119 Assessment of Health-Related Quality of Life and Health Status in Patients with Treatment-resistant Depression

Carol Jamieson, Vanina Popova, Ella Daly, Kimberly Cooper, Madhukar H. Trivedi, Wayne Drevets, Jaskaran Singh

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To assess health-related quality of life (HRQoL) and health status of patients with treatment resistant depression (TRD), treated with esketamine nasal spray+oral antidepressant (ESK+AD) vs oral antidepressant+placebo nasal spray (AD+PBO) using European Quality of Life Group-5-Dimension-5-Level (EQ-5D-5L). The EQ-5D-5L descriptive system consists of five domains relevant for patients with depression (mobility, self-care, usual activities, pain, anxiety/depression) and the EQ-Visual Analogue Scale (EQ-VAS). METHODS: Data from TRANSFORM-2 (NCT02418585), a randomized, double-blind short-term study were analyzed. Patients (18-64 years inclusive) with TRD were included. Patient reported health status change using EQ-5D-5L and EQ-VAS was measured from baseline to end of 4-week induction phase (endpoint). Each domain of EQ-5D-5L included 5 levels of perceived problems (L1: no problems; L5: extreme problems). RESULTS: Full analysis set included 223 patients (ESK+AD: 114; AD+PBO: 109). At endpoint, mean (SD) change in health status index was 0.288 (0.2317) for ESK+AD group and 0.231 (0.2506) for AD+PBO group with higher score reflecting higher levels of functioning. At endpoint, percentage of patients reporting problems (grouped L2-L5 responses for each dimension) in ESK+AD vs AD+PBO group: mobility (13.5% vs 25.7%), self-care (16.2% vs 30.5%), usual activities (55.0% vs 71.4%), pain (38.7% vs 52.4%), and anxiety/depression (71.2% vs 78.1%). Mean (SD) change in EQ-VAS score at endpoint was 29.1 (26.32) for ESK+AD and 20.9 (26.60) for AD+PBO group. CONCLUSION: Greater improvement in HRQoL and health status using EQ-5D-5L and EQ-VAS was observed among patients with TRD treated with ESK+AD vs AD+PBO. FUNDING ACKNOWLEDGEMENTS: This study was sponsored by Janssen Research and Development, LLC.

Original languageEnglish (US)
Pages (from-to)277-278
Number of pages2
JournalCNS spectrums
Volume25
Issue number2
DOIs
StatePublished - Apr 1 2020

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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