TY - JOUR
T1 - β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease
AU - Richardson, Jason R.
AU - Roy, Ananya
AU - Shalat, Stuart L.
AU - Buckley, Brian
AU - Winnik, Bozena
AU - Gearing, Marla
AU - Levey, Allan I.
AU - Factor, Stewart A.
AU - O'Suilleabhain, Padraig
AU - German, Dwight C.
N1 - Funding Information:
Support provided by the Michael J. Fox Foundation for Parkinson's Research, the Dallas Area Parkinsonism Society , the Dallas Foundation , the Close to a Cure Foundation , and the National Institutes of Health P30ES005022 , P01ES016731 , and P50AG025688 .
PY - 2011/10
Y1 - 2011/10
N2 - Pesticide exposure has been implicated as an environmental risk factor for the development of Parkinson's disease (PD). However, few studies have identified specific pesticides. Previously, we identified elevated serum levels of the organochlorine pesticide β-hexachlorocyclohexane (β-HCH) in PD patients from a small clinical sample. Here, we conducted a case-control study to confirm the association between β-HCH and PD in a larger sample size (n= 283) with serum samples of PD patients and controls obtained from UT Southwestern Medical Center and Emory University. Samples were obtained from two discrete periods at both sites, 2001-2003 and 2006-2008, and were analyzed for β-HCH levels. Adjusted odds ratios (ORs) for PD were estimated using logistic regression and generalized estimating equations. The mean serum β-HCH level across all cohorts in this study was 22.3. ng/mg cholesterol (range: 0-376.7), and the levels were significantly higher and samples collected in 2001-2003 vs. 2006-2008. After controlling for age and gender, the OR for increased risk of PD for every 1. ng/mg increase in serum β-HCH ranged from 1.02 to 1.12 across the four different cohorts, and 1.03 (95% CI: 1.00-1.07, p value = 0.031) in the pooled analysis. Furthermore, the OR for increased risk of PD of subjects having serum β-HCH levels above the inter-quartile range of 39.08. ng/mg cholesterol was 2.85 (95% CI: 1.8, 4.48; p value < 0.001). These data are consistent with environmental decreases in β-HCH levels between 2001 and 2008, but they indicate that elevated levels of serum β-HCH are still associated with heightened risk for PD.
AB - Pesticide exposure has been implicated as an environmental risk factor for the development of Parkinson's disease (PD). However, few studies have identified specific pesticides. Previously, we identified elevated serum levels of the organochlorine pesticide β-hexachlorocyclohexane (β-HCH) in PD patients from a small clinical sample. Here, we conducted a case-control study to confirm the association between β-HCH and PD in a larger sample size (n= 283) with serum samples of PD patients and controls obtained from UT Southwestern Medical Center and Emory University. Samples were obtained from two discrete periods at both sites, 2001-2003 and 2006-2008, and were analyzed for β-HCH levels. Adjusted odds ratios (ORs) for PD were estimated using logistic regression and generalized estimating equations. The mean serum β-HCH level across all cohorts in this study was 22.3. ng/mg cholesterol (range: 0-376.7), and the levels were significantly higher and samples collected in 2001-2003 vs. 2006-2008. After controlling for age and gender, the OR for increased risk of PD for every 1. ng/mg increase in serum β-HCH ranged from 1.02 to 1.12 across the four different cohorts, and 1.03 (95% CI: 1.00-1.07, p value = 0.031) in the pooled analysis. Furthermore, the OR for increased risk of PD of subjects having serum β-HCH levels above the inter-quartile range of 39.08. ng/mg cholesterol was 2.85 (95% CI: 1.8, 4.48; p value < 0.001). These data are consistent with environmental decreases in β-HCH levels between 2001 and 2008, but they indicate that elevated levels of serum β-HCH are still associated with heightened risk for PD.
KW - Beta-hexachlorocyclohexane
KW - Organochlorine
KW - Parkinson's disease
KW - Pesticide
UR - http://www.scopus.com/inward/record.url?scp=82455162500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82455162500&partnerID=8YFLogxK
U2 - 10.1016/j.neuro.2011.04.002
DO - 10.1016/j.neuro.2011.04.002
M3 - Article
C2 - 21620887
AN - SCOPUS:82455162500
SN - 0161-813X
VL - 32
SP - 640
EP - 645
JO - NeuroToxicology
JF - NeuroToxicology
IS - 5
ER -