shi, X., Li, W., Barton, M. C., Dent, S. Y. R. & Kraus, W. L., Feb 1 2018, In : Genome Research. 28, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Generating protein-linked and protein-free mono-, oligo-, and poly(ADP-ribose) in vitro

Lin, K. Y., Huang, D. & Lee Kraus, W., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 91-108 18 p. (Methods in Molecular Biology; vol. 1813).

Research output: Chapter in Book/Report/Conference proceedingChapter

Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes

Xi, Y., Shi, J., Li, W., Tanaka, K., Allton, K. L., Richardson, D., Li, J., Franco, H. L., Nagari, A., Malladi, V. S., Coletta, L. D., Simper, M. S., Keyomarsi, K., Shen, J., Bedford, M. T., Shi, X., Barton, M. C., Lee Kraus, W., Li, W. & Dent, S. Y. R., Feb 20 2018, In : BMC Genomics. 19, 1, 150.

Research output: Contribution to journalArticle

5 Scopus citations

Identifying genomic sites of adp-ribosylation mediated by specific nuclear parp enzymes using Click-ChIP

Rogge, R. A., Gibson, B. A. & Kraus, W. L., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 371-387 17 p. (Methods in Molecular Biology; vol. 1813).

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis

Ryu, K. W., Nandu, T., Kim, J., Challa, S., DeBerardinis, R. J. & Lee Kraus, W., May 11 2018, In : Science. 360, 6389, Y.

Research output: Contribution to journalArticle

29 Scopus citations

Transcriptome signature identifies distinct cervical pathways induced in lipopolysaccharide-mediated preterm birth

Willcockson, A. R., Nandu, T., Liu, C. L., Nallasamy, S., Kraus, W. L. & Mahendroo, M., Mar 1 2018, In : Biology of Reproduction. 98, 3, p. 408-421 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci

Liu, Z. & Kraus, W. L., Feb 16 2017, In : Molecular Cell. 65, 4, p. 589-603.e9

Research output: Contribution to journalArticle

25 Scopus citations

Computational approaches for mining GRO-seq data to identify and characterize active enhancers

Nagari, A., Murakami, S., Malladi, V. S. & Kraus, W. L., 2017, In : Methods in Molecular Biology. 1468, p. 121-138 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Dynamic assembly and activation of estrogen receptor α enhancers through coregulator switching

Murakami, S., Nagari, A. & Kraus, W. L., Aug 1 2017, In : Genes and Development. 31, 15, p. 1535-1548 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Generation and Characterization of Recombinant Antibody-like ADP-Ribose Binding Proteins

Gibson, B. A., Conrad, L. B., Huang, D. & Kraus, W. L., Dec 5 2017, In : Biochemistry. 56, 48, p. 6305-6316 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of protein substrates of specific PARP enzymes using analog-sensitive PARP mutants and a “Clickable” NAD+ analog

Gibson, B. A. & Kraus, W. L., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1608. p. 111-135 25 p. (Methods in Molecular Biology; vol. 1608).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity

Luo, X., Ryu, K. W., Kim, D. S., Nandu, T., Medina, C. J., Gupte, R., Gibson, B. A., Soccio, R. E., Yu, Y., Gupta, R. K. & Kraus, W. L., Jan 19 2017, In : Molecular Cell. 65, 2, p. 260-271 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

PARP Inhibitors for Cancer Therapy

Lin, K. Y. & Kraus, W. L., Apr 6 2017, In : Cell. 169, 2, p. 183 1 p.

Research output: Contribution to journalShort survey

36 Scopus citations

Parps and adp-ribosylation: Recent advances linking molecular functions to biological outcomes

Gupte, R., Liu, Z. & Kraus, W. L., Jan 15 2017, In : Genes and Development. 31, 2, p. 101-126 26 p.

Research output: Contribution to journalReview article

135 Scopus citations
2016

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

Gibson, B. A., Zhang, Y., Jiang, H., Hussey, K. M., Shrimp, J. H., Lin, H., Schwede, F., Yu, Y. & Kraus, W. L., Jul 1 2016, In : Science. 353, 6294, p. 45-50 6 p.

Research output: Contribution to journalArticle

129 Scopus citations

miR-200 regulates endometrial development during early pregnancy

Jimenez, P. T., Mainigi, M. A., Word, R. A., Kraus, W. L. & Mendelson, C. R., Sep 1 2016, In : Molecular Endocrinology. 30, 9, p. 977-987 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation

Doiguchi, M., Nakagawa, T., Imamura, Y., Yoneda, M., Higashi, M., Kubota, K., Yamashita, S., Asahara, H., Iida, M., Fujii, S., Ikura, T., Liu, Z., Nandu, T., Kraus, W. L., Ueda, H. & Ito, T., Feb 18 2016, In : Scientific Reports. 6, 20179.

Research output: Contribution to journalArticle

9 Scopus citations

Who Put the “A” in ATP? Generation of ATP from ADP-Ribose in the Nucleus for Hormone-Dependent Gene Regulation

Ryu, K. W. & Kraus, W. L., Aug 4 2016, In : Molecular Cell. 63, 3, p. 349-351 3 p.

Research output: Contribution to journalShort survey

2015

A PreSTIGEous use of LncRNAs to predict enhancers

Murakami, S., Gadad, S. S. & Kraus, W. L., Jan 1 2015, In : Cell Cycle. 14, 11, p. 1619-1620 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery, Annotation, and Functional Analysis of Long Noncoding RNAs Controlling Cell-Cycle Gene Expression and Proliferation in Breast Cancer Cells

Sun, M., Gadad, S. S., Kim, D. S. & Kraus, W. L., Aug 20 2015, In : Molecular Cell. 59, 4, p. 698-711 14 p.

Research output: Contribution to journalArticle

75 Scopus citations

Editorial: Would you like a hypothesis with those data? Omics and the age of discovery science

Lee Kraus, W., Nov 1 2015, In : Molecular Endocrinology. 29, 11, p. 1531-1534 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

From discovery to function: The expanding roles of long noncoding RNAs in physiology and disease

Sun, M. & Kraus, W. L., 2015, In : Endocrine Reviews. 36, 1, p. 25-64 40 p.

Research output: Contribution to journalArticle

147 Scopus citations
19 Scopus citations

Identification of active transcriptional regulatory elements from GRO-seq data

Danko, C. G., Hyland, S. L., Core, L. J., Martins, A. L., Waters, C. T., Lee, H. W., Cheung, V. G., Kraus, W. L., Lis, J. T. & Siepel, A., Apr 29 2015, In : Nature Methods. 12, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8<sup>+</sup> T cell responses

Winans, B., Nagari, A., Chae, M., Post, C. M., Ko, C. I., Puga, A., Kraus, W. L. & Lawrence, B. P., May 1 2015, In : Journal of Immunology. 194, 9, p. 4446-4457 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases

Ryu, K. W., Kim, D. S. & Kraus, W. L., Mar 25 2015, In : Chemical Reviews. 115, 6, p. 2453-2481 29 p.

Research output: Contribution to journalArticle

55 Scopus citations

No Driver behind the Wheel? Targeting Transcription in Cancer

Franco, H. L. & Kraus, W. L., Sep 24 2015, In : Cell. 163, 1, p. 28-30 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

PARPs and ADP-Ribosylation: 50 Years . . . and Counting

Kraus, W. L., Jun 18 2015, In : Molecular Cell. 58, 6, p. 902-910 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

PARPs and ADP-Ribosylation Come Into Focus

Kraus, W. L., Jun 18 2015, In : Molecular Cell. 58, 6, p. 901 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Ready, pause, go: Regulation of RNA polymerase II pausing and release by cellular signaling pathways

Liu, X., Kraus, W. L. & Bai, X., Sep 1 2015, In : Trends in Biochemical Sciences. 40, 9, p. 516-525 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

TNFα signaling exposes latent estrogen receptor binding sites to alter the breast cancer cell transcriptome

Franco, H. L., Nagari, A. & Kraus, W. L., Apr 2 2015, In : Molecular Cell. 58, 1, p. 21-34 14 p.

Research output: Contribution to journalArticle

56 Scopus citations
2014

Dynamic reorganization of the AC16 cardiomyocyte transcriptome in response to TNFα signaling revealed by integrated genomic analyses

Luo, X., Chae, M., Krishnakumar, R., Danko, C. G. & Kraus, W. L., Feb 24 2014, In : BMC Genomics. 15, 1, 155.

Research output: Contribution to journalArticle

22 Scopus citations

Editorial: Do you see what i see?: Quality, reliability, and reproducibility in biomedical research

Lee Kraus, W., Mar 2014, In : Molecular Endocrinology. 28, 3, p. 277-280 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

Allen, M. A., Andrysik, Z., Dengler, V. L., Mellert, H. S., Guarnieri, A., Freeman, J. A., Sullivan, K. D., Galbraith, M. D., Luo, X., Lee Kraus, W., Dowell, R. D. & Espinosa, J. M., May 27 2014, In : eLife. 2014, 3, e02200.

Research output: Contribution to journalArticle

92 Scopus citations

Hormone-regulated transcriptomes: Lessons learned from estrogen signaling pathways in breast cancer cells

Hah, N. & Kraus, W. L., Jan 25 2014, In : Molecular and Cellular Endocrinology. 382, 1, p. 652-664 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Regulation of chromatin structure and function by PARP-1 and ADP-ribosylation

Liu, Z. & Kraus, W. L., May 1 2014, Fundamentals of Chromatin. Springer New York, Vol. 9781461486244. p. 309-339 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1

Hussey, K. M., Chen, H., Yang, C., Park, E., Hah, N., Erdjument-Bromage, H., Tempst, P., Gamble, M. J. & Kraus, W. L., 2014, In : Molecular and Cellular Biology. 34, 13, p. 2437-2449 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Enhancer transcripts mark active estrogen receptor binding sites

Hah, N., Murakami, S., Nagari, A., Danko, C. G. & Lee Kraus, W., Aug 2013, In : Genome Research. 23, 8, p. 1210-1223 14 p.

Research output: Contribution to journalArticle

251 Scopus citations

Erratum to Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells [Molecular Cell 50, (2013) 778]

Danko, C. G., Hah, N., Luo, X., Martins, A. L., Core, L., Lis, J. T., Siepel, A. & Kraus, W. L., Jun 6 2013, In : Molecular Cell. 50, 5, p. 778 1 p.

Research output: Contribution to journalArticle

Mapping ERβ Genomic Binding Sites Reveals Unique Genomic Features and Identifies EBF1 as an ERβ Interactor

Le, T. P., Sun, M., Luo, X., Kraus, W. L. & Greene, G. L., Aug 8 2013, In : PLoS One. 8, 8, e71355.

Research output: Contribution to journalArticle

10 Scopus citations

Minireview: Long noncoding RNAs: New "links" between gene expression and cellular outcomes in endocrinology

Sun, M. & Lee Kraus, W., Sep 1 2013, In : Molecular Endocrinology. 27, 9, p. 1390-1402 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

PARP-1 and gene regulation: Progress and puzzles

Kraus, W. L. & Hottiger, M. O., Dec 2013, In : Molecular Aspects of Medicine. 34, 6, p. 1109-1123 15 p.

Research output: Contribution to journalArticle

146 Scopus citations

Signaling Pathways Differentially Affect RNA Polymerase II Initiation, Pausing, and Elongation Rate in Cells

Danko, C. G., Hah, N., Luo, X., Martins, A. L., Core, L., Lis, J. T., Siepel, A. & Kraus, W. L., Apr 25 2013, In : Molecular Cell. 50, 2, p. 212-222 11 p.

Research output: Contribution to journalArticle

164 Scopus citations
2012
5 Scopus citations

Estrogen regulates JNK1 genomic localization to control gene expression and cell growth in breast cancer cells

Sun, M., Isaacs, G. D., Hah, N., Heldring, N., Fogarty, E. A. & Lee Kraus, W., May 2012, In : Molecular Endocrinology. 26, 5, p. 736-747 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

Gibson, B. A. & Kraus, W. L., Jul 2012, In : Nature Reviews Molecular Cell Biology. 13, 7, p. 411-424 14 p.

Research output: Contribution to journalArticle

564 Scopus citations

On par with PARP: Cellular stress signaling through poly(ADP-ribose) and PARP-1

Luo, X. & Lee Kraus, W., Mar 1 2012, In : Genes and Development. 26, 5, p. 417-432 16 p.

Research output: Contribution to journalArticle

385 Scopus citations