• 33997 Citations
  • 84 h-Index
1990 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors

Padilla-Salinas, R., Sun, L., Anderson, R., Yang, X., Zhang, S., Chen, Z. J. & Yin, H., Feb 7 2020, In : Journal of Organic Chemistry. 85, 3, p. 1579-1600 22 p.

Research output: Contribution to journalArticle

Type I Interferon Response in Radiation-Induced Anti-Tumor Immunity

Zhang, F., Manna, S., Pop, L. M., Chen, Z. J., Fu, Y. X. & Hannan, R., Apr 2020, In : Seminars in Radiation Oncology. 30, 2, p. 129-138 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Gui, X., Yang, H., Li, T., Tan, X., Shi, P., Li, M., Du, F. & Chen, Z. J., Mar 14 2019, In : Nature. 567, 7747, p. 262-266 5 p.

Research output: Contribution to journalArticle

76 Scopus citations

Structural basis of STING binding with and phosphorylation by TBK1

Zhang, C., Shang, G., Gui, X., Zhang, X., Bai, X. C. & Chen, Z. J., Mar 21 2019, In : Nature. 567, 7748, p. 394-398 5 p.

Research output: Contribution to journalArticle

49 Scopus citations
2018

A GTPase-activating protein– binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells

Ramachandran, B., Stabley, J. N., Cheng, S. L., Behrmann, A. S., Gay, A., Li, L., Mead, M., Kozlitina, J., Lemoff, A., Mirzaei, H., Chen, Z. & Towler, D. A., May 25 2018, In : Journal of Biological Chemistry. 293, 21, p. 7942-7968 27 p.

Research output: Contribution to journalArticle

9 Scopus citations

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

Tian, J., Wu, J., Chen, X., Guo, T., Chen, Z. J., Goldstein, J. L. & Brown, M. S., Jun 27 2018, In : eLife. 7, e36826.

Research output: Contribution to journalArticle

4 Scopus citations

Cytosolic DNA sensing promotes macrophage transformation and governs myocardial ischemic injury

Cao, D. J., Schiattarella, G. G., Villalobos, E., Jiang, N., May, H. I., Li, T., Chen, Z., Gillette, T. G. & Hill, J. A., Jun 12 2018, In : Circulation. 137, 24, p. 2613-2634 22 p.

Research output: Contribution to journalArticle

31 Scopus citations

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

Du, M. & Chen, Z. J., Jul 5 2018, (Accepted/In press) In : Science.

Research output: Contribution to journalArticle

94 Scopus citations

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

Chen, J. & Chen, Z., Dec 6 2018, In : Nature. 564, 7734, p. 71-76 6 p.

Research output: Contribution to journalArticle

76 Scopus citations

Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression

Zhang, K., Shang, G., Padavannil, A., Wang, J., Sakthivel, R., Chen, X., Kim, M., Thompson, M. G., García-Sastre, A., Lynch, K. W., Chen, Z., Chook, Y. M. & Fontoura, B. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12218-E12227

Research output: Contribution to journalArticle

2 Scopus citations
2017

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

Golden, R. J., Chen, B., Li, T., Braun, J., Manjunath, H., Chen, X., Wu, J., Schmid, V., Chang, T. C., Kopp, F., Ramirez-Martinez, A., Tagliabracci, V. S., Chen, Z. J., Xie, Y. & Mendell, J. T., Feb 9 2017, In : Nature. 542, 7640, p. 197-202 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

A STING-activating nanovaccine for cancer immunotherapy

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y. X., Chen, Z. J. & Gao, J., Jul 1 2017, In : Nature Nanotechnology. 12, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

179 Scopus citations

cGAS is essential for the antitumor effect of immune checkpoint blockade

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L. & Chen, Z. J., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

Xu, M. M., Pu, Y., Han, D., Shi, Y., Cao, X., Liang, H., Chen, X., Li, X. D., Deng, L., Chen, Z. J., Weichselbaum, R. R. & Fu, Y. X., Aug 15 2017, In : Immunity. 47, 2, p. 363-373.e5

Research output: Contribution to journalArticle

62 Scopus citations

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication

Kuss-Duerkop, S. K., Wang, J., Mena, I., White, K., Metreveli, G., Sakthivel, R., Mata, M. A., Muñoz-Moreno, R., Chen, X., Krammer, F., Diamond, M. S., Chen, Z. J., García-Sastre, A. & Fontoura, B. M. A., Sep 2017, In : PLoS pathogens. 13, 9, e1006635.

Research output: Contribution to journalArticle

19 Scopus citations

Innate immune activation by cGMP-AMP nanoparticles leads to potent and long-acting antiretroviral response against HIV-1

Aroh, C., Wang, Z., Dobbs, N., Luo, M., Chen, Z., Gao, J. & Yan, N., Dec 1 2017, In : Journal of Immunology. 199, 11, p. 3840-3848 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage

Zhou, W., Xu, J., Li, H., Xu, M., Chen, Z. J., Wei, W., Pan, Z. & Sun, Y., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 1104-1116 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Prion-like polymerization in immunity and inflammation

Cai, X., Xu, H. & Chen, Z. J., Apr 1 2017, In : Cold Spring Harbor perspectives in biology. 9, 4, a023580.

Research output: Contribution to journalArticle

16 Scopus citations

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

Moretti, J., Roy, S., Bozec, D., Martinez, J., Chapman, J. R., Ueberheide, B., Lamming, D. W., Chen, Z. J., Horng, T., Yeretssian, G., Green, D. R. & Blander, J. M., Nov 2 2017, In : Cell. 171, 4, p. 809-823.e13

Research output: Contribution to journalArticle

86 Scopus citations

TEMPORARY REMOVAL: Synthetic nanovaccines for immunotherapy

Luo, M., Samandi, L. Z., Wang, Z., Chen, Z. J. & Gao, J., Jan 16 2017, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

32 Scopus citations

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects

Choo, M. K., Sano, Y., Kim, C., Yasuda, K., Li, X. D., Lin, X., Stenzel-Poore, M., Alexopoulou, L., Ghosh, S., Latz, E., Rifkin, I. R., Chen, Z. J., Stewart, G. C., Chong, H. & Park, J. M., May 1 2017, In : Journal of Experimental Medicine. 214, 5, p. 1297-1311 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

Christensen, M. H., Jensen, S. B., Miettinen, J. J., Luecke, S., Prabakaran, T., Reinert, L. S., Mettenleiter, T., Chen, Z. J., Knipe, D. M., Sandri-Goldin, R. M., Enquist, L. W., Hartmann, R., Mogensen, T. H., Rice, S. A., Nyman, T. A., Matikainen, S. & Paludan, S. R., Jul 1 2016, In : EMBO Journal. 35, 13, p. 1385-1399 15 p.

Research output: Contribution to journalArticle

76 Scopus citations

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., Chen, Z. J., Busch, J., Schmitz, M. L. & Kracht, M., Jun 16 2016, In : Molecular Cell. 62, 6, p. 943-957 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Streptococci engage TLR13 on myeloid cells in a site-specific fashion

Kolter, J., Feuerstein, R., Spoeri, E., Gharun, K., Elling, R., Trieu-Cuot, P., Goldmann, T., Waskow, C., Chen, Z. J., Kirschning, C. J., Deshmukh, S. D. & Henneke, P., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2733-2741 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X. D., Chen, X., Li, Q. Z., Wight-Carter, M. & Chen, Z. J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5699-E5705

Research output: Contribution to journalArticle

216 Scopus citations

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

Stein, K., Brand, S., Jenckel, A., Sigmund, A., Chen, Z. J., Kirschning, C. J., Kauth, M. & Heine, H., Sep 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

10 Scopus citations

Innate immune response to streptococcus pyogenes depends on the combined activation of TLR13 and TLR2

Fieber, C., Janos, M., Koestler, T., Gratz, N., Li, X. D., Castiglia, V., Aberle, M., Sauert, M., Wegner, M., Alexopoulou, L., Kirschning, C. J., Chen, Z. J., Von Haeseler, A. & Kovarik, P., Mar 10 2015, In : PloS one. 10, 3, e0119727.

Research output: Contribution to journalArticle

26 Scopus citations
25 Scopus citations

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y. T., Grishin, N. V. & Chen, Z. J., Mar 13 2015, In : Science. 347, 6227, aaa2630.

Research output: Contribution to journalArticle

463 Scopus citations
2014

A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells

Dubois, S. M., Alexia, C., Wu, Y., Leclair, H. M., Leveau, C., Schol, E., Fest, T., Tarte, K., Chen, Z. J., Gavard, J. & Bidère, N., Apr 3 2014, In : Blood. 123, 14, p. 2199-2203 5 p.

Research output: Contribution to journalArticle

63 Scopus citations

A novel mitochondrial MAVS/caspase-8 platform links RNA virus-induced innate antiviral signaling to bax/bak-independent apoptosis

Maadidi, S. E., Faletti, L., Berg, B., Wenzl, C., Wieland, K., Chen, Z. J., Maurer, U. & Borner, C., Feb 1 2014, In : Journal of Immunology. 192, 3, p. 1171-1183 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Apoptotic caspases prevent the induction of type i interferons by mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., De Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C. Y., Taniguchi, T., Shadel, G. S., Chen, Z. J., Iwasaki, A. & Flavell, R. A., Dec 18 2014, In : Cell. 159, 7, p. 1563-1577 15 p.

Research output: Contribution to journalArticle

278 Scopus citations

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

Collins, A. C., Cai, H., Li, T., Franco, L. H., Li, X. D., Nair, V. R., Scharn, C. R., Stamm, C. E., Levine, B., Chen, Z. J. & Shiloh, M. U., Nov 20 2014, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

171 Scopus citations

IKKβ is an IRF5 kinase that instigates inflammation

Ren, J., Chen, X. & Chen, Z. J., Dec 9 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17438-17443 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

Yuan, W. C., Lee, Y. R., Lin, S. Y., Chang, L. Y., Tan, Y. P., Hung, C. C., Kuo, J. C., Liu, C. H., Lin, M. Y., Xu, M., Chen, Z. J. & Chen, R. H., May 22 2014, In : Molecular cell. 54, 4, p. 586-600 15 p.

Research output: Contribution to journalArticle

67 Scopus citations

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M. Y., Pedersen, G., McInerney, G. M., Hedestam, G. B. K., Chen, Z. J. & Beutler, B., Dec 19 2014, In : Science. 346, 6216, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway

Dai, P., Wang, W., Cao, H., Avogadri, F., Dai, L., Drexler, I., Joyce, J. A., Li, X. D., Chen, Z., Merghoub, T., Shuman, S. & Deng, L., Apr 2014, In : PLoS pathogens. 10, 4, e1003989.

Research output: Contribution to journalArticle

69 Scopus citations

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

Chong, R. A., Wu, K., Spratt, D. E., Yang, Y., Lee, C., Nayak, J., Xu, M., Elkholi, R., Tappin, I., Li, J., Hurwitz, J., Brown, B. D., Chipuk, J. E., Chen, Z. J., Sanchez, R., Shaw, G. S., Huang, L. & Pan, A. Z. Q., Jun 10 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 23, p. 8434-8439 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q. X., Halfmann, R. & Chen, Z. J., Mar 13 2014, In : Cell. 156, 6, p. 1207-1222 16 p.

Research output: Contribution to journalArticle

287 Scopus citations

STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X. D., Mauceri, H., Beckett, M., Darga, T., Huang, X., Gajewski, T. F., Chen, Z. J., Fu, Y. X. & Weichselbaum, R. R., Nov 20 2014, In : Immunity. 41, 5, p. 843-852 10 p.

Research output: Contribution to journalArticle

577 Scopus citations

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Xu, H., He, X., Zheng, H., Huang, L. J., Hou, F., Yu, Z., de la Cruz, M. J., Borkowski, B., Zhang, X., Chen, Z. J. & Jiang, Q. X., Feb 25 2014, In : eLife. 2014, 3, e01489.

Research output: Contribution to journalArticle

97 Scopus citations

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

Peisley, A., Wu, B., Xu, H., Chen, Z. J. & Hur, S., Jan 1 2014, In : Nature. 508, 7498, p. 110-114 5 p.

Research output: Contribution to journalArticle

178 Scopus citations

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X. & Chen, Z., Feb 13 2014, In : Cell Reports. 6, 3, p. 421-430 10 p.

Research output: Contribution to journalArticle

137 Scopus citations
2013

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

Zhang, L., Xu, M., Scotti, E., Chen, Z. J. & Tontonoz, P., May 1 2013, In : Journal of lipid research. 54, 5, p. 1410-1420 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm

Yoo, S. H., Mohawk, J. A., Siepka, S. M., Shan, Y., Huh, S. K., Hong, H. K., Kornblum, I., Kumar, V., Koike, N., Xu, M., Nussbaum, J., Liu, X., Chen, Z., Chen, Z. J., Green, C. B. & Takahashi, J. S., Feb 28 2013, In : Cell. 152, 5, p. 1091-1105 15 p.

Research output: Contribution to journalArticle

156 Scopus citations

Cyclic GMP-AMP containing mixed Phosphodiester linkages is an endogenous high-affinity ligand for STING

Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C. & Chen, Z., Jul 25 2013, In : Molecular cell. 51, 2, p. 226-235 10 p.

Research output: Contribution to journalArticle

363 Scopus citations

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C. & Chen, Z. J., Feb 15 2013, In : Science. 339, 6121, p. 826-830 5 p.

Research output: Contribution to journalArticle

806 Scopus citations

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J., Feb 15 2013, In : Science. 339, 6121, p. 786-791 6 p.

Research output: Contribution to journalArticle

1446 Scopus citations

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

Gao, D., Wu, J., Wu, Y. T., Du, F., Aroh, C., Yan, N., Sun, L. & Chen, Z. J., Jan 1 2013, In : Science. 341, 6148, p. 903-906 4 p.

Research output: Contribution to journalArticle

493 Scopus citations

IKKε-Mediated Tumorigenesis Requires K63-Linked Polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 Ubiquitin Ligase Complex

Zhou, A. Y., Shen, R. R., Kim, E., Lock, Y. J., Xu, M., Chen, Z. J. & Hahn, W. C., Mar 1 2013, In : Cell Reports. 3, 3, p. 724-733 10 p.

Research output: Contribution to journalArticle

31 Scopus citations