β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD +, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The clinical utility of cisplatin is limited by nephrotoxicity. Oh et al. report that β-lapachone prevents this nephrotoxicity but not cisplatin's cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin acute kidney injury may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular reactive oxygen species on the one hand, with inflammation and cell death on the other hand.

Original languageEnglish (US)
Pages (from-to)496-498
Number of pages3
JournalKidney International
Volume85
Issue number3
DOIs
StatePublished - 2014

Fingerprint

NAD
Cisplatin
Inflammation
Wounds and Injuries
Acute Kidney Injury
Reactive Oxygen Species
Cell Death
Food
Neoplasms

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

@article{3f659aeceb84462cbcbab81efbfce2df,
title = "β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD +, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation",
abstract = "The clinical utility of cisplatin is limited by nephrotoxicity. Oh et al. report that β-lapachone prevents this nephrotoxicity but not cisplatin's cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin acute kidney injury may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular reactive oxygen species on the one hand, with inflammation and cell death on the other hand.",
author = "Lu, {Christopher Y.}",
year = "2014",
doi = "10.1038/ki.2013.419",
language = "English (US)",
volume = "85",
pages = "496--498",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - β-Lapachone ameliorates murine cisplatin nephrotoxicity

T2 - NAD +, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation

AU - Lu, Christopher Y.

PY - 2014

Y1 - 2014

N2 - The clinical utility of cisplatin is limited by nephrotoxicity. Oh et al. report that β-lapachone prevents this nephrotoxicity but not cisplatin's cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin acute kidney injury may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular reactive oxygen species on the one hand, with inflammation and cell death on the other hand.

AB - The clinical utility of cisplatin is limited by nephrotoxicity. Oh et al. report that β-lapachone prevents this nephrotoxicity but not cisplatin's cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin acute kidney injury may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular reactive oxygen species on the one hand, with inflammation and cell death on the other hand.

UR - http://www.scopus.com/inward/record.url?scp=84895139578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895139578&partnerID=8YFLogxK

U2 - 10.1038/ki.2013.419

DO - 10.1038/ki.2013.419

M3 - Article

C2 - 24583980

AN - SCOPUS:84895139578

VL - 85

SP - 496

EP - 498

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 3

ER -