ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli

Mary Kay Lobo, Samir Zaman, Diane M. Damez-Werno, Ja Wook Koo, Rosemary C. Bagot, Jennifer A. DiNieri, Alexandria Nugent, Eric Finkel, Dipesh Chaudhury, Ramesh Chandra, Efrain Riberio, Jacqui Rabkin, Ezekiell Mouzon, Roger Cachope, Joseph F. Cheer, Ming Hu Han, David M. Dietz, David W. Self, Yasmin L. Hurd, Vincent Vialou & 1 others Eric J. Nestler

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree ofΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes.Wemake use of fluorescent reporter BAC transgenic mice to evaluate induction ofΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)- tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli inducesΔFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of ΔFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of ΔFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum.

Original languageEnglish (US)
Pages (from-to)18381-18395
Number of pages15
JournalJournal of Neuroscience
Volume33
Issue number47
DOIs
StatePublished - 2013

Fingerprint

Optogenetics
Corpus Striatum
Nucleus Accumbens
Pharmacology
Neurons
Dopamine Receptors
Street Drugs
Antipsychotic Agents
Opiate Alkaloids
Ventral Tegmental Area
Dronabinol
Fluoxetine
Serotonin Uptake Inhibitors
Haloperidol
Amygdala
Prefrontal Cortex
Reward
Cocaine
Transgenic Mice
Antidepressive Agents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., ... Nestler, E. J. (2013). ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. Journal of Neuroscience, 33(47), 18381-18395. https://doi.org/10.1523/JNEUROSCI.1875-13.2013

ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. / Lobo, Mary Kay; Zaman, Samir; Damez-Werno, Diane M.; Koo, Ja Wook; Bagot, Rosemary C.; DiNieri, Jennifer A.; Nugent, Alexandria; Finkel, Eric; Chaudhury, Dipesh; Chandra, Ramesh; Riberio, Efrain; Rabkin, Jacqui; Mouzon, Ezekiell; Cachope, Roger; Cheer, Joseph F.; Han, Ming Hu; Dietz, David M.; Self, David W.; Hurd, Yasmin L.; Vialou, Vincent; Nestler, Eric J.

In: Journal of Neuroscience, Vol. 33, No. 47, 2013, p. 18381-18395.

Research output: Contribution to journalArticle

Lobo, MK, Zaman, S, Damez-Werno, DM, Koo, JW, Bagot, RC, DiNieri, JA, Nugent, A, Finkel, E, Chaudhury, D, Chandra, R, Riberio, E, Rabkin, J, Mouzon, E, Cachope, R, Cheer, JF, Han, MH, Dietz, DM, Self, DW, Hurd, YL, Vialou, V & Nestler, EJ 2013, 'ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli', Journal of Neuroscience, vol. 33, no. 47, pp. 18381-18395. https://doi.org/10.1523/JNEUROSCI.1875-13.2013
Lobo, Mary Kay ; Zaman, Samir ; Damez-Werno, Diane M. ; Koo, Ja Wook ; Bagot, Rosemary C. ; DiNieri, Jennifer A. ; Nugent, Alexandria ; Finkel, Eric ; Chaudhury, Dipesh ; Chandra, Ramesh ; Riberio, Efrain ; Rabkin, Jacqui ; Mouzon, Ezekiell ; Cachope, Roger ; Cheer, Joseph F. ; Han, Ming Hu ; Dietz, David M. ; Self, David W. ; Hurd, Yasmin L. ; Vialou, Vincent ; Nestler, Eric J. / ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 47. pp. 18381-18395.
@article{9224da08fe244936b8dd1e4c12696fb0,
title = "ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli",
abstract = "The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree ofΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes.Wemake use of fluorescent reporter BAC transgenic mice to evaluate induction ofΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)- tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli inducesΔFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of ΔFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of ΔFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum.",
author = "Lobo, {Mary Kay} and Samir Zaman and Damez-Werno, {Diane M.} and Koo, {Ja Wook} and Bagot, {Rosemary C.} and DiNieri, {Jennifer A.} and Alexandria Nugent and Eric Finkel and Dipesh Chaudhury and Ramesh Chandra and Efrain Riberio and Jacqui Rabkin and Ezekiell Mouzon and Roger Cachope and Cheer, {Joseph F.} and Han, {Ming Hu} and Dietz, {David M.} and Self, {David W.} and Hurd, {Yasmin L.} and Vincent Vialou and Nestler, {Eric J.}",
year = "2013",
doi = "10.1523/JNEUROSCI.1875-13.2013",
language = "English (US)",
volume = "33",
pages = "18381--18395",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "47",

}

TY - JOUR

T1 - ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli

AU - Lobo, Mary Kay

AU - Zaman, Samir

AU - Damez-Werno, Diane M.

AU - Koo, Ja Wook

AU - Bagot, Rosemary C.

AU - DiNieri, Jennifer A.

AU - Nugent, Alexandria

AU - Finkel, Eric

AU - Chaudhury, Dipesh

AU - Chandra, Ramesh

AU - Riberio, Efrain

AU - Rabkin, Jacqui

AU - Mouzon, Ezekiell

AU - Cachope, Roger

AU - Cheer, Joseph F.

AU - Han, Ming Hu

AU - Dietz, David M.

AU - Self, David W.

AU - Hurd, Yasmin L.

AU - Vialou, Vincent

AU - Nestler, Eric J.

PY - 2013

Y1 - 2013

N2 - The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree ofΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes.Wemake use of fluorescent reporter BAC transgenic mice to evaluate induction ofΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)- tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli inducesΔFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of ΔFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of ΔFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum.

AB - The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree ofΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes.Wemake use of fluorescent reporter BAC transgenic mice to evaluate induction ofΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)- tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli inducesΔFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of ΔFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of ΔFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum.

UR - http://www.scopus.com/inward/record.url?scp=84887839161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887839161&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.1875-13.2013

DO - 10.1523/JNEUROSCI.1875-13.2013

M3 - Article

VL - 33

SP - 18381

EP - 18395

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 47

ER -