• 1250 Citations
  • 15 h-Index
19992019
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Research Output 1999 2019

  • 1250 Citations
  • 15 h-Index
  • 35 Article
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Article
2019
2 Citations (Scopus)
Hedgehogs
Zinc Fingers
Transcription
Proteomics
Modulators

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Regulatory T-Lymphocytes
Colitis
Dendritic Cells
1 Citation (Scopus)

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang Ph.D., D-W., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 others, Moresco, E. Y. & Beutler, B., Jan 1 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

Lymphopoiesis
Catenins
Wnt2 Protein
Ethylnitrosourea
Wnt Signaling Pathway

Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

Zhang, D., Yue, T., Choi, J. H., Nair-Gill, E., Zhong, X., Wang, K. W., Zhan, X., Li, X., Choi, M., Tang, M., Quan, J., Hildebrand, S., Moresco, E. M. Y. & Beutler, B., Jan 1 2019, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

Spliceosomes
Immune System Diseases
Alleles
Hematopoietic Stem Cells
U5 Small Nuclear Ribonucleoproteins
2018
13 Citations (Scopus)

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

Melanoma
Cytotoxic T-Lymphocytes
Immunization
Toll-Like Receptor 1
Neoplasms
2 Citations (Scopus)

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Turer, E. E., San Miguel, M., Wang, K. W., McAlpine, W., Ou, F., Li, X., Tang, M., Zang, Z., Wang, J., Hayse, B., Evers, B., Zhan, X., Russell, J. L. & Beutler, B. A., Dec 18 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptor Nuclear Translocator
Medical problems
Clustered Regularly Interspaced Short Palindromic Repeats
Obesity
Mutation

The class i myosin MYO1D binds to lipid and protects against colitis

McAlpine, W., Wang, K. W., Choi, J. H., Miguel, M. S., McAlpine, S. G., Russell, J., Ludwig, S., Li, X., Tang, M., Zhan, X., Choi, M., Wang, T., Bu, C. H., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Sep 1 2018, In : DMM Disease Models and Mechanisms. 11, 9, dmm035923.

Research output: Contribution to journalArticle

Dextran Sulfate
Colitis
Myosins
Myosin Type I
Ethylnitrosourea
2017
16 Citations (Scopus)

Creatine maintains intestinal homeostasis and protects against colitis

Turer, E. E., McAlpine, W., Wang, K. W., Lu, T., Li, X., Tang, M., Zhan, X., Wang, T., Zhan, X., Bu, C. H., Murray, A. R. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1273-E1281

Research output: Contribution to journalArticle

Creatine
Colitis
Dextran Sulfate
Homeostasis
Clustered Regularly Interspaced Short Palindromic Repeats
7 Citations (Scopus)

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

Sun, L., Jiang, Z., Acosta-Rodriguez, V. A., Berger, M., Du, X., Choi, J. H., Wang, J., Wang, K. W., Kilaru, G. K., Mohawk, J. A., Quan, J., Scott, L., Hildebrand, S., Li, X., Tang, M., Zhan, X., Murray, A. R., Vine, D. L., Moresco, E. M. Y., Takahashi, J. S. & 1 others, Beutler, B., Nov 1 2017, In : Journal of Experimental Medicine. 214, 11, p. 3263-3277 15 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-1
Toll-Like Receptor 3
Virus Diseases
Double-Stranded RNA
Interferons
16 Citations (Scopus)

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
Immunoglobulin D
Microbiota
Lymphoid Tissue
Mucous Membrane
6 Citations (Scopus)

Skin-specific regulation of SREBP processing & lipid biosynthesis by glycerol kinase 5

Zhang, D., Tomisato, W., Su, L., Sun, L., Choi, J. H., Zhang, Z., Wang, K. W., Zhan, X., Choi, M., Li, X., Tang, M., Castro-Perez, J. M., Hildebrand, S., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Jun 27 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 26, p. E5197-E5206

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Glycerol Kinase
Hair
Lipids
Skin
2016
9 Citations (Scopus)
MEF2 Transcription Factors
Autistic Disorder
Synapses
Chromatin
Genes
3 Citations (Scopus)

Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893))

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. E2096

Research output: Contribution to journalArticle

11 Citations (Scopus)

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice

Zhang, Z., Turer, E., Li, X., Zhan, X., Choi, M., Tang, M., Press, A., Smith, S. R., Divoux, A., Moresco, E. M. Y. & Beutler, B., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6418-E6426

Research output: Contribution to journalArticle

Insulin Resistance
Insulin
Diet
Clustered Regularly Interspaced Short Palindromic Repeats
Cullin Proteins
50 Citations (Scopus)

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E884-E893

Research output: Contribution to journalArticle

Lipopolysaccharides
Lipid A
Ligands
Peptidomimetics
Toll-Like Receptor 4
2015
4 Citations (Scopus)
Medulloblastoma
Protein-Tyrosine Kinases
Tyrosine
Neoplasms
src-Family Kinases
3 Citations (Scopus)

Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities

Zhan, X., Cao, M., Yoo, A. S., Zhang, Z., Chen, L., Crabtree, G. R. & Wu, J. I., Jul 1 2015, In : Genesis. 53, 7, p. 440-448 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Neurons
Artificial Chromosomes
Genes
Chromatin Assembly and Disassembly
7 Citations (Scopus)

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection

Siggs, O. M., Popkin, D. L., Krebs, P., Li, X., Tang, M., Zhan, X., Zeng, M., Lin, P., Xia, Y., Oldstone, M. B. A., Cornall, R. J. & Beutler, B., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5706-E5714

Research output: Contribution to journalArticle

Lymphopenia
Virus Diseases
Endoplasmic Reticulum
Mutation
T-Cell Antigen Receptor
158 Citations (Scopus)

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., Lyon, S., Scott, L., Quan, J., Sun, Q., Russell, J., Arnett, S., Jurek, P., Chen, D., Kravchenko, V. V., Mathison, J. C. & 4 others, Moresco, E. M. Y., Monson, N. L., Ulevitch, R. J. & Beutler, B., Dec 7 2015, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

Inflammasomes
Mitosis
Caspase 1
Interleukin-18
Protein-Serine-Threonine Kinases
29 Citations (Scopus)

Real-time resolution of point mutations that cause phenovariance in mice

Wang, T., Zhan, X., Bua, C. H., Lyona, S., Pratta, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E. E., Chen, Z., Zhang Ph.D., D-W., Yue, T., Wang, Y., Shi, H-X., Wang, J., Sun, L., SoRelle, J., McAlpine, W. & 28 others, Hutchins, N., Zhan, X., Fin, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J. L., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M. Y., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. & Beutler, B. A., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E440-E449

Research output: Contribution to journalArticle

Point Mutation
Mutation
Ethylnitrosourea
Phenotype
High-Throughput Nucleotide Sequencing
2014
45 Citations (Scopus)

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., Wang, C., Ge, K. & Wu, J., 2014, In : Nature Communications. 5, 6425.

Research output: Contribution to journalArticle

Medulloblastoma
Methyltransferases
Growth and Development
Epigenomics
genes
74 Citations (Scopus)

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M. Y., Pedersen, G., McInerney, G. M., Hedestam, G. B. K., Chen, Z. J. & Beutler, B., Dec 19 2014, In : Science. 346, 6216, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Antiviral Agents
B-Lymphocytes
RNA
Antibody Formation
13 Citations (Scopus)

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. Y. & Beutler, B., May 20 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7367-7372 6 p.

Research output: Contribution to journalArticle

Mitochondrial Myopathies
Thinness
Respiration
Mutation
Proteins
2011
44 Citations (Scopus)
Chromatin Assembly and Disassembly
Hedgehogs
Activator Appliances
Genes
Telencephalon
2009
15 Citations (Scopus)

Monoclonal antibodies against IREM-1: Potential for targeted therapy of AML

Korver, W., Zhao, X., Singh, S., Pardoux, C., Zhao, J., Guzman, M. L., Sen, S., Yonkovich, S., Liu, S., Zhan, X., Tomasevic, N., Zhou, C., Gros, D., Jordan, C. T., Gotlib, J., Hsi, E. D. & Abo, A., Sep 2009, In : Leukemia. 23, 9, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Monoclonal Antibodies
Myeloid Cells
Therapeutics
Cell Line
15 Citations (Scopus)

The first propeller domain of LRP6 regulates sensitivity to DKK1

Binnerts, M. E., Tomasevic, N., Bright, J. M., Leung, J., Ahn, V. E., Kim, K. A., Zhan, X., Liu, S., Yonkovich, S., Williams, J., Zhou, M., Gros, D., Dixon, M., Korver, W., Weis, W. I. & Abo, A., Aug 1 2009, In : Molecular Biology of the Cell. 20, 15, p. 3552-3560 9 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
2008
195 Citations (Scopus)

R-Spondin family members regulate the Wnt pathway by a common mechanism

Kim, K. A., Wagle, M., Tran, K., Zhan, X., Dixon, M. A., Liu, S., Gros, D., Korver, W., Yonkovich, S., Tomasevic, N., Binnerts, M. & Abo, A., Jun 2008, In : Molecular Biology of the Cell. 19, 6, p. 2588-2596 9 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Proteins
Furin
Ligands
Knockout Mice
2007
72 Citations (Scopus)

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

Nam, J. S., Park, E., Turcotte, T. J., Palencia, S., Zhan, X., Lee, J., Yun, K., Funk, W. D. & Yoon, J. K., Nov 1 2007, In : Developmental Biology. 311, 1, p. 124-135 12 p.

Research output: Contribution to journalArticle

Catenins
Hindlimb
Maintenance
Fibroblast Growth Factor 8
Developmental Genes
191 Citations (Scopus)

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

Binnerts, M. E., Kim, K. A., Bright, J. M., Patel, S. M., Tran, K., Zhou, M., Leung, J. M., Liu, Y., Lomas, W. E., Dixon, M., Hazell, S. A., Wagle, M., Nie, W. S., Tomasevic, N., Williams, J., Zhan, X., Levy, M. D., Funk, W. D. & Abo, A., Sep 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 37, p. 14700-14705 6 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Ligands
Catenins
Proteins
Epithelium
11 Citations (Scopus)

The lymphoid cell surface receptor NTB-A: A novel monoclonal antibody target for leukaemia and lymphoma therapeutics

Korver, W., Singh, S., Liu, S., Zhao, X., Yonkovich, S., Sweeney, A., Anton, K., Lomas, W. E., Greenwood, R., Smith, A., Tran, D. H., Shinkawa, P., Jimenez, M., Yeung, P., Aguilar, G., Palencia, S., Vatta, P., Mueller, M., Zhan, X., Newton, E. M. & 7 others, Liu, Y., Zhao, J., Emtage, P., Levy, M. D., Hsi, E. D., Funk, W. D. & Abo, A., May 2007, In : British Journal of Haematology. 137, 4, p. 307-318 12 p.

Research output: Contribution to journalArticle

Cell Surface Receptors
B-Cell Chronic Lymphocytic Leukemia
Lymphoma
Leukemia
Monoclonal Antibodies
2006
89 Citations (Scopus)

Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome

Gao, J., Lee, K., Zhao, M., Qiu, J., Zhan, X., Saxena, A., Moore, C. J., Cohen, S. N. & Georgiou, G., Jul 2006, In : Molecular Microbiology. 61, 2, p. 394-406 13 p.

Research output: Contribution to journalArticle

Escherichia coli
Messenger RNA
Endonucleases
Proteins
RNA Cleavage
2004
10 Citations (Scopus)

Genetic Analysis of Disulfide Isomerization in Escherichia coli: Expression of DsbC Is Modulated by RNase E-Dependent mRNA Processing

Zhan, X., Gao, J., Jain, C., Cieslewicz, M. J., Swartz, J. R. & Georgiou, G., Feb 2004, In : Journal of Bacteriology. 186, 3, p. 654-660 7 p.

Research output: Contribution to journalArticle

Protein Disulfide-Isomerases
Tissue Plasminogen Activator
Disulfides
4-Aminobenzoic Acid
Periplasm
2003
111 Citations (Scopus)

RraA: A protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli

Lee, K., Zhan, X., Gao, J., Qiu, J., Feng, Y., Meganathan, R., Cohen, S. N. & Georgiou, G., Sep 5 2003, In : Cell. 114, 5, p. 623-634 12 p.

Research output: Contribution to journalArticle

Ribonucleases
Escherichia coli
RNA
Proteins
RNA Stability
4 Citations (Scopus)

Screening and selection strategies for disulfide isomerase activity.

Lafond, R., Zhan, X. & Georgiou, G., 2003, In : Methods in molecular biology (Clifton, N.J.). 230, p. 239-257 19 p.

Research output: Contribution to journalArticle

Directed Molecular Evolution
Protein Disulfide-Isomerases
Peptide Library
Protein Folding
Molecular Cloning
1999
24 Citations (Scopus)

Facilitating the formation of disulfide bonds in the Escherichia coli periplasm via coexpression of yeast protein disulfide isomerase

Zhan, X., Schwaller, M., Gilbert, H. F. & Georgiou, G., Nov 1999, In : Biotechnology Progress. 15, 6, p. 1033-1038 6 p.

Research output: Contribution to journalArticle

protein disulfide-isomerase
Protein Disulfide-Isomerases
Periplasm
Fungal Proteins
disulfide bonds