• 780 Citations
  • 14 h-Index
20092019

Research output per year

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Research Output

  • 780 Citations
  • 14 h-Index
  • 18 Article
  • 2 Letter
  • 1 Review article
2009

Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage

Li, X., Wang, B., Feng, L., Kang, H., Qi, Y., Wang, J. & Shi, Y., Sep 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 35, p. 14837-14842 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Structure and mechanism of an amino acid antiporter

Gao, X., Lu, F., Zhou, L., Dang, S., Sun, L., Li, X., Wang, J. & Shi, Y., Jun 19 2009, In : Science. 324, 5934, p. 1565-1568 4 p.

Research output: Contribution to journalArticle

167 Scopus citations
2011

Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE

Li, X., Wang, J. & Shi, Y., Aug 11 2011, In : Nature Communications. 2, 1, 408.

Research output: Contribution to journalArticle

19 Scopus citations
2013

Structure of a presenilin family intramembrane aspartate protease

Li, X., Dang, S., Yan, C., Gong, X., Wang, J. & Shi, Y., Jan 3 2013, In : Nature. 493, 7430, p. 56-61 6 p.

Research output: Contribution to journalArticle

132 Scopus citations
2014

Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies

Condon, S. M., Mitsuuchi, Y., Deng, Y., Laporte, M. G., Rippin, S. R., Haimowitz, T., Alexander, M. D., Kumar, P. T., Hendi, M. S., Lee, Y. H., Benetatos, C. A., Yu, G., Kapoor, G. S., Neiman, E., Seipel, M. E., Burns, J. M., Graham, M. A., McKinlay, M. A., Li, X., Wang, J. & 9 others, Shi, Y., Feltham, R., Bettjeman, B., Cumming, M. H., Vince, J. E., Khan, N., Silke, J., Day, C. L. & Chunduru, S. K., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3666-3677 12 p.

Research output: Contribution to journalArticle

83 Scopus citations
2015

Crystal structure of a phosphorylation-coupled vitamin C transporter

Luo, P., Yu, X., Wang, W., Fan, S., Li, X. & Wang, J., Jan 1 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 238-241 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

Li, X., Roberti, R. & Blobel, G., Jan 1 2015, In : Nature. 517, 7532, p. 104-107 4 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

Li, X., Saha, P., Lib, J., Blobel, G. & Pfeffer, S. R., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. 10079-10084 6 p.

Research output: Contribution to journalArticle

52 Scopus citations

Structural biology of intramembrane proteases: Mechanistic insights from rhomboid and S2P to γ-secretase

Sun, L., Li, X. & Shi, Y., Apr 1 2016, In : Current Opinion in Structural Biology. 37, p. 97-107 11 p.

Research output: Contribution to journalReview article

18 Scopus citations

Structure of human Niemann-Pick C1 protein

Li, X., Wang, J., Coutavas, E., Shi, H., Hao, Q. & Blobel, G., Jul 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 29, p. 8212-8217 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism

Vastermark, A., Driker, A., Weng, J., Li, X., Wang, J. & Saier, M. H., Dec 1 2016, In : Journal of Structural Biology. 196, 3, p. 496-502 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017
24 Scopus citations

Difference distance map data of alternative crystal forms of UlaA

Vastermark, A., Driker, A., Weng, J., Li, X., Wang, J. & Saier, M. H., Feb 1 2017, In : Data in Brief. 10, p. 198-201 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human TRPML1 channel structures in open and closed conformations

Schmiege, P., Fine, M., Blobel, G. & Li, X., Oct 19 2017, In : Nature. 550, 7676, 24036.

Research output: Contribution to journalArticle

42 Scopus citations

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

Trinha, M. N., Lua, F., Lib, X., Dasa, A., Liangd, Q., De Brabanderd, J. K., Browna, M. S. & Goldsteina, J. L., Jan 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2018

Structural basis for PtdInsP2-mediated human TRPML1 regulation

Fine, M., Schmiege, P. & Li, X., Dec 1 2018, In : Nature Communications. 9, 1, 4192.

Research output: Contribution to journalArticle

11 Scopus citations

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

Qi, X., Schmiege, P., Coutavas, E., Wang, J. & Li, X., Aug 2 2018, In : Nature. 560, 7716, p. 128-132 5 p.

Research output: Contribution to journalLetter

38 Scopus citations

The regulatory mechanism of mammalian TRPMLs revealed by cryo-EM

Schmiege, P., Fine, M. & Li, X., Jan 1 2018, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

1 Scopus citations

Two patched molecules engage distinct sites on hedgehog yielding a signaling-competent complex

Qi, X., Schmiege, P., Coutavas, E. & Li, X., Oct 5 2018, In : Science. 362, 6410, eaas8843.

Research output: Contribution to journalArticle

26 Scopus citations
2019

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

Qi, X., Liu, H., Thompson, B., McDonald, J., Zhang, C. & Li, X., Jan 1 2019, (Accepted/In press) In : Nature.

Research output: Contribution to journalLetter

12 Scopus citations

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Long, T., Hassan, A., Thompson, B. M., McDonald, J. G., Wang, J. & Li, X., Dec 1 2019, In : Nature communications. 10, 1, 2452.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations