14-3-3s are potential biomarkers for HIV-related neurodegeneration

Diana Morales, Efthimios C M Skoulakis, Summer F. Acevedo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Over the last decade, it has become evident that 14-3-3 proteins are essential for primary cell functions. These proteins are abundant throughout the body, including the central nervous system and interact with other proteins in both cell cycle and apoptotic pathways. Examination of cerebral spinal fluid in humans suggests that 14-3-3s including 14-3-3ε (YWHAE) are up-regulated in several neurological diseases, and loss or duplication of the YWHAE gene leads to Miller-Dieker syndrome. The goal of this review is to examine the utility of 14-3-3s as a marker of human immune deficiency virus (HIV)-dependent neurodegeneration and also as a tool to track disease progression. To that end, we describe mechanisms implicating 14-3-3s in neurological diseases and summarize evidence of its interactions with HIV accessory and co-receptor proteins.

Original languageEnglish (US)
Pages (from-to)341-353
Number of pages13
JournalJournal of NeuroVirology
Volume18
Issue number5
DOIs
StatePublished - Oct 2012

Fingerprint

Biomarkers
Viruses
Classical Lissencephalies and Subcortical Band Heterotopias
14-3-3 Proteins
Proteins
Gene Duplication
Disease Progression
Cell Cycle
Central Nervous System

Keywords

  • 14-3-3
  • Gp120
  • GPR15
  • Hepatitis C virus
  • HIV accessory proteins
  • Nef
  • Neurocognition
  • Vpr
  • Vpu

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

14-3-3s are potential biomarkers for HIV-related neurodegeneration. / Morales, Diana; Skoulakis, Efthimios C M; Acevedo, Summer F.

In: Journal of NeuroVirology, Vol. 18, No. 5, 10.2012, p. 341-353.

Research output: Contribution to journalArticle

Morales, Diana ; Skoulakis, Efthimios C M ; Acevedo, Summer F. / 14-3-3s are potential biomarkers for HIV-related neurodegeneration. In: Journal of NeuroVirology. 2012 ; Vol. 18, No. 5. pp. 341-353.
@article{f85383360948457fb35d53282b40a334,
title = "14-3-3s are potential biomarkers for HIV-related neurodegeneration",
abstract = "Over the last decade, it has become evident that 14-3-3 proteins are essential for primary cell functions. These proteins are abundant throughout the body, including the central nervous system and interact with other proteins in both cell cycle and apoptotic pathways. Examination of cerebral spinal fluid in humans suggests that 14-3-3s including 14-3-3ε (YWHAE) are up-regulated in several neurological diseases, and loss or duplication of the YWHAE gene leads to Miller-Dieker syndrome. The goal of this review is to examine the utility of 14-3-3s as a marker of human immune deficiency virus (HIV)-dependent neurodegeneration and also as a tool to track disease progression. To that end, we describe mechanisms implicating 14-3-3s in neurological diseases and summarize evidence of its interactions with HIV accessory and co-receptor proteins.",
keywords = "14-3-3, Gp120, GPR15, Hepatitis C virus, HIV accessory proteins, Nef, Neurocognition, Vpr, Vpu",
author = "Diana Morales and Skoulakis, {Efthimios C M} and Acevedo, {Summer F.}",
year = "2012",
month = "10",
doi = "10.1007/s13365-012-0121-2",
language = "English (US)",
volume = "18",
pages = "341--353",
journal = "Journal of NeuroVirology",
issn = "1355-0284",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - 14-3-3s are potential biomarkers for HIV-related neurodegeneration

AU - Morales, Diana

AU - Skoulakis, Efthimios C M

AU - Acevedo, Summer F.

PY - 2012/10

Y1 - 2012/10

N2 - Over the last decade, it has become evident that 14-3-3 proteins are essential for primary cell functions. These proteins are abundant throughout the body, including the central nervous system and interact with other proteins in both cell cycle and apoptotic pathways. Examination of cerebral spinal fluid in humans suggests that 14-3-3s including 14-3-3ε (YWHAE) are up-regulated in several neurological diseases, and loss or duplication of the YWHAE gene leads to Miller-Dieker syndrome. The goal of this review is to examine the utility of 14-3-3s as a marker of human immune deficiency virus (HIV)-dependent neurodegeneration and also as a tool to track disease progression. To that end, we describe mechanisms implicating 14-3-3s in neurological diseases and summarize evidence of its interactions with HIV accessory and co-receptor proteins.

AB - Over the last decade, it has become evident that 14-3-3 proteins are essential for primary cell functions. These proteins are abundant throughout the body, including the central nervous system and interact with other proteins in both cell cycle and apoptotic pathways. Examination of cerebral spinal fluid in humans suggests that 14-3-3s including 14-3-3ε (YWHAE) are up-regulated in several neurological diseases, and loss or duplication of the YWHAE gene leads to Miller-Dieker syndrome. The goal of this review is to examine the utility of 14-3-3s as a marker of human immune deficiency virus (HIV)-dependent neurodegeneration and also as a tool to track disease progression. To that end, we describe mechanisms implicating 14-3-3s in neurological diseases and summarize evidence of its interactions with HIV accessory and co-receptor proteins.

KW - 14-3-3

KW - Gp120

KW - GPR15

KW - Hepatitis C virus

KW - HIV accessory proteins

KW - Nef

KW - Neurocognition

KW - Vpr

KW - Vpu

UR - http://www.scopus.com/inward/record.url?scp=84867301434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867301434&partnerID=8YFLogxK

U2 - 10.1007/s13365-012-0121-2

DO - 10.1007/s13365-012-0121-2

M3 - Article

VL - 18

SP - 341

EP - 353

JO - Journal of NeuroVirology

JF - Journal of NeuroVirology

SN - 1355-0284

IS - 5

ER -