• 2240 Citations
  • 23 h-Index
19972019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1997 2019

Filter
Article
2018
8 Citations (Scopus)

mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1

Huynh, H. D. & Wan, Y., Dec 1 2018, In : Communications Biology. 1, 1, 29.

Research output: Contribution to journalArticle

Open Access
osteoclasts
Calcineurin
Osteoclasts
Bone
bones
2017
33 Citations (Scopus)

Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis

Chen, P., Zuo, H., Xiong, H., Kolar, M. J., Chu, Q., Saghatelian, A., Siegwart, D. J. & Wan, Y., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 580-585 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Lactic Acid
Macrophages
Breast Neoplasms
Neoplasm Metastasis
22 Citations (Scopus)
Liver
Bone
Fluorescence
Water
Polyethylene glycols
3 Citations (Scopus)

Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model

Du, Y., Sun, T., Liang, X., Li, Y., Jin, Z., Xue, H., Wan, Y. & Tian, J., Nov 21 2017, In : International Journal of Nanomedicine. 12, p. 8337-8351 15 p.

Research output: Contribution to journalArticle

Immunotherapy
Surgery
Tumors
Fluorescence
Neoplasms
4 Citations (Scopus)

Lipid osteoclastokines regulate breast cancer bone metastasis

Krzeszinski, J. Y., Schwaid, A. G., Cheng, W. Y., Jin, Z., Gallegos, Z. R., Saghatelian, A. & Wan, Y., Mar 1 2017, In : Endocrinology. 158, 3, p. 477-489 13 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Osteoclasts
Breast Neoplasms
Neoplasm Metastasis
Lipids
2 Citations (Scopus)

Milk lipid regulation at the maternal-offspring interface

Yang, D., Huynh, H. D. & Wan, Y., 2017, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

Milk
Mothers
Lipids
Essential Fatty Acids
Genetically Modified Animals
3 Citations (Scopus)

mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss

Huynh, H. D., Wei, W. & Wan, Y., Jun 6 2017, In : Cell Reports. 19, 10, p. 2014-2025 12 p.

Research output: Contribution to journalArticle

Milk
Mothers
Osteopetrosis
Bone
Osteoclasts
1 Citation (Scopus)

Nuclear Receptors in Skeletal Homeostasis

Zuo, H. & Wan, Y., 2017, (Accepted/In press) In : Current Topics in Developmental Biology.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Homeostasis
Bone and Bones
Ligands
Osteoporosis
2016
3 Citations (Scopus)

Gata2 is a rheostat for mesenchymal stem cell fate in male mice

Li, X., Huynh, H., Zuo, H., Salminen, M. & Wan, Y., Mar 1 2016, In : Endocrinology. 157, 3, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Adipocytes
Osteoblasts
Adipogenesis
Zinc Fingers
43 Citations (Scopus)

Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects

Wei, W., Schwaid, A. G., Wang, X., Wang, X., Chen, S., Chu, Q., Saghatelian, A. & Wan, Y., Mar 8 2016, In : Cell Metabolism. 23, 3, p. 479-491 13 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diphosphonates
Estrogen Receptors
Cholesterol
Ligands
11 Citations (Scopus)

Macrophage PPARγ inhibits GPR132 to mediate the anti-tumor effects of rosiglitazone

Cheng, W. Y., Huynh, H., Chen, P., Penã-Llopis, S. & Wan, Y., Oct 1 2016, In : eLife. 5, OCTOBER2016, e18501.

Research output: Contribution to journalArticle

rosiglitazone
Peroxisome Proliferator-Activated Receptors
Macrophages
Tumors
Neoplasms
6 Citations (Scopus)

Unique epigenetic gene profiles define human breast cancers with poor prognosis

Peña-Llopis, S., Wan, Y. & Martinez, E. D., 2016, In : Oncotarget. 7, 52, p. 85819-85831 13 p.

Research output: Contribution to journalArticle

Epigenomics
Breast Neoplasms
Genes
Neoplasms
Breast
2015
43 Citations (Scopus)

A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption

Wang, X., Wei, W., Krzeszinski, J. Y., Wang, Y. & Wan, Y., Nov 3 2015, In : Cell Metabolism. 22, 5, p. 811-824 14 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 1
Bone Resorption
Osteogenesis
Bone and Bones
Liver
23 Citations (Scopus)

HDAC9 inhibits osteoclastogenesis via mutual suppression of PPARγ/RANKL signaling

Jin, Z., Wei, W., Huynh, H. & Wan, Y., 2015, In : Molecular Endocrinology. 29, 5, p. 730-738 9 p.

Research output: Contribution to journalArticle

RANK Ligand
Peroxisome Proliferator-Activated Receptors
Nuclear Receptor Co-Repressor 2
Bone Resorption
Osteogenesis
7 Citations (Scopus)

Maternal adiponectin controls milk composition to prevent neonatal inflammation

Jin, Z., Du, Y., Schwaid, A. G., Asterholm, I. W., Scherer, P. E., Saghatelian, A. & Wan, Y., Apr 1 2015, In : Endocrinology. 156, 4, p. 1504-1513 10 p.

Research output: Contribution to journalArticle

Adiponectin
Milk
Mothers
Inflammation
Alopecia
17 Citations (Scopus)

Minireview: Nuclear receptor regulation of osteoclast and bone remodeling

Jin, Z., Li, X. & Wan, Y., 2015, In : Molecular Endocrinology. 29, 2, p. 172-186 15 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoclasts
Cytoplasmic and Nuclear Receptors
Pycnodysostosis
Essential Osteolysis
34 Citations (Scopus)

New therapeutic targets for cancer bone metastasis

Krzeszinski, J. Y. & Wan, Y., 2015, In : Trends in Pharmacological Sciences. 36, 6, p. 360-373 14 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Tumors
Bone
Neoplasm Metastasis
Bone and Bones
9 Citations (Scopus)

Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation

Li, X., Wei, W., Huynh, H., Zuo, H., Wang, X. & Wan, Y., Jul 14 2015, In : eLife. 4, JULY 2015, e07217.

Research output: Contribution to journalArticle

Osteoclasts
Ligases
Ubiquitin
Osteogenesis
Bone
1 Citation (Scopus)

Sim1 inhibits bone formation by enhancing the sympathetic tone in male mice

Wang, X., Wei, W., Zinn, A. R. & Wan, Y., Apr 1 2015, In : Endocrinology. 156, 4, p. 1408-1415 8 p.

Research output: Contribution to journalArticle

Osteogenesis
Bone and Bones
Adrenergic Agonists
Bone Remodeling
Sympathetic Nervous System
2014
29 Citations (Scopus)

FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice

Bornstein, S., Brown, S. A., Le, P. T., Wang, X., DeMambro, V., Horowitz, M. C., MacDougald, O., Baron, R., Lotinun, S., Karsenty, G., Wei, W., Ferron, M., Kovacs, C. S., Clemmons, D., Wan, Y. & Rosen, C. J., Sep 1 2014, In : Endocrinology. 155, 9, p. 3516-3526 11 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Lactation
Body Composition
Bone Resorption
Bone Density
193 Citations (Scopus)

MiR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

Krzeszinski, J. Y., Wei, W., Huynh, H., Jin, Z., Wang, X., Chang, T. C., Xie, X. J., He, L., Mangala, L. S., Lopez-Berestein, G., Sood, A. K., Mendell, J. T. & Wan, Y., Aug 28 2014, In : Nature. 512, 7515, p. 431-435 5 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Osteogenesis
Osteoporosis
Bone Resorption
Neoplasm Metastasis
64 Citations (Scopus)

Mitochondrial complex i activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization

Jin, Z., Wei, W., Yang, M., Du, Y. & Wan, Y., Sep 2 2014, In : Cell Metabolism. 20, 3, p. 483-498 16 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Osteopetrosis
Fatty Acids
Macrophages
14 Citations (Scopus)

Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action

Wei, W., Motoike, T., Krzeszinski, J. Y., Jin, Z., Xie, X-J., Dechow, P. C., Yanagisawa, M. & Wan, Y., Jun 3 2014, In : Cell Metabolism. 19, 6, p. 927-940 14 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone and Bones
Orexin Receptors
Osteogenesis
Yin-Yang
2013
15 Citations (Scopus)

Bone marrow mesenchymal stem cells: Fat on and blast off by FGF21

Wan, Y., Mar 2013, In : International Journal of Biochemistry and Cell Biology. 45, 3, p. 546-549 4 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Bone
Bone Marrow
Fats
22 Citations (Scopus)

HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered β-catenin switch

Jin, Z., Wei, W., Dechow, P. C. & Wan, Y., Feb 2013, In : Molecular Endocrinology. 27, 2, p. 325-335 11 p.

Research output: Contribution to journalArticle

Catenins
Histone Deacetylases
Osteogenesis
Osteoclasts
Bone Resorption
1 Citation (Scopus)

IBAT on bone

Wan, Y., Aug 1 2013, In : Endocrinology. 154, 8, p. 2579-2580 2 p.

Research output: Contribution to journalArticle

Osteocytes
Brown Adipose Tissue
Osteoblasts
Bone and Bones
60 Citations (Scopus)

Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen

Gautron, L., Rutkowski, J. M., Burton, M. D., Wei, W., Wan, Y. & Elmquist, J. K., 2013, In : Journal of Comparative Neurology. 521, 16, p. 3741-3767 27 p.

Research output: Contribution to journalArticle

Cholinergic Agents
Gastrointestinal Tract
Spleen
Lymphocytes
Peyer's Patches
2012
222 Citations (Scopus)

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., Mangelsdorf, D. J., Kliewer, S. A. & Wan, Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3143-3148 6 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Bone and Bones
rosiglitazone
Adipogenesis
fibroblast growth factor 21
13 Citations (Scopus)

Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates

Du, Y., Yang, M., Wei, W., Huynh, H. D., Herz, J., Saghatelian, A. & Wan, Y., 2012, In : Nature Communications. 3, 2011.

Research output: Contribution to journalArticle

lipoproteins
secretions
macrophages
milk
Nursing
29 Citations (Scopus)

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A. & Wan, Y., Jun 2012, In : Genes and Development. 26, 12, p. 1306-1311 6 p.

Research output: Contribution to journalArticle

Milk
Mothers
Ceramides
Poisons
Toll-Like Receptors
167 Citations (Scopus)

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Colbert Coate, K., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., Yu, R. T., Evans, R. M., Kliewer, S. A. & Mangelsdorf, D. J., Oct 15 2012, In : eLife. 2012, 1, e00065.

Research output: Contribution to journalArticle

Starvation
Hormones
Liver
Adenylate Kinase
Bone Development
39 Citations (Scopus)

Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake

Zeve, D., Seo, J., Suh, J. M., Stenesen, D., Tang, W., Berglund, E. D., Wan, Y., Williams, L. J., Lim, A., Martinez, M. J., McKay, R. M., Millay, D. P., Olson, E. N. & Graff, J. M., Apr 4 2012, In : Cell Metabolism. 15, 4, p. 492-504 13 p.

Research output: Contribution to journalArticle

Fats
Insulin
Lipodystrophy
Glucose
Muscles
2011
104 Citations (Scopus)

Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin

Wei, W., Zeve, D., Suh, J. M., Wang, X., Du, Y., Zerwekh, J. E., Dechow, P. C., Graff, J. M. & Wan, Y., Dec 2011, In : Molecular and Cellular Biology. 31, 23, p. 4706-4719 14 p.

Research output: Contribution to journalArticle

Catenins
Osteogenesis
Osteoclasts
Osteopetrosis
Bone Diseases
30 Citations (Scopus)

Osteoclast progenitors reside in the peroxisome proliferator-activated receptor γ-expressing bone marrow cell population

Wei, W., Zeve, D., Wang, X., Du, Y., Tang, W., Dechow, P. C., Graff, J. M. & Wan, Y., Dec 2011, In : Molecular and Cellular Biology. 31, 23, p. 4692-4705 14 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Osteoclasts
Bone Marrow Cells
Population
Bone and Bones
22 Citations (Scopus)

Thiazolidinediones on PPARγ: The roles in bone remodeling

Wei, W. & Wan, Y., 2011, In : PPAR Research. 867180.

Research output: Contribution to journalArticle

Thiazolidinediones
Bone Remodeling
PPAR gamma
Bone and Bones
rosiglitazone
2010
1 Citation (Scopus)

Erratum: Pgc1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss (Cell Metabolism (2010) 11 (503-516))

Wei, W., Wang, X., Yang, M., Smith, L. C., Dechow, P. C., Sonoda, J., Evans, R. M. & Wan, Y., Aug 4 2010, In : Cell Metabolism. 12, 2, p. 202 1 p.

Research output: Contribution to journalArticle

rosiglitazone
Osteogenesis
Bone and Bones
135 Citations (Scopus)

PGC1β mediates PPARγ activation of osteoclastogenesis and rosiglitazone-induced bone loss

Wei, W., Wang, X., Yang, M., Smith, L. C., Dechow, P. C. & Wan, Y., Jun 9 2010, In : Cell Metabolism. 11, 6, p. 503-516 14 p.

Research output: Contribution to journalArticle

rosiglitazone
Peroxisome Proliferator-Activated Receptors
Osteogenesis
Bone and Bones
Osteoclasts
77 Citations (Scopus)

PPARγ in bone homeostasis

Wan, Y., Dec 2010, In : Trends in Endocrinology and Metabolism. 21, 12, p. 722-728 7 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Homeostasis
rosiglitazone
Bone and Bones
Osteogenesis
18 Citations (Scopus)

Rosiglitazone activation of PPARg suppresses fractalkine signaling

Wan, Y. & Evans, R. M., Feb 2010, In : Journal of Molecular Endocrinology. 44, 2, p. 135-142 8 p.

Research output: Contribution to journalArticle

rosiglitazone
Chemokine CX3CL1
Peroxisome Proliferator-Activated Receptors
Thiazolidinediones
Cell Nucleus Active Transport
2007
79 Citations (Scopus)

Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk

Wan, Y., Saghatelian, A., Chong, L. W., Zhang, C. L., Cravatt, B. F. & Evans, R. M., Aug 1 2007, In : Genes and Development. 21, 15, p. 1895-1908 14 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Milk
Nursing
Mothers
Human Mammary Glands
371 Citations (Scopus)

PPAR-γ regulates osteoclastogenesis in mice

Wan, Y., Chong, L. W. & Evans, R. M., Dec 2007, In : Nature Medicine. 13, 12, p. 1496-1503 8 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Osteoclasts
Osteogenesis
Bone
Osteopetrosis
2003
16 Citations (Scopus)

Overlapping but Distinct Profiles of Gene Expression Elicited by Glucocorticoids and Progestins

Wan, Y. & Nordeen, S. K., 2003, In : Recent Progress in Hormone Research. 58, p. 199-226 28 p.

Research output: Contribution to journalArticle

Progestins
Transcriptome
Glucocorticoids
Genes
Hormones
57 Citations (Scopus)

Protein 14-3-3σ interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway

Kino, T., Souvatzoglou, E., De Martino, M. U., Tsopanomihalu, M., Wan, Y. & Chrousos, G. P., Jul 11 2003, In : Journal of Biological Chemistry. 278, 28, p. 25651-25656 6 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Glucocorticoid Receptors
Glucocorticoids
Ligands
Nuclear Export Signals
2002
13 Citations (Scopus)
Progestins
Glucocorticoids
Hormones
Genes
Glucocorticoid Receptors

Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells

Wan, Y. & Nordeen, S. K., 2002, In : Molecular Endocrinology. 16, 6, p. 1204-1214 11 p.

Research output: Contribution to journalArticle

Overlapping Genes
Progestins
Glucocorticoids
Breast Neoplasms
Genes
60 Citations (Scopus)

Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells

Wan, Y. & Nordeen, S. K., Jan 1 2002, In : Molecular Endocrinology. 16, 6, p. 1204-1214 11 p.

Research output: Contribution to journalArticle

Overlapping Genes
Progestins
Glucocorticoids
Breast Neoplasms
Genes
2001
3 Citations (Scopus)

Application of green fluorescent protein to the study of dynamic protein-protein interactions and subcellular trafficking of steroid receptors.

Nordeen, S. K., Housley, P. R., Wan, Y. & Day, R. N., 2001, In : Methods in molecular biology (Clifton, N.J.). 176, p. 179-199 21 p.

Research output: Contribution to journalArticle

Biological Transport
Luminescent Proteins
Subcellular Fractions
Steroid Receptors
Fluorescence Spectrometry
26 Citations (Scopus)

Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor

Wan, Y., Coxe, K. K., Thackray, V. G., Housley, P. R. & Nordeen, S. K., 2001, In : Molecular Endocrinology. 15, 1, p. 17-31 15 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Progesterone Receptors
Ligands
Green Fluorescent Proteins
Cell Nucleus Active Transport
2000
51 Citations (Scopus)

Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor

Schaufele, F., Chang, C. Y., Liu, W., Baxter, J. D., Nordeen, S. K., Wan, Y., Day, R. N. & McDonnell, D. P., 2000, In : Molecular Endocrinology. 14, 12, p. 2024-2039 16 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Ligands
Peptides
1999
29 Citations (Scopus)

Visualizing protein-protein interactions in the nucleus of the living cell

Day, R. N., Nordeen, S. K. & Wan, Y., 1999, In : Molecular Endocrinology. 13, 4, p. 517-526 10 p.

Research output: Contribution to journalArticle

Luminescent Proteins
Image Enhancement
Recombinant Fusion Proteins
Green Fluorescent Proteins
Cell Nucleus