β Cell Renewal versus Differentiation: Slow and Steady Wins the Race

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

Pancreatic endocrine progenitor cells proliferate and transiently express the bHLH transcription factor Ngn3. In recent issues of Developmental Cell, Azzarelli et al. (2017) and Krentz et al. (2017) demonstrate how CDK phosphorylation of Ngn3 governs the switch between their renewal and differentiation. Lengthening the cell cycle allows Ngn3 accumulation, outpacing phosphorylation-induced degradation.

Original languageEnglish (US)
Pages (from-to)223-225
Number of pages3
JournalDevelopmental Cell
Volume41
Issue number3
DOIs
StatePublished - May 8 2017

ASJC Scopus subject areas

  • Developmental Biology

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