α-Blocker Therapy of Hypertension: An Unfulfilled Promise

Alexander F. Khoury, Norman M Kaplan

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

For various reasons, the α1-receptor blocker prazosin has been used infrequently as initial therapy for hypertension. The introduction of additional agents of this class with properties different from prazosin provides slower onset of action, which should reduce the degree of first-dose and postural hypotension and a longer duration of action, which allows for once-a-day dosage. A summary of the published data on efficacy, side effects, and special properties of this class of agents indicates that they will probably be used more extensively, particularly because of their ability to improve lipid and glucose-insulin metabolism.

Original languageEnglish (US)
Pages (from-to)394-398
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume266
Issue number3
DOIs
StatePublished - Jul 17 1991

ASJC Scopus subject areas

  • Medicine(all)

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