β-Fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: The Atherosclerosis Risk in Communities (ARIC) Study

Aaron R. Folsom, Nena Aleksic, Chul Ahn, Eric Boerwinkle, Kenneth K. Wu

Research output: Contribution to journalLetter

38 Scopus citations

Abstract

PURPOSE: The -455G/A (HaeIII) polymorphism of the β-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease. METHODS: We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their -455G/A status with a random sample of the cohort (n = 498). RESULTS: Plasma fibrinogen was higher (p = 0.04) in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between -455G/A and incident CHD. CONCLUSIONS: Although a small effect cannot be excluded, -455G/A does not appear to be an important genetic determinant of CHD.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalAnnals of Epidemiology
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2001

Keywords

  • Coronary disease
  • Fibrinogen
  • Prospective study

ASJC Scopus subject areas

  • Epidemiology

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