• 761 Citations
  • 14 h-Index
20092019
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Research Output 2009 2019

  • 761 Citations
  • 14 h-Index
  • 18 Article
  • 2 Letter
  • 1 Review article
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Article
2019
3 Citations (Scopus)

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Long, T., Hassan, A., Thompson, B. M., McDonald, J. G., Wang, J. & Li, X., Dec 1 2019, In : Nature communications. 10, 1, 2452.

Research output: Contribution to journalArticle

Open Access
human EBP protein
biosynthesis
Biosynthesis
cholesterol
Carrier Proteins
2018
11 Citations (Scopus)

Structural basis for PtdInsP2-mediated human TRPML1 regulation

Fine, M., Schmiege, P. & Li, X., Dec 1 2018, In : Nature Communications. 9, 1, 4192.

Research output: Contribution to journalArticle

Phosphatidylinositol 4,5-Diphosphate
lipids
calcium
Lipids
efflux
1 Citation (Scopus)

The regulatory mechanism of mammalian TRPMLs revealed by cryo-EM

Schmiege, P., Fine, M. & Li, X., Jan 1 2018, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
S 6
Conformations
Viperidae
Dilatation
24 Citations (Scopus)

Two patched molecules engage distinct sites on hedgehog yielding a signaling-competent complex

Qi, X., Schmiege, P., Coutavas, E. & Li, X., Oct 5 2018, In : Science. 362, 6410, eaas8843.

Research output: Contribution to journalArticle

Binding Sites
Calcium
Cryoelectron Microscopy
Palmitates
Epitopes
2017
21 Citations (Scopus)
Cholesterol
Mutation
Proteins
Lysosomal Storage Diseases
Endosomes
1 Citation (Scopus)

Difference distance map data of alternative crystal forms of UlaA

Vastermark, A., Driker, A., Weng, J., Li, X., Wang, J. & Saier, M. H., Feb 1 2017, In : Data in Brief. 10, p. 198-201 4 p.

Research output: Contribution to journalArticle

Elevators and Escalators
Temperature
Proteins
42 Citations (Scopus)

Human TRPML1 channel structures in open and closed conformations

Schmiege, P., Fine, M., Blobel, G. & Li, X., Oct 19 2017, In : Nature. 550, 7676, 24036.

Research output: Contribution to journalArticle

Mucolipidoses
S 6
Cryoelectron Microscopy
Calcium Signaling
Lysosomes
11 Citations (Scopus)

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

Trinha, M. N., Lua, F., Lib, X., Dasa, A., Liangd, Q., De Brabanderd, J. K., Browna, M. S. & Goldsteina, J. L., Jan 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

Triazoles
Lysosomes
Cholesterol
Itraconazole
Binding Sites
2016
49 Citations (Scopus)

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

Li, X., Saha, P., Lib, J., Blobel, G. & Pfeffer, S. R., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. 10079-10084 6 p.

Research output: Contribution to journalArticle

Cholesterol
Type C Niemann-Pick Disease
Ebolavirus
Lysosomes
LDL Cholesterol
55 Citations (Scopus)

Structure of human Niemann-Pick C1 protein

Li, X., Wang, J., Coutavas, E., Shi, H., Hao, Q. & Blobel, G., Jul 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 29, p. 8212-8217 6 p.

Research output: Contribution to journalArticle

Sterols
Cholesterol
Ebola Hemorrhagic Fever
Proteins
Type C Niemann-Pick Disease
2 Citations (Scopus)

The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism

Vastermark, A., Driker, A., Weng, J., Li, X., Wang, J. & Saier, M. H., Dec 1 2016, In : Journal of Structural Biology. 196, 3, p. 496-502 7 p.

Research output: Contribution to journalArticle

Elevators and Escalators
Ascorbic Acid
Hydrogen
Salts
Proteins
2015
21 Citations (Scopus)

Crystal structure of a phosphorylation-coupled vitamin C transporter

Luo, P., Yu, X., Wang, W., Fan, S., Li, X. & Wang, J., Jan 1 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 238-241 4 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Phosphorylation
Protein Subunits
Phosphoenolpyruvate
Enzymes
17 Citations (Scopus)

Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

Li, X., Roberti, R. & Blobel, G., Jan 1 2015, In : Nature. 517, 7532, p. 104-107 4 p.

Research output: Contribution to journalArticle

Sterols
Oxidoreductases
Membranes
NADP
Carbon
2014
83 Citations (Scopus)

Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies

Condon, S. M., Mitsuuchi, Y., Deng, Y., Laporte, M. G., Rippin, S. R., Haimowitz, T., Alexander, M. D., Kumar, P. T., Hendi, M. S., Lee, Y. H., Benetatos, C. A., Yu, G., Kapoor, G. S., Neiman, E., Seipel, M. E., Burns, J. M., Graham, M. A., McKinlay, M. A., Li, X., Wang, J. & 9 others, Shi, Y., Feltham, R., Bettjeman, B., Cumming, M. H., Vince, J. E., Khan, N., Silke, J., Day, C. L. & Chunduru, S. K., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3666-3677 12 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Caspases
Neoplasms
Proteins
In Vitro Techniques
2013
131 Citations (Scopus)

Structure of a presenilin family intramembrane aspartate protease

Li, X., Dang, S., Yan, C., Gong, X., Wang, J. & Shi, Y., Jan 3 2013, In : Nature. 493, 7430, p. 56-61 6 p.

Research output: Contribution to journalArticle

Presenilins
Aspartic Acid
Peptide Hydrolases
Methanomicrobiaceae
Aspartic Acid Proteases
2011
19 Citations (Scopus)

Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE

Li, X., Wang, J. & Shi, Y., Aug 11 2011, In : Nature Communications. 2, 1, 408.

Research output: Contribution to journalArticle

Effector Caspases
Inhibitor of Apoptosis Proteins
Apoptosis Regulatory Proteins
Ubiquitination
Caspases
2009
42 Citations (Scopus)

Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage

Li, X., Wang, B., Feng, L., Kang, H., Qi, Y., Wang, J. & Shi, Y., Sep 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 35, p. 14837-14842 6 p.

Research output: Contribution to journalArticle

PDZ Domains
Peptide Hydrolases
Amino Acids
Escherichia coli Proteins
Proteolysis
167 Citations (Scopus)

Structure and mechanism of an amino acid antiporter

Gao, X., Lu, F., Zhou, L., Dang, S., Sun, L., Li, X., Wang, J. & Shi, Y., Jun 19 2009, In : Science. 324, 5934, p. 1565-1568 4 p.

Research output: Contribution to journalArticle

Antiporters
Agmatine
Arginine
Escherichia coli O157
Amino Acids