β Cell Renewal versus Differentiation: Slow and Steady Wins the Race

Ondine Cleaver

doi:10.1016/j.devcel.2017.04.017

β Cell Renewal versus Differentiation: Slow and Steady Wins the Race

Ondine Cleaver

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Pancreatic endocrine progenitor cells proliferate and transiently express the bHLH transcription factor Ngn3. In recent issues of Developmental Cell, Azzarelli et al. (2017) and Krentz et al. (2017) demonstrate how CDK phosphorylation of Ngn3 governs the switch between their renewal and differentiation. Lengthening the cell cycle allows Ngn3 accumulation, outpacing phosphorylation-induced degradation.

Original language	English (US)
Pages (from-to)	223-225
Number of pages	3
Journal	Developmental cell
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2017.04.017
State	Published - May 8 2017

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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title = "β Cell Renewal versus Differentiation: Slow and Steady Wins the Race",

abstract = "Pancreatic endocrine progenitor cells proliferate and transiently express the bHLH transcription factor Ngn3. In recent issues of Developmental Cell, Azzarelli et al. (2017) and Krentz et al. (2017) demonstrate how CDK phosphorylation of Ngn3 governs the switch between their renewal and differentiation. Lengthening the cell cycle allows Ngn3 accumulation, outpacing phosphorylation-induced degradation.",

author = "Ondine Cleaver",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

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AB - Pancreatic endocrine progenitor cells proliferate and transiently express the bHLH transcription factor Ngn3. In recent issues of Developmental Cell, Azzarelli et al. (2017) and Krentz et al. (2017) demonstrate how CDK phosphorylation of Ngn3 governs the switch between their renewal and differentiation. Lengthening the cell cycle allows Ngn3 accumulation, outpacing phosphorylation-induced degradation.

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β Cell Renewal versus Differentiation: Slow and Steady Wins the Race

Abstract

ASJC Scopus subject areas

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