β-Catenin regulates tumor-derived PD-L1

Chuanhui Han, Yang Xin Fu

Research output: Contribution to journalComment/debatepeer-review

4 Scopus citations

Abstract

In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin-dependent manner, and blocking the AKT pathway synergizes with anti-PD-1 in a glioblastoma model.

Original languageEnglish (US)
JournalThe Journal of experimental medicine
Volume217
Issue number11
DOIs
StatePublished - Nov 2 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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