• 1372 Citations
  • 17 h-Index
19992020

Research output per year

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Research Output

  • 1372 Citations
  • 17 h-Index
  • 39 Article
2020

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development

Choi, J. H., Zhong, X., Zhang, Z., Su, L., McAlpine, W., Misawa, T., Liao, T. C., Zhan, X., Russell, J., Ludwig, S., Li, X., Tang, M., Anderton, P., Moresco, E. M. Y. & Beutler, B., 2020, In : Journal of Experimental Medicine. 217, 4, e20190006.

Research output: Contribution to journalArticle

Open Access

Essential requirement for nicastrin in marginal zone and B-1 B cell development

Choi, J. H., Han, J., Theodoropoulos, P. C., Zhong, X., Wang, J., Medler, D., Ludwig, S., Zhan, X., Li, X., Tang, M., Gallagher, T., Yu, G. & Beutler, B., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4894-4901 8 p.

Research output: Contribution to journalArticle

Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation

Misawa, T., SoRelle, J. A., Choi, J. H., Yue, T., Wang, K. W., McAlpine, W., Wang, J., Liu, A., Tabeta, K., Turer, E. E., Evers, B., Nair-Gill, E., Poddar, S., Su, L., Ou, F., Yu, L., Russell, J., Ludwig, S., Zhan, X., Hildebrand, S. & 5 others, Li, X., Tang, M., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Jan 24 2020, In : Science Immunology. 5, 43

Research output: Contribution to journalArticle

2019
3 Scopus citations

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang, D., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang, D., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 others, Moresco, E. Y. & Beutler, B., 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

4 Scopus citations

Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

Zhang, D., Yue, T., Choi, J. H., Nair-Gill, E., Zhong, X., Wang, K. W., Zhan, X., Li, X., Choi, M., Tang, M., Quan, J., Hildebrand, S., Moresco, E. M. Y. & Beutler, B., Jan 1 2019, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

23 Scopus citations

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Turer, E. E., San Miguel, M., Wang, K. W., McAlpine, W., Ou, F., Li, X., Tang, M., Zang, Z., Wang, J., Hayse, B., Evers, B., Zhan, X., Russell, J. L. & Beutler, B. A., Dec 18 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

2 Scopus citations

The class i myosin MYO1D binds to lipid and protects against colitis

McAlpine, W., Wang, K. W., Choi, J. H., Miguel, M. S., McAlpine, S. G., Russell, J., Ludwig, S., Li, X., Tang, M., Zhan, X., Choi, M., Wang, T., Bu, C. H., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Sep 2018, In : DMM Disease Models and Mechanisms. 11, 9, dmm035923.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Creatine maintains intestinal homeostasis and protects against colitis

Turer, E. E., McAlpine, W., Wang, K. W., Lu, T., Li, X., Tang, M., Zhan, X., Wang, T., Zhan, X., Bu, C. H., Murray, A. R. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1273-E1281

Research output: Contribution to journalArticle

18 Scopus citations

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

Sun, L., Jiang, Z., Acosta-Rodriguez, V. A., Berger, M., Du, X., Choi, J. H., Wang, J., Wang, K. W., Kilaru, G. K., Mohawk, J. A., Quan, J., Scott, L., Hildebrand, S., Li, X., Tang, M., Zhan, X., Murray, A. R., Vine, D. L., Moresco, E. M. Y., Takahashi, J. S. & 1 others, Beutler, B., Nov 1 2017, In : Journal of Experimental Medicine. 214, 11, p. 3263-3277 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204

Research output: Contribution to journalArticle

21 Scopus citations

Skin-specific regulation of SREBP processing & lipid biosynthesis by glycerol kinase 5

Zhang, D., Tomisato, W., Su, L., Sun, L., Choi, J. H., Zhang, Z., Wang, K. W., Zhan, X., Choi, M., Li, X., Tang, M., Castro-Perez, J. M., Hildebrand, S., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Jun 27 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 26, p. E5197-E5206

Research output: Contribution to journalArticle

8 Scopus citations
2016
10 Scopus citations

Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893))

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. E2096

Research output: Contribution to journalArticle

3 Scopus citations

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice

Zhang, Z., Turer, E., Li, X., Zhan, X., Choi, M., Tang, M., Press, A., Smith, S. R., Divoux, A., Moresco, E. M. Y. & Beutler, B., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6418-E6426

Research output: Contribution to journalArticle

14 Scopus citations

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E884-E893

Research output: Contribution to journalArticle

56 Scopus citations
2015
4 Scopus citations

Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities

Zhan, X., Cao, M., Yoo, A. S., Zhang, Z., Chen, L., Crabtree, G. R. & Wu, J. I., Jul 1 2015, In : Genesis. 53, 7, p. 440-448 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection

Siggs, O. M., Popkin, D. L., Krebs, P., Li, X., Tang, M., Zhan, X., Zeng, M., Lin, P., Xia, Y., Oldstone, M. B. A., Cornall, R. J. & Beutler, B., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5706-E5714

Research output: Contribution to journalArticle

7 Scopus citations

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., Lyon, S., Scott, L., Quan, J., Sun, Q., Russell, J., Arnett, S., Jurek, P., Chen, D., Kravchenko, V. V., Mathison, J. C. & 4 others, Moresco, E. M. Y., Monson, N. L., Ulevitch, R. J. & Beutler, B., Dec 7 2015, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

195 Scopus citations

Real-time resolution of point mutations that cause phenovariance in mice

Wang, T., Zhan, X., Bua, C. H., Lyona, S., Pratta, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E. E., Chen, Z., Zhang Ph.D., D-W., Yue, T., Wang, Y., Shi, H-X., Wang, J., Sun, L., SoRelle, J., McAlpine, W. & 28 others, Hutchins, N., Zhan, X., Fin, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J. L., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M. Y., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. & Beutler, B. A., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E440-E449

Research output: Contribution to journalArticle

36 Scopus citations
2014

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., Wang, C., Ge, K. & Wu, J., 2014, In : Nature communications. 5, 6425.

Research output: Contribution to journalArticle

47 Scopus citations

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M. Y., Pedersen, G., McInerney, G. M., Hedestam, G. B. K., Chen, Z. J. & Beutler, B., Dec 19 2014, In : Science. 346, 6216, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. Y. & Beutler, B., May 20 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7367-7372 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011
46 Scopus citations
2009

Monoclonal antibodies against IREM-1: Potential for targeted therapy of AML

Korver, W., Zhao, X., Singh, S., Pardoux, C., Zhao, J., Guzman, M. L., Sen, S., Yonkovich, S., Liu, S., Zhan, X., Tomasevic, N., Zhou, C., Gros, D., Jordan, C. T., Gotlib, J., Hsi, E. D. & Abo, A., Sep 2009, In : Leukemia. 23, 9, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

The first propeller domain of LRP6 regulates sensitivity to DKK1

Binnerts, M. E., Tomasevic, N., Bright, J. M., Leung, J., Ahn, V. E., Kim, K. A., Zhan, X., Liu, S., Yonkovich, S., Williams, J., Zhou, M., Gros, D., Dixon, M., Korver, W., Weis, W. I. & Abo, A., Aug 1 2009, In : Molecular biology of the cell. 20, 15, p. 3552-3560 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2008

R-Spondin family members regulate the Wnt pathway by a common mechanism

Kim, K. A., Wagle, M., Tran, K., Zhan, X., Dixon, M. A., Liu, S., Gros, D., Korver, W., Yonkovich, S., Tomasevic, N., Binnerts, M. & Abo, A., Jun 1 2008, In : Molecular biology of the cell. 19, 6, p. 2588-2596 9 p.

Research output: Contribution to journalArticle

205 Scopus citations
2007

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

Nam, J. S., Park, E., Turcotte, T. J., Palencia, S., Zhan, X., Lee, J., Yun, K., Funk, W. D. & Yoon, J. K., Nov 1 2007, In : Developmental Biology. 311, 1, p. 124-135 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

Binnerts, M. E., Kim, K. A., Bright, J. M., Patel, S. M., Tran, K., Zhou, M., Leung, J. M., Liu, Y., Lomas, W. E., Dixon, M., Hazell, S. A., Wagle, M., Nie, W. S., Tomasevic, N., Williams, J., Zhan, X., Levy, M. D., Funk, W. D. & Abo, A., Sep 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 37, p. 14700-14705 6 p.

Research output: Contribution to journalArticle

193 Scopus citations

The lymphoid cell surface receptor NTB-A: A novel monoclonal antibody target for leukaemia and lymphoma therapeutics

Korver, W., Singh, S., Liu, S., Zhao, X., Yonkovich, S., Sweeney, A., Anton, K., Lomas, W. E., Greenwood, R., Smith, A., Tran, D. H., Shinkawa, P., Jimenez, M., Yeung, P., Aguilar, G., Palencia, S., Vatta, P., Mueller, M., Zhan, X., Newton, E. M. & 7 others, Liu, Y., Zhao, J., Emtage, P., Levy, M. D., Hsi, E. D., Funk, W. D. & Abo, A., May 1 2007, In : British Journal of Haematology. 137, 4, p. 307-318 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2006

Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome

Gao, J., Lee, K., Zhao, M., Qiu, J., Zhan, X., Saxena, A., Moore, C. J., Cohen, S. N. & Georgiou, G., Jul 1 2006, In : Molecular Microbiology. 61, 2, p. 394-406 13 p.

Research output: Contribution to journalArticle

92 Scopus citations
2004

Genetic Analysis of Disulfide Isomerization in Escherichia coli: Expression of DsbC Is Modulated by RNase E-Dependent mRNA Processing

Zhan, X., Gao, J., Jain, C., Cieslewicz, M. J., Swartz, J. R. & Georgiou, G., Feb 1 2004, In : Journal of bacteriology. 186, 3, p. 654-660 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2003

RraA: A protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli

Lee, K., Zhan, X., Gao, J., Qiu, J., Feng, Y., Meganathan, R., Cohen, S. N. & Georgiou, G., Sep 5 2003, In : Cell. 114, 5, p. 623-634 12 p.

Research output: Contribution to journalArticle

114 Scopus citations

Screening and selection strategies for disulfide isomerase activity.

Lafond, R., Zhan, X. & Georgiou, G., 2003, In : Methods in molecular biology (Clifton, N.J.). 230, p. 239-257 19 p.

Research output: Contribution to journalArticle

4 Scopus citations
1999

Facilitating the formation of disulfide bonds in the Escherichia coli periplasm via coexpression of yeast protein disulfide isomerase

Zhan, X., Schwaller, M., Gilbert, H. F. & Georgiou, G., Nov 1 1999, In : Biotechnology Progress. 15, 6, p. 1033-1038 6 p.

Research output: Contribution to journalArticle

24 Scopus citations