γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

Xue Gao; Liang Zhao; Shuangping Liu; Yuancheng Li; Siyuan Xia; Dong Chen; Mei Wang; Shaoxiong Wu; Qing Dai; Hieu Vu; Lauren Zacharias; Ralph DeBerardinis; Esther Lim; Christian Metallo; Titus J. Boggon; Sagar Lonial; Ruiting Lin; Hui Mao; Yaozhu Pan; Changliang Shan; Jing Chen

doi:10.1016/j.molcel.2019.09.007

γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

Xue Gao, Liang Zhao, Shuangping Liu, Yuancheng Li, Siyuan Xia, Dong Chen, Mei Wang, Shaoxiong Wu, Qing Dai, Hieu Vu, Lauren Zacharias, Ralph DeBerardinis, Esther Lim, Christian Metallo, Titus J. Boggon, Sagar Lonial, Ruiting Lin, Hui Mao, Yaozhu Pan, Changliang ShanJing Chen

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

“Dead-end” metabolites in the metabolic reaction network do not have known metabolic functions. In this article, Gao et al. report that γ-6PGL, a byproduct of the oxiPPP, contributes to the Src-PP2A-AMPK signaling pathway by binding to Src and consequently enhancing PP2A recruitment, suggesting that “dead-end” metabolites may function as signaling molecules.

Original language	English (US)
Pages (from-to)	857-871.e9
Journal	Molecular cell
Volume	76
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2019.09.007
State	Published - Dec 19 2019

Keywords

▪▪▪

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2019.09.007

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Gao, X., Zhao, L., Liu, S., Li, Y., Xia, S., Chen, D., Wang, M., Wu, S., Dai, Q., Vu, H., Zacharias, L., DeBerardinis, R., Lim, E., Metallo, C., Boggon, T. J., Lonial, S., Lin, R., Mao, H., Pan, Y., ... Chen, J. (2019). γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Molecular cell, 76(6), 857-871.e9. https://doi.org/10.1016/j.molcel.2019.09.007

Gao, X, Zhao, L, Liu, S, Li, Y, Xia, S, Chen, D, Wang, M, Wu, S, Dai, Q, Vu, H, Zacharias, L, DeBerardinis, R, Lim, E, Metallo, C, Boggon, TJ, Lonial, S, Lin, R, Mao, H, Pan, Y, Shan, C & Chen, J 2019, 'γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A', Molecular cell, vol. 76, no. 6, pp. 857-871.e9. https://doi.org/10.1016/j.molcel.2019.09.007

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abstract = "“Dead-end” metabolites in the metabolic reaction network do not have known metabolic functions. In this article, Gao et al. report that γ-6PGL, a byproduct of the oxiPPP, contributes to the Src-PP2A-AMPK signaling pathway by binding to Src and consequently enhancing PP2A recruitment, suggesting that “dead-end” metabolites may function as signaling molecules.",

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AU - Gao, Xue

AU - Zhao, Liang

AU - Liu, Shuangping

AU - Li, Yuancheng

AU - Xia, Siyuan

AU - Chen, Dong

AU - Wang, Mei

AU - Wu, Shaoxiong

AU - Dai, Qing

AU - Vu, Hieu

AU - Zacharias, Lauren

AU - DeBerardinis, Ralph

AU - Lim, Esther

AU - Metallo, Christian

AU - Boggon, Titus J.

AU - Lonial, Sagar

AU - Lin, Ruiting

AU - Mao, Hui

AU - Pan, Yaozhu

AU - Shan, Changliang

AU - Chen, Jing

PY - 2019/12/19

Y1 - 2019/12/19

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AB - “Dead-end” metabolites in the metabolic reaction network do not have known metabolic functions. In this article, Gao et al. report that γ-6PGL, a byproduct of the oxiPPP, contributes to the Src-PP2A-AMPK signaling pathway by binding to Src and consequently enhancing PP2A recruitment, suggesting that “dead-end” metabolites may function as signaling molecules.

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γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

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