• 32397 Citations
  • 81 h-Index
1990 …2019

Research output per year

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Research Output

2019

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Gui, X., Yang, H., Li, T., Tan, X., Shi, P., Li, M., Du, F. & Chen, Z., Mar 14 2019, In : Nature. 567, 7747, p. 262-266 5 p.

Research output: Contribution to journalLetter

42 Scopus citations

cGAS in action: Expanding roles in immunity and inflammation

Ablasser, A. & Chen, Z., Mar 8 2019, In : Science (New York, N.Y.). 363, 6431

Research output: Contribution to journalReview article

44 Scopus citations

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

Shang, G., Zhang, C., Chen, Z., Bai, X. & Zhang, X., Mar 21 2019, In : Nature. 567, 7748, p. 389-393 5 p.

Research output: Contribution to journalLetter

26 Scopus citations

Structural basis of STING binding with and phosphorylation by TBK1

Zhang, C., Shang, G., Gui, X., Zhang, X., Bai, X. & Chen, Z., Jan 1 2019, In : Nature.

Research output: Contribution to journalLetter

26 Scopus citations
2018

A GTPase-activating protein– binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells

Ramachandran, B., Stabley, J. N., Cheng, S. L., Behrmann, A. S., Gay, A., Li, L., Mead, M., Kozlitina, J., Lemoff, A., Mirzaei, H., Chen, Z. & Towler, D. A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 21, p. 7942-7968 27 p.

Research output: Contribution to journalArticle

7 Scopus citations

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

Tian, J., Wu, J., Chen, X., Guo, T., Chen, Z. J., Goldstein, J. L. & Brown, M. S., Jun 27 2018, In : eLife. 7, e36826.

Research output: Contribution to journalArticle

4 Scopus citations

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J. B., Cannon-Albright, L. A., Cantley, L. C., Cavenee, W. K., Chen, Z., Croce, C. M., Andrea, A. D., Gandara, D., Giorgi, C., Jia, W., Lan, Q., Mak, T. W., Manley, J. L., Mikoshiba, K., Onuchic, J. N., Pass, H. I., Pinton, P. & 8 others, Prives, C., Rothman, N., Sebti, S. M., Turkson, J., Wu, X., Yang, H., Yu, H. & Melino, G., Nov 1 2018, In : Cell Death and Differentiation. 25, 11, p. 1885-1904 20 p.

Research output: Contribution to journalReview article

7 Scopus citations

Cytosolic DNA sensing promotes macrophage transformation and governs myocardial ischemic injury

Cao, D. J., Schiattarella, G. G., Villalobos, E., Jiang, N., May, H. I., Li, T., Chen, Z., Gillette, T. G. & Hill, J. A., Jun 12 2018, In : Circulation. 137, 24, p. 2613-2634 22 p.

Research output: Contribution to journalArticle

20 Scopus citations

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

Tan, X., Sun, L., Chen, J. & Chen, Z. J., Sep 8 2018, In : Annual Review of Microbiology. 72, p. 447-478 32 p.

Research output: Contribution to journalReview article

41 Scopus citations

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

Du, M. & Chen, Z. J., Jul 5 2018, (Accepted/In press) In : Science.

Research output: Contribution to journalArticle

66 Scopus citations

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

Chen, J. & Chen, Z., Dec 6 2018, In : Nature. 564, 7734, p. 71-76 6 p.

Research output: Contribution to journalArticle

49 Scopus citations

Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression

Zhang, K., Shang, G., Padavannil, A., Wang, J., Sakthivel, R., Chen, X., Kim, M., Thompson, M. G., García-Sastre, A., Lynch, K. W., Chen, Z., Chook, Y. M. & Fontoura, B. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12218-E12227

Research output: Contribution to journalArticle

1 Scopus citations

The cGAS-cGAMP-STI NG pathway connects DNA damage to inflammation, senescence, and cancer

Li, T. & Chen, Z. J., May 1 2018, In : Journal of Experimental Medicine. 215, 5, p. 1287-1299 13 p.

Research output: Contribution to journalReview article

119 Scopus citations
2017

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

Golden, R. J., Chen, B., Li, T., Braun, J., Manjunath, H., Chen, X., Wu, J., Schmid, V., Chang, T. C., Kopp, F., Ramirez-Martinez, A., Tagliabracci, V. S., Chen, Z. J., Xie, Y. & Mendell, J. T., Feb 9 2017, In : Nature. 542, 7640, p. 197-202 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

A STING-activating nanovaccine for cancer immunotherapy

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y. X., Chen, Z. J. & Gao, J., Jul 1 2017, In : Nature Nanotechnology. 12, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

147 Scopus citations

cGAS is essential for the antitumor effect of immune checkpoint blockade

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L. & Chen, Z. J., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

102 Scopus citations

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

Xu, M. M., Pu, Y., Han, D., Shi, Y., Cao, X., Liang, H., Chen, X., Li, X. D., Deng, L., Chen, Z. J., Weichselbaum, R. R. & Fu, Y. X., Aug 15 2017, In : Immunity. 47, 2, p. 363-373.e5

Research output: Contribution to journalArticle

47 Scopus citations

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication

Kuss-Duerkop, S. K., Wang, J., Mena, I., White, K., Metreveli, G., Sakthivel, R., Mata, M. A., Muñoz-Moreno, R., Chen, X., Krammer, F., Diamond, M. S., Chen, Z. J., García-Sastre, A. & Fontoura, B. M. A., Sep 1 2017, In : PLoS Pathogens. 13, 9, e1006635.

Research output: Contribution to journalArticle

12 Scopus citations

Innate immune activation by cGMP-AMP nanoparticles leads to potent and long-acting antiretroviral response against HIV-1

Aroh, C., Wang, Z., Dobbs, N., Luo, M., Chen, Z., Gao, J. & Yan, N., Dec 1 2017, In : Journal of Immunology. 199, 11, p. 3840-3848 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage

Zhou, W., Xu, J., Li, H., Xu, M., Chen, Z. J., Wei, W., Pan, Z. & Sun, Y., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 1104-1116 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Prion-like polymerization in immunity and inflammation

Cai, X., Xu, H. & Chen, Z. J., Apr 1 2017, In : Cold Spring Harbor perspectives in biology. 9, 4, a023580.

Research output: Contribution to journalArticle

15 Scopus citations

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

Moretti, J., Roy, S., Bozec, D., Martinez, J., Chapman, J. R., Ueberheide, B., Lamming, D. W., Chen, Z. J., Horng, T., Yeretssian, G., Green, D. R. & Blander, J. M., Nov 2 2017, In : Cell. 171, 4, p. 809-823.e13

Research output: Contribution to journalArticle

72 Scopus citations

TEMPORARY REMOVAL: Synthetic nanovaccines for immunotherapy

Luo, M., Samandi, L. Z., Wang, Z., Chen, Z. J. & Gao, J., Jan 16 2017, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

27 Scopus citations

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects

Choo, M. K., Sano, Y., Kim, C., Yasuda, K., Li, X. D., Lin, X., Stenzel-Poore, M., Alexopoulou, L., Ghosh, S., Latz, E., Rifkin, I. R., Chen, Z. J., Stewart, G. C., Chong, H. & Park, J. M., May 1 2017, In : Journal of Experimental Medicine. 214, 5, p. 1297-1311 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Erratum: K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping (Molecular Cell (2016) 63(3) (540) (S1097276516301800) (10.1016/j.molcel.2016.05.017))

Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., Chen, Z. J., Busch, J., Schmitz, M. L. & Kracht, M., Aug 4 2016, In : Molecular Cell. 63, 3, p. 540 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

Christensen, M. H., Jensen, S. B., Miettinen, J. J., Luecke, S., Prabakaran, T., Reinert, L. S., Mettenleiter, T., Chen, Z. J., Knipe, D. M., Sandri-Goldin, R. M., Enquist, L. W., Hartmann, R., Mogensen, T. H., Rice, S. A., Nyman, T. A., Matikainen, S. & Paludan, S. R., Jul 1 2016, In : EMBO Journal. 35, 13, p. 1385-1399 15 p.

Research output: Contribution to journalArticle

63 Scopus citations

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., Chen, Z. J., Busch, J., Schmitz, M. L. & Kracht, M., Jun 16 2016, In : Molecular Cell. 62, 6, p. 943-957 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L. & Chen, Z. J., Sep 20 2016, In : Nature Immunology. 17, 10, p. 1142-1149 8 p.

Research output: Contribution to journalReview article

375 Scopus citations

Streptococci engage TLR13 on myeloid cells in a site-specific fashion

Kolter, J., Feuerstein, R., Spoeri, E., Gharun, K., Elling, R., Trieu-Cuot, P., Goldmann, T., Waskow, C., Chen, Z. J., Kirschning, C. J., Deshmukh, S. D. & Henneke, P., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2733-2741 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X. D., Chen, X., Li, Q. Z., Wight-Carter, M. & Chen, Z. J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5699-E5705

Research output: Contribution to journalArticle

193 Scopus citations

Editorial overview: Innate immunity

Chen, Z. J. & Amigorena, S., Feb 1 2015, In : Current Opinion in Immunology. 32, p. 5-6 2 p.

Research output: Contribution to journalEditorial

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

Stein, K., Brand, S., Jenckel, A., Sigmund, A., Chen, Z. J., Kirschning, C. J., Kauth, M. & Heine, H., Sep 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

10 Scopus citations

Innate immune response to streptococcus pyogenes depends on the combined activation of TLR13 and TLR2

Fieber, C., Janos, M., Koestler, T., Gratz, N., Li, X. D., Castiglia, V., Aberle, M., Sauert, M., Wegner, M., Alexopoulou, L., Kirschning, C. J., Chen, Z. J., Von Haeseler, A. & Kovarik, P., Mar 10 2015, In : PloS one. 10, 3, e0119727.

Research output: Contribution to journalArticle

26 Scopus citations
22 Scopus citations

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y. T., Grishin, N. V. & Chen, Z. J., Mar 13 2015, In : Science. 347, 6227, aaa2630.

Research output: Contribution to journalArticle

416 Scopus citations
2014

A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells

Dubois, S. M., Alexia, C., Wu, Y., Leclair, H. M., Leveau, C., Schol, E., Fest, T., Tarte, K., Chen, Z. J., Gavard, J. & Bidère, N., Apr 3 2014, In : Blood. 123, 14, p. 2199-2203 5 p.

Research output: Contribution to journalArticle

57 Scopus citations

A novel mitochondrial MAVS/caspase-8 platform links RNA virus-induced innate antiviral signaling to bax/bak-independent apoptosis

Maadidi, S. E., Faletti, L., Berg, B., Wenzl, C., Wieland, K., Chen, Z. J., Maurer, U. & Borner, C., Feb 1 2014, In : Journal of Immunology. 192, 3, p. 1171-1183 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Apoptotic caspases prevent the induction of type i interferons by mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., De Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C. Y., Taniguchi, T., Shadel, G. S., Chen, Z. J., Iwasaki, A. & Flavell, R. A., Dec 18 2014, In : Cell. 159, 7, p. 1563-1577 15 p.

Research output: Contribution to journalArticle

243 Scopus citations

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

Collins, A. C., Cai, H., Li, T., Franco, L. H., Li, X. D., Nair, V. R., Scharn, C. R., Stamm, C. E., Levine, B., Chen, Z. J. & Shiloh, M. U., Nov 20 2014, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

156 Scopus citations

IKKβ is an IRF5 kinase that instigates inflammation

Ren, J., Chen, X. & Chen, Z. J., Dec 9 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17438-17443 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Innate immune sensing and signaling of cytosolic nucleic acids

Wu, J. & Chen, Z. J., Jan 1 2014, In : Annual review of immunology. 32, p. 461-488 28 p.

Research output: Contribution to journalReview article

443 Scopus citations

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

Yuan, W. C., Lee, Y. R., Lin, S. Y., Chang, L. Y., Tan, Y. P., Hung, C. C., Kuo, J. C., Liu, C. H., Lin, M. Y., Xu, M., Chen, Z. J. & Chen, R. H., May 22 2014, In : Molecular cell. 54, 4, p. 586-600 15 p.

Research output: Contribution to journalArticle

64 Scopus citations

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M. Y., Pedersen, G., McInerney, G. M., Hedestam, G. B. K., Chen, Z. J. & Beutler, B., Dec 19 2014, In : Science. 346, 6216, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway

Dai, P., Wang, W., Cao, H., Avogadri, F., Dai, L., Drexler, I., Joyce, J. A., Li, X. D., Chen, Z., Merghoub, T., Shuman, S. & Deng, L., Apr 2014, In : PLoS pathogens. 10, 4, e1003989.

Research output: Contribution to journalArticle

66 Scopus citations

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

Chong, R. A., Wu, K., Spratt, D. E., Yang, Y., Lee, C., Nayak, J., Xu, M., Elkholi, R., Tappin, I., Li, J., Hurwitz, J., Brown, B. D., Chipuk, J. E., Chen, Z. J., Sanchez, R., Shaw, G. S., Huang, L. & Pan, A. Z. Q., Jun 10 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 23, p. 8434-8439 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prion-like polymerization as a signaling mechanism

Cai, X. & Chen, Z. J., Dec 1 2014, In : Trends in Immunology. 35, 12, p. 622-630 9 p.

Research output: Contribution to journalReview article

20 Scopus citations

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q. X., Halfmann, R. & Chen, Z. J., Mar 13 2014, In : Cell. 156, 6, p. 1207-1222 16 p.

Research output: Contribution to journalArticle

269 Scopus citations

STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X. D., Mauceri, H., Beckett, M., Darga, T., Huang, X., Gajewski, T. F., Chen, Z. J., Fu, Y. X. & Weichselbaum, R. R., Nov 20 2014, In : Immunity. 41, 5, p. 843-852 10 p.

Research output: Contribution to journalArticle

510 Scopus citations

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Xu, H., He, X., Zheng, H., Huang, L. J., Hou, F., Yu, Z., de la Cruz, M. J., Borkowski, B., Zhang, X., Chen, Z. J. & Jiang, Q. X., Feb 25 2014, In : eLife. 2014, 3, e01489.

Research output: Contribution to journalArticle

93 Scopus citations

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

Peisley, A., Wu, B., Xu, H., Chen, Z. J. & Hur, S., Jan 1 2014, In : Nature. 508, 7498, p. 110-114 5 p.

Research output: Contribution to journalArticle

171 Scopus citations