γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

Xue Gao, Liang Zhao, Shuangping Liu, Yuancheng Li, Siyuan Xia, Dong Chen, Mei Wang, Shaoxiong Wu, Qing Dai, Hieu Vu, Lauren Zacharias, Ralph DeBerardinis, Esther Lim, Christian Metallo, Titus J. Boggon, Sagar Lonial, Ruiting Lin, Hui Mao, Yaozhu Pan, Changliang ShanJing Chen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

“Dead-end” metabolites in the metabolic reaction network do not have known metabolic functions. In this article, Gao et al. report that γ-6PGL, a byproduct of the oxiPPP, contributes to the Src-PP2A-AMPK signaling pathway by binding to Src and consequently enhancing PP2A recruitment, suggesting that “dead-end” metabolites may function as signaling molecules.

Original languageEnglish (US)
Pages (from-to)857-871.e9
JournalMolecular cell
Volume76
Issue number6
DOIs
StatePublished - Dec 19 2019

Keywords

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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