• 1450 Citations
  • 17 h-Index
19992019

Research output per year

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Research Output

  • 1450 Citations
  • 17 h-Index
  • 27 Article

Activated RhoA binds to the Pleckstrin Homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation

Chen, Z., Medina, F., Liu, M. Y., Thomas, C., Sprang, S. R. & Sternweis, P. C., Jul 2 2010, In : Journal of Biological Chemistry. 285, 27, p. 21070-21081 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Medina, F., Carter, A. M., Dada, O., Gutowski, S., Hadas, J., Chen, Z. & Sternweis, P. C., Apr 19 2013, In : Journal of Biological Chemistry. 288, 16, p. 11325-11333 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Activation of p115-RhoGEF requires direct association of Gα13and the Dbl homology domain

Chen, Z., Guo, L., Hadas, J., Gutowski, S., Sprang, S. R. & Sternweis, P. C., Jul 20 2012, In : Journal of Biological Chemistry. 287, 30, p. 25490-25500 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue

Majumdar, S., Kim, T., Chen, Z., Munyoki, S., Tso, S. C., Brautigam, C. A. & Rice, L. M., Jun 1 2018, In : Molecular Biology of the Cell. 29, 11, p. 1359-1375 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

Atypical activation of the G protein Gαq by the oncogenic mutation Q209P

Maziarz, M., Leyme, A., Marivin, A., Luebbers, A., Patel, P. P., Chen, Z., Sprang, S. R. & Garcia-Marcos, M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 51, p. 19586-19599 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity

Nalefski, E. A., Wisner, M. A., Chen, J. Z., Sprang, S. R., Fukuda, M., Mikoshiba, K. & Falke, J. J., Mar 13 2001, In : Biochemistry. 40, 10, p. 3089-3100 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase

Chen, Z., Gutowski, S. & Sternweis, P. C., Apr 1 2018, In : Data in Brief. 17, p. 356-362 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Direct regulation of p190RhoGEF by activated Rho and Rac GTPases

Dada, O., Gutowski, S., Brautigam, C. A., Chen, Z. & Sternweis, P. C., Jan 1 2017, (Accepted/In press) In : Journal of Structural Biology.

Research output: Contribution to journalArticle

4 Scopus citations

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

Hunter, J. C., Gurbani, D., Ficarro, S. B., Carrasco, M. A., Lim, S. M., Choi, H. G., Xie, T., Marto, J. A., Chen, Z., Gray, N. S. & Westover, K. D., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 24, p. 8895-8900 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity

Ye, R., Gordillo, R., Shao, M., Onodera, T., Chen, Z., Chen, S., Lin, X., SoRelle, J. A., Li, X., Tang, M., Keller, M. P., Kuliawat, R., Attie, A. D., Gupta, R. K., Holland, W. L., Beutler, B. A., Herz, J. & Scherer, P. E., Mar 1 2018, In : Journal of Clinical Investigation. 128, 3, p. 1178-1189 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mapping the Gα13 binding interface of the rgRGS domain of p115RhoGEF

Chen, Z., Singer, W. D., Wells, C. D., Sprang, S. R. & Sternweis, P. C., Mar 14 2003, In : Journal of Biological Chemistry. 278, 11, p. 9912-9919 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

Chen, Z., Guo, L., Sprang, S. R. & Sternweis, P. C., Jan 2011, In : Protein Science. 20, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. Y. & Beutler, B., May 20 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7367-7372 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Real-time resolution of point mutations that cause phenovariance in mice

Wang, T., Zhan, X., Bua, C. H., Lyona, S., Pratta, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E. E., Chen, Z., Zhang Ph.D., D-W., Yue, T., Wang, Y., Shi, H-X., Wang, J., Sun, L., SoRelle, J., McAlpine, W. & 28 others, Hutchins, N., Zhan, X., Fin, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J. L., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M. Y., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. & Beutler, B. A., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E440-E449

Research output: Contribution to journalArticle

30 Scopus citations

Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF

Chen, Z., Singer, W. D., Danesh, S. M., Sternweis, P. C. & Sprang, S. R., Oct 8 2008, In : Structure. 16, 10, p. 1532-1543 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Regulation of Rho Guanine Nucleotide Exchange Factors by G Proteins

Sternweis, P. C., Carter, A. M., Chen, Z., Danesh, S. M., Hsiung, Y. F. & Singer, W. D., 2007, In : Advances in Protein Chemistry. 74, p. 189-228 40 p.

Research output: Contribution to journalArticle

43 Scopus citations

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

Volkov, O. A., Kinch, L., Ariagno, C., Deng, X., Zhong, S., Grishin, N., Tomchick, D. R., Chen, Z. & Phillips, M. A., Dec 15 2016, In : eLife. 5, DECEMBER2016, e20198.

Research output: Contribution to journalArticle

12 Scopus citations

Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated

Melkonian, K. A., Ostermeyer, A. G., Chen, J. Z., Roth, M. G. & Brown, D. A., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3910-3917 8 p.

Research output: Contribution to journalArticle

531 Scopus citations
6 Scopus citations

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase

Volkov, O. A., Brockway, A. J., Wring, S. A., Peel, M., Chen, Z., Phillips, M. A. & De Brabander, J. K., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1182-1203 22 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural Basis of Effector Regulation and Signal Termination in Heterotrimeric Gα Proteins

Sprang, S. R., Chen, Z. & Du, X., 2007, In : Advances in Protein Chemistry. 74, p. 1-65 65 p.

Research output: Contribution to journalArticle

69 Scopus citations

Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan

Li, F., Raczynska, J. E., Chen, Z. & Yu, H., Mar 19 2019, In : Cell Reports. 26, 12, p. 3336-3346.e4

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion

Hara, K., Zheng, G., Qu, Q., Liu, H., Ouyang, Z., Chen, Z., Tomchick, D. R. & Yu, H., Jan 1 2014, In : Nature Structural and Molecular Biology. 21, 10, p. 864-870 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Structure of the p115RhoGEF rgRGS domain-Gα13/i1 chimera complex suggests convergent evolution of a GTPase activator

Chen, Z., Singer, W. D., Sternweis, P. C. & Sprang, S. R., Feb 20 2005, In : Nature Structural and Molecular Biology. 12, 2, p. 191-197 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

Structure of the rgRGs domain of p115RhoGEF

Chen, Z., Wells, C. D., Sternweis, P. C. & Sprang, S. R., 2001, In : Nature Structural Biology. 8, 9, p. 805-809 5 p.

Research output: Contribution to journalArticle

50 Scopus citations

The bacterial effector VopL organizes actin into filament-like structures

Zahm, J. A., Padrick, S. B., Chen, Z., Pak, C. W., Yunus, A. A., Henry, L., Tomchick, D. R., Chen, Z. & Rosen, M. K., Oct 10 2013, In : Cell. 155, 2, p. 423-434 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X. & Chen, Z., Feb 13 2014, In : Cell Reports. 6, 3, p. 421-430 10 p.

Research output: Contribution to journalArticle

116 Scopus citations