• 6871 Citations
  • 31 h-Index
19962019

Research output per year

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Research Output

  • 6871 Citations
  • 31 h-Index
  • 49 Article
  • 2 Comment/debate
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Article
2019

Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations

Kim, S., Zeng, W., Bernard, S., Liao, J., Venkateshwaran, M., Ane, J. M. & Jiang, Y., Dec 1 2019, In : Nature communications. 10, 1, 3703.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structural and functional characterization of an otopetrin family proton channel

Chen, Q., Zeng, W., She, J., Bai, X. & Jiang, Y., Apr 11 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

Wang, Y., Nguyen, N. X., She, J., Zeng, W., Yang, Y., Bai, X. & Jiang, Y., May 16 2019, In : Cell. 177, 5, p. 1252-1261.e13

Research output: Contribution to journalArticle

6 Scopus citations

Structural mechanisms of phospholipid activation of the human TPC2 channel

She, J., Zeng, W., Guo, J., Chen, Q., Bai, X. & Jiang, Y., Mar 12 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Cryo-EM structure of a fungal mitochondrial calcium uniporter

Nguyen, N. X., Armache, J. P., Lee, C., Yang, Y., Zeng, W., Mootha, V. K., Cheng, Y., Bai, X. C. & Jiang, Y., Jul 26 2018, In : Nature. 559, 7715, p. 570-574 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

She, J., Guo, J., Chen, Q., Zeng, W., Jiang, Y. & Bai, X. C., Apr 5 2018, In : Nature. 556, 7699, p. 130-134 5 p.

Research output: Contribution to journalArticle

43 Scopus citations
2017

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

Chen, Q., She, J., Zeng, W., Guo, J., Xu, H., Bai, X. C. & Jiang, Y., Oct 19 2017, In : Nature. 550, 7676, 24035.

Research output: Contribution to journalArticle

50 Scopus citations

Structures of the calcium-activated, non-selective cation channel TRPM4

Guo, J., She, J., Zeng, W., Chen, Q., Bai, X. C. & Jiang, Y., Dec 14 2017, In : Nature. 552, 7684, p. 205-209 5 p.

Research output: Contribution to journalArticle

60 Scopus citations

The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture

Lee, C., Guo, J., Zeng, W., Kim, S., She, J., Cang, C., Ren, D. & Jiang, Y., Jul 27 2017, In : Nature. 547, 7664, p. 472-475 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tuning the ion selectivity of two-pore channels

Guo, J., Zeng, W. & Jiang, Y., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1009-1014 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
2016

Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology

Barthmes, M., Liao, J., Jiang, Y., Brüggemann, A. & Wahl-Schott, C., 2016, In : Journal of General Physiology. 147, 6, p. 485-496 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger

Liao, J., Marinelli, F., Lee, C., Huang, Y., Faraldo-Gómez, J. D. & Jiang, Y., Jun 7 2016, In : Nature Structural and Molecular Biology. 23, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

Guo, J., Zeng, W., Chen, Q., Lee, C., Chen, L., Yang, Y., Cang, C., Ren, D. & Jiang, Y., Mar 10 2016, In : Nature. 531, 7593, p. 196-201 6 p.

Research output: Contribution to journalArticle

108 Scopus citations
2015

Structural and mechanistic roles of novel chemical ligands on the SdiA quorum-sensing transcription regulator

Nguyen, Y., Nguyen, N. X., Rogers, J. L., Liao, J., Macmillan, J. B., Jiang, Y. & Sperandio, V., Mar 31 2015, In : mBio. 6, 2, e02429-14.

Research output: Contribution to journalArticle

32 Scopus citations

Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide-gated channels

Lam, Y. L., Zeng, W., Derebe, M. G. & Jiang, Y., Sep 1 2015, In : Journal of General Physiology. 146, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

A motif in LILRB2 critical for Angptl2 binding and activation

Deng Ph.D., M., Lu, Z., Zheng, J., Wan, X., Chen, X., Hirayasu, K., Sun, H., Lam, Y., Chen, L., Wang, Q., Song, C., Huang, N., Gao, G. F., Jiang, Y., Arase, H. & Zhang, C., Aug 7 2014, In : Blood. 124, 6, p. 924-935 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome

Lee, E. E., Ma, J., Sacharidou, A., Mi, W., Salato, V. K., Nguyen, N., Jiang, Y., Pascual, J. M., North, P. E., Shaul, P. W., Mettlen, M. & Wang, R. C., Nov 24 2014, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

35 Scopus citations

Lipopolysaccharide assembly in the bacterial outer membrane revealed by X-ray crystallography

Jiang, Y. X., Sep 1 2014, In : Science China. Life sciences. 57, 9, p. 954-956 3 p.

Research output: Contribution to journalArticle

The conserved potassium channel filter can have distinct ion binding profiles: Structural analysis of rubidium, cesium, and barium binding in NaK2K

Lam, Y. L., Zeng, W., Sauer, D. B. & Jiang, Y., 2014, In : Journal of General Physiology. 144, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Sodium and potassium competition in potassium-selective and non-selective channels

Sauer, D. B., Zeng, W., Canty, J., Lam, Y. & Jiang, Y., 2013, In : Nature Communications. 4, 2721.

Research output: Contribution to journalArticle

32 Scopus citations

The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways

John, S. A., Liao, J., Jiang, Y. & Ottolia, M., Apr 30 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 18, p. 7500-7505 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

Kong, C., Zeng, W., Ye, S., Chen, L., Sauer, D. B., Lam, Y., Derebe, M. G. & Jiang, Y., Dec 13 2012, In : eLife. 2012, 1, e00184.

Research output: Contribution to journalArticle

16 Scopus citations

Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger

Liao, J., Li, H., Zeng, W., Sauer, D. B., Belmares, R. & Jiang, Y., Feb 10 2012, In : Science. 335, 6069, p. 686-690 5 p.

Research output: Contribution to journalArticle

149 Scopus citations
2011

Crucial points within the pore as Determinants of K+ channel conductance and gating

Shi, N., Zeng, W., Ye, S., Li, Y. & Jiang, Y., Aug 5 2011, In : Journal of Molecular Biology. 411, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Crystal structure of a potassium ion transporter, TrkH

Cao, Y., Jin, X., Huang, H., Derebe, M. G., Levin, E. J., Kabaleeswaran, V., Pan, Y., Punta, M., Love, J., Weng, J., Quick, M., Ye, S., Kloss, B., Bruni, R., Martinez-Hackert, E., Hendrickson, W. A., Rost, B., Javitch, J. A., Rajashankar, K. R., Jiang, Y. & 1 others, Zhou, M., Mar 17 2011, In : Nature. 471, 7338, p. 336-341 6 p.

Research output: Contribution to journalArticle

81 Scopus citations
25 Scopus citations
25 Scopus citations

Structural studies of ion selectivity in tetrameric cation channels

Alam, A. & Jiang, Y., May 2011, In : Journal of General Physiology. 137, 5, p. 397-403 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites

Derebe, M. G., Sauer, D. B., Zeng, W., Alam, A., Shia, N. & Jiang, Y., Jan 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 2, p. 598-602 5 p.

Research output: Contribution to journalArticle

61 Scopus citations
2010

Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore

Ye, S., Li, Y. & Jiang, Y., Aug 2010, In : Nature Structural and Molecular Biology. 17, 8, p. 1019-1023 5 p.

Research output: Contribution to journalArticle

96 Scopus citations
48 Scopus citations

Semisynthesis of NaK, a Na+ and K+ conducting ion channel

Linn, K. M., Derebe, M. G., Jiang, Y. & Valiyaveetil, F. I., Jun 1 2010, In : Biochemistry. 49, 21, p. 4450-4456 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structure of the gating ring from the human large-conductance Ca 2+-gated K+ channel

Wu, Y., Yang, Y., Ye, S. & Jiang, Y., Jul 15 2010, In : Nature. 466, 7304, p. 393-397 5 p.

Research output: Contribution to journalArticle

143 Scopus citations
2009

High-resolution structure of the open NaK channel

Alam, A. & Jiang, Y., Jan 2009, In : Nature Structural and Molecular Biology. 16, 1, p. 30-34 5 p.

Research output: Contribution to journalArticle

94 Scopus citations

Structural analysis of ion selectivity in the NaK channel

Alam, A. & Jiang, Y., Jan 2009, In : Nature Structural and Molecular Biology. 16, 1, p. 35-41 7 p.

Research output: Contribution to journalArticle

65 Scopus citations
2007

Gating and inward rectifying properties of the MthK K+ channel with and without the gating ring

Li, Y., Berke, I., Chen, L. & Jiang, Y., Feb 2007, In : Journal of General Physiology. 129, 2, p. 109-120 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Structural insight into Ca2+ specificity in tetrameric cation channels

Alam, A., Shi, N. & Jiang, Y., Sep 25 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 39, p. 15334-15339 6 p.

Research output: Contribution to journalArticle

36 Scopus citations
2006

Atomic structure of a Na+- and K+-conducting channel

Shi, N., Ye, S., Alam, A., Chen, L. & Jiang, Y., Mar 23 2006, In : Nature. 440, 7083, p. 570-574 5 p.

Research output: Contribution to journalArticle

176 Scopus citations

Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K+ Channels

Ye, S., Li, Y., Chen, L. & Jiang, Y., Sep 22 2006, In : Cell. 126, 6, p. 1161-1173 13 p.

Research output: Contribution to journalArticle

79 Scopus citations
2005

Structural of the MthK RCK domain and the effect of Ca2+ on gating ring stability

Dong, J., Shi, N., Berke, I., Chen, L. & Jiang, Y., Dec 16 2005, In : Journal of Biological Chemistry. 280, 50, p. 41716-41724 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
2003

Functional analysis of an archaebacterial voltage-dependent K+ channel

Ruta, V., Jiang, Y., Lee, A., Chen, J. & MacKinnon, R., Mar 13 2003, In : Nature. 422, 6928, p. 180-185 6 p.

Research output: Contribution to journalArticle

180 Scopus citations

The principle of gating charge movement in a voltage-dependent K+ channel

Jiang, Y., Ruta, V., Chen, J., Lee, A. & MacKinnon, R., 2003, In : Nature. 423, 6935, p. 42-48 7 p.

Research output: Contribution to journalArticle

678 Scopus citations

X-ray structure of a voltage-dependent K+ channel

Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B. T. & MacKinnon, R., 2003, In : Nature. 423, 6935, p. 33-41 9 p.

Research output: Contribution to journalArticle

1547 Scopus citations
2002

Crystal structure and mechanism of a calcium-gated potassium channel

Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T. & MacKinnon, R., May 30 2002, In : Nature. 417, 6888, p. 515-522 8 p.

Research output: Contribution to journalArticle

1146 Scopus citations

The open pore conformation of potassium channels

Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T. & MacKinnon, R., May 30 2002, In : Nature. 417, 6888, p. 523-526 4 p.

Research output: Contribution to journalArticle

1007 Scopus citations
2001

Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel

Jiang, Y., Pico, A., Cadene, M., Chait, B. T. & MacKinnon, R., 2001, In : Neuron. 29, 3, p. 593-601 9 p.

Research output: Contribution to journalArticle

238 Scopus citations
2000

The barium site in a potassium channel by X-ray crystallography

Jiang, Y. & MacKinnon, R., 2000, In : Journal of General Physiology. 115, 3, p. 269-272 4 p.

Research output: Contribution to journalArticle

158 Scopus citations
1997

Crystal structure of the EF-Tu·EF-Ts complex from Thermus thermophilus

Wang, Y., Jiang, Y., Meyering-Voss, M., Sprinzl, M. & Sigler, P. B., 1997, In : Nature Structural Biology. 4, 8, p. 650-656 7 p.

Research output: Contribution to journalArticle

120 Scopus citations
1996

Structure and importance of the dimerization domain in elongation factor Ts from Thermus thermophilus

Jiang, Y., Nock, S., Nesper, M., Sprinzl, M. & Sigler, P. B., 1996, In : Biochemistry. 35, 32, p. 10269-10278 10 p.

Research output: Contribution to journalArticle

36 Scopus citations