α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?

Claus Roehrborn, Francisco Cruz, Ferdinando Fusco

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Available α1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the α1A adrenergic receptor. This pharmacological feature couples with a singular urodynamic and clinical profile. The magnitude of bladder outlet obstruction improvement in patients receiving silodosin is higher if compared to other ABs. From a clinical point of view, current evidence suggests an advantage in favor of silodosin in terms of nocturia improvement and cardiovascular safety. The incidence of ejaculatory dysfunction with silodosin is higher compared to other Abs.

Original languageEnglish (US)
Pages (from-to)2110-2121
Number of pages12
JournalAdvances in Therapy
Volume33
Issue number12
DOIs
StatePublished - Jan 1 2017

Keywords

  • Alpha-blockers
  • Silodosin
  • Urology

ASJC Scopus subject areas

  • Pharmacology (medical)

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