11,12-Epoxyeicosatrienoic acid (11,12-EET): Structural determinants for inhibition of TNF-α-induced VCAM-1 expression

J R Falck, L. Manmohan Reddy, Y. Krishna Reddy, Muralidhar Bondlela, U. Murali Krishna, Yu Ji, Jianxin Sun, James K. Liao

Research output: Contribution to journalArticle

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Abstract

A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-α-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET.

Original languageEnglish (US)
Pages (from-to)4011-4014
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number22
DOIs
Publication statusPublished - Nov 17 2003

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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