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Research Output 1990 2019

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Article
2018
6 Citations (Scopus)

A GTPase-activating protein– binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells

Ramachandran, B., Stabley, J. N., Cheng, S. L., Behrmann, A. S., Gay, A., Li, L., Mead, M., Kozlitina, J., Lemoff, A., Mirzaei, H., Chen, Z. & Towler, D. A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 21, p. 7942-7968 27 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Methylation
Vascular Smooth Muscle
Protein Binding
Smooth Muscle Myocytes
3 Citations (Scopus)

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

Tian, J., Wu, J., Chen, X., Guo, T., Chen, Z. J., Goldstein, J. L. & Brown, M. S., Jun 27 2018, In : eLife. 7, e36826.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Liver
Rodentia
Transcription Factors
Insulin
16 Citations (Scopus)

Cytosolic DNA sensing promotes macrophage transformation and governs myocardial ischemic injury

Cao, D. J., Schiattarella, G. G., Villalobos, E., Jiang, N., May, H. I., Li, T., Chen, Z., Gillette, T. G. & Hill, J. A., Jun 12 2018, In : Circulation. 137, 24, p. 2613-2634 22 p.

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Macrophages
DNA
Wounds and Injuries
Phenotype
60 Citations (Scopus)

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

Du, M. & Chen, Z. J., Jul 5 2018, (Accepted/In press) In : Science.

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
DNA
cyclic guanosine monophosphate-adenosine monophosphate
40 Citations (Scopus)

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

Chen, J. & Chen, Z., Dec 6 2018, In : Nature. 564, 7734, p. 71-76 6 p.

Research output: Contribution to journalArticle

Inflammasomes
trans-Golgi Network
Polymerization
Proteins
phosphatidylinositol 4-phosphate
1 Citation (Scopus)

Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression

Zhang, K., Shang, G., Padavannil, A., Wang, J., Sakthivel, R., Chen, X., Kim, M., Thompson, M. G., García-Sastre, A., Lynch, K. W., Chen, Z., Chook, Y. M. & Fontoura, B. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12218-E12227

Research output: Contribution to journalArticle

Protein Splicing
Viral Genes
Gene Expression
Messenger RNA
Cell Nucleus Active Transport
2017
64 Citations (Scopus)

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

Golden, R. J., Chen, B., Li, T., Braun, J., Manjunath, H., Chen, X., Wu, J., Schmid, V., Chang, T. C., Kopp, F., Ramirez-Martinez, A., Tagliabracci, V. S., Chen, Z. J., Xie, Y. & Mendell, J. T., Feb 9 2017, In : Nature. 542, 7640, p. 197-202 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Phosphorylation
Clustered Regularly Interspaced Short Palindromic Repeats
Argonaute Proteins
Complementary RNA
131 Citations (Scopus)

A STING-activating nanovaccine for cancer immunotherapy

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y. X., Chen, Z. J. & Gao, J., Jul 1 2017, In : Nature Nanotechnology. 12, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

interferon
Interferons
genes
Tumors
tumors
94 Citations (Scopus)

cGAS is essential for the antitumor effect of immune checkpoint blockade

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L. & Chen, Z. J., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Cross-Priming
Interferon Type I
Experimental Melanomas
Antibodies
41 Citations (Scopus)

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

Xu, M. M., Pu, Y., Han, D., Shi, Y., Cao, X., Liang, H., Chen, X., Li, X. D., Deng, L., Chen, Z. J., Weichselbaum, R. R. & Fu, Y. X., Aug 15 2017, In : Immunity. 47, 2, p. 363-373.e5

Research output: Contribution to journalArticle

Cross-Priming
Mitochondrial DNA
Dendritic Cells
Macrophages
Neoplasms
10 Citations (Scopus)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication

Kuss-Duerkop, S. K., Wang, J., Mena, I., White, K., Metreveli, G., Sakthivel, R., Mata, M. A., Muñoz-Moreno, R., Chen, X., Krammer, F., Diamond, M. S., Chen, Z. J., García-Sastre, A. & Fontoura, B. M. A., Sep 1 2017, In : PLoS Pathogens. 13, 9, e1006635.

Research output: Contribution to journalArticle

Orthomyxoviridae
Virus Diseases
Viral Proteins
TOR complex 2
mechanistic target of rapamycin complex 1
11 Citations (Scopus)

Innate immune activation by cGMP-AMP nanoparticles leads to potent and long-acting antiretroviral response against HIV-1

Aroh, C., Wang, Z., Dobbs, N., Luo, M., Chen, Z., Gao, J. & Yan, N., Dec 1 2017, In : Journal of Immunology. 199, 11, p. 3840-3848 9 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Nanoparticles
HIV-1
Anti-Retroviral Agents
Pattern Recognition Receptors
25 Citations (Scopus)

Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage

Zhou, W., Xu, J., Li, H., Xu, M., Chen, Z. J., Wei, W., Pan, Z. & Sun, Y., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 1104-1116 13 p.

Research output: Contribution to journalArticle

Cullin Proteins
Ligases
Lung Neoplasms
Survival
Ubiquitin
15 Citations (Scopus)

Prion-like polymerization in immunity and inflammation

Cai, X., Xu, H. & Chen, Z. J., Apr 1 2017, In : Cold Spring Harbor perspectives in biology. 9, 4, a023580.

Research output: Contribution to journalArticle

Prions
Polymerization
Immunity
Inflammation
Antiviral Agents
66 Citations (Scopus)

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

Moretti, J., Roy, S., Bozec, D., Martinez, J., Chapman, J. R., Ueberheide, B., Lamming, D. W., Chen, Z. J., Horng, T., Yeretssian, G., Green, D. R. & Blander, J. M., Nov 2 2017, In : Cell. 171, 4, p. 809-823.e13

Research output: Contribution to journalArticle

Microbial Viability
Autophagy
Endoplasmic Reticulum
Interferons
Genes
25 Citations (Scopus)

TEMPORARY REMOVAL: Synthetic nanovaccines for immunotherapy

Luo, M., Samandi, L. Z., Wang, Z., Chen, Z. J. & Gao, J., Jan 16 2017, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Immunotherapy
Emotions
8 Citations (Scopus)

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects

Choo, M. K., Sano, Y., Kim, C., Yasuda, K., Li, X. D., Lin, X., Stenzel-Poore, M., Alexopoulou, L., Ghosh, S., Latz, E., Rifkin, I. R., Chen, Z. J., Stewart, G. C., Chong, H. & Park, J. M., May 1 2017, In : Journal of Experimental Medicine. 214, 5, p. 1297-1311 15 p.

Research output: Contribution to journalArticle

Bacterial Spores
Bacillus anthracis
Spores
RNA
Bacteria
2016
61 Citations (Scopus)

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

Christensen, M. H., Jensen, S. B., Miettinen, J. J., Luecke, S., Prabakaran, T., Reinert, L. S., Mettenleiter, T., Chen, Z. J., Knipe, D. M., Sandri-Goldin, R. M., Enquist, L. W., Hartmann, R., Mogensen, T. H., Rice, S. A., Nyman, T. A., Matikainen, S. & Paludan, S. R., Jul 1 2016, In : EMBO Journal. 35, 13, p. 1385-1399 15 p.

Research output: Contribution to journalArticle

Macrophages
Human Herpesvirus 1
Viruses
Herpesviridae
Viral Proteins
10 Citations (Scopus)

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., Chen, Z. J., Busch, J., Schmitz, M. L. & Kracht, M., Jun 16 2016, In : Molecular Cell. 62, 6, p. 943-957 15 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Ubiquitination
RNA Stability
Messenger RNA
Ubiquitin
11 Citations (Scopus)

Streptococci engage TLR13 on myeloid cells in a site-specific fashion

Kolter, J., Feuerstein, R., Spoeri, E., Gharun, K., Elling, R., Trieu-Cuot, P., Goldmann, T., Waskow, C., Chen, Z. J., Kirschning, C. J., Deshmukh, S. D. & Henneke, P., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2733-2741 9 p.

Research output: Contribution to journalArticle

Streptococcus agalactiae
Microglia
Myeloid Cells
Streptococcus
Monocytes
2015
181 Citations (Scopus)

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X. D., Chen, X., Li, Q. Z., Wight-Carter, M. & Chen, Z. J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5699-E5705

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Autoimmune Diseases
DNA
Phenotype
Interferons

Editorial overview: Innate immunity

Chen, Z. J. & Amigorena, S., Feb 1 2015, In : Current Opinion in Immunology. 32, p. 5-6 2 p.

Research output: Contribution to journalArticle

Innate Immunity
10 Citations (Scopus)

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

Stein, K., Brand, S., Jenckel, A., Sigmund, A., Chen, Z. J., Kirschning, C. J., Kauth, M. & Heine, H., Sep 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Lactococcus lactis
Dendritic Cells
Hypersensitivity
RNA
Bone Marrow
26 Citations (Scopus)

Innate immune response to streptococcus pyogenes depends on the combined activation of TLR13 and TLR2

Fieber, C., Janos, M., Koestler, T., Gratz, N., Li, X. D., Castiglia, V., Aberle, M., Sauert, M., Wegner, M., Alexopoulou, L., Kirschning, C. J., Chen, Z. J., Von Haeseler, A. & Kovarik, P., Mar 10 2015, In : PLoS One. 10, 3, e0119727.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Macrophages
Innate Immunity
Chemical activation
Mammals
21 Citations (Scopus)
Ligands
Proteins
Protein Conformation
Entropy
Second Messenger Systems
396 Citations (Scopus)

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y. T., Grishin, N. V. & Chen, Z. J., Mar 13 2015, In : Science. 347, 6227, aaa2630.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Phosphorylation
Interferon Type I
Proteins
Toll-Like Receptors
2014
56 Citations (Scopus)

A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells

Dubois, S. M., Alexia, C., Wu, Y., Leclair, H. M., Leveau, C., Schol, E., Fest, T., Tarte, K., Chen, Z. J., Gavard, J. & Bidère, N., Apr 3 2014, In : Blood. 123, 14, p. 2199-2203 5 p.

Research output: Contribution to journalArticle

Antigen Receptors
Ubiquitin
Lymphoma
Chemical activation
Cells
37 Citations (Scopus)

A novel mitochondrial MAVS/caspase-8 platform links RNA virus-induced innate antiviral signaling to bax/bak-independent apoptosis

Maadidi, S. E., Faletti, L., Berg, B., Wenzl, C., Wieland, K., Chen, Z. J., Maurer, U. & Borner, C., Feb 1 2014, In : Journal of Immunology. 192, 3, p. 1171-1183 13 p.

Research output: Contribution to journalArticle

Caspase 8
RNA Viruses
Antiviral Agents
Apoptosis
Semliki forest virus
233 Citations (Scopus)

Apoptotic caspases prevent the induction of type i interferons by mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., De Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C. Y., Taniguchi, T., Shadel, G. S., Chen, Z. J., Iwasaki, A. & Flavell, R. A., Dec 18 2014, In : Cell. 159, 7, p. 1563-1577 15 p.

Research output: Contribution to journalArticle

Mitochondria
Caspases
Mitochondrial DNA
Interferons
Cell death
154 Citations (Scopus)

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

Collins, A. C., Cai, H., Li, T., Franco, L. H., Li, X. D., Nair, V. R., Scharn, C. R., Stamm, C. E., Levine, B., Chen, Z. J. & Shiloh, M. U., Nov 20 2014, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Mycobacterium tuberculosis
Tuberculosis
DNA
Autophagy
42 Citations (Scopus)

IKKβ is an IRF5 kinase that instigates inflammation

Ren, J., Chen, X. & Chen, Z. J., Dec 9 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17438-17443 6 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Phosphotransferases
Inflammation
Serine
Phospho-Specific Antibodies
431 Citations (Scopus)

Innate immune sensing and signaling of cytosolic nucleic acids

Wu, J. & Chen, Z. J., 2014, In : Annual Review of Immunology. 32, p. 461-488 28 p.

Research output: Contribution to journalArticle

Nucleic Acids
Pattern Recognition Receptors
Immune System
Interferon Type I
Toll-Like Receptors
60 Citations (Scopus)

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

Yuan, W. C., Lee, Y. R., Lin, S. Y., Chang, L. Y., Tan, Y. P., Hung, C. C., Kuo, J. C., Liu, C. H., Lin, M. Y., Xu, M., Chen, Z. J. & Chen, R. H., May 22 2014, In : Molecular Cell. 54, 4, p. 586-600 15 p.

Research output: Contribution to journalArticle

Cullin Proteins
trans-Golgi Network
Ubiquitin-Protein Ligases
Protein Transport
Ubiquitination
74 Citations (Scopus)

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M. Y., Pedersen, G., McInerney, G. M., Hedestam, G. B. K., Chen, Z. J. & Beutler, B., Dec 19 2014, In : Science. 346, 6216, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Antiviral Agents
B-Lymphocytes
RNA
Antibody Formation
63 Citations (Scopus)

Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway

Dai, P., Wang, W., Cao, H., Avogadri, F., Dai, L., Drexler, I., Joyce, J. A., Li, X. D., Chen, Z., Merghoub, T., Shuman, S. & Deng, L., 2014, In : PLoS Pathogens. 10, 4, e1003989.

Research output: Contribution to journalArticle

Interferon Type I
Vaccinia virus
Dendritic Cells
DNA
Interferon Regulatory Factor-3
10 Citations (Scopus)

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

Chong, R. A., Wu, K., Spratt, D. E., Yang, Y., Lee, C., Nayak, J., Xu, M., Elkholi, R., Tappin, I., Li, J., Hurwitz, J., Brown, B. D., Chipuk, J. E., Chen, Z. J., Sanchez, R., Shaw, G. S., Huang, L. & Pan, A. Z. Q., Jun 10 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 23, p. 8434-8439 6 p.

Research output: Contribution to journalArticle

Ubiquitin
Lysine
Polyubiquitin
Ubiquitin-Protein Ligases
Ubiquitination
20 Citations (Scopus)

Prion-like polymerization as a signaling mechanism

Cai, X. & Chen, Z. J., Dec 1 2014, In : Trends in Immunology. 35, 12, p. 622-630 9 p.

Research output: Contribution to journalArticle

Prions
Polymerization
Signal Transduction
Pattern Recognition Receptors
Immune System
263 Citations (Scopus)

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q. X., Halfmann, R. & Chen, Z. J., Mar 13 2014, In : Cell. 156, 6, p. 1207-1222 16 p.

Research output: Contribution to journalArticle

Inflammasomes
Signal transduction
Prions
Polymerization
Antiviral Agents
482 Citations (Scopus)

STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X. D., Mauceri, H., Beckett, M., Darga, T., Huang, X., Gajewski, T. F., Chen, Z. J., Fu, Y. X. & Weichselbaum, R. R., Nov 20 2014, In : Immunity. 41, 5, p. 543-852 310 p.

Research output: Contribution to journalArticle

Interferon Type I
Dendritic Cells
Immunity
Radiation
Interferons
92 Citations (Scopus)

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Xu, H., He, X., Zheng, H., Huang, L. J., Hou, F., Yu, Z., de la Cruz, M. J., Borkowski, B., Zhang, X., Chen, Z. J. & Jiang, Q. X., Feb 25 2014, In : eLife. 2014, 3, e01489.

Research output: Contribution to journalArticle

Prions
Innate Immunity
Antiviral Agents
Viruses
Caspases
166 Citations (Scopus)

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

Peisley, A., Wu, B., Xu, H., Chen, Z. J. & Hur, S., 2014, In : Nature. 508, 7498, p. 110-114 5 p.

Research output: Contribution to journalArticle

Ubiquitin
Antiviral Agents
Viral RNA
328 Citations (Scopus)

The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling

Cai, X., Chiu, Y. H. & Chen, Z. J., Apr 24 2014, In : Molecular Cell. 54, 2, p. 289-296 8 p.

Research output: Contribution to journalArticle

DNA
Autoimmunity
Innate Immunity
Nucleic Acids
Immune System
113 Citations (Scopus)

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X. & Chen, Z., Feb 13 2014, In : Cell Reports. 6, 3, p. 421-430 10 p.

Research output: Contribution to journalArticle

Chemical activation
Switches
DNA
Sensors
GMP synthase (glutamine-hydrolyzing)
2013
27 Citations (Scopus)

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

Zhang, L., Xu, M., Scotti, E., Chen, Z. J. & Tontonoz, P., May 2013, In : Journal of Lipid Research. 54, 5, p. 1410-1420 11 p.

Research output: Contribution to journalArticle

LDL Receptors
Ubiquitin
Degradation
Ubiquitination
Cells
147 Citations (Scopus)

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm

Yoo, S. H., Mohawk, J. A., Siepka, S. M., Shan, Y., Huh, S. K., Hong, H. K., Kornblum, I., Kumar, V., Koike, N., Xu, M., Nussbaum, J., Liu, X., Chen, Z., Chen, Z. J., Green, C. B. & Takahashi, J. S., Feb 28 2013, In : Cell. 152, 5, p. 1091-1105 15 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Periodicity
Cytoplasm
Degradation
Circadian Clocks
319 Citations (Scopus)

Cyclic GMP-AMP containing mixed Phosphodiester linkages is an endogenous high-affinity ligand for STING

Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C. & Chen, Z., Jul 25 2013, In : Molecular Cell. 51, 2, p. 226-235 10 p.

Research output: Contribution to journalArticle

Ligands
GMP synthase (glutamine-hydrolyzing)
Adenosine Monophosphate
Phosphates
Guanosine Monophosphate
709 Citations (Scopus)

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C. & Chen, Z. J., Feb 15 2013, In : Science. 339, 6121, p. 826-830 5 p.

Research output: Contribution to journalArticle

Second Messenger Systems
DNA
Interferons
DNA Virus Infections
Interferon Type I
1287 Citations (Scopus)

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J., Feb 15 2013, In : Science. 339, 6121, p. 786-791 6 p.

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Interferon Type I
DNA
Interferons
DNA Virus Infections
459 Citations (Scopus)

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

Gao, D., Wu, J., Wu, Y. T., Du, F., Aroh, C., Yan, N., Sun, L. & Chen, Z. J., 2013, In : Science. 341, 6148, p. 903-906 4 p.

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Retroviridae
HIV
Innate Immunity
Cytokines
29 Citations (Scopus)

IKKε-Mediated Tumorigenesis Requires K63-Linked Polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 Ubiquitin Ligase Complex

Zhou, A. Y., Shen, R. R., Kim, E., Lock, Y. J., Xu, M., Chen, Z. J. & Hahn, W. C., 2013, In : Cell Reports. 3, 3, p. 724-733 10 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 2
Ubiquitin-Protein Ligases
Lysine
Carcinogenesis
Phosphotransferases