α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation

Hsi Chiao, Steve Foster, Robyn Thomas, James Lipton, Robert A. Star

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

α-Melanocyte-stimulating hormone (MSH) is a potent antiinflammatory agent in many models of inflammation, suggesting that it inhibits a critical step common to different forms of inflammation. We showed previously that α-MSH inhibits nitric oxide (NO) production in cultured macrophages. To determine how α-MSH acts in vivo, we induced acute hepatic inflammation by administering endotoxin (LPS) to mice pretreated with Corynebacterium parvum. α-MSH prevented liver inflammation even when given 30 min after LPS administration. To determine the mechanisms of action of α-MSH, we tested its influence on NO, infiltrating inflammatory cells, cytokines, and chemokines. α-MSH inhibited systemic NO production, hepatic neutropHil infiltration, and increased hepatic mRNA abundance for TNFα, and the neutropHil and monocyte chemokines (KC/IL-8 and MCP-1). We conclude that α- MSH prevents LPS-induced hepatic inflammation by inhibiting production of chemoattractant chemokines which then modulate infiltration of inflammatory cells. Thus, α-MSH has an effect very early in the inflammatory cascade.

Original languageEnglish (US)
Pages (from-to)2038-2044
Number of pages7
JournalJournal of Clinical Investigation
Volume97
Issue number9
StatePublished - May 1 1996

Fingerprint

Melanocyte-Stimulating Hormones
Endotoxins
Inflammation
Liver
Chemokines
Nitric Oxide
Propionibacterium acnes
Neutrophil Infiltration
Chemotactic Factors
Interleukin-8
Monocytes
Neutrophils
Anti-Inflammatory Agents
Macrophages
Cytokines
Messenger RNA

Keywords

  • KC/IL-8
  • MCP-1
  • neutrophils
  • nitric oxide
  • TNFα

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chiao, H., Foster, S., Thomas, R., Lipton, J., & Star, R. A. (1996). α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation. Journal of Clinical Investigation, 97(9), 2038-2044.

α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation. / Chiao, Hsi; Foster, Steve; Thomas, Robyn; Lipton, James; Star, Robert A.

In: Journal of Clinical Investigation, Vol. 97, No. 9, 01.05.1996, p. 2038-2044.

Research output: Contribution to journalArticle

Chiao, H, Foster, S, Thomas, R, Lipton, J & Star, RA 1996, 'α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation', Journal of Clinical Investigation, vol. 97, no. 9, pp. 2038-2044.
Chiao, Hsi ; Foster, Steve ; Thomas, Robyn ; Lipton, James ; Star, Robert A. / α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation. In: Journal of Clinical Investigation. 1996 ; Vol. 97, No. 9. pp. 2038-2044.
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