• 1436 Citations
  • 17 h-Index
19992019
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Research Output 1999 2019

  • 1436 Citations
  • 17 h-Index
  • 27 Article
2019
3 Citations (Scopus)

Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan

Li, F., Raczynska, J. E., Chen, Z. & Yu, H., Mar 19 2019, In : Cell Reports. 26, 12, p. 3336-3346.e4

Research output: Contribution to journalArticle

Open Access
Metalloproteases
Single-Stranded DNA
Chemical activation
DNA
Progeria
2018
4 Citations (Scopus)

An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue

Majumdar, S., Kim, T., Chen, Z., Munyoki, S., Tso, S. C., Brautigam, C. A. & Rice, L. M., Jun 1 2018, In : Molecular Biology of the Cell. 29, 11, p. 1359-1375 17 p.

Research output: Contribution to journalArticle

Microtubules
Tubulin
Proteins
Chromosome Segregation
Point Mutation
4 Citations (Scopus)

Atypical activation of the G protein Gαq by the oncogenic mutation Q209P

Maziarz, M., Leyme, A., Marivin, A., Luebbers, A., Patel, P. P., Chen, Z., Sprang, S. R. & Garcia-Marcos, M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 51, p. 19586-19599 14 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
GTP Phosphohydrolases
Bearings (structural)
Chemical activation
RGS Proteins
2 Citations (Scopus)

Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase

Chen, Z., Gutowski, S. & Sternweis, P. C., Apr 1 2018, In : Data in Brief. 17, p. 356-362 7 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
GTP Phosphohydrolases
rho GTP-Binding Proteins
Manuscripts
Pleckstrin Homology Domains
9 Citations (Scopus)

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity

Ye, R., Gordillo, R., Shao, M., Onodera, T., Chen, Z., Chen, S., Lin, X., SoRelle, J. A., Li, X., Tang, M., Keller, M. P., Kuliawat, R., Attie, A. D., Gupta, R. K., Holland, W. L., Beutler, B. A., Herz, J. & Scherer, P. E., Mar 1 2018, In : Journal of Clinical Investigation. 128, 3, p. 1178-1189 12 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipid Metabolism
Obesity
Insulin
Diet
4 Citations (Scopus)

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase

Volkov, O. A., Brockway, A. J., Wring, S. A., Peel, M., Chen, Z., Phillips, M. A. & De Brabander, J. K., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1182-1203 22 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Trypanosoma brucei brucei
African Trypanosomiasis
Parasites
Enzymes
2017
4 Citations (Scopus)

Direct regulation of p190RhoGEF by activated Rho and Rac GTPases

Dada, O., Gutowski, S., Brautigam, C. A., Chen, Z. & Sternweis, P. C., Jan 1 2017, (Accepted/In press) In : Journal of Structural Biology.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
rho GTP-Binding Proteins
Cell Shape
Cell Movement
Nucleotides
2016
12 Citations (Scopus)

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

Volkov, O. A., Kinch, L., Ariagno, C., Deng, X., Zhong, S., Grishin, N., Tomchick, D. R., Chen, Z. & Phillips, M. A., Dec 15 2016, In : eLife. 5, DECEMBER2016, e20198.

Research output: Contribution to journalArticle

Enzyme Activation
Chemical activation
Switches
Enzymes
Adenosylmethionine Decarboxylase
2015
29 Citations (Scopus)

Real-time resolution of point mutations that cause phenovariance in mice

Wang, T., Zhan, X., Bua, C. H., Lyona, S., Pratta, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E. E., Chen, Z., Zhang Ph.D., D-W., Yue, T., Wang, Y., Shi, H-X., Wang, J., Sun, L., SoRelle, J., McAlpine, W. & 28 others, Hutchins, N., Zhan, X., Fin, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J. L., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M. Y., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. & Beutler, B. A., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E440-E449

Research output: Contribution to journalArticle

Point Mutation
Mutation
Ethylnitrosourea
Phenotype
High-Throughput Nucleotide Sequencing
5 Citations (Scopus)
Rho Guanine Nucleotide Exchange Factors
PDZ Domains
Binding Sites
Ligands
Guanine Nucleotide Exchange Factors
2014
105 Citations (Scopus)

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

Hunter, J. C., Gurbani, D., Ficarro, S. B., Carrasco, M. A., Lim, S. M., Choi, H. G., Xie, T., Marto, J. A., Chen, Z., Gray, N. S. & Westover, K. D., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 24, p. 8895-8900 6 p.

Research output: Contribution to journalArticle

Guanine Nucleotides
Catalytic Domain
ras Proteins
ras Genes
Guanosine Triphosphate
13 Citations (Scopus)

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. Y. & Beutler, B., May 20 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7367-7372 6 p.

Research output: Contribution to journalArticle

Mitochondrial Myopathies
Thinness
Respiration
Mutation
Proteins
67 Citations (Scopus)

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion

Hara, K., Zheng, G., Qu, Q., Liu, H., Ouyang, Z., Chen, Z., Tomchick, D. R. & Yu, H., Jan 1 2014, In : Nature Structural and Molecular Biology. 21, 10, p. 864-870 7 p.

Research output: Contribution to journalArticle

Separase
Prophase
Chromosome Segregation
Anaphase
Chromatids
113 Citations (Scopus)

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X. & Chen, Z., Feb 13 2014, In : Cell Reports. 6, 3, p. 421-430 10 p.

Research output: Contribution to journalArticle

Chemical activation
Switches
DNA
Sensors
GMP synthase (glutamine-hydrolyzing)
2013
27 Citations (Scopus)

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Medina, F., Carter, A. M., Dada, O., Gutowski, S., Hadas, J., Chen, Z. & Sternweis, P. C., Apr 19 2013, In : Journal of Biological Chemistry. 288, 16, p. 11325-11333 9 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
GTP Phosphohydrolases
Feedback
Proteins
Pleckstrin Homology Domains
25 Citations (Scopus)

The bacterial effector VopL organizes actin into filament-like structures

Zahm, J. A., Padrick, S. B., Chen, Z., Pak, C. W., Yunus, A. A., Henry, L., Tomchick, D. R., Chen, Z. & Rosen, M. K., Oct 10 2013, In : Cell. 155, 2, p. 423-434 12 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actins
Monomers
Actin-Related Protein 2-3 Complex
Vibrio parahaemolyticus
2012
26 Citations (Scopus)

Activation of p115-RhoGEF requires direct association of Gα13and the Dbl homology domain

Chen, Z., Guo, L., Hadas, J., Gutowski, S., Sprang, S. R. & Sternweis, P. C., Jul 20 2012, In : Journal of Biological Chemistry. 287, 30, p. 25490-25500 11 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Chemical activation
Association reactions
Guanine Nucleotide Exchange Factors
Binding Sites
2011
22 Citations (Scopus)

Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

Chen, Z., Guo, L., Sprang, S. R. & Sternweis, P. C., Jan 2011, In : Protein Science. 20, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Guanine Nucleotides
Crystal structure
Switches
Modulation
2010
36 Citations (Scopus)

Activated RhoA binds to the Pleckstrin Homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation

Chen, Z., Medina, F., Liu, M. Y., Thomas, C., Sprang, S. R. & Sternweis, P. C., Jul 2 2010, In : Journal of Biological Chemistry. 285, 27, p. 21070-21081 12 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Homeostasis
Nucleotides
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
2008
30 Citations (Scopus)

Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF

Chen, Z., Singer, W. D., Danesh, S. M., Sternweis, P. C. & Sprang, S. R., Oct 8 2008, In : Structure. 16, 10, p. 1532-1543 12 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
GTPase-Activating Proteins
Binding Sites
Heterotrimeric GTP-Binding Proteins
Protein Binding
2007
43 Citations (Scopus)

Regulation of Rho Guanine Nucleotide Exchange Factors by G Proteins

Sternweis, P. C., Carter, A. M., Chen, Z., Danesh, S. M., Hsiung, Y. F. & Singer, W. D., 2007, In : Advances in Protein Chemistry. 74, p. 189-228 40 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
GTP-Binding Proteins
G12-G13 GTP-Binding Protein alpha Subunits
Genes
Heterotrimeric GTP-Binding Proteins
68 Citations (Scopus)

Structural Basis of Effector Regulation and Signal Termination in Heterotrimeric Gα Proteins

Sprang, S. R., Chen, Z. & Du, X., 2007, In : Advances in Protein Chemistry. 74, p. 1-65 65 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
Guanosine Triphosphate
Switches
GTP-Binding Proteins
Hydrolysis
2005
76 Citations (Scopus)

Structure of the p115RhoGEF rgRGS domain-Gα13/i1 chimera complex suggests convergent evolution of a GTPase activator

Chen, Z., Singer, W. D., Sternweis, P. C. & Sprang, S. R., Feb 20 2005, In : Nature Structural and Molecular Biology. 12, 2, p. 191-197 7 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolase Activators
Rho Guanine Nucleotide Exchange Factors
GTP-Binding Protein Regulators
GTPase-Activating Proteins
Guanine Nucleotide Exchange Factors
2003
34 Citations (Scopus)

Mapping the Gα13 binding interface of the rgRGS domain of p115RhoGEF

Chen, Z., Singer, W. D., Wells, C. D., Sprang, S. R. & Sternweis, P. C., Mar 14 2003, In : Journal of Biological Chemistry. 278, 11, p. 9912-9919 8 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
GTP-Binding Protein Regulators
GTP-Binding Proteins
GTPase-Activating Proteins
Mutation
2001
94 Citations (Scopus)

C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity

Nalefski, E. A., Wisner, M. A., Chen, J. Z., Sprang, S. R., Fukuda, M., Mikoshiba, K. & Falke, J. J., Mar 13 2001, In : Biochemistry. 40, 10, p. 3089-3100 12 p.

Research output: Contribution to journalArticle

Cytosolic Phospholipases A2
Synaptotagmins
Membranes
Protein Kinase C
Static Electricity
50 Citations (Scopus)

Structure of the rgRGs domain of p115RhoGEF

Chen, Z., Wells, C. D., Sternweis, P. C. & Sprang, S. R., 2001, In : Nature Structural Biology. 8, 9, p. 805-809 5 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
GTP-Binding Protein Regulators
GTPase-Activating Proteins
GTP-Binding Proteins
RGS Proteins
1999
531 Citations (Scopus)

Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated

Melkonian, K. A., Ostermeyer, A. G., Chen, J. Z., Roth, M. G. & Brown, D. A., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3910-3917 8 p.

Research output: Contribution to journalArticle

Protein Transport
Detergents
Membranes
Lipids
Proteins