• 2481 Citations
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19972020

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2020

Differential regulation of breast cancer bone metastasis by PARP1 and PARP2

Zuo, H., Yang, D., Yang, Q., Tang, H., Fu, Y. X. & Wan, Y., Dec 1 2020, In : Nature communications. 11, 1, 1578.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Opposing Functions of BRD4 Isoforms in Breast Cancer

Wu, S. Y., Lee, C. F., Lai, H. T., Yu, C. T., Lee, J. E., Zuo, H., Tsai, S. Y., Tsai, M. J., Ge, K., Wan, Y. & Chiang, C. M., Jun 18 2020, In : Molecular cell. 78, 6, p. 1114-1132.e10

Research output: Contribution to journalArticle

2018

mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1

Huynh, H. D. & Wan, Y., Dec 1 2018, In : Communications Biology. 1, 1, 29.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
2017

Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis

Chen, P., Zuo, H., Xiong, H., Kolar, M. J., Chu, Q., Saghatelian, A., Siegwart, D. J. & Wan, Y., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 580-585 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

High-Contrast Fluorescence Detection of Metastatic Breast Cancer Including Bone and Liver Micrometastases via Size-Controlled pH-Activatable Water-Soluble Probes

Xiong, H., Zuo, H., Yan, Y., Occhialini, G., Zhou, K., Wan, Y. & Siegwart, D. J., 2017, (Accepted/In press) In : Advanced Materials.

Research output: Contribution to journalArticle

27 Scopus citations

Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model

Du, Y., Sun, T., Liang, X., Li, Y., Jin, Z., Xue, H., Wan, Y. & Tian, J., Nov 21 2017, In : International Journal of Nanomedicine. 12, p. 8337-8351 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Lipid osteoclastokines regulate breast cancer bone metastasis

Krzeszinski, J. Y., Schwaid, A. G., Cheng, W. Y., Jin, Z., Gallegos, Z. R., Saghatelian, A. & Wan, Y., Mar 1 2017, In : Endocrinology. 158, 3, p. 477-489 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Milk lipid regulation at the maternal-offspring interface

Yang, D., Huynh, H. D. & Wan, Y., 2017, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

3 Scopus citations

mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss

Huynh, H. D., Wei, W. & Wan, Y., Jun 6 2017, In : Cell Reports. 19, 10, p. 2014-2025 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Nuclear Receptors in Skeletal Homeostasis

Zuo, H. & Wan, Y., 2017, (Accepted/In press) In : Current Topics in Developmental Biology.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Gata2 is a rheostat for mesenchymal stem cell fate in male mice

Li, X., Huynh, H., Zuo, H., Salminen, M. & Wan, Y., Mar 2016, In : Endocrinology. 157, 3, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects

Wei, W., Schwaid, A. G., Wang, X., Wang, X., Chen, S., Chu, Q., Saghatelian, A. & Wan, Y., Mar 8 2016, In : Cell Metabolism. 23, 3, p. 479-491 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Macrophage PPARγ inhibits GPR132 to mediate the anti-tumor effects of rosiglitazone

Cheng, W. Y., Huynh, H., Chen, P., Penã-Llopis, S. & Wan, Y., Oct 1 2016, In : eLife. 5, OCTOBER2016, e18501.

Research output: Contribution to journalArticle

14 Scopus citations

Unique epigenetic gene profiles define human breast cancers with poor prognosis

Peña-Llopis, S., Wan, Y. & Martinez, E. D., Jan 1 2016, In : Oncotarget. 7, 52, p. 85819-85831 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption

Wang, X., Wei, W., Krzeszinski, J. Y., Wang, Y. & Wan, Y., Nov 3 2015, In : Cell Metabolism. 22, 5, p. 811-824 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

HDAC9 inhibits osteoclastogenesis via mutual suppression of PPARγ/RANKL signaling

Jin, Z., Wei, W., Huynh, H. & Wan, Y., 2015, In : Molecular Endocrinology. 29, 5, p. 730-738 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Maternal adiponectin controls milk composition to prevent neonatal inflammation

Jin, Z., Du, Y., Schwaid, A. G., Asterholm, I. W., Scherer, P. E., Saghatelian, A. & Wan, Y., Apr 1 2015, In : Endocrinology. 156, 4, p. 1504-1513 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Minireview: Nuclear receptor regulation of osteoclast and bone remodeling

Jin, Z., Li, X. & Wan, Y., Jan 1 2015, In : Molecular Endocrinology. 29, 2, p. 172-186 15 p.

Research output: Contribution to journalArticle

24 Scopus citations

New therapeutic targets for cancer bone metastasis

Krzeszinski, J. Y. & Wan, Y., 2015, In : Trends in Pharmacological Sciences. 36, 6, p. 360-373 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation

Li, X., Wei, W., Huynh, H., Zuo, H., Wang, X. & Wan, Y., Jul 14 2015, In : eLife. 4, JULY 2015, e07217.

Research output: Contribution to journalArticle

10 Scopus citations

Sim1 inhibits bone formation by enhancing the sympathetic tone in male mice

Wang, X., Wei, W., Zinn, A. R. & Wan, Y., Apr 1 2015, In : Endocrinology. 156, 4, p. 1408-1415 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice

Bornstein, S., Brown, S. A., Le, P. T., Wang, X., DeMambro, V., Horowitz, M. C., MacDougald, O., Baron, R., Lotinun, S., Karsenty, G., Wei, W., Ferron, M., Kovacs, C. S., Clemmons, D., Wan, Y. & Rosen, C. J., Sep 1 2014, In : Endocrinology. 155, 9, p. 3516-3526 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

MiR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

Krzeszinski, J. Y., Wei, W., Huynh, H., Jin, Z., Wang, X., Chang, T. C., Xie, X. J., He, L., Mangala, L. S., Lopez-Berestein, G., Sood, A. K., Mendell, J. T. & Wan, Y., Aug 28 2014, In : Nature. 512, 7515, p. 431-435 5 p.

Research output: Contribution to journalArticle

220 Scopus citations

Mitochondrial complex i activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization

Jin, Z., Wei, W., Yang, M., Du, Y. & Wan, Y., Sep 2 2014, In : Cell Metabolism. 20, 3, p. 483-498 16 p.

Research output: Contribution to journalArticle

73 Scopus citations

Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action

Wei, W., Motoike, T., Krzeszinski, J. Y., Jin, Z., Xie, X-J., Dechow, P. C., Yanagisawa, M. & Wan, Y., Jun 3 2014, In : Cell Metabolism. 19, 6, p. 927-940 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered β-catenin switch

Jin, Z., Wei, W., Dechow, P. C. & Wan, Y., Feb 1 2013, In : Molecular Endocrinology. 27, 2, p. 325-335 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

IBAT on bone

Wan, Y., Aug 1 2013, In : Endocrinology. 154, 8, p. 2579-2580 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen

Gautron, L., Rutkowski, J. M., Burton, M. D., Wei, W., Wan, Y. & Elmquist, J. K., Jan 1 2013, In : Journal of Comparative Neurology. 521, 16, p. 3741-3767 27 p.

Research output: Contribution to journalArticle

69 Scopus citations
2012

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., Mangelsdorf, D. J., Kliewer, S. A. & Wan, Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3143-3148 6 p.

Research output: Contribution to journalArticle

236 Scopus citations

Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates

Du, Y., Yang, M., Wei, W., Huynh, H. D., Herz, J., Saghatelian, A. & Wan, Y., 2012, In : Nature communications. 3, 1008.

Research output: Contribution to journalArticle

16 Scopus citations

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A. & Wan, Y., Jun 1 2012, In : Genes and Development. 26, 12, p. 1306-1311 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Colbert Coate, K., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., Yu, R. T., Evans, R. M., Kliewer, S. A. & Mangelsdorf, D. J., Oct 15 2012, In : eLife. 2012, 1, e00065.

Research output: Contribution to journalArticle

181 Scopus citations

Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake

Zeve, D., Seo, J., Suh, J. M., Stenesen, D., Tang, W., Berglund, E. D., Wan, Y., Williams, L. J., Lim, A., Martinez, M. J., McKay, R. M., Millay, D. P., Olson, E. N. & Graff, J. M., Apr 4 2012, In : Cell Metabolism. 15, 4, p. 492-504 13 p.

Research output: Contribution to journalArticle

42 Scopus citations
2011

Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin

Wei, W., Zeve, D., Suh, J. M., Wang, X., Du, Y., Zerwekh, J. E., Dechow, P. C., Graff, J. M. & Wan, Y., Dec 2011, In : Molecular and cellular biology. 31, 23, p. 4706-4719 14 p.

Research output: Contribution to journalArticle

118 Scopus citations

Osteoclast progenitors reside in the peroxisome proliferator-activated receptor γ-expressing bone marrow cell population

Wei, W., Zeve, D., Wang, X., Du, Y., Tang, W., Dechow, P. C., Graff, J. M. & Wan, Y., Dec 2011, In : Molecular and cellular biology. 31, 23, p. 4692-4705 14 p.

Research output: Contribution to journalArticle

32 Scopus citations
2010

PGC1β mediates PPARγ activation of osteoclastogenesis and rosiglitazone-induced bone loss

Wei, W., Wang, X., Yang, M., Smith, L. C., Dechow, P. C. & Wan, Y., Jun 9 2010, In : Cell Metabolism. 11, 6, p. 503-516 14 p.

Research output: Contribution to journalArticle

146 Scopus citations

Rosiglitazone activation of PPARg suppresses fractalkine signaling

Wan, Y. & Evans, R. M., Feb 1 2010, In : Journal of molecular endocrinology. 44, 2, p. 135-142 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2007

Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk

Wan, Y., Saghatelian, A., Chong, L. W., Zhang, C. L., Cravatt, B. F. & Evans, R. M., Aug 1 2007, In : Genes and Development. 21, 15, p. 1895-1908 14 p.

Research output: Contribution to journalArticle

79 Scopus citations

PPAR-γ regulates osteoclastogenesis in mice

Wan, Y., Chong, L. W. & Evans, R. M., Dec 1 2007, In : Nature medicine. 13, 12, p. 1496-1503 8 p.

Research output: Contribution to journalArticle

386 Scopus citations
2003

Protein 14-3-3σ interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway

Kino, T., Souvatzoglou, E., De Martino, M. U., Tsopanomihalu, M., Wan, Y. & Chrousos, G. P., Jul 11 2003, In : Journal of Biological Chemistry. 278, 28, p. 25651-25656 6 p.

Research output: Contribution to journalArticle

57 Scopus citations
2002
13 Scopus citations

Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells

Wan, Y. & Nordeen, S. K., 2002, In : Molecular Endocrinology. 16, 6, p. 1204-1214 11 p.

Research output: Contribution to journalArticle

Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells

Wan, Y. & Nordeen, S. K., Jan 1 2002, In : Molecular Endocrinology. 16, 6, p. 1204-1214 11 p.

Research output: Contribution to journalArticle

60 Scopus citations
2001

Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor

Wan, Y., Coxe, K. K., Thackray, V. G., Housley, P. R. & Nordeen, S. K., Jan 1 2001, In : Molecular Endocrinology. 15, 1, p. 17-31 15 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
2000

Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor

Schaufele, F., Chang, C. Y., Liu, W., Baxter, J. D., Nordeen, S. K., Wan, Y., Day, R. N. & McDonnell, D. P., 2000, In : Molecular Endocrinology. 14, 12, p. 2024-2039 16 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations
1997

Genome analysis on linkage group VI of Neurospora crassa

Wan, Y., Liu, H., Li, C. & Schmidhauser, T. J., Jun 1997, In : Fungal Genetics and Biology. 21, 3, p. 329-336 8 p.

Research output: Contribution to journalArticle

4 Scopus citations