α1-Adrenoceptor subtypes and lower urinary tract symptoms

Debra A. Schwinn, Claus Roehrborn

Research output: Contribution to journalReview article

127 Scopus citations

Abstract

Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in aging men leading to lower urinary tract symptoms (LUTS). α1-Adrenoceptors (α1ARs) antagonists (blockers) have become a mainstay of LUTS treatment because they relax prostate smooth muscle and decrease urethral resistance, as well as relieving bladder LUTS symptoms. A review of key recent clinical trials suggests new insights into the role of specific α1AR subtypes in the treatment of LUTS.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalInternational Journal of Urology
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2008

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Keywords

  • Adrenergic
  • Adrenoceptor
  • Alpha blockers
  • BPH
  • Benign prostatic hyperplasia
  • Prostate

ASJC Scopus subject areas

  • Urology

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